公开(公告)号：WO2003038130A2

公开(公告)日：2003-05-08

申请号：PCT/US2002/034888

申请日：2002-10-31

Applicant: PFIZER PRODUCTS INC. ,  MAX-DELBRUCK-CENTRE FOR MOLECULAR MEDICINE ,  BRISSETTE, William, H. ,  NEOTE, Kuldeep, S. ,  ZAGOURAS, Panayiotis ,  ZENKE, Martin ,  LEMKE, Britt ,  HACKER, Christine

Inventor： BRISSETTE, William, H. ,  NEOTE, Kuldeep, S. ,  ZAGOURAS, Panayiotis ,  ZENKE, Martin ,  LEMKE, Britt ,  HACKER, Christine

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: The present invention provides novel panels of molecular targets that regulate erythropoiesis. The novel panels of the invention may be used, for example, in therapeutic intervention, therapeutic agent screening, and in diagnostic methods for diseases and/or disorders of erythropoiesis.

Abstract translation: 本发明提供调节红细胞生成的分子靶标的新颖小组。 本发明的新颖小组可用于例如治疗干预，治疗剂筛选和用于红细胞生成疾病和/或病症的诊断方法。

公开(公告)号：WO2002072020A3

公开(公告)日：2002-09-19

申请号：PCT/US2002/007426

申请日：2002-03-12

Applicant: CERNO BIOSCIENCES, LLC. ,  ALBERTE, Randall, S. ,  SMITH, Robert, D.

Inventor： ALBERTE, Randall, S. ,  SMITH, Robert, D.

IPC: C07C335/00

Abstract: Compounds which exhibit anti-adhesive properties are described. The compounds may be monomers or polymers. Methods for treating receptor mediated diseases are provided using compounds of the invention. Further methods are provided for crop protection, medical devices and anti-fouling.

公开(公告)号：WO2014043660A3

公开(公告)日：2014-03-20

申请号：PCT/US2013/060029

申请日：2013-09-17

Applicant: BRANDEIS UNIVERSITY

Inventor： RICE, John ,  JIA, Yanwei ,  WANGH, Lawrence J.

IPC: C12Q1/68

Abstract: This invention includes methods for analyzing single-stranded nucleic acid sequences, either RNA sequences or DNA sequences (ssDNA) utilizing dyes that fluoresce when associated with double strands, so-called DNA binding dyes or dsDNA-dyes. Methods according to this invention utilize a dsDNA-dye in combination with one or more hybridization probes that hybridize to a target nucleic acid sequence and that are labeled with a non-fluorescent quencher moiety, for example, a Black Hole quencher.

公开(公告)号：WO2013192294A1

公开(公告)日：2013-12-27

申请号：PCT/US2013/046533

申请日：2013-06-19

Applicant: BOSTON 3T BIOTECHNOLOGIES, INC.

Inventor： YANG, Meijia

IPC: C12N1/00 ,  C12N5/0783 ,  C12N15/09

CPC classification number: C12N1/00 ,  C07K14/70503 ,  C07K2319/33 ,  C12N5/0636 ,  C12N15/09 ,  C12N2510/00

Abstract: Featured herein are engineered human cells, which express an exogenous extracellular binding partner to an apoptotic or necrotic cellular antigen and at least one exogenous intracellular signaling domain. These genetically-engineered cells can function as immune modulators that specifically recognize dying cells or tissues and upon binding, secrete Th1 cytokines including IL-2 and IFN-gamma, thereby achieving a localized pro-inflammatory response at the site of tumor tissues.

Abstract translation: 本文特征是工程化的人细胞，其表达外源细胞外结合配偶体到凋亡或坏死细胞抗原和至少一个外源细胞内信号结构域。 这些遗传工程改造的细胞可以作为特异性识别死亡细胞或组织的免疫调节剂，并在结合时分泌包括IL-2和IFN-γ在内的Th1细胞因子，从而在肿瘤组织部位达到局部促炎反应。

公开(公告)号：WO2012170206A2

公开(公告)日：2012-12-13

申请号：PCT/US2012/039147

申请日：2012-05-23

Applicant: DIAGNOSTIC INNOVATIONS, LLC ,  KOVALENKO, Victor

Inventor： KOVALENKO, Victor

CPC classification number: G01N33/545 ,  C07K17/02 ,  C07K17/08 ,  C08G81/02 ,  C12Q1/28 ,  G01N33/535 ,  G01N33/581 ,  G01N2333/908

Abstract: Provided herein are novel reagents and their use in color-producing detection systems for performing diagnostic tests and analytical assays.

Abstract translation: 本文提供了新颖的试剂及其在色彩生成检测系统中用于进行诊断测试和分析测定的用途。

公开(公告)号：WO2012112299A1

公开(公告)日：2012-08-23

申请号：PCT/US2012/023315

申请日：2012-01-31

Applicant: GET SASSIE, INC. ,  STEVENS ADAMS, Amy ,  SEDIVY, John, R. ,  TEMPLE, Victor, J.

Inventor： STEVENS ADAMS, Amy ,  SEDIVY, John, R. ,  TEMPLE, Victor, J.

IPC: A23G3/28 ,  B65D35/00 ,  B05B11/00 ,  B05C5/04

CPC classification number: A23G3/0097

Abstract: Described herein are edible glues and customized applicators for delivering the same.

Abstract translation: 这里描述的是可食用胶水和用于传送它们的定制涂布器。

公开(公告)号：WO2011109217A2

公开(公告)日：2011-09-09

申请号：PCT/US2011/026049

申请日：2011-02-24

Applicant: IMMUNODIAGNOSTICS, INC. ,  RAINA, Jawahar ,  MASCARENO, Eduardo, Javier

Inventor： RAINA, Jawahar ,  MASCARENO, Eduardo, Javier

CPC classification number: A61K31/444 ,  A61K31/517 ,  A61K31/7088 ,  Y02A50/393 ,  Y02A50/463

Abstract: The present invention is directed to methods of treating or preventing RNA polymerase dependent viral disorders using JAK2 kinase inhibitors or agents that inhibit HEXIM1 tyrosine phosphorylation. In a particular aspect the present invention is directed to the treatment of prevention of HIV infection in a subject by administration of JAK2 kinase inhibitors or agents that inhibit HEXIM1 tyrosine phosphorylation.

Abstract translation: 本发明涉及使用JAK2激酶抑制剂或抑制HEXIM1酪氨酸磷酸化的试剂治疗或预防RNA聚合酶依赖性病毒病症的方法。 在一个特定方面，本发明涉及通过施用JAK2激酶抑制剂或抑制HEXIM1酪氨酸磷酸化的试剂来治疗预防受试者的HIV感染。

公开(公告)号：WO2011025883A2

公开(公告)日：2011-03-03

申请号：PCT/US2010/046814

申请日：2010-08-26

Applicant: IMMUNE DISEASE INSTITUTE ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  CARROLL, Michael, C. ,  MOORE, Francis, D. ,  HECHTMAN, Herbert, B.

Inventor： CARROLL, Michael, C. ,  MOORE, Francis, D. ,  HECHTMAN, Herbert, B.

IPC: C07K16/18 ,  C12N15/13 ,  C12N15/63 ,  A61K39/395 ,  A61P9/10

CPC classification number: C07K16/28 ,  C07K2317/21 ,  C07K2317/565

Abstract: The invention provides natural IgM antibodies that may be used to induce inflammatory diseases or disorders such as ischemia-reperfusion injury to create animal models of such inflammatory diseases or disorders.

Abstract translation: 本发明提供了天然IgM抗体，其可用于诱导炎症性疾病或病症如缺血再灌注损伤，从而产生此类炎性疾病或病症的动物模型。

公开(公告)号：WO2010028037A2

公开(公告)日：2010-03-11

申请号：PCT/US2009/055723

申请日：2009-09-02

Applicant: RYNEL INC. ,  KENNEDY, T., Scott

Inventor： KENNEDY, T., Scott

IPC: A01G9/10 ,  A01G31/00

CPC classification number: A01G24/00

Abstract: Compositions and methods are disclosed that relate to a biopolymer medium for growing plants. In certain embodiments, the biopolymer growth medium comprises or consists essentially of polylactic acid (PLA), polyhydroxyalkanoate (PHA) or a mixture of them. Another aspect of the invention relates to a method of producing a biopolymer growth medium.

Abstract translation: 公开了涉及用于生长植物的生物聚合物培养基的组合物和方法。 在某些实施方案中，生物聚合物生长培养基包含或基本上由聚乳酸（PLA），聚羟基链烷酸酯（PHA）或它们的混合物组成。 本发明的另一方面涉及生产生物聚合物生长培养基的方法。

公开(公告)号：WO2009149181A2

公开(公告)日：2009-12-10

申请号：PCT/US2009/046125

申请日：2009-06-03

Applicant: ORGANOGENESIS, INC. ,  SIMPSON, David, G. ,  BOWLIN, Gary, L. ,  MAHAJAN, Raul ,  AYRES, Chantal ,  BOWMAN, James, R. ,  NEWTOM, Daniel

Inventor： SIMPSON, David, G. ,  BOWLIN, Gary, L. ,  MAHAJAN, Raul ,  AYRES, Chantal ,  BOWMAN, James, R. ,  NEWTOM, Daniel

IPC: A61L27/24 ,  A61L27/50

CPC classification number: A61L27/24 ,  A61L27/50 ,  D01D5/0038

Abstract: The present invention is directed to methods and compositions for manipulating electroprocessed scaffold material properties using cross-linking and fiber tertiary structure. The methods and compositions can be combined with methods and compositions directed to formation and use of electroprocessed materials, such as collagen and fibrin.

Abstract translation: 本发明涉及使用交联和纤维三级结构操作电加工脚手架材料性质的方法和组合物。 方法和组合物可以与针对电处理材料如胶原和纤维蛋白的形成和使用的方法和组合物组合。