公开(公告)号：WO2014158639A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/018971

申请日：2014-02-27

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  WILSON, Anne M. ,  BORROMEO, Peter ,  DEAMICIS, Carl ,  PATZNER, Jerod

IPC: C07C241/00 ,  C07C241/02 ,  C07C243/00 ,  C07C249/16 ,  C07C251/72

CPC classification number: C07D249/08 ,  C07C257/22

Abstract: This document is related to the preparation of certain (substituted-phenyl)-triazolyl-(substituted phenyl) molecules, and intermediates related thereto, where said intermediates are useful in preparing certain insecticides.

Abstract translation: 本文件涉及某些（取代 - 苯基） - 三唑基 - （取代苯基）分子及其相关中间体的制备，其中所述中间体可用于制备某些杀虫剂。

公开(公告)号：WO2013169664A3

公开(公告)日：2013-11-14

申请号：PCT/US2013/039735

申请日：2013-05-06

Applicant: DOW AGROSCIENCES LLC

Inventor： MEYER, Kevin G. ,  RENGA, James M. ,  NUGENT, Benjamin M. ,  LI, Fangzheng ,  OWEN, W. John ,  YAO, Chenglin ,  WANG, NICK X.

IPC: C07D405/12

Abstract: The present disclosure relates to macrocyclic picolinamides and their use as fungicides. The compounds of the present disclosure may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes. The present disclosure presents a method for the control or prevention of fungal attack on a plant, the method including the steps of applying a fungicidally effective amount of one or more of the compounds described to at least one of the fungus, the plant, and an area adjacent to the plant.

公开(公告)号：WO2016007634A1

公开(公告)日：2016-01-14

申请号：PCT/US2015/039565

申请日：2015-07-08

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  CHOY, Nakyen ,  STOCKMAN, Kenneth E.

IPC: A61K31/535

CPC classification number: C07D213/803 ,  C07D213/79 ,  C07D213/84 ,  C07D307/54

Abstract: 4,6-Dibromo-3-hydroxypicolinonitrile may be prepared from furfural in a series of chemical steps selected from cyano-amination, amine salt formation and bromination-rearrangement. 4-Alkoxy-3-hydroxypicolinic acids may be conveniently prepared from 4,6-dibromo-3-hydroxypicolinonitrile in a series of chemical steps selected from bromo substitution, nitrile hydrolysis and halogen reduction.

Abstract translation: 4,6-二溴-3-羟基吡啶腈可以从选自氰基胺化，胺盐形成和溴化重排的一系列化学步骤中由糠醛制备。 4-烷氧基-3-羟基吡啶甲酸可以从选自溴取代，腈水解和卤素还原的一系列化学步骤中方便地从4,6-二溴-3-羟基吡啶腈制备。

公开(公告)号：WO2014158640A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/018977

申请日：2014-02-27

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  WILSON, Anne M. ,  CROUSE, Gary D.

IPC: A01N57/00 ,  A61K31/67

CPC classification number: C07H13/12

Abstract: Triaryl rhamnose carbamate insecticides are prepared from triaryl carbamates and the tetrahydropyran-2-ols in good yield without the use of a hydride base.

Abstract translation: 三芳基鼠李糖氨基甲酸酯杀虫剂由三芳基氨基甲酸酯和四氢吡喃-2-醇以良好的产率制备而不使用氢化物​​碱。

公开(公告)号：WO2014158638A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/018967

申请日：2014-02-27

Applicant: DOW AGROSCIENCES LLC

Inventor： RENGA, James M. ,  WILSON, Anne M. ,  BORROMEO, Peter ,  DEAMICIS, Carl ,  PATZNER, Jerod

IPC: C07C241/00 ,  C07C241/02 ,  C07C243/00 ,  C07C249/16 ,  C07C251/72

CPC classification number: C07D249/08

Abstract: This disclosure is related to the field of preparation of certain (substituted phenyl)-triazolyl-(substituted phenyl) molecules, and intermediates related thereto, where said intermediates are useful in the preparation of certain insecticides.

Abstract translation: 本公开涉及某些（取代的苯基） - 三唑基 - （取代的苯基）分子的制备领域以及与之有关的中间体，其中所述中间体可用于制备某些杀虫剂。

公开(公告)号：WO2013148338A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/032270

申请日：2013-03-15

Applicant: DOW AGROSCIENCES LLC

Inventor： ROSS, Ronald ,  RENGA, James M. ,  BLAND, Douglas C. ,  ROTH, Gary ,  FUNG, Alexander P. ,  DAVIS, Clark S.

IPC: C07D213/127 ,  C07D213/26

CPC classification number: C07D213/61 ,  C07D213/26

Abstract: 3-substituted 6-trifluoromethyl pyridines are useful synthetic intermediates in the preparation of the N substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines, which are useful in forming potent insecticides. Methods of forming such 3 substituted 6 trifluoromethyl pyridines are disclosed. Also disclosed are methods of using 6-trichloromethyl halogenated pyridines to form 3-substituted 6-trifluoromethyl pyridines are disclosed.

Abstract translation: 3-取代的6-三氟甲基吡啶在制备用于形成有效杀虫剂的N取代的（6-卤代烷基吡啶-3-基）烷基亚磺酰亚胺中是有用的合成中间体。 公开了形成这种3个取代的6个三氟甲基吡啶的方法。 还公开了使用6-三氯甲基卤代吡啶形成3-取代的6-三氟甲基吡啶的方法。

公开(公告)号：WO2012103041A3

公开(公告)日：2012-08-02

申请号：PCT/US2012/022285

申请日：2012-01-24

Applicant: DOW AGROSCIENCES LLC ,  ARNDT, Kim E. ,  RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  LOWE, Christian T.

Inventor： ARNDT, Kim E. ,  RENGA, James M. ,  ZHU, Yuanming ,  WHITEKER, Gregory T. ,  LOWE, Christian T.

IPC: A01N43/40

Abstract: 4-Amino-3-chloro-5-fluoro-6-(substituted) picolinates are conveniently prepared from 3,4;5,6-tetrachloropicolinonitrile by a series of steps involving fluorine exchange, amination, halogen exchange and hydrolysis, esterification and transition metal assisted coupling. The present invention concerns a process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates. More particularly, the present invention concerns a process for the preparation of 4-amino-3-chloro-5-fluoro-6-(substituted)picolinates in which the 5-fluoro substituent is introduced by a halogen exchange early in the process scheme.