公开(公告)号：WO2022251666A2

公开(公告)日：2022-12-01

申请号：PCT/US2022/031384

申请日：2022-05-27

Applicant: CARBON HOLDINGS INTELLECTUAL PROPERTIES, LLC

Inventor： ATKINS, Charles Agee ,  LINDEMANN, Garrett W.

IPC: G01N21/65 ,  G01N21/17 ,  G01N21/25 ,  G01N21/31 ,  G01N21/00 ,  G01J3/44 ,  G01N15/1475 ,  G06T7/30 ,  G06V20/693 ,  G06V20/698

Abstract: A system for analyzing biological specimens by spectral imaging includes a biosensor comprising at least one graphene layer on a substrate and a memory in communication with a processor. The biosensor is configured to acquire a biological specimen sample. The memory and the processor are configured to conduct Raman spectroscopy to obtain spectral data for the sample, transmit the spectral data to a hub for direct or indirect transmission to one or more servers, perform multivariate analysis on the spectral data, and deliver a report based on the multivariate analysis of the spectral data.

公开(公告)号：WO2022054009A2

公开(公告)日：2022-03-17

申请号：PCT/IB2021/058273

申请日：2021-09-11

Applicant: ASTRAZENECA UK LIMITED ,  DAIICHI SANKYO COMPANY, LIMITED

Inventor： SCHMIDT, Guenter ,  BRIEU, Nicolas ,  SPITZMUELLER, Andreas ,  KAPIL, Ansh

IPC: G06K9/00 ,  G06K9/62 ,  G06K9/46 ,  G06K9/6271 ,  G06V10/454 ,  G06V10/751 ,  G06V20/698

Abstract: A method for predicting how a cancer patient will respond to an antibody drug conjugate (ADC) therapy involves computing a predictive response score based on single-cell ADC scores for each cancer cell. The ADC includes an ADC payload and an ADC antibody that targets a protein on each cancer cell, wherein the protein is human epidermal growth factor receptor 2 (HER2). A tissue sample is immunohistochemically stained using a dye linked to a diagnostic antibody that binds to the protein on cancer cells in the tissue sample. Cancer cells in a digital image of the tissue are detected. For each cancer cell, a single-cell ADC score is computed based on the staining intensities of the dye in the membrane and/or cytoplasm of the cancer cell and/or in the membranes and cytoplasms of neighboring cancer cells. The response of the cancer patient to the ADC therapy is predicted by aggregating all single-cell ADC scores of the tissue sample using a statistical operation.

公开(公告)号：WO2021258651A1

公开(公告)日：2021-12-30

申请号：PCT/CN2020/133954

申请日：2020-12-04

Applicant: 珠海圣美生物诊断技术有限公司 ,  珠海横琴圣澳云智科技有限公司

Inventor： 范献军 ,  蓝兴杰 ,  叶莘 ,  张义 ,  李丛胜

IPC: G06T7/00 ,  G06K9/629 ,  G06N3/0454 ,  G06T2207/10061 ,  G06T7/0012 ,  G06V20/695 ,  G06V20/698

Abstract: 一种检测循环异常细胞的方法及装置，其中，所述检测循环异常细胞的方法包括：利用图像处理算法和形态学算法，对多个探针通道的DF显微镜图像中包含的细胞核分别进行分割和标记（101）；将标记细胞核的多个探针通道的暗视野显微镜图像输入预先构建的循环异常细胞检测模型，得到每一探针通道的暗视野显微镜图像中每个标记的细胞核包含的染色信号数（102）；针对每个标记的细胞核，基于得到的每一探针通道的暗视野显微镜图像中，该标记的细胞核包含的染色信号数，确定所述标记的细胞核是否属于循环异常细胞（103）。该方法可以有效提高检测循环异常细胞的可靠性。

公开(公告)号：WO2021141742A8

公开(公告)日：2021-07-15

申请号：PCT/US2020/065306

申请日：2020-12-16

Applicant: PAIGE.AI, INC.

Inventor： DOGDAS, Belma ,  KANAN, Christopher ,  FUCHS, Thomas ,  GRADY, Leo

IPC: G16H50/20 ,  G16H30/40 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024 ,  G06T7/0012 ,  G06T7/11 ,  G06V20/698

Abstract: Systems and methods are disclosed for receiving a digital image corresponding to a target specimen associated with a pathology category, wherein the digital image is an image of tissue specimen, determining a detection machine learning model, the detection machine learning model being generated by processing a plurality of training images to output a cancer qualification and further a cancer quantification if the cancer qualification is an confirmed cancer qualification, providing the digital image as an input to the detection machine learning model, receiving one of a pathological complete response (pCR) cancer qualification or a confirmed cancer quantification as an output from the detection machine learning model, and outputting the pCR cancer qualification or the confirmed cancer quantification.