公开(公告)号：WO2010093419A1

公开(公告)日：2010-08-19

申请号：PCT/US2010/000313

申请日：2010-02-04

Applicant: MERCK PATENT GMBH ,  SUTTON, Amanda E. ,  RICHARDSON, Thomas E. ,  HUCK, Bayard R. ,  KARRA, Srinivasa R. ,  CHEN, Xiaoling ,  XIAO, Yufang ,  GOUTOPOULOS, Andreas ,  LAN, Ruoxi ,  PERREY, David ,  VANDEVEER, Harold, George ,  LIU-BUJALSKI, Lesley ,  STIEBER, Frank ,  HODOUS, Brian L. ,  QIU, Hui ,  JONES, Reinaldo C. ,  HEASLEY, Brian

Inventor： SUTTON, Amanda E. ,  RICHARDSON, Thomas E. ,  HUCK, Bayard R. ,  KARRA, Srinivasa R. ,  CHEN, Xiaoling ,  XIAO, Yufang ,  GOUTOPOULOS, Andreas ,  LAN, Ruoxi ,  PERREY, David ,  VANDEVEER, Harold, George ,  LIU-BUJALSKI, Lesley ,  STIEBER, Frank ,  HODOUS, Brian L. ,  QIU, Hui ,  JONES, Reinaldo C. ,  HEASLEY, Brian

IPC: C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04 ,  A61K31/517 ,  A61P35/00

CPC classification number: C07D215/04 ,  A61K31/47 ,  C07D239/94 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D413/04

Abstract: The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

Abstract translation: 本发明提供根据式（I）的新型取代的氨基氮杂环甲酰胺化合物，其用于治疗过度增殖性疾病如癌症的制备和用途。

公开(公告)号：WO2010080253A1

公开(公告)日：2010-07-15

申请号：PCT/US2009/066534

申请日：2009-12-03

Applicant: MERCK PATENT GMBH ,  JONES, Christopher Charles Victor ,  HUCK, Bayard R. ,  SUTTON, Amanda E. ,  ASKEW, JR., Benny C. ,  BRUGGER, Nadia ,  SMITH, Garry R.

Inventor： JONES, Christopher Charles Victor ,  HUCK, Bayard R. ,  SUTTON, Amanda E. ,  ASKEW, JR., Benny C. ,  BRUGGER, Nadia ,  SMITH, Garry R.

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: Disclosed are dipyridyl-pyrrole derivative compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes for preparing the same. The compounds are useful in the treatment of diseases amenable to protein kinase signal transduction inhibition, regulation and/or modulation.

Abstract translation: 公开了联吡啶基 - 吡咯衍生物化合物及其类似物，包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗适于蛋白激酶信号转导抑制，调节和/或调节的疾病。