公开(公告)号：WO2009006409A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068797

申请日：2008-06-30

Applicant: HARVARD COLLEGE ,  PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

Inventor： PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

IPC: G01N33/53

CPC classification number: G01N33/5434 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/50825 ,  B01L2200/0652 ,  B01L2300/045 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N33/54333 ,  G01R33/1269

Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.

Abstract translation: 描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。 该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。 所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。

公开(公告)号：WO2010022324A3

公开(公告)日：2010-06-03

申请号：PCT/US2009054601

申请日：2009-08-21

Applicant: HARVARD COLLEGE ,  MARTINEZ ANDRES W ,  PHILLIPS SCOTT T ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M

Inventor： MARTINEZ ANDRES W ,  PHILLIPS SCOTT T ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M

IPC: D21H19/72 ,  D21H25/06

CPC classification number: D21H27/02 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2300/165 ,  D21H21/16 ,  D21H25/06

Abstract: Methods of patterning hydrophobic materials onto hydrophilic substrates are described. Also described are articles comprising a hydrophilic substrate impregnated with a hydrophobic material, and a transparent layer capable of being patterned in contact with one surface of the substrate.

Abstract translation: 描述了将疏水性材料图案化到亲水性基材上的方法。 还描述了包含浸渍有疏水材料的亲水基材和能够与基材的一个表面接触图案化的透明层的制品。

公开(公告)号：WO2010022324A2

公开(公告)日：2010-02-25

申请号：PCT/US2009/054601

申请日：2009-08-21

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  MARTINEZ, Andres, W. ,  PHILLIPS, Scott, T. ,  WILEY, Benjamin ,  WHITESIDES, George, M.

Inventor： MARTINEZ, Andres, W. ,  PHILLIPS, Scott, T. ,  WILEY, Benjamin ,  WHITESIDES, George, M.

IPC: D21H19/72 ,  D21H25/06

CPC classification number: D21H27/02 ,  B01L3/5023 ,  B01L3/502707 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/126 ,  B01L2300/165 ,  D21H21/16 ,  D21H25/06

Abstract: Methods of patterning hydrophobic materials onto hydrophilic substrates are described. Also described are articles comprising a hydrophilic substrate impregnated with a hydrophobic material, and a transparent layer capable of being patterned in contact with one surface of the substrate.

Abstract translation: 描述疏水性材料在亲水性基材上的图案化方法。 还描述了包含浸渍有疏水材料的亲水性基材的物品，以及能够被图案化以与基底的一个表面接触的透明层。