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    STYLI USED TO POSITION DEVICE FOR CARRYING OUT SELECTIVE DISCECTOMY
    11.
    发明申请
    STYLI USED TO POSITION DEVICE FOR CARRYING OUT SELECTIVE DISCECTOMY 审中-公开
    STYLI用于定位设备，用于进行选择性切除术

    公开(公告)号：WO2008094439A2

    公开(公告)日：2008-08-07

    申请号：PCT/US2008/000920

    申请日：2008-01-23

    Applicant: LAURIMED LLC ,  SAAL, Jeffrey Alan ,  SAAL, Joel Stuart ,  DUBOIS, Brian R. ,  CHRISTIAN, Jeff

    Inventor： SAAL, Jeffrey Alan ,  SAAL, Joel Stuart ,  DUBOIS, Brian R. ,  CHRISTIAN, Jeff

    CPC classification number: A61B17/3421 ,  A61B17/320783 ,  A61B90/37 ,  A61B2017/00261 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/2905

    Abstract: A set of styli comprised of a shaped memory or elastic metal are disclosed wherein each stylus has a different preformed curvatures for use with a cutting device for performing a selective discectomy. The device is inserted at a point chosen from contralateral, anterior or anterolateral relative to a herniation site. Once the cutting device is inserted its cutting window is moved to the desired position by inserting a first stylus having an appropriate curvature and moving the device, removing the stylus, inserting a second stylus with a different curvature relative to the first stylus before or after moving the device. By using a plurality of styli with different curvatures and using positioning movements the cutting window is positioned at the site of herniation and a selective discectomy is carried out.

    Abstract translation: 公开了一套由形状记忆或弹性金属构成的测针，其中每个触针具有不同的预先形成的曲率，用于与用于执行选择性椎间盘切除术的切割装置一起使用。 该装置插入在从对侧，前部或前外侧相对于疝部位选择的点处。 一旦插入切割装置，通过插入具有适当曲率的第一触针并移动装置，移除触针，在移动之前或之后插入具有相对于第一触针的不同曲率的第二触针，将切割窗口移动到期望位置 装置。 通过使用多个具有不同曲率并使用定位运动的测针，将切割窗口定位在疝的部位并进行选择性椎间盘切除。

    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE
    12.
    发明申请
    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE 审中-公开
    NICOTINE配方，套件及系统及其使用方法

    公开(公告)号：WO2008069970A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/024636

    申请日：2007-11-30

    Applicant: ARADIGM CORPORATION ,  GONDA, Igor

    Inventor： GONDA, Igor

    IPC: A61K31/465 ,  A61K9/127 ,  A61P43/00

    CPC classification number: A61K31/465 ,  A61K9/0058 ,  A61K9/008 ,  A61K9/7023

    Abstract: This invention relates generally to formulations, compositions, aerosols and kits used to provide habitual tobacco users with products, methods and apparatus to reduce and eventually terminate their dependence on nicotine containing products. More specifically, the invention relates to a nicotine-based medicament and dosage forms thereof formulated in such a way as to effectively reduce or eliminate the sensations of craving associated with addictive nicotine use.

    Abstract translation: 本发明一般涉及用于向习惯性烟草使用者提供产品，方法和装置以减少并最终终止其对含尼古丁产品的依赖性的制剂，组合物，气溶胶和试剂盒。 更具体地说，本发明涉及一种基于尼古丁的药物及其剂型，以有效地减少或消除与上瘾的尼古丁使用相关的渴望的感觉。

    METHOD AND SYSTEM FOR DELIVERY OF NEUROTOXINS
    14.
    发明申请
    METHOD AND SYSTEM FOR DELIVERY OF NEUROTOXINS 审中-公开
    神经毒素递送方法和系统

    公开(公告)号：WO2007098057A2

    公开(公告)日：2007-08-30

    申请号：PCT/US2007/004201

    申请日：2007-02-16

    Applicant: ZOGENIX, INC. ,  CIPOLLA, David

    Inventor： CIPOLLA, David

    IPC: A61M5/46

    CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61M2037/0046

    Abstract: A method and system for delivering a neurotoxin into the body of a subject is disclosed. The method includes sequentially applying one or more arrays of micro needles on a portion of the skin of the subject that requires treatment. The micro needles are pre-coated with the neurotoxin. The sequential application of the one or more arrays of micro needles on the portion of the skin of the subject results in delivery of the neurotoxin into the subject.

    Abstract translation: 公开了一种将神经毒素递送到受试者体内的方法和系统。 该方法包括在需要治疗的受试者皮肤的一部分上依次施加一个或多个微针阵列。 微针预先涂有神经毒素。 将一个或多个微针阵列顺序施用在受试者的皮肤部分上导致神经毒素递送到受试者中。

    REGULATION OF MINERAL AND SKELETAL METABOLISM
    15.
    发明申请
    REGULATION OF MINERAL AND SKELETAL METABOLISM 审中-公开
    矿物和骨骼代谢调控

    公开(公告)号：WO2007027510A2

    公开(公告)日：2007-03-08

    申请号：PCT/US2006/033133

    申请日：2006-08-23

    Applicant: ACOLOGIX, INC. ,  HABERBERGER, Thomas ,  ROSEN, David ,  KUMAGAI, Yoshinari

    Inventor： HABERBERGER, Thomas ,  ROSEN, David ,  KUMAGAI, Yoshinari

    IPC: A61K38/22

    CPC classification number: A61K38/1703 ,  Y02A50/473

    Abstract: A method is disclosed whereby levels of calcium, phosphate and parathyroid hormone are measured in a patient. The patient is treated with a formulation comprising a compound having phosphotonin activity and thereafter measurements are made again. Dosing of the formulation is adjusted based on measurements with measuring, administering and adjusting dosing continually repeated as needed.

    Abstract translation: 公开了一种在患者体内测量钙，磷酸盐和甲状旁腺激素水平的方法。 用包含具有磷酸肌醇蛋白活性的化合物的制剂治疗患者，然后再次进行测量。 基于测量，根据需要，连续重复测量，施用和调整剂量来调节配方的剂量。

    PROTEIN FORMULATION FOR PROMOTING HARD TISSUE FORMATION
    16.
    发明申请
    PROTEIN FORMULATION FOR PROMOTING HARD TISSUE FORMATION 审中-公开
    用于促进硬组织形成的蛋白质制剂

    公开(公告)号：WO2007011610A2

    公开(公告)日：2007-01-25

    申请号：PCT/US2006/027075

    申请日：2006-07-12

    Applicant: ACOLOGIX, INC. ,  LAZAROV, Mirella ,  MIDDLETON-HARDIE, Catherine ,  ROSEN, David

    Inventor： LAZAROV, Mirella ,  MIDDLETON-HARDIE, Catherine ,  ROSEN, David

    IPC: A61K38/48

    CPC classification number: A61K38/1709 ,  A61K38/1875 ,  A61K2300/00

    Abstract: Formulations and kits used to promote biological processes to form or regenerate new hard tissues such as bones, cartilage, and/or dental tissues are disclosed. The formulation comprises a carrier and two or more proteins and enhances biological activities of a hard tissue growth and differentiation factor characterized by specific and selective upregulation and/or extension of the retention time of the intracellular enzymes and signaling molecules that play important roles to proliferate, differentiate, maturate, and/or mineralize the hard tissue forming cells.

    Abstract translation: 公开了用于促进生物过程以形成或再生新的硬组织如骨，软骨和/或牙科组织的制剂和试剂盒。 该制剂包含载体和两种或更多种蛋白质，并增强硬组织生长和分化因子的生物学活性，其特征在于细胞内酶和信号分子的保留时间的特异性和选择性上调和/或延长，所述细胞内酶和信号分子起着重要作用以增殖， 分化，成熟和/或矿化硬组织形成细胞。

    ORAL FORMULATION OF CREATINE DERIVATIVES AND METHOD OF MANUFACTURING SAME
    18.
    发明申请
    ORAL FORMULATION OF CREATINE DERIVATIVES AND METHOD OF MANUFACTURING SAME 审中-公开
    制备衍生物的口服制剂及其制备方法

    公开(公告)号：WO2006034358A1

    公开(公告)日：2006-03-30

    申请号：PCT/US2005/033857

    申请日：2005-09-20

    Applicant: MEDICAL RESEARCH INSTITUTE ,  BYRD, Edward, A.

    Inventor： BYRD, Edward, A.

    IPC: A61K9/22

    CPC classification number: A61K9/1611 ,  A61K9/1635 ,  A61K9/1652 ,  A61K31/22 ,  A61K45/06 ,  A61K2300/00

    Abstract: Oral formulation of creatine derivative and in particular creatine esters and more particularly ethyl esters of creatine are described. The formulations comprise a phosphate such as dicalcium phosphate, a biodegradable polymer such as a polyvinyl pyrrolidine and a starch. The formulation may further comprise other excipients such as metal salt of a stearate, e.g. magnesium stearates. The formulation is produced as flowable particles with a sieve size of about 20 to 60 which particles are coated with a shellac to mask taste, avoid moisture uptake, and extend shelf life.

    Abstract translation: 描述了肌酸衍生物，特别是肌酸酯，更特别是肌酸乙酯的口服制剂。 制剂包括磷酸盐如磷酸二钙，可生物降解的聚合物如聚乙烯吡咯烷和淀粉。 制剂还可以包含其它赋形剂，例如硬脂酸盐的金属盐，例如 硬脂酸镁 该制剂是以约20至60的筛子尺寸的可流动颗粒生产的，该颗粒用虫胶涂覆以掩盖味道，避免水分吸收并延长保质期。

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