公开(公告)号：WO2008156656A2

公开(公告)日：2008-12-24

申请号：PCT/US2008/007378

申请日：2008-06-13

Applicant: STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY ,  CARTER, Rich, Garrett ,  ASHBURN, Bradley, O. ,  NAFFZIGER, Michael, R. ,  SCHWARTZ, Johanna, P.

Inventor： CARTER, Rich, Garrett ,  ASHBURN, Bradley, O. ,  NAFFZIGER, Michael, R. ,  SCHWARTZ, Johanna, P.

IPC: C07F9/30

CPC classification number: C07F9/5022 ,  C07C205/20 ,  C07C205/35 ,  C07C205/45 ,  C07C215/74 ,  C07C217/80 ,  C07C233/11 ,  C07C235/46 ,  C07C255/54 ,  C07C271/38 ,  C07C2601/14 ,  C07D209/88 ,  C07F9/4015 ,  C07F9/4021 ,  C07F9/532 ,  C07F9/5325

Abstract: Certain disclosed embodiments of the present invention concern a method for making biaryl compounds by combining a diene with a dienophile under reaction conditions that facilitate a Diels-Alder reaction. Certain embodiments are particularly directed to making a tetra- ortho -substituted biaryl compounds. The disclosed method may involve using novel dienes, dienophiles, or both. Similarly, certain of the biaryl compounds are novel compounds too. Additional disclosed embodiments concern a method for making useful compounds by first making a Diels-Alder adduct. The Diels-Alder adduct is then further modified or coupled to other compounds. The method can be used to make carbazoles, such as Siamenol. Disclosed biaryl compounds are useful for a number of applications, such as pharmacophores and organocatalysts.

Abstract translation: 本发明的某些公开的实施方案涉及通过在促进Diels-Alder反应的反应条件下将二烯与亲二烯体组合来制备联芳基化合物的方法。 某些实施方案特别涉及制备四邻位取代的联芳基化合物。 所公开的方法可以涉及使用新型二烯，亲双烯体或两者。 类似地，某些联芳基化合物也是新化合物。 另外公开的实施方案涉及通过首先制备Diels-Alder加合物来制备有用化合物的方法。 然后将Diels-Alder加合物进一步修饰或与其它化合物偶联。 该方法可用于制备咔唑，例如西门子醇。 公开的联芳基化合物可用于许多应用，例如药效团和有机催化剂。

公开(公告)号：WO2004017920A2

公开(公告)日：2004-03-04

申请号：PCT/US2003/026585

申请日：2003-08-25

Applicant: UNIVERSITY OF CONNECTICUT

Inventor： MAKRIYANNIS, Alexandros ,  LAI, Xin-Zhong ,  LU, Dai

IPC: A61K

CPC classification number: C07D307/68 ,  C07C39/15 ,  C07C39/367 ,  C07C43/23 ,  C07C47/57 ,  C07C49/83 ,  C07C69/732 ,  C07C69/94 ,  C07C205/20 ,  C07C215/74 ,  C07C215/78 ,  C07C217/80 ,  C07C235/42 ,  C07C235/46 ,  C07C255/53 ,  C07D213/55

Abstract: Novel biphenyl and biphenyl-like cannabinoid compounds are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, result in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response useful to treat a number of physiological conditions.

Abstract translation: 介绍了新颖的联苯和联苯类大麻素化合物。 这些化合物当以治疗有效量给予个体或动物时，导致个体或动物中该化合物的水平足够高以引起生理反应。 对治疗许多生理状况有用的生理反应。