公开(公告)号：WO2022243281A1

公开(公告)日：2022-11-24

申请号：PCT/EP2022/063262

申请日：2022-05-17

Applicant: TECHNISCHE UNIVERSITÄT MÜNCHEN

Inventor： BUCHER, Dominik ,  ALLERT, Robin Derek ,  DEEG, Andreas

IPC: B01L3/00 ,  G01N15/14 ,  G01N21/64 ,  G01N21/17 ,  G01N21/25 ,  G01N15/10

Abstract: Disclosed herein is a method for parallelized probing of a plurality of samples, a sensor chip for parallelized probing of a plurality of samples, a sensing device for parallelized probing of a plurality of samples, and a measurement system for parallelized probing of a plurality of samples. The method comprises providing a sensor chip, the sensor chip comprising a sensing layer arranged in or on a substrate and a measurement volume adjacent to the sensing layer. The sensing layer comprises a plurality of sensing elements, each of which is configured to generate a sensor signal characterizing a physical observable in the vicinity of the respective sensing element. A carrier fluid comprising a plurality of sample objects is provided to the measurement volume, wherein each of the sample objects comprises or forms a respective sample. A number of sample objects in the measurement volume is controlled such that the sample objects form a self-organized structure in the measurement volume. The self-organized structure is a structure in which the arrangement of the sample objects is at least in part defined by interactions between the sample objects themselves. A measurement is performed on one or more of the samples while the sample objects are arranged in the self-organized structure, wherein a measurement on a sample is performed using one or more sensing elements arranged adjacent to the respective sample object in the self-organized structure.

公开(公告)号：WO2022242931A1

公开(公告)日：2022-11-24

申请号：PCT/EP2022/057426

申请日：2022-03-22

Applicant: ROBERT BOSCH GMBH

Inventor： MAUCHER, Tanja ,  GRUMAZ, Christian ,  BUDDE, Martina

IPC: C12N15/10 ,  B01L3/00 ,  C12Q1/68

Abstract: Die Erfindung betrifft ein Verfahren (500) zur Aufreinigung von Nukleinsäuren, insbesondere in einer mikrofluidischen Vorrichtung (100), umfassend ein Freisetzen (501) von Nukleinsäuren aus einer Probe durch chaotrope Substanzen in einem Transportmedium (10) und ein Binden (502) der Nukleinsäuren an einen Filter (141), wobei das Transportmedium (10) mit einem ersten Teil (21) eines Waschpuffers (20) zur Einstellung von Bindebedingungen vermischt wird. Ferner betrifft die Erfindung ein Mikrofluidisches Kit (200) zur Durchführung des Verfahrens (500).

公开(公告)号：WO2022240193A1

公开(公告)日：2022-11-17

申请号：PCT/KR2022/006749

申请日：2022-05-11

Applicant: (주)인벤티지랩

Inventor： 한의돈 ,  이상훈 ,  전찬희 ,  김동훈 ,  김주희

IPC: B01L3/00 ,  B01F33/30 ,  B01F33/301 ,  B01F25/00 ,  B01F23/80

Abstract: 지질 나노 입자 제조용 칩은 mRNA를 포함하는 제1 원료와 지질(lipid)를 포함하는 제2 원료를 혼합하여 혼합액을 형성하는 믹서부, 상기 믹서부와 연결되고, 희석액을 이용하여 상기 혼합액을 희석하는 희석부, 및 상기 희석부에 연결되고, 희석된 혼합액으로부터 지질 나노 입자(Lipid Nanoparticles; LNP)를 농축하여 농축액을 수득하는 농축부를 포함한다.

公开(公告)号：WO2022235673A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/027476

申请日：2022-05-03

Applicant: CO-DIAGNOSTICS, INC

Inventor： ABBOTT, Richard, David ,  NIELSEN, David ,  JONES, Connor ,  PORITZ, Mark, Aaron ,  RIRIE, Kirk, M. ,  THURSTON, Christopher, M. ,  DAVID, Derek ,  SANDSTROM, Craig

IPC: B01L3/00 ,  C12Q1/686

Abstract: Systems, apparatus, and methods for conducting amplification-based analyses, including PCR testing. In one illustrative embodiment, a system may include a testing container assembly and a testing unit. The testing container assembly may include a sample collection port, a sample preparation chamber, and a reaction chamber. The sample collection port may include a bottom opening sealed by a plug member. In use, the testing container assembly may be placed in a seat of the testing unit with a sample in the sample collection port, closed by a lid. A plunger may dislodge the plug member and the sample drawn into the sample preparation chamber. Once sample preparation is complete, a channel may be opened, and the prepared sample flows into the reaction chamber which is then sealed. Testing including amplification reactions, may then be performed, followed by detection, as by detecting fluorescent emissions in the reaction chamber.

公开(公告)号：WO2022235612A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/027385

申请日：2022-05-03

Applicant: RESTEK CORPORATION

Inventor： STEVENS, Shane C. ,  MICKLITSCH, Ryan D. ,  GOMEZ-RIOS, German A. ,  PETERS, Tracey A. ,  KANE, Thomas E.

IPC: H01J49/16 ,  B01L3/00 ,  B01L9/00 ,  B05B5/025

Abstract: A Taylor cone emitter device repository is disclosed including a repository plate, a repository wall extending therefrom, and an array of orifices and an array of clocking feature interfaces disposed therein. The array of orifices receives and retains an array of Taylor cone emitter devices. The array of clocking feature interfaces guide clocking features of the array of Taylor cone emitter devices into predetermined radial orientations. The repository wall peripherally surrounds a substrate chamber configured to receive a microtiter array tray with the array of solid phase microextractiosn devices each disposed within a separate well of the microtiter array tray. A Taylor cone emitter device repository system is disclosed including the microtiter array tray, the array of Taylor cone emitter devices, and the Taylor cone emitter device repository system. A method for analyzing a population of samples with the Taylor cone emitter device repository system is disclosed.

公开(公告)号：WO2022233783A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/061706

申请日：2022-05-02

Applicant: IMEC VZW

Inventor： VLEUGELS, Wouter ,  VANDEVELDE, Bart ,  EMMEN, Erik

IPC: B01L7/00

Abstract: A temperature controller (100) for controlling a sample temperature comprises: a heater block (112) and a cooler block (122; 222), the heater block (112) being between the cooler block (122; 222) and the sample (102); wherein the temperature controller (100) controls switching of sample 5temperature between a first, high and a second, low sample temperature; wherein the temperature controller (100) provides heat by the heater block (112) and transports fluid of a first, high fluid temperature through at least one cooler block conduit (124; 224a, 224b) for bringing the sample to the first sample temperature; and wherein the temperature controller (100) provides10cooling by the cooler block (122; 222) by transporting fluid of a second, low fluid temperature through the at least one cooler block conduit (124; 224a, 224b) for bringing the sample to the second sample temperature, wherein the second fluid temperature is lower than the second sample temperature.15Figure for publication:

公开(公告)号：WO2022233765A1

公开(公告)日：2022-11-10

申请号：PCT/EP2022/061662

申请日：2022-05-02

Applicant: PAUL SCHERRER INSTITUT

Inventor： MORTELMANS, Thomas ,  EKINCI, Yasin ,  LI, Dr. Xiaodan

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/569

Abstract: The planetary outbreak of COVID-19 has led to a substantial death toll and has hindered the functioning of modern society, despite countermeasures of previously unimaginable magnitude. This underlines the importance of accurate, cost-effective serological antibody tests as well as point-of-care diagnostics to monitor the viral spread and to contain pandemics and endemics. Here, the present invention discloses a cost-effective three- dimensional (3D) nanofluidic device for rapid and multiplexed detection of viral antibodies. The device is designed to size- dependently immobilize particles at predefined positions from a multiparticle mixture, giving rise to distinct trapping lines. It is shown with the device that distinctive lines can be used as an on-chip and on-bead fluorescent linked immunosorbent assay for the detection of immunoglobulin G (IgG) antibodies against the receptor-binding domain of SARS- CoV-2 in human serum. Device versatility is exhibited by on-20 bead color multiplexing for simultaneous detection of IgG and IgM in convalescent human serum and by concurrent detection of anti-spike (SARS-CoV-2) and anti-hemagglutinin (Influenza A) antibodies. This device can be further extended to detect a plethora of diseases simultaneously or to distinguish different mutations.

公开(公告)号：WO2022232519A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026949

申请日：2022-04-29

Applicant: INVITAE CORPORATION

Inventor： FUSARO, Vincent, Alfred ,  GUCKENBERGER, David, John Jr. ,  WHITTAKER, Johnathan, Carl Hoar

IPC: B01L9/00 ,  B01L3/00 ,  B01L9/06 ,  A61B5/15 ,  A61B5/154 ,  A61B10/00

Abstract: An accessioning system is configured to retrieve sample vials from a container. An assembly system is configured to assemble a container containing a sample vial. The container includes a base and a cap, where the cap may have a larger longitudinal length than the base. The longitudinal length of the cap may form a majority of an overall length of the container. The container may include a watertight seal. The container may also include a hydrochromic indicator configured to indicate the present or past presence of a liquid, solution, or other substance inside an internal volume of the container.

公开(公告)号：WO2022231665A1

公开(公告)日：2022-11-03

申请号：PCT/US2021/071151

申请日：2021-08-10

Applicant: MICRO LAB SOLUTIONS, LLC

Inventor： EL-HOSSEINY, Ryan

IPC: B01L9/06 ,  A61B5/15

Abstract: A blood collection tube funnel (10), comprising a funnel having a spout (12), a stand (30, 32) fixedly secured to the funnel and the spout, and a base (20) secured to a distal end of the stand (30b, 32b). The stand further includes a transverse support member (33; 34, 36) having a gripping means (70; 80; 61; 92) arranged to removably secure a blood collection tube (202) thereon. A method of using the blood collection tube funnel is also provided.

公开(公告)号：WO2022227853A1

公开(公告)日：2022-11-03

申请号：PCT/CN2022/078956

申请日：2022-03-03

Applicant: 京东方科技集团股份有限公司 ,  北京京东方技术开发有限公司

Inventor： 杨帆 ,  邓林 ,  丁丁

IPC: B01L3/00 ,  C12M1/00

Abstract: 一种微流控芯片、适配该微流控芯片的盒体装置、以及包括该微流控芯片和盒体装置的微流控装置。该微流控芯片（300）包括：容纳第一流体的第一容纳部（301）、容纳第二流体的第二容纳部（302）、输送流道（303）、分选流道（305）及收集部（306）。输送流道（303）的形状被设计为使得第一流体和第二流体在汇合点（304）处汇合。分选流道（305）包括第一分选流道（3051）和第二分选流道（3052）。收集部（306）包括第一收集部（3061）和第二收集部（3062）。