公开(公告)号：WO2008030559A2

公开(公告)日：2008-03-13

申请号：PCT/US2007019529

申请日：2007-09-06

Applicant: CORIXA CORP ,  XU JIANGCHUN ,  KING GORDON E ,  MEAGHER MADELEINE JOY ,  CHENAULT RUTH A ,  SECRIST HEATHER ,  HARLOCKER SUSAN L ,  WANG SIQING

Inventor： XU JIANGCHUN ,  KING GORDON E ,  MEAGHER MADELEINE JOY ,  CHENAULT RUTH A ,  SECRIST HEATHER ,  HARLOCKER SUSAN L ,  WANG SIQING

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158

Abstract: Methods and compositions for the diagnosis and monitoring of colon cancer are disclosed.

Abstract translation: 公开了用于诊断和监测结肠癌的方法和组合物。

公开(公告)号：WO2007120753A3

公开(公告)日：2008-02-21

申请号：PCT/US2007009007

申请日：2007-04-11

Applicant: CORIXA CORP ,  ALGATE PAUL A ,  MANNION JANE ,  GORDON BRIAN

Inventor： ALGATE PAUL A ,  MANNION JANE ,  GORDON BRIAN

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106

Abstract: Methods and compositions for the diagnosis and monitoring of bladder cancer are disclosed.

Abstract translation: 公开了用于诊断和监测膀胱癌的方法和组合物。

公开(公告)号：WO2006104890A3

公开(公告)日：2007-03-29

申请号：PCT/US2006010793

申请日：2006-03-24

Applicant: GLAXOSMITHKLINE BIOLOG SA ,  CORIXA CORP ,  BARTH BRENDA ,  BHATIA AJAY ,  ALDERSON MARK ,  MAISONNEUVE JEAN-FRANCOIS L ,  LOBET YVES ,  NOZAY FLORENCE BERNADETTE ,  MARCHAND MARTINE ,  METTENS PASCAL ,  SKEIKY YASIR A ,  PROBST PETER

Inventor： BARTH BRENDA ,  BHATIA AJAY ,  ALDERSON MARK ,  MAISONNEUVE JEAN-FRANCOIS L ,  LOBET YVES ,  NOZAY FLORENCE BERNADETTE ,  MARCHAND MARTINE ,  METTENS PASCAL ,  SKEIKY YASIR A ,  PROBST PETER

IPC: A61K39/118

CPC classification number: A61K39/118 ,  A61K2039/55572 ,  A61K2039/55577 ,  C07K14/295

Abstract: The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.

Abstract translation: 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。

公开(公告)号：WO2004005308A2

公开(公告)日：2004-01-15

申请号：PCT/US0321504

申请日：2003-07-08

Applicant: CORIXA CORP ,  JOHNSON DAVID A ,  JOHNSON CRAIG L ,  BAZIN-LEE HELENE G ,  SOWELL C GREGORY

Inventor： JOHNSON DAVID A ,  JOHNSON CRAIG L ,  BAZIN-LEE HELENE G ,  SOWELL C GREGORY

IPC: C07H5/02 ,  C07H9/02 ,  C07H11/04 ,  C07H13/04 ,  C07H13/06 ,  C07H15/04

CPC classification number: C07H15/04 ,  C07H5/02 ,  C07H11/04 ,  C07H13/04 ,  Y02P20/55

Abstract: This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are produced by reaction of an O-silyl glycoside with a dihalomethyl alkyl ether.

Abstract translation: 本发明涉及生产烷基氨基葡糖苷磷酸酯化合物的方法，以及涉及各种新型中间体和中间体方法的二糖化合物。 一方面，通过O-甲硅烷基糖苷与二卤代甲基烷基醚的反应来制备糖基卤化物。

公开(公告)号：WO02072792A8

公开(公告)日：2003-08-07

申请号：PCT/US0208223

申请日：2002-03-13

Applicant: CORIXA CORP ,  SKEIKY YASIR ,  BRANNON MARK ,  GUDERIAN JEFFREY

Inventor： SKEIKY YASIR ,  BRANNON MARK ,  GUDERIAN JEFFREY

IPC: A61K39/00 ,  C07K14/35 ,  C07K14/44 ,  C12N1/21 ,  C07H21/04 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74

CPC classification number: C07K14/35 ,  A61K39/00 ,  A61K2039/53 ,  C07K14/44 ,  C07K2319/00

Abstract: The present invention provides a recombinant nucleic acid molecule encoding a fusion polypeptide, wherein the recombinant nucleic acid comprises a heterologous polynucleotide sequence encoding an antigen or an antigenic fragment, and a Leishmania polynucleotide sequence encoding a polypeptide or fragment thereof, wherein the Leishmania polynucleotide is selected from the group consisting of TSA polynucleotide, LeIF polynucleotide, M15 polynucleotide, and 6H polynucleotide. The invention also provides an expression cassette comprising the recombinant nucleic acid molecule, host cells comprising the expression cassette, compositions, fusion polypeptides, and methods of their use in diagnosis or in generating a protective immune response in hosts.

公开(公告)号：WO03005952A3

公开(公告)日：2003-05-30

申请号：PCT/US0221758

申请日：2002-07-10

Applicant: CORIXA CORP

Inventor： JOHNSON MARK E ,  EVANS JAY T ,  KERN JEFFREY A

IPC: A61K9/107 ,  A61K9/00 ,  A61K9/16 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/14 ,  A61K47/18 ,  A61K47/28 ,  A61K47/34 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  C07K17/02 ,  A01N37/18

CPC classification number: A61K9/1647 ,  A61K9/1694 ,  A61K9/5084 ,  A61K9/5153 ,  A61K9/5192 ,  A61K39/0011 ,  A61K39/04 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55572

Abstract: Hydrophobic ion pairing (HIP) is applied to solubilize proteins and/or adjuvants in an organic medium. A polymer is cosolubilized in the medium and microspheres encapsulating the protein and/or adjuvant can be produced by a single emulsion method. Microspheres prepared by this method exhibit low initial burst of the protein and gradual release over time, and elicit a strong and comprehensive immune response. Compositions comprising a protein and an adjuvant co-encapsulated in microspheres are provided.

Abstract translation: 疏水性离子配对（HIP）用于在有机介质中溶解蛋白质和/或佐剂。 聚合物在培养基中共溶解，并且包封蛋白质和/或佐剂的微球体可以通过单一乳液法制备。 通过该方法制备的微球表现出蛋白质的初始爆发和随着时间的推移逐渐释放，并引起强烈和全面的免疫应答。 提供了包含蛋白质和辅助包囊在微球体中的佐剂的组合物。

公开(公告)号：WO0212328A3

公开(公告)日：2003-02-20

申请号：PCT/US0124218

申请日：2001-07-31

Applicant: CORIXA CORP ,  KING GORDON E ,  MEAGHER MADELEINE JOY ,  XU JIANGCHUN ,  SECRIST HEATHER

Inventor： KING GORDON E ,  MEAGHER MADELEINE JOY ,  XU JIANGCHUN ,  SECRIST HEATHER

IPC: A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  A61K38/17 ,  C12Q1/68 ,  G01N33/574

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly colon cancer, are disclosed. Illustrative compositions comprise one or more colon tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly colon cancer.

公开(公告)号：WO0179286A3

公开(公告)日：2003-01-30

申请号：PCT/US0112164

申请日：2001-04-12

Applicant: CORIXA CORP ,  JIANG YUQIU ,  DILLON DAVIN C ,  MITCHAM JENNIFER L ,  XU JIANGCHUN ,  HARLOCKER SUSAN L ,  HEPLER WILLIAM T

Inventor： JIANG YUQIU ,  DILLON DAVIN C ,  MITCHAM JENNIFER L ,  XU JIANGCHUN ,  HARLOCKER SUSAN L ,  HEPLER WILLIAM T

IPC: C12N15/09 ,  A61K35/12 ,  A61K35/14 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  A61P35/00 ,  A61P43/00 ,  C07K7/00 ,  C07K14/47 ,  C07K14/82 ,  C07K16/32 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N9/00 ,  C12Q1/68 ,  A61K38/37 ,  C12N15/62 ,  C12N15/86 ,  G01N33/68

CPC classification number: C07K14/47 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/57 ,  C07K14/4748 ,  C07K2319/00 ,  C12N9/00 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S977/924

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Abstract translation: 公开了用于治疗和诊断癌症的组合物和方法，例如乳腺癌。 组合物可以包含一种或多种乳腺肿瘤蛋白，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达乳腺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和治疗诸如乳腺癌的疾病。 还提供了基于检测样品中的乳腺肿瘤蛋白或编码这种蛋白质的mRNA的诊断方法。

公开(公告)号：WO0196390A3

公开(公告)日：2002-12-27

申请号：PCT/US0118577

申请日：2001-06-08

Applicant: CORIXA CORP ,  JIANG YUQIU ,  HEPLER WILLIAM T ,  CLAPPER JONATHAN D ,  WANG AIJUN ,  SECRIST HEATHER

Inventor： JIANG YUQIU ,  HEPLER WILLIAM T ,  CLAPPER JONATHAN D ,  WANG AIJUN ,  SECRIST HEATHER

IPC: C12N15/09 ,  A61K35/12 ,  A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K14/47 ,  C07K14/705 ,  C07K16/18 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N15/12 ,  C12Q1/68 ,  A61K31/7088 ,  A61K35/14 ,  A61K38/17 ,  A61K39/395 ,  C12N15/62 ,  G01N33/68

CPC classification number: C07K14/70575 ,  A61K38/00

Abstract: Compositions and methods for the therapy and diagnosis of cancer, such as colon cancer, are disclosed. Compositions may comprise one or more colon tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a colon tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as colon cancer. Diagnostic methods based on detecting a colon tumor protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：WO0151633A9

公开(公告)日：2002-10-31

申请号：PCT/US0101574

申请日：2001-01-16

Applicant: CORIXA CORP ,  XU JIANGCHUN ,  DILLON DAVIN C ,  MITCHAM JENNIFER L ,  HARLOCKER SUSAN L ,  JIANG YUQIU ,  REED STEVEN G ,  KALOS MICHAEL D ,  FANGER GARY RICHARD ,  DAY CRAIG H ,  RETTER MARC W ,  STOLK JOHN A ,  SKEIKY YASIR A W ,  WANG AIJUN ,  MEAGHER MADELEINE JOY

Inventor： XU JIANGCHUN ,  DILLON DAVIN C ,  MITCHAM JENNIFER L ,  HARLOCKER SUSAN L ,  JIANG YUQIU ,  REED STEVEN G ,  KALOS MICHAEL D ,  FANGER GARY RICHARD ,  DAY CRAIG H ,  RETTER MARC W ,  STOLK JOHN A ,  SKEIKY YASIR A W ,  WANG AIJUN ,  MEAGHER MADELEINE JOY

IPC: G01N33/574 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  A61P37/04 ,  C07K14/11 ,  C07K14/47 ,  C07K16/18 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N9/64 ,  C12N15/09 ,  C12N15/12 ,  C12Q1/02 ,  C12Q1/68 ,  A61K38/17 ,  A61K48/00 ,  C12N15/11 ,  G01N33/68

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

Abstract translation: 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。