公开(公告)号：WO0196388A3

公开(公告)日：2002-10-03

申请号：PCT/US0118557

申请日：2001-06-08

Applicant: CORIXA CORP ,  JIANG YUQIU ,  HARLOCKER SUSAN L ,  SECRIST HEATHER

Inventor： JIANG YUQIU ,  HARLOCKER SUSAN L ,  SECRIST HEATHER

IPC: G01N33/53 ,  A61K31/7088 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K39/39 ,  A61K48/00 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/47 ,  C07K16/30 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/574 ,  C07K14/82 ,  C12N15/12 ,  C12N15/62

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如结肠癌。 组合物可以包含一种或多种结肠肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达结肠肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如结肠癌的疾病。 还提供了在样品中检测结肠肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：WO0170976A3

公开(公告)日：2002-10-03

申请号：PCT/US0109062

申请日：2001-03-20

Applicant: CORIXA CORP ,  XU JIANGCHUN ,  PYLE RUTH A ,  STOLK JOHN A

Inventor： XU JIANGCHUN ,  PYLE RUTH A ,  STOLK JOHN A

IPC: C07K14/47 ,  C12N15/12 ,  C12Q1/68 ,  A61K39/00 ,  A61K39/395 ,  C07K16/18 ,  C12N15/62 ,  G01N33/53

CPC classification number: C07K14/4748 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as ovarian or endometrial cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses such an antigen, or a T cell that is specific for cells expressing such an antigen. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian and endometrial cancer. Diagnostic methods based on detecting an ovarian carcinoma protein, or mRNA encoding such an antigen, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢或子宫内膜癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达这种抗原的抗原呈递细胞，或对表达这种抗原的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如卵巢和子宫内膜癌之类的疾病。 还提供了基于检测样品中卵巢癌蛋白或编码这种抗原的mRNA的诊断方法。

公开(公告)号：WO0181379A3

公开(公告)日：2002-09-19

申请号：PCT/US0113081

申请日：2001-04-23

Applicant: CORIXA CORP ,  BHATIA AJAY ,  PROBST PETER ,  STROMBERG ERIKA JEAN

Inventor： BHATIA AJAY ,  PROBST PETER ,  STROMBERG ERIKA JEAN

IPC: A61K39/00 ,  C07K14/295 ,  C12N1/21 ,  C12N15/31 ,  A61K39/118 ,  A61K39/40 ,  A61K48/00 ,  C07K16/12 ,  C07K19/00 ,  C12N5/06 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/571 ,  G01N33/68

CPC classification number: C07K14/295 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

Abstract translation: 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：WO0212476A3

公开(公告)日：2002-09-12

申请号：PCT/US0124110

申请日：2001-07-31

Applicant: CORIXA CORP ,  PYLE RUTH A ,  XU JIANGCHUN

Inventor： PYLE RUTH A ,  XU JIANGCHUN

IPC: A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  A61K35/26 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  C07K16/18 ,  C12N5/08 ,  C12N5/10 ,  C12N15/62 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as pancreatic cancer, are disclosed. Compositions may comprise one or more pancreatic tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a pancreatic tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as pancreatic cancer. Diagnostic methods based on detecting a pancreatic tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 披露了用于治疗和诊断癌症的组合物和方法，例如胰腺癌。 组合物可以包含一种或多种胰腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可包含表达胰腺肿瘤蛋白的抗原呈递细胞或对表达此类蛋白的细胞特异的T细胞。 例如，这种组合物可用于预防和治疗诸如胰腺癌等疾病。 还提供了基于检测样品中的胰腺肿瘤蛋白质或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：WO0195945A3

公开(公告)日：2002-08-15

申请号：PCT/US0118903

申请日：2001-06-11

Applicant: CORIXA CORP

Inventor： NIEDER MATTHEW H ,  DUBOIS VINCENT ,  GANGWAR SANJEEV ,  LOBL THOMAS J ,  PICKFORD LESLEY B ,  TROUET ANDRE ,  YARRANTON GEOFFREY T

IPC: A61K31/704 ,  A61K47/48 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P43/00

CPC classification number: A61K47/65

Abstract: The prodrug of the invention is a modified form of a therapeutic agent and comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the enzyme Thimet oligopeptidase, or TOP. Also disclosed are methods of designing prodrugs by utilizing TOP-cleavage sequences within the conjugate and methods of treating patients with prodrugs of the invention.

Abstract translation: 本发明的前药是治疗剂的修饰形式，并且包含治疗剂，寡肽，稳定基团和任选的连接基团。 前药可通过Thimet寡肽酶或TOP切割。 还公开了通过利用缀合物内的TOP-切割序列设计前药的方法和用本发明的前药治疗患者的方法。

公开(公告)号：WO02060317A2

公开(公告)日：2002-08-08

申请号：PCT/US0202781

申请日：2002-01-30

Applicant: CORIXA CORP ,  BENSON DARIN R ,  KALOS MICHAEL D ,  LODES MICHAEL J ,  PERSING DAVID H ,  HEPLER WILLIAM T ,  JIANG YUQIU

Inventor： BENSON DARIN R ,  KALOS MICHAEL D ,  LODES MICHAEL J ,  PERSING DAVID H ,  HEPLER WILLIAM T ,  JIANG YUQIU

IPC: A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  A61B

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly pancreatic cancer, are disclosed. Illustrative compositions comprise one or more pancreatic tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly pancreatic cancer.

Abstract translation: 披露了用于治疗和诊断癌症，特别是胰腺癌的组合物和方法。 说明性组合物包含一种或多种胰腺肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞和对表达此类多肽的细胞具有特异性的T细胞。 所公开的组合物可用于例如诊断，预防和/或治疗疾病，特别是胰腺癌。

公开(公告)号：WO0125273A3

公开(公告)日：2002-07-11

申请号：PCT/US0027465

申请日：2000-10-04

Applicant: CORIXA CORP ,  SKEIKY YASIR A W ,  XU JIANGCHUN ,  CHEEVER MARTIN A ,  REED STEVEN G

Inventor： SKEIKY YASIR A W ,  XU JIANGCHUN ,  CHEEVER MARTIN A ,  REED STEVEN G

IPC: A61K38/00 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  A61K38/17 ,  A61K48/00 ,  C07K16/30 ,  G01N33/50

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00

Abstract: Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.

公开(公告)号：WO0185949A3

公开(公告)日：2002-06-27

申请号：PCT/US0114518

申请日：2001-05-04

Applicant: CORIXA CORP ,  REED STEVEN G ,  LODES MICHAEL J ,  HOUGHTON RAYMOND L ,  MCNEILL PATRICIA D

Inventor： REED STEVEN G ,  LODES MICHAEL J ,  HOUGHTON RAYMOND L ,  MCNEILL PATRICIA D

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/29 ,  C12N15/31 ,  A61K39/02 ,  A61K39/40 ,  A61K48/00 ,  C07K16/12 ,  C07K19/00 ,  C12N15/63 ,  C12Q1/68 ,  G01N33/569 ,  G01N33/68

CPC classification number: C07K14/29 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

Abstract translation: 公开了用于诊断和治疗埃里希氏菌感染的化合物和方法，特别是人粒细胞性脑炎病毒。 提供的化合物包括含有至少一个抗原部分的埃里希菌抗原的多肽和编码这种多肽的DNA序列。 也提供了包含这种多肽或DNA序列的药物组合物和疫苗。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃里希氏杆菌感染。 还提供了针对这种多肽的抗体。

公开(公告)号：WO0177168A3

公开(公告)日：2002-06-13

申请号：PCT/US0111859

申请日：2001-04-11

Applicant: CORIXA CORP ,  LODES MICHAEL J ,  WANG TONGTONG ,  MOHAMATH RAODOH ,  INDIRIAS CAROL YOSEPH

Inventor： LODES MICHAEL J ,  WANG TONGTONG ,  MOHAMATH RAODOH ,  INDIRIAS CAROL YOSEPH

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C12N15/12 ,  A61K31/711 ,  A61K35/14 ,  A61K38/17 ,  A61K39/395 ,  C07K16/30 ,  C12N5/08 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：WO0190129A3

公开(公告)日：2002-06-06

申请号：PCT/US0116327

申请日：2001-05-18

Applicant: CORIXA CORP ,  PERSING DAVID H ,  CRANE RICHARD THOMAS ,  ELLIOT GARY T ,  ULRICH J TERRY ,  LACY MICHAEL J ,  JOHNSON DAVID A ,  BALDRIDGE JORY R ,  WANG RONG

Inventor： PERSING DAVID H ,  CRANE RICHARD THOMAS ,  ELLIOT GARY T ,  ULRICH J TERRY ,  LACY MICHAEL J ,  JOHNSON DAVID A ,  BALDRIDGE JORY R ,  WANG RONG

IPC: C07H15/04 ,  A61K31/7024 ,  A61K47/24 ,  A61P1/02 ,  A61P1/04 ,  A61P1/16 ,  A61P11/00 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P25/28 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P33/02 ,  A61P37/00 ,  A61P37/04 ,  A61P37/08 ,  C07H11/00 ,  C07H13/04 ,  C07H13/06 ,  C07H15/14

CPC classification number: C07H13/04 ,  A61K31/7024 ,  C07H11/00 ,  C07H13/06 ,  C07H15/14

Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.

Abstract translation: 提供了治疗或改善疾病和其他病症如感染性疾病，自身免疫疾病和过敏症的方法和组合物。 该方法使用基于单糖和二糖的化合物来选择性地刺激动物和植物中的免疫应答。