公开(公告)号：WO2022236103A1

公开(公告)日：2022-11-10

申请号：PCT/US2022/028145

申请日：2022-05-06

Applicant: LUNG BIOTECHNOLOGY PBC

Inventor： MELICAN, Mora Carolynne ,  MURCIN, Lara ,  LIN, Richmon ,  MORRIS, Derek ,  NSIAH, Barbara ,  ALVAREZ, Luis ,  SAFAVIEH, Mohammadali

IPC: B29C64/182 ,  B29C64/129 ,  B33Y10/00 ,  B33Y80/00 ,  A61F2/06 ,  A61L27/52

Abstract: Embodiments of the present disclosure include methods of simultaneously manufacturing two or more hydrogel constructs (e.g., tubular hydrogel constructs). In some embodiments, the method comprises one or more of the following steps: providing a vat comprising a bio-ink composition containing one or more monomers and/or one or more polymers; applying electromagnetic radiation from an electromagnetic radiation source to cure a layer of the hydrogel constructs (e.g., tubular hydrogel constructs); and applying electromagnetic radiation from the electromagnetic radiation source one or more additional times to produce one or more additional layers of the hydrogel constructs (e.g., tubular hydrogel constructs).

公开(公告)号：WO2022178378A1

公开(公告)日：2022-08-25

申请号：PCT/US2022/017207

申请日：2022-02-22

Applicant: W. L. GORE & ASSOCIATES, INC.

Inventor： BIRDNO, Merrill J. ,  CRAWLEY, Jerald M. ,  MAJOLAGBE, Kehinde A. ,  SHORT, Brandon C. ,  WARD, Derek M. ,  YOUNG, Patrick S.

IPC: A61F2/07 ,  A61F2/06

Abstract: A multibranch implantable device including a main body including a tubular element having wall defining a main lumen, the tubular element having a first end defining a first opening into the main lumen and a second end defining a second opening in the main lumen, the tubular element including at least one side branch portal defining an aperture through the wall between the first longitudinal end and the second longitudinal end of the tubular element and at least one secondary body defining a secondary lumen, the at least one secondary body operable to be deployed with a portion of the secondary body positioned in the at least one side branch portal of the main body.

公开(公告)号：WO2022177848A1

公开(公告)日：2022-08-25

申请号：PCT/US2022/016290

申请日：2022-02-14

Applicant: SIEGENTHALER, Michael ,  SCHULICK, Andrew Howard

Inventor： SIEGENTHALER, Michael ,  SCHULICK, Andrew Howard

IPC: A61F2/06

Abstract: A device is provided to be implanted to create a temporary or permanent connection between two hollow structures. The hollow structures may be, for example, an aortic or large vessel aneurysm sac and a large adjacent vein.

公开(公告)号：WO2022169459A1

公开(公告)日：2022-08-11

申请号：PCT/US2021/016811

申请日：2021-02-05

Applicant: W. L. GORE & ASSOCIATES, INC.

Inventor： MAJOLAGBE, Kehinde A. ,  SILVERMAN, James D.

IPC: A61F2/07 ,  A61F2/06

Abstract: Examples of an implantable conduit that is tubular in shape and has an inner lumen and an outer surface, the implantable conduit are disclosed. The implantable conduit includes a plurality of overlap elements including a first overlap element and a second overlap element positioned adjacent the first overlap element to define an adjacent pair of the plurality of overlap elements. The first overlap element overlaps onto the second overlap element to define an overlapping portion between an inward facing surface of the first overlap element and an outward facing surface of the second overlap element. The implantable conduit also includes a plurality of attachment features coupling the first overlap element to the second overlap element. The inward facing surface of the first overlap element and the outward facing surface of the second overlap element are separable at the overlapping portion by an external force to open an aperture in the overlapping portion between at least two of the plurality of attachment features such that the aperture defines a path between the inner lumen and outer surface of the implantable conduit. The path is sealed absent the external force.

公开(公告)号：WO2022153259A1

公开(公告)日：2022-07-21

申请号：PCT/IB2022/050329

申请日：2022-01-16

Applicant: INSPIREMD LTD.

Inventor： DRAKE, Jesse ,  MCCARTHY, Justin ,  COHEN, Itshak

IPC: A61M1/36 ,  A61F2/06 ,  G01F1/00

Abstract: An apparatus (20) for shunting blood (22) includes a flow-indication chamber (24) shaped to define an entry port (26) and an exit port (28), and one or more moveable objects (46) disposed within the flow-indication chamber (24) and configured to move in response to a flowing of the blood (22) from the entry port (26) to the exit port (28). At least a portion of a wall (52) of the flow-indication chamber (24) is transparent so as to expose the moveable objects (46) to sight. Other embodiments are also described.

公开(公告)号：WO2022098591A1

公开(公告)日：2022-05-12

申请号：PCT/US2021/057506

申请日：2021-11-01

Applicant: WALZMAN, Daniel, Ezra

Inventor： WALZMAN, Daniel, Ezra

IPC: A61F2/06 ,  A61F2/82 ,  A61F2/88

Abstract: An orientable intravascular device having a "twelve o'clock" marker on a. proximal and distal end for treating an aneurysm, including a packaging catheter with an identical fixed non-circular shaped inner lumen, a pusher wire having an occlusion device releasably disposed on the distal end of said pusher wire, pre-loaded at a fixed circumferential orientation, with corresponding markers on the outside of said packaging catheter, a hub having an inner lumen that is shaped to marry with the outer lumen of the packaging catheter to deliver a delivery wire and occlusion stent in a predicted orientation, and maintaining such orientation as the wire and stent are advanced through said delivery catheter, and while said delivery catheter is withdrawn. Methods of using same are disclosed.

公开(公告)号：WO2022081644A1

公开(公告)日：2022-04-21

申请号：PCT/US2021/054691

申请日：2021-10-13

Applicant: NANOFIBER SOLUTIONS, LLC

Inventor： JOHNSON, Jed, K. ,  NELSON, Kevin ,  GROEHL, Tyler

IPC: D04H1/728 ,  A61F2/04 ,  A61F2/06 ,  A61L27/14 ,  D01D5/00

Abstract: Systems and methods of fabricating corrugated electrospun fiber assemblies are disclosed herein. The method can include placing an electrospun fiber scaffold on a corrugation rod, wherein the corrugation rod comprises a helical structure; applying a monofilament fiber about the electrospun fiber scaffold and the corrugation rod from a dispenser as the dispenser is translated longitudinally and the corrugation rod is rotated such that the monofilament fiber is wrapped about the electrospun fiber scaffold at a defined threads per inch (TPI) to form a wrapped electrospun fiber assembly; and longitudinally compressing the corrugated electrospun fiber assembly until it has been compressed from a first length to a second length to form the corrugated electrospun fiber assembly. The corrugated electrospun fiber assemblies can be kink-resistant as compared to conventional electrospun fiber scaffolds. The corrugated electrospun fiber assemblies can be used in, for example, biological applications within a subject.

公开(公告)号：WO2022074412A1

公开(公告)日：2022-04-14

申请号：PCT/IB2020/000796

申请日：2020-10-06

Applicant: UNIVERSITE D'AIX-MARSEILLE ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE ,  UNIVERSITÉ GUSTAVE EIFFEL

Inventor： ALIMI, Yves

IPC: A61F2/07 ,  A61F2/06

Abstract: A percutaneous bypass method for implanting a bypass graft (1) between two vessels (2, 3) 5 is described. The bypass graft (1) comprises a first part (20) and a second part (30), each having a tubular shape and comprising respective lumens. The method comprises the step of inserting a second sheath (3000), from the outside to the inside of a bypass portion (202) of the first part (20), through a puncture (2021) therein, and retracting the second sheath (3000) so as to deploy and implant a hook portion (301) of the second part (30) into the second 10 vessel (3), and deploy a bypass portion (302) of the second part (30) outside the second vessel (3), from the second vessel (3) to the first part (20), and within the lumen of the first part (20).

公开(公告)号：WO2022056168A1

公开(公告)日：2022-03-17

申请号：PCT/US2021/049721

申请日：2021-09-09

Applicant: ENDOSHAPE, INC.

Inventor： CASTLEBERRY, Jeffrey, P. ,  CHOI, Steve ,  GOODRICH, Stephen, D. ,  RICKERT, Ryan

IPC: C08L33/16 ,  C08L101/04 ,  A61K49/04 ,  A61L27/18 ,  A61L27/50 ,  A61F2/06 ,  A61L2/24 ,  A61L2/28

Abstract: A polymer composition is provided. The polymer composition comprises a polymer with a cross-linked network, the cross-linked network comprising: a) one or more first repeating units of Formula (I) and b) one or more second repeating units of Formula (II), wherein: each n independently is an integer from 2 to 16; each R1 independently is hydrogen or methyl; and Ar is an iodinated 5-membered or 6-membered aryl or heteroaryl. A polymer, a method of making the polymer, and a device containing the polymer composition are also provided.

公开(公告)号：WO2022051698A8

公开(公告)日：2022-03-10

申请号：PCT/US2021/049182

申请日：2021-09-06

Applicant: FRONTIER BIO CORPORATION

Inventor： BENNETT, Eric

IPC: A61F2/06 ,  A61F2/82 ,  A61F2/062 ,  A61F2/064 ,  A61F2240/004 ,  B33Y10/00 ,  B33Y80/00 ,  D01D11/00 ,  D01D5/0076

Abstract: According to an embodiment of the disclosure, a method of creating an object with a conduit is disclosed. A material is deposited on a sacrificial collector; and, the sacrificial collector is then removed to create the object with the conduit. Both the object and the sacrificial collector can approximate the shape of desired blood vessel. The method can also include a 3-D printing of the desired shape of the mold and utilization of Gallium as the sacrificial collector. The sacrificial object is created by insertion of the gallium in the mold. After removal of the gallium from the mold, fibers are electrospun onto the gallium. The gallium is removed through melting - leaving a scaffold, the object with the conduit. In addition to the gallium, an extra sacrificial layer of a water-soluble material may be utilized.