公开(公告)号：WO2009009564A1

公开(公告)日：2009-01-15

申请号：PCT/US2008/069475

申请日：2008-07-09

Applicant: SUN MICROSYSTEMS, INC. ,  SUN MICROSYSTEMS TECHNOLOGY LTD. ,  BHATIA, Ajay

Inventor： BHATIA, Ajay

IPC: G11C11/419

CPC classification number: G11C11/417 ,  G11C11/412 ,  G11C11/419

Abstract: Static random access memory (SRAM) cells and methods of operation are provided which may be used to provide improved writeability and stability to support low voltage operation of memory devices. For example, in one implementation, by temporarily interrupting the connection between portions of an SRAM cell (125,145) and a power source (105) such as a reference voltage or current source, the writeability of SRAM cells can be improved. Additional read port implementations are also provided to facilitate low voltage operation. In another implementation, a power switch circuit (101) responsive to a word line (190) and logic signals (102,103) may be used to provide such interruptions.

Abstract translation: 提供了静态随机存取存储器（SRAM）单元和操作方法，其可用于提供改进的可写性和稳定性以支持存储器件的低电压操作。 例如，在一个实现中，通过暂时中断SRAM单元（125,145）的部分与诸如参考电压或电流源的电源（105）之间的连接，可以提高SRAM单元的可写性。 还提供附加的读端口实现以便于低电压操作。 在另一实现中，可以使用响应于字线（190）的电源开关电路（101）和逻辑信号（102,103）来提供这种中断。

公开(公告)号：WO0181581A9

公开(公告)日：2003-01-03

申请号：PCT/US0112865

申请日：2001-04-20

Applicant: CORIXA CORP ,  SKEIKY YASIR A W ,  PERSING DAVID H ,  MITCHAM JENNIFER L ,  WANG SIQING STEVEN ,  BHATIA AJAY ,  L MAISONNEUVE JEAN-FRANCOIS ,  ZHANG YANNI ,  JEN SHYIAN ,  CARTER DARRICK

Inventor： SKEIKY YASIR A W ,  PERSING DAVID H ,  MITCHAM JENNIFER L ,  WANG SIQING STEVEN ,  BHATIA AJAY ,  L MAISONNEUVE JEAN-FRANCOIS ,  ZHANG YANNI ,  JEN SHYIAN ,  CARTER DARRICK

IPC: G01N33/53 ,  A61K39/00 ,  A61K39/07 ,  A61K39/39 ,  A61K48/00 ,  A61P17/02 ,  A61P29/00 ,  C07K14/195 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/68 ,  C12R1/01 ,  G01N33/566 ,  G01N33/569 ,  A61K39/05 ,  A61K39/40 ,  C07K16/40 ,  C12N9/02 ,  C12N9/10 ,  C12N9/20 ,  C12N9/24 ,  C12N9/50 ,  C12N15/63 ,  G01N33/68

CPC classification number: C07K14/195 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of acne vulgaris and other related conditions are disclosed. Compositions may comprise one or more Propionibacterium acnes proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antibody that binds a Propionibacterium acnes protein, antigen presenting cell that expresses a Propionibacterium acnes protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and/or treatment of acne.

Abstract translation: 公开了治疗寻常痤疮和其他相关病症的治疗和诊断的组合物和方法。 组合物可以包含一种或多种痤疮丙酸杆菌蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含结合痤疮丙酸杆菌蛋白质的抗体，表达痤疮丙酸杆菌蛋白质的抗原呈递细胞或表达细胞的细胞特异性的T细胞 这样的蛋白质。 这样的组合物可用于例如预防和/或治疗痤疮。

公开(公告)号：WO0179276A3

公开(公告)日：2002-09-06

申请号：PCT/US0111254

申请日：2001-04-05

Applicant: CORIXA CORP ,  REED STEVEN G ,  CAMPOS-NETO ANTONIO ,  WEBB JOHN R ,  DILLON DAVIN C ,  SKEIKY YASIR A W ,  BHATIA AJAY ,  COLER RHEA M ,  PROBST PETER

Inventor： REED STEVEN G ,  CAMPOS-NETO ANTONIO ,  WEBB JOHN R ,  DILLON DAVIN C ,  SKEIKY YASIR A W ,  BHATIA AJAY ,  COLER RHEA M ,  PROBST PETER

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  A61K39/008 ,  C12N15/30 ,  G01N33/569

CPC classification number: C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Abstract translation: 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供了包含这种多肽的疫苗和药物组合物，或编码这些多肽的多核苷酸，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。

公开(公告)号：WO03041560A2

公开(公告)日：2003-05-22

申请号：PCT/US0235624

申请日：2002-11-05

Applicant: CORIXA CORP ,  BHATIA AJAY ,  GUDERIAN JEFF ,  SKEIKY YASIR A W ,  MAISONNEUVE JEAN-FRANCOIS L ,  BARTH BRENDA ,  PROBST PETER

Inventor： BHATIA AJAY ,  GUDERIAN JEFF ,  SKEIKY YASIR A W ,  MAISONNEUVE JEAN-FRANCOIS L ,  BARTH BRENDA ,  PROBST PETER

IPC: A61K35/12 ,  A61K39/00 ,  A61K39/02 ,  A61K39/118 ,  C07H21/04 ,  C07K14/295 ,  C12N1/21 ,  C12N5/0783 ,  C12Q1/68 ,  G01N33/554 ,  G01N33/569 ,  A61B

CPC classification number: C12N5/0636 ,  A61K39/00 ,  A61K39/118 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/295 ,  C07K2319/00 ,  G01N33/56927

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

Abstract translation: 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：WO0181581A2

公开(公告)日：2001-11-01

申请号：PCT/US0112865

申请日：2001-04-20

Applicant: CORIXA CORP ,  SKEIKY YASIR A W ,  PERSING DAVID H ,  MITCHAM JENNIFER L ,  WANG SIQING STEVEN ,  BHATIA AJAY ,  MAISONNEUVE JEAN FRANCOIS L ,  ZHANG YANNI ,  JEN SHYIAN ,  CARTER DARRICK

Inventor： SKEIKY YASIR A W ,  PERSING DAVID H ,  MITCHAM JENNIFER L ,  WANG SIQING STEVEN ,  BHATIA AJAY ,  L MAISONNEUVE JEAN-FRANCOIS ,  ZHANG YANNI ,  JEN SHYIAN ,  CARTER DARRICK

IPC: G01N33/53 ,  A61K39/00 ,  A61K39/07 ,  A61K39/39 ,  A61K48/00 ,  A61P17/02 ,  A61P29/00 ,  C07K14/195 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/68 ,  C12R1/01 ,  G01N33/566 ,  G01N33/569 ,  A61K39/05 ,  A61K39/40 ,  C07K16/40 ,  C12N9/02 ,  C12N9/10 ,  C12N9/20 ,  C12N9/24 ,  C12N9/50 ,  C12N15/63 ,  G01N33/68

CPC classification number: C07K14/195 ,  A61K39/00 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of acne vulgaris and other related conditions are disclosed. Compositions may comprise one or more Propionibacterium acnes proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antibody that binds a Propionibacterium acnes protein, antigen presenting cell that expresses a Propionibacterium acnes protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and/or treatment of acne.

Abstract translation: 公开了治疗寻常痤疮和其他相关病症的治疗和诊断的组合物和方法。 组合物可以包含一种或多种痤疮丙酸杆菌蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含结合痤疮丙酸杆菌蛋白质的抗体，表达痤疮丙酸杆菌蛋白质的抗原呈递细胞或表达细胞的细胞特异性的T细胞 这样的蛋白质。 这样的组合物可用于例如预防和/或治疗痤疮。

公开(公告)号：WO2003041560A3

公开(公告)日：2003-05-22

申请号：PCT/US2002/035624

申请日：2002-11-05

Applicant: CORIXA CORPORATION ,  BHATIA, Ajay ,  GUDERIAN, Jeff ,  SKEIKY, Yasir, A., W. ,  MAISONNEUVE, Jean-Francois, L. ,  BARTH, Brenda ,  PROBST, Peter

Inventor： BHATIA, Ajay ,  GUDERIAN, Jeff ,  SKEIKY, Yasir, A., W. ,  MAISONNEUVE, Jean-Francois, L. ,  BARTH, Brenda ,  PROBST, Peter

IPC: A61K39/118

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：WO2003033515A1

公开(公告)日：2003-04-24

申请号：PCT/US2002/032727

申请日：2002-10-11

Applicant: CORIXA CORPORATION ,  MITCHAM, Jennifer, L. ,  SKEIKY, Yasir, A., W. ,  PERSING, David, H. ,  BHATIA, Ajay ,  MAISONNEUVE, Jean-François, L. ,  ZHANG, Yanni ,  WANG, Siqing ,  JEN, Shyian ,  LODES, Michael, J. ,  BENSON, Darin, R. ,  JONES, Robert ,  CARTER, Darrick ,  BARTH, Brenda ,  VALLIEVE-DOUGLASS, John

Inventor： MITCHAM, Jennifer, L. ,  SKEIKY, Yasir, A., W. ,  PERSING, David, H. ,  BHATIA, Ajay ,  MAISONNEUVE, Jean-François, L. ,  ZHANG, Yanni ,  WANG, Siqing ,  JEN, Shyian ,  LODES, Michael, J. ,  BENSON, Darin, R. ,  JONES, Robert ,  CARTER, Darrick ,  BARTH, Brenda ,  VALLIEVE-DOUGLASS, John

IPC: C07H21/04

CPC classification number: C07K14/195 ,  C07K2319/00

Abstract: Compositions and methods for the therapy and diagnosis of acne vulgaris and other related conditions are disclosed. Compositions may comprise one or more Propionibacterium acnes proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antibody that binds a Propionibacterium acnes protein, antigen presenting cell that expresses a Propionibacterium acnes protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and/or treatment of acne.

Abstract translation: 公开了治疗寻常痤疮和其他相关病症的治疗和诊断的组合物和方法。 组合物可以包含一种或多种痤疮丙酸杆菌蛋白质，其免疫原性部分或编码这些部分的多核苷酸。 或者，治疗组合物可以包含结合丙酸杆菌蛋白质的抗体，表达丙酸杆菌属蛋白酶的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可用于例如预防和/或治疗痤疮。

公开(公告)号：WO02098359A3

公开(公告)日：2003-04-03

申请号：PCT/US0217598

申请日：2002-06-03

Applicant: CORIXA CORP ,  REED STEVEN G ,  CAMPOS-NETO ANTONIO ,  WEBB JOHN R ,  DILLON DAVIN C ,  SKEIKY YASIR A W ,  BHATIA AJAY ,  COLER RHEA N ,  PROBST PETER ,  BRANNON MARK

Inventor： REED STEVEN G ,  CAMPOS-NETO ANTONIO ,  WEBB JOHN R ,  DILLON DAVIN C ,  SKEIKY YASIR A W ,  BHATIA AJAY ,  COLER RHEA N ,  PROBST PETER ,  BRANNON MARK

IPC: A61K38/00 ,  A61K39/00 ,  C07K14/44 ,  A61K39/008 ,  A61K31/70 ,  A61K48/00 ,  C07K14/00

CPC classification number: C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

Abstract translation: 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供了包含这种多肽的疫苗和药物组合物，或编码这些多肽的多核苷酸，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。

公开(公告)号：WO0208267A3

公开(公告)日：2003-02-27

申请号：PCT/US0123121

申请日：2001-07-20

Applicant: CORIXA CORP ,  FLING STEVEN P ,  SKEIKY YASIR A W ,  PROBST PETER ,  BHATIA AJAY

Inventor： FLING STEVEN P ,  SKEIKY YASIR A W ,  PROBST PETER ,  BHATIA AJAY

IPC: G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/118 ,  A61K48/00 ,  A61P31/00 ,  A61P37/04 ,  A61P43/00 ,  C07K14/295 ,  C07K16/12 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/06 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/06 ,  G01N33/566 ,  G01N33/569 ,  A61K31/711 ,  A61K39/40 ,  C12N15/62 ,  C12N15/63 ,  C12Q1/68

CPC classification number: C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：WO2001081581A3

公开(公告)日：2001-11-01

申请号：PCT/US2001/012865

申请日：2001-04-20

Applicant: CORIXA CORPORATION ,  SKEIKY, Yasir, A., W. ,  PERSING, David, H. ,  MITCHAM, Jennifer, L. ,  WANG, Siqing, Steven ,  BHATIA, Ajay ,  L'MAISONNEUVE, Jean-Francois ,  ZHANG, Yanni ,  JEN, Shyian ,  CARTER, Darrick

Inventor： SKEIKY, Yasir, A., W. ,  PERSING, David, H. ,  MITCHAM, Jennifer, L. ,  WANG, Siqing, Steven ,  BHATIA, Ajay ,  L'MAISONNEUVE, Jean-Francois ,  ZHANG, Yanni ,  JEN, Shyian ,  CARTER, Darrick

IPC: C12N15/31

Abstract: Compositions and methods for the therapy and diagnosis of acne vulgaris and other related conditions are disclosed. Compositions may comprise one or more Propionibacterium acnes proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antibody that binds a Propionibacterium acnes protein, antigen presenting cell that expresses a Propionibacterium acnes protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and/or treatment of acne.