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    A RAPID MULTIPLEX RPA BASED NANOPORE SEQUENCING METHOD FOR REAL-TIME DETECTION AND SEQUENCING OF MULTIPLE VIRAL PATHOGENS
    11.
    发明申请
    A RAPID MULTIPLEX RPA BASED NANOPORE SEQUENCING METHOD FOR REAL-TIME DETECTION AND SEQUENCING OF MULTIPLE VIRAL PATHOGENS 审中-公开

    公开(公告)号：WO2021250617A1

    公开(公告)日：2021-12-16

    申请号：PCT/IB2021/055127

    申请日：2021-06-10

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： LI, Mo ,  BI, Chongwei

    IPC: C12Q1/70 ,  C12Q1/6844 ,  C12Q1/701 ,  C12Q2600/16

    Abstract: Methods for the rapid and accurate detection and characterization of a viral nucleic acid in a sample are provided. The method is a method for multiplex isothermal amplification-based sequencing and real-time analysis of multiple viral genomes. It can simultaneously detect SARS-CoV-2 and co-infecting respiratory viruses, and monitor mutations for up to 96 samples in real time. The method, termed NIRVANA for Nanopore sequencing of Isothermal Rapid Viral Amplification for Near real-time Analysis, showed high sensitivity and specificity for SARS-CoV-2 in 70 clinical samples. It also simultaneously detected other viral pathogens (e.g. influenza A) in clinical and municipal wastewater samples. It provides a rapid field-deployable solution of COVID-19 and co-infection detection and surveillance of the evolution of pandemic strains.

    RESONANT FREQUENCY-BASED MAGNETIC SENSOR AT VEERING ZONE AND METHOD
    15.
    发明申请
    RESONANT FREQUENCY-BASED MAGNETIC SENSOR AT VEERING ZONE AND METHOD 审中-公开

    公开(公告)号：WO2021144641A1

    公开(公告)日：2021-07-22

    申请号：PCT/IB2020/062307

    申请日：2020-12-21

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： ALCHEIKH, Nouha ,  BEN MBAREK, Sofiane ,  YOUNIS, Mohammad

    IPC: G01R33/028 ,  G01R33/0286

    Abstract: A method for measuring a magnetic field with a micro-sensor system (200) includes applying (1700) a direct current (ITh) to a curved micro-beam (110) to control a stiffness of the curved micro-beam (110); placing (1702) the micro-sensor system (200) into an external magnetic field (B); selecting (1704) with a controller (130), based on an expected value of the external magnetic field (B), a given resonant frequency of the micro-beam (110); measuring (1706) with a resonant frequency tracking device (150) the given resonant frequency of the micro-beam (110); and calculating (1706) in the controller (130) the external magnetic field (B), based on (1) the measured resonant frequency, (2) the applied current (ITh), and (3) calibration data stored in the controller (130). The calibration data is indicative of a dependency between a change of the selected resonant frequency and the external magnetic field.

    METHOD TO IMPROVE TOUGHNESS OF ADHESIVELY BONDED COMPOSITE JOINTS
    16.
    发明申请
    METHOD TO IMPROVE TOUGHNESS OF ADHESIVELY BONDED COMPOSITE JOINTS 审中-公开

    公开(公告)号：WO2021140391A1

    公开(公告)日：2021-07-15

    申请号：PCT/IB2020/062128

    申请日：2020-12-17

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： TAO, Ran ,  WAGIH, Ahmed ,  YUDHANTO, Arief ,  LUBINEAU, Gilles

    IPC: C09J7/10 ,  C09J2301/21

    Abstract: A self-standing adhesive layer (900) is configured to join a first adherend to a second adherend, with no additional adhesive. The adhesive layer includes a material (900) that self-stands and is configured to adhere to the first and second adherends; a first surface (960A) of the material (900) is opposite to a second surface (960B) of the material (900); a first area (904) of the first surface (960A) has a first smoothness and/or morphology and/or adhesion properties; and a second area (906) of the first surface (960A) has a second smoothness and/or morphology and/or adhesion properties, different from the first smoothness and/or morphology and/or adhesion properties. The first and second areas (904, 906) form a preset pattern on the first surface (960A).

    ELECTRICAL CURRENT DISTRIBUTION IMAGINING SYSTEM AND METHOD
    18.
    发明申请
    ELECTRICAL CURRENT DISTRIBUTION IMAGINING SYSTEM AND METHOD 审中-公开

    公开(公告)号：WO2021044300A1

    公开(公告)日：2021-03-11

    申请号：PCT/IB2020/058144

    申请日：2020-09-01

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： ZHANG, Senfu ,  ZHANG, Xixiang

    IPC: G01R33/032 ,  G01R19/08 ,  G01R33/12

    Abstract: A method for generating an electrical current distribution that is associated with a target conductor structure (100) is described. The method includes receiving (1600) information about the target conductor structure (100), providing (1602) a multi-layer structure (200) having two heavy-metal layers (204 and 208) and a ferromagnetic layer (206), adding (1604) corresponding at least first and second electrodes (404, 406) to a surface of the multi-layer structure (200) so that a same geometry is obtained as for the target conductor structure (100), injecting (1606) one or more electrical current pulses into the at least first and second electrodes (404, 406) to generate half-skyrmions (504) into the multi-layer structure (200), imagining (1608) a trajectory of the half-skyrmion (504) with a Kerr effect microscope, and mapping (1610) the trajectory of the half-skyrmion (504) to the target conductor structure (100) after correcting the trajectory with a Hall angle corresponding to the half-skyrmion (504). The corrected trajectory represents the electrical current distribution of the target conductor structure.

    DETECTING TEMPERATURE ABUSE
    19.
    发明申请
    DETECTING TEMPERATURE ABUSE 审中-公开

    公开(公告)号：WO2021044264A1

    公开(公告)日：2021-03-11

    申请号：PCT/IB2020/058025

    申请日：2020-08-27

    Applicant: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

    Inventor： RUEPING, Magnus ,  BANALA, Srinivas ,  MERKES, Jean Michel

    IPC: C09K9/02

    Abstract: The present disclosure provides oxadiazaborinine (ODB) dyes represented by Formula (I) wherein each of R1 through R7 are independently selected from the group consisting of hydrogen, halogen, alkyl, cycloalkyl, aryl, arylalkyl, acyl, groups containing oxygen, groups containing nitrogen, groups containing sulfur, groups containing phosphorous, groups containing boron, and groups containing metals, alone or in combination; R8 is selected from the group consisting of C, N, and P; and each X is halogen; and wherein the ODB dye exhibits an irreversible conversion to a dipyrrometheneboron difloro-based chromophore or fluorophore when exposed to a temperature at or greater than a predetermined threshold temperature. Articles and devices comprising ODB dyes for use as Time-Temperature Indicators and methods of detecting temperature abuse are described.

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