公开(公告)号：WO2022031623A1

公开(公告)日：2022-02-10

申请号：PCT/US2021/044228

申请日：2021-08-02

Applicant: MEDTRONIC NAVIGATION, INC.

Inventor： JACOBSEN, Bradley W. ,  WALD, Andrew J. ,  TTEMNYK, Kristen H.

IPC: A61B90/00 ,  A61B5/00 ,  B82Y30/00 ,  B82Y40/00 ,  A61L24/00 ,  A61L31/00 ,  D01D5/00 ,  D04H1/728 ,  A61B17/00 ,  A61B34/20

Abstract: A tracker system (100) for use in image guided surgery is disclosed. The tracker system may couple to wet tissue and may include a navigation tracker (110) and a base pad (120) that couple to each other. The base pad may be fabricated from a plurality of nonwoven nanofibers (122). The base pad is configured to couple to body tissue of a patient via at least one of adsorption, hydration equilibrium, and macromolecular interpenetration.

公开(公告)号：WO2020247793A1

公开(公告)日：2020-12-10

申请号：PCT/US2020/036383

申请日：2020-06-05

Applicant: LIFECELL CORPORATION

Inventor： XU, Hui ,  STEC, Eric ,  POMERLEAU, Ming, F.

IPC: A61L27/36 ,  A61L31/00

Abstract: The present application relates to injectable tissue products and their production and use thereof. The tissue products include a group of acellular tissue matrix particles, a bioadhesive, and a biocompatible polymer. The tissue products may be used to treat hernia defects.

公开(公告)号：WO2020163471A1

公开(公告)日：2020-08-13

申请号：PCT/US2020/016782

申请日：2020-02-05

Applicant: LIFECELL CORPORATION

Inventor： XU, Hui ,  PARK, Sangwook ,  BOWLEY, Melissa, Richter

IPC: A61L27/36 ,  A61L31/00

Abstract: The present disclosure provides meshed acellular dermal tissue matrix compositions, devices, and methods of use. The meshed devices can be used in conjunction with a variety of implants such as breast implants or tissue expanders.

公开(公告)号：WO2019173393A1

公开(公告)日：2019-09-12

申请号：PCT/US2019/020827

申请日：2019-03-05

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： MARTINEZ, Carolyn Sue

IPC: A61L27/36 ,  A61L27/50 ,  A61L31/00 ,  A61L31/14

Abstract: An optical method for determining collagen bundle orientation in bovine pericardium includes the use of a system having a light source which transmits light through a first polarizer, a tissue for making a prosthetic valve leaflet, and a second polarizer, where the light then illuminates a detector plate. The light that illuminates the detector plate is used to determine the orientation of collagen fiber bundles. The orientation of the collagen fiber bundles is used to determine where to cut the leaflet edges.

公开(公告)号：WO2019142213A3

公开(公告)日：2019-07-25

申请号：PCT/IN2019/050042

申请日：2019-01-17

Applicant: INDIAN INSTITUTE OF TECHNOLOGY BOMBAY

Inventor： SRIVASTAVA, Rohit ,  PAWAR, Vaishali Pundlik ,  MULLAJI, Arun ,  SHETTY, Gautam

IPC: A61M5/00 ,  A61F2/30 ,  A61L31/00 ,  A61K47/36

Abstract: The present invention relates to a drug delivery system comprising a stack of five layered polymer films and a drug loaded into each of the five layered polymer films. The polymer film having a size in the range of 2 mm to 5 mm. The drug delivery system of the present invention is used for the management of post-operative complications such as pain, infection, inflammation and uncontrolled bleeding.

公开(公告)号：WO2019118487A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/064988

申请日：2018-12-11

Applicant: INNOVATIVE SURFACE TECHNOLOGIES, INC.

Inventor： TATON, Kristin ,  GUIRE, Patrick ,  LEIR, Charles

IPC: A61L27/00 ,  A61L29/00 ,  A61L31/00 ,  C08G18/00 ,  C08G18/61

CPC classification number: A61L27/00 ,  A61L29/00 ,  A61L31/00 ,  C08G18/00 ,  C08G18/61

Abstract: Silicone polyurea block copolymers are prepared by copolymerizing: (a) a diamine composition that includes a polyethylene glycol diamine, and optionally, a dipiperidyl alkane; (b) a monofunctional silicone isocyanate; and (c) a diisocyanate. Compositions useful as passivating coatings comprising the block copolymer are also provided, and substrates coated with the compositions. Methods of preparing and using the compositions are also described.

公开(公告)号：WO2018122861A1

公开(公告)日：2018-07-05

申请号：PCT/IN2017/050155

申请日：2017-05-02

Applicant: MERIL LIFE SCIENCES PVT LTD

Inventor： KOTHWALA, Deveshkumar Mahendralal ,  VYAS, Rajnikant Gandalal ,  MINOCHA, Pramod Kumar

IPC: A61F2/82 ,  A61L31/00

CPC classification number: A61L31/148 ,  A61F2/82 ,  A61F2240/001 ,  A61L31/06 ,  A61L31/14 ,  C08L67/04

Abstract: The present invention discloses a multi-stage process for yielding bioabsorbable stents with enhanced shelf life. The process includes annealing a scaffold obtained from the deformed tube, coating the annealed scaffold in low humidity environment, crimping the coated scaffold, packaging the scaffold and then sterilizing the crimped scaffold. The annealing includes heating the scaffold at 100-150° C in vacuum for 10-24 hrs, and cooling the heated scaffold in the presence of an inert gas for 3-6 hrs to ambient temperature to form an annealed scaffold. The annealed scaffold has molecular weight M w range of 320000 g/mol to 410000, M n between 190000-250000 g/mol and possesses narrow molecular weight distribution of poly dispersity index between 1.5 to 1.9. Each of the steps of the multi-stage process results in enhanced shelf-life of the bioabsorbable stents.

公开(公告)号：WO2017120486A1

公开(公告)日：2017-07-13

申请号：PCT/US2017/012556

申请日：2017-01-06

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： SHEA, Lonnie, D. ,  RAO, Shreyas, S. ,  AZARIN, Samira ,  JERUSS, Jacqueline, S. ,  BUSHNELL, Grace

IPC: A61P35/04 ,  A61K31/00 ,  A61K31/74 ,  A61K31/765 ,  A61L31/00 ,  A61L31/16

CPC classification number: A61L27/56 ,  A61L27/18 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/252 ,  C08L67/04 ,  C08L71/02

Abstract: The present disclosure relates generally to techniques for capturing cancer cells and, more particularly, to techniques for capturing metastatic cancer cells in vivo.

Abstract translation: 技术领域本公开一般涉及用于捕获癌细胞的技术，并且更具体地涉及用于在体内捕获转移性癌细胞的技术。

公开(公告)号：WO2017066242A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056531

申请日：2016-10-12

Applicant: LUBRIZOL ADVANCED MATERIALS, INC.

Inventor： DAY, Roger W. ,  ZHANG, Hua ,  WOOFTER, Richard ,  MAKAL, Umit G.

IPC: A01N33/12 ,  A01N47/44 ,  A01N25/10 ,  A61L29/00 ,  A61L31/00 ,  A61L33/00 ,  A61L2/00 ,  C08K5/00

CPC classification number: A01N47/44 ,  A01N33/12 ,  A61L2/00 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/404 ,  C08K5/00 ,  A01N25/10

Abstract: A biocidally active polymer composition formed from an oligomeric or polymeric additive and a thermoplastic polyurethane polymer is disclosed. The biocidally active polymer may further include a non-fouling and/or non-thrombogenic polymer. The biocidally active polymer provides biocidally active properties, and may also provide non-fouling and/or non-thrombogenic properties. The composition is particularly useful in articles and materials for medical applications.

Abstract translation: 公开了由低聚或聚合物添加剂和热塑性聚氨酯聚合物形成的杀生物活性聚合物组合物。 杀生物活性聚合物可以进一步包括不结垢和/或非血栓形成聚合物。 杀生物活性聚合物提供杀生物活性，并且还可以提供不结垢和/或非血栓形成性质。 该组合物在用于医疗应用的物品和材料中特别有用。

公开(公告)号：WO2017047474A1

公开(公告)日：2017-03-23

申请号：PCT/JP2016/076347

申请日：2016-09-07

Applicant: 株式会社ソフセラ

Inventor： 岩本　多加志 ,  小粥　康充 ,  河邉　カーロ　和重

IPC: C04B35/447 ,  A61L31/00 ,  B01J20/04 ,  B01J20/30 ,  C01B25/32 ,  C04B38/06

CPC classification number: A61L31/00 ,  B01J20/04 ,  B01J20/30 ,  C01B25/32 ,  C04B35/447 ,  C04B38/06

Abstract: 【課題】　リン酸カルシウムを焼成してリン酸カルシウム焼成体を製造する技術において、焼成しても酸化カルシウムの発生を抑制する技術の提供。 【解決手段】　リン酸カルシウム微粒子とポリエーテルとの複合体を少なくとも含む組成物を加熱し、前記リン酸カルシウム微粒子同士を焼結させる工程を含むことを特徴とする、焼成リン酸カルシウム成形体の製造方法。

Abstract translation: [问题]提供一种通过烧结磷酸钙制造磷酸钙烧结体的技术，使得当烧结时氧化钙的产生最小化。 [解决方案]一种烧结磷酸钙体的制造方法，其特征在于，包括加热至少包含磷酸钙颗粒和聚醚的复合体并将磷酸钙颗粒烧结在一起的组合物的步骤。