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    PAPER-BASED MICROFLUIDIC SYSTEMS
    2.
    发明申请
    PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
    基于纸张的微流体系统

    公开(公告)号：WO2009121041A3

    公开(公告)日：2009-12-17

    申请号：PCT/US2009038699

    申请日：2009-03-27

    Applicant: HARVARD COLLEGE ,  SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    Inventor： SIEGEL ADAM C ,  PHILLIPS SCOTT T ,  DICKEY MICHAEL D ,  ROZKIEWICZ DOROTA ,  WILEY BENJAMIN ,  WHITESIDES GEORGE M ,  MARTINEZ ANDRES W

    IPC: G01N35/00 ,  G01N27/26 ,  G01N33/48

    CPC classification number: B01L3/502707 ,  B01L2200/027 ,  B01L2200/0642 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/025 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0809 ,  B01L2300/0819 ,  B01L2300/087 ,  B01L2300/12 ,  B01L2300/126 ,  B01L2300/161 ,  B01L2300/1827 ,  B01L2400/0406 ,  Y10T436/25 ,  Y10T436/2575

    Abstract: The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.

    Abstract translation: 本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。 测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。 微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

    MICROFLUIDIC, ELECTROMECHANICAL DEVICES
    10.
    发明申请
    MICROFLUIDIC, ELECTROMECHANICAL DEVICES 审中-公开
    微流体，机电设备

    公开(公告)号：WO2010102279A1

    公开(公告)日：2010-09-10

    申请号：PCT/US2010/026499

    申请日：2010-03-08

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  NEI, Zhihong ,  NIJHUIS, Christian ,  CHEN, Xin ,  MARTINEZ, Andres, W. ,  NAROVLYANSKY, Max ,  WHITESIDES, George, M.

    Inventor： NEI, Zhihong ,  NIJHUIS, Christian ,  CHEN, Xin ,  MARTINEZ, Andres, W. ,  NAROVLYANSKY, Max ,  WHITESIDES, George, M.

    IPC: B01L3/00

    CPC classification number: B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    Abstract: Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fiuidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    Abstract translation: 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水性通道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。

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