公开(公告)号：WO2018204289A1

公开(公告)日：2018-11-08

申请号：PCT/US2018/030321

申请日：2018-04-30

Applicant: 480 BIOMEDICAL, INC.

Inventor： CONCAGH, Danny ,  YOU, Changcheng

IPC: A61L31/02 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61K9/00 ,  A61F2/88

CPC classification number: A61L31/10 ,  A61F2/88 ,  A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2230/0091 ,  A61F2250/003 ,  A61F2250/0067 ,  A61K31/337 ,  A61L31/022 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/16 ,  A61L2420/06 ,  A61L2420/08 ,  C08L67/04

Abstract: Disclosed are medical implants for placement within a lumen of a patient. The implants comprise a polymer and drug-coated metal structure having a tubular configuration and designed to deliver the drug to target tissue at tailored linear drug elution rate.

公开(公告)号：WO2018201116A1

公开(公告)日：2018-11-01

申请号：PCT/US2018/030066

申请日：2018-04-28

Applicant: ALUTA BIOSCIENCES LLC

Inventor： BEAUDRY, Christian ,  SENNER, Grant, Dakota ,  STROMER, Merrill, B.

IPC: A61N1/375 ,  A61L31/00

CPC classification number: A61L31/16 ,  A61L31/005 ,  A61L31/148 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2300/64 ,  A61N1/3605 ,  A61N1/37512 ,  A61N1/3956

Abstract: An implantable cover for an implantable article, such as a pacemaker utilizes umbilical cord tissue to form art envelope around at least two opposing sides of the article. A pouch may be formed from the umbilical cord tissue having a single opening for receiving the implantable article. An en velope may be formed by removing the i nterior portion of the umbilical cord to form a tube having two open ends or by forming a cover sheet from the umbilical cord and then folding the cover sheet to form the envelope, A poach may be formed by attaching sides of an envelope, such as either- or both of the sides extending from the fold of the envelope and/or the extended ends of the en velope. The implantable cover derived from the umbilical cord may have some thickness of Wharton's Jelly and/or amniotic membrane. The implantable cover derived from the umbilical cord may be biologically active.

公开(公告)号：WO2018101578A1

公开(公告)日：2018-06-07

申请号：PCT/KR2017/009583

申请日：2017-09-01

Applicant: (주)엔앤비랩 ,  (주)이시스코스메틱

Inventor： 황광석

IPC: A61M37/00 ,  A61L31/14 ,  A61K9/00 ,  A45D34/04 ,  A45D40/26 ,  A45D34/00

CPC classification number: A61M37/0015 ,  A45D34/041 ,  A45D40/261 ,  A45D2034/002 ,  A45D2040/0006 ,  A45D2200/10 ,  A61K9/0021 ,  A61L31/148 ,  A61M2037/0023 ,  A61M2037/0053 ,  A61M2210/0606

Abstract: 본 발명의 마이크로 니들을 이용한 롤러형 피부 미용기기는, 롤러와; 라이너 상에 형성된 마이크로 니들의 표면은 생분해성 미용물질로 이루어지며, 마이크로 니들 시트 원판으로부터 재단되어 롤러의 원주면에 부착된 마이크로 니들부와; 상기 롤러가 회전가능하게 결합되는 손잡이부로 이루어진 것을 특징으로 한다.

公开(公告)号：WO2017156521A1

公开(公告)日：2017-09-14

申请号：PCT/US2017/022036

申请日：2017-03-13

Applicant: THE JOHNS HOPKINS UNIVERSITY

Inventor： PARIKH, Kunal, S. ,  PATEL, Himat ,  HANES, Justin

IPC: D01D5/00 ,  D01F1/10 ,  D01H7/02 ,  A61L17/00

CPC classification number: A61L17/005 ,  A61B17/06166 ,  A61K31/5383 ,  A61L17/105 ,  A61L17/12 ,  A61L31/06 ,  A61L31/148 ,  A61L2300/216 ,  A61L2300/402 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2400/12 ,  D01D5/0076 ,  D01D5/0084 ,  D01F1/10 ,  D01F1/103 ,  D01H7/02 ,  D04C1/06 ,  D10B2331/04 ,  D10B2331/041 ,  D10B2401/12 ,  D10B2509/04 ,  D10B2509/06

Abstract: A system for forming twisted or aligned electrospun fibers has been developed. The collector for the electrospun fibers is capable of rotation. In some instances, fibers are formed between two collectors, at least one of which rotates to twist the fibers into a multifilament bundle with increased strength. In a second embodiment, a cylindrical collector rotates, and charged polymer jet uniformly coats the surface of the collector. When a drum collector rotates at a high speed, electrospun fibers align and form an array. Optionally, different active agents can be included in the electrospinning solutions to form fiber constructs with different strengths and controlled release profiles, providing a reproducible method to generate complexed structures based on electrospun fibers and controlled drug delivery profiles.

Abstract translation: 已经开发了用于形成扭曲或排列的电纺丝纤维的系统。 电纺纤维的收集器能够旋转。 在一些情况下，纤维在两个收集器之间形成，其中至少一个收集器旋转以将纤维扭转成具有增加的强度的复丝束。 在第二实施例中，圆柱形收集器旋转，并且带电聚合物喷射均匀地涂布收集器的表面。 当鼓式收集器高速旋转时，电纺纤维对齐并形成阵列。 任选地，静电纺丝溶液中可以包含不同的活性剂以形成具有不同强度和控制释放曲线的纤维构造，提供可再现的方法以产生基于电纺纤维和受控药物递送曲线的复合结构。

公开(公告)号：WO2017141246A1

公开(公告)日：2017-08-24

申请号：PCT/IL2017/050201

申请日：2017-02-15

Applicant: SCHNEIDERMAN, Jacob

Inventor： SCHNEIDERMAN, Jacob

IPC: A61F2/07 ,  A61F2/82 ,  A61L31/08 ,  A61L31/16

CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2230/0021 ,  A61F2250/0068 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/436 ,  A61L2300/602 ,  A61L2300/604 ,  C08L67/04

Abstract: Devices and methods for treating ischemia and reperfusion injury (IRI) are configured for sustained-release of anti-proliferative drug into the wall of a blood vessel (to prevent in-stent stenosis), and for sustained-release of leptin antagonist into the lumen to be carried by the blood and be uptaken by tissue cells that were subjected to IRI.

Abstract translation: 用于治疗局部缺血和再灌注损伤（IRI）的装置和方法被配置用于将抗增殖药物缓释到血管壁（以防止支架内狭窄），并且用于持续释放 - 将瘦素拮抗剂释放到管腔中，由血液携带并被经受IRI的组织细胞摄取。

公开(公告)号：WO2017136726A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016506

申请日：2017-02-03

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ORAL, Ebru ,  SUHARDI, Jeremy V. ,  MURATOGLU, Orhun K. ,  MALCHAU, Henrik ,  RUBASH, Harry E. ,  FREIBERG, Andrew A.

IPC: C08G63/08 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  C08G63/664 ,  C08G63/91 ,  C08G64/18 ,  C08F299/04

CPC classification number: C08G63/664 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  C08F299/024 ,  C08G63/08 ,  C08G63/912 ,  C08G64/183 ,  C08L71/02

Abstract: This present invention relates to drug eluting polymers, including novel biodegradable drug eluting polymers, which are added to the surface of a medical device to treat device associated complications and to deliver drug locally around the device. Methods of making polymers, for example, drug-eluting polymers, polymer compositions, and materials used therewith also are provided. The drug eluting polymers are obtained from the polymerization of macromonomers made of a connecting moiety, a biodegradable moiety and a cross- linkable moiety that are liquids at a temperature of 10°C to 40°C.

Abstract translation: 本发明涉及药物洗脱聚合物，包括新型生物可降解药物洗脱聚合物，其被添加到医疗装置的表面以治疗与装置相关的并发症并且在装置周围局部递送药物。 还提供了制备聚合物的方法，例如药物洗脱聚合物，聚合物组合物和与其一起使用的材料。 药物洗脱聚合物由在10℃至40℃的温度下为液体的由连接部分，生物可降解部分和可交联部分组成的大分子单体的聚合反应获得。

公开(公告)号：WO2017136624A1

公开(公告)日：2017-08-10

申请号：PCT/US2017/016347

申请日：2017-02-03

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： BENIASH, Elia ,  PATIL, Avinash Jagannath

IPC: A61L27/04 ,  A61L27/28 ,  A61L27/54

CPC classification number: A61L27/28 ,  A61L27/047 ,  A61L27/54 ,  A61L27/58 ,  A61L31/022 ,  A61L31/08 ,  A61L31/148 ,  A61L31/16

Abstract: The invention relates to self-assembled organosilane coatings for resorbable medical implant devices. The coatings can be prepared from coating compositions containing organosilane and can be applied to metal or metal alloy substrates. Prior to applying the coatings, the surfaces of the substrates can be pretreated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be selectively removed, e.g., patterned, to expose portions of the uncoated substrate. Selecting different patterns can provide the ability to regulate or control various properties, such as, corrosion and hydrogen generation.

Abstract translation: 本发明涉及用于可再吸收医疗植入物装置的自组装有机硅烷涂层。 该涂层可以由含有有机硅烷的涂料组合物制备并且可以涂覆到金属或金属合金基材上。 在涂覆涂层之前，可以对基材的表面进行预处理。 涂层可以用与活性组分结合的结合化合物官能化。 涂层可以被选择性地去除，例如图案化，以暴露部分未涂覆的基底。 选择不同的模式可以提供调节或控制各种性质的能力，如腐蚀和氢气生成。

公开(公告)号：WO2016120338A3

公开(公告)日：2017-08-03

申请号：PCT/EP2016051720

申请日：2016-01-27

Applicant: LIMEDION GMBH

Inventor： KOVACS ADALBERT ,  SCHIESTEL STEFANIE

IPC: A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  C22C18/00

CPC classification number: A61L27/047 ,  A61L27/58 ,  A61L31/022 ,  A61L31/148 ,  C22C18/00 ,  C22C18/02 ,  C22C18/04

Abstract: The invention relates to a biodegradable alloy, to the production and use thereof, in particular for producing stents and other implants. The invention also relates to implants, preferably stents or bone implants, which comprise the claimed biodegradable alloy. According to the invention, a biodegradable alloy having a high zinc content is provided, said claimed alloy having, in addition to zinc, at least one other metal. The dissolution kinetics of the claimed alloy in vivo is clearly below those of known magnesium alloys, resulting in an extended period of time before the implant dissolves. On the other hand, implants, in particular stents, which comprise the claimed zinc alloy, can display mechanical properties which are clearly higher compared to implants made from pure zinc.

Abstract translation: 生物可降解合金及其生产和应用技术领域本发明涉及生物可降解合金及其生产和应用，特别是用于生产支架和其他植入物。 此外，本发明涉及包含根据本发明的生物可降解合金的植入物，优选支架或骨植入物。 在本发明的背景下，提出了具有高锌含量的可生物降解合金，其中除了锌以外，根据本发明的合金还具有至少一种其他金属。 本发明合金的体内溶解动力学显着低于已知镁合金的溶解动力学，因此可以实现延长的时间直到植入物溶解。 另一方面，植入物，特别是具有根据本发明的锌合金的支架，在某些情况下，与纯锌制成的植入物相比，显示出显着改善的机械性能。

公开(公告)号：WO2017127840A1

公开(公告)日：2017-07-27

申请号：PCT/US2017/014628

申请日：2017-01-23

Applicant: TRANSDERM INC.

Inventor： KASPAR, Roger L. ,  SPEAKER, Tycho

IPC: A61M37/00

CPC classification number: A61K38/4893 ,  A61K9/0014 ,  A61K9/0021 ,  A61L31/048 ,  A61L31/148 ,  A61L31/16 ,  C12Y304/24069

Abstract: A therapeutic toxin dosage form for treating a disease, disorder, or condition in a subject can include a microneedle array and a therapeutically effective amount of a therapeutic toxin loaded to the microneedle array for administration to the subject. Additionally, a method of treating a disease, disorder, or condition in a subject can include administering a therapeutically effective amount of a therapeutic toxin to the subject via a microneedle array.

Abstract translation: 用于治疗受试者中的疾病，病症或病症的治疗性毒素剂型可以包括微针阵列和治疗有效量的加载到微针阵列的治疗毒素以施用于受试者。 另外，治疗受试者的疾病，病症或病症的方法可包括通过微针阵列向受试者施用治疗有效量的治疗性毒素。

公开(公告)号：WO2017112779A1

公开(公告)日：2017-06-29

申请号：PCT/US2016/068038

申请日：2016-12-21

Applicant: THE UNIVERSITY OF TOLEDO

Inventor： IBRAHIM, Hamdy ,  ELAHINIA, Mohammad

IPC: A61F2/86 ,  A61L31/14 ,  A61L31/02

CPC classification number: A61L31/022 ,  A61F2/28 ,  A61L31/148

Abstract: A Quaternary Mg-Zn-Ca-based alloy and a heat treatment process for producing bioresorbable bone fixation implants are described thereof. The mechanical and biocorrosion properties of the fabricated Mg-based alloy were improved by combining careful selection of the alloy's chemical composition and subsequent post-shaping process (heat treatments). Heat treatment process is more privileged especially after fabricating the part into its final shape such as in additive manufacturing (3D-printing) and powder metallurgy. In this way, it is possible to produce biocompatible, strong and less corrosive patient-specific bone fixation hardware. Also, such heat-treated Mg-Zn-Ca-based parts can be further coated with various types of biocompatible ceramic coatings for slower and more tailored biocorrosion rates.

Abstract translation: 描述了第四代Mg-Zn-Ca基合金和用于生产生物可再吸收骨固定植入物的热处理工艺。 通过仔细选择合金的化学成分和随后的成形过程（热处理），可以改善制造的镁基合金的机械和生物腐蚀性能。 热处理工艺尤其在将部件制造成其最终形状（如增材制造（3D印刷）和粉末冶金）后更具优势。 通过这种方式，可以生产生物相容性强，腐蚀性较小的患者特异性骨固定硬件。 此外，这种经过热处理的Mg-Zn-Ca基零件可以进一步涂覆各种生物相容性陶瓷涂层，以获得更慢且更适合的生物腐蚀速率。