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    GRAMICIDIN A MUTANTS THAT FUNCTION AS ANTIBIOTICS WITH IMPROVED SOLUBILITY AND REDUCED TOXICITY
    21.
    发明申请
    GRAMICIDIN A MUTANTS THAT FUNCTION AS ANTIBIOTICS WITH IMPROVED SOLUBILITY AND REDUCED TOXICITY 审中-公开
    GRAMICIDIN作为具有改善溶解性和降低毒性的抗生素功能的突变体

    公开(公告)号：WO2013071049A1

    公开(公告)日：2013-05-16

    申请号：PCT/US2012/064364

    申请日：2012-11-09

    Applicant: TRUSTEES OF BOSTON COLLEGE

    Inventor： Gao, Jianmin ,  Wang, Fang

    IPC: A61K38/10 ,  C07K7/28

    CPC classification number: C07K7/28 ,  A01N43/38 ,  A61K38/00 ,  A61K38/10

    Abstract: Described herein are antimicrobial peptides for use in pharmaceutical antibiotic compositions and methods of use thereof. These antimicrobial peptides are Gramicidin A (gA) peptide analogs that, in addition to having potent anti-microbial activity, have greatly increased solubility and significantly reduced toxicity in comparison to the wild-type Gramicidin A peptide.

    Abstract translation: 本文描述了用于药物抗生素组合物的抗微生物肽及其使用方法。 这些抗微生物肽是革兰定酸A（gA）肽类似物，除了具有有效的抗微生物活性之外，与野生型格列美星肽A相比，其具有大大增加的溶解度和显着降低的毒性。

    METHOD FOR BACTERIAL LYSIS
    24.
    发明申请
    METHOD FOR BACTERIAL LYSIS 审中-公开
    细菌裂解方法

    公开(公告)号：WO2009002580A9

    公开(公告)日：2008-12-31

    申请号：PCT/US2008/059158

    申请日：2008-04-02

    Applicant: BOSTON MEDICAL CENTER CORPORATION ,  KLAPPERICH, Catherine ,  KAUFMAN, Jessica ,  KULINSKI, Maria, Dominika ,  ALTMAN, David ,  SINGH, Satish

    Inventor： KLAPPERICH, Catherine ,  KAUFMAN, Jessica ,  KULINSKI, Maria, Dominika ,  ALTMAN, David ,  SINGH, Satish

    IPC: B01L3/00 ,  C01B31/02 ,  C12N1/06 ,  G01N1/28

    Abstract: The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microf luidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes.The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria. In some embodiments, the microfluidic devices of the present invention can also optionally comprise other modules enabling further processing of the biological sample, for example isolation, purification and detection of biomolecules released from the lysed cells, such as but not limited to nucleic acids or proteins or peptides from the lysed cells, providing a complete Lab- on- a- Chip analysis system for biomolecules released from difficult to lyse microorganisms in a single step or process. The microfluidic devices of the present invention can also be adapted and are useful to methods to enrich for microorganisms in a biological sample, for example enrich for a desired type of bacteria within a biological sample. The microfluidic devices and methods of the present invention can be adapted to perform highly efficient lysis of microorganisms within a biological sample for diagnostic tests, for example for diagnosis of infectious agents and pathogens, such as bacteria, viruses or parasites.

    Abstract translation: 本发明涉及用于裂解细胞如细菌和微生物的微流体装置。 具体而言，本发明涉及微流体装置和这种微流体装置的制造方法，该微流体装置包括具有至少一个填充有嵌入有碳颗粒的聚合物整料的通道的基底，例如碳纳米管。本发明的微流体装置和方法 本发明可用于生物样品（例如包含微生物的未经处理的生物样品，例如但不限于革兰氏阳性和革兰氏阴性细菌）内细胞的细胞裂解。 在一些实施方案中，本发明的微流体装置还可以任选地包含能够进一步处理生物样品的其它模块，例如分离，纯化和检测从裂解的细胞释放的生物分子，例如但不限于核酸或蛋白质 或来自裂解细胞的肽，提供完整的Lab-on-Chip分析系统，用于在单个步骤或过程中从难以裂解的微生物中释放的生物分子。 本发明的微流体装置也可适用于并且可用于丰富生物样品中的微生物的方法，例如富集生物样品内的期望类型的细菌。 本发明的微流体装置和方法可以适用于对生物样品中的微生物进行高效裂解以进行诊断测试，例如用于诊断感染物和病原体，如细菌，病毒或寄生虫。

    TREATING CANCERS WITH ACTIVATED RAS THROUGH INHIBITION OF PKC DELTA
    26.
    发明申请
    TREATING CANCERS WITH ACTIVATED RAS THROUGH INHIBITION OF PKC DELTA 审中-公开

    公开(公告)号：WO2007106424A3

    公开(公告)日：2007-09-20

    申请号：PCT/US2007/006174

    申请日：2007-03-12

    Applicant: THE TRUSTEES OF BOSTON UNIVERSITY ,  FALLER, Douglas, V.

    Inventor： FALLER, Douglas, V.

    IPC: C12N15/11 ,  A61K31/00 ,  A61K31/7088

    Abstract: Disclosed herein are methods for treating a subject with, or at risk for, developing a tumor which has aberrantly increased Ras signaling. The method involves obtaining a biological sample from the subject, determining whether the biological sample contains cells which have aberrantly increased Ras signaling, and administering an agent that selectively inhibits Protein Kinase C (PKC) delta to the subject upon determination of the aberrantly increased Ras signaling, to thereby inhibit PKC-delta in the cell. The increased Ras signaling may result from expression of activated Ras, e.g. resulting from mutations in codon (12, 13, 59, 61, 63, 116, 117, or 146). Such mutations can be determined by detection of a nucleotide sequence encoding an activated form of Ras protein, or by detection of the activated Ras protein. The increased Ras signaling may result from over-expression of wild-type Ras, over-activation of wild-type Ras, or increased activation of one or more effector pathways downstream of Ras. The tumor cells of the individual may be malignant or non-malignant. The inhibitor(s) of PKC-delta may inhibit PKC-delta gene expression, reduce PKC-delta protein levels, and/or inhibit PKC-delta protein function by inhibiting kinase activity. Appropriate inhibitors are Rottlerin, Balanol, balanol analogs, KAI 9S03, and combinations thereof. Also disclosed are methods for determining the likelihood of effectiveness of administering an agent that selectively inhibits PKC-delta to a subject with a tumor. The methods involve determining the presence or absence of aberrantly increased Ras signaling in the tumor, wherein the presence of aberrantly increased Ras signaling indicates that administration of the PKC-delta inhibitor is likely to be effective.

    NUCLEIC ACID SEQUENCES ASSOCIATED WITH CELL STATES
    28.
    发明申请
    NUCLEIC ACID SEQUENCES ASSOCIATED WITH CELL STATES 审中-公开
    与细胞状态相关的核酸序列

    公开(公告)号：WO2007019499A2

    公开(公告)日：2007-02-15

    申请号：PCT/US2006/030887

    申请日：2006-08-08

    Applicant: MASSACHUSETTS INTITUTE OF TECHNOLOGY ,  SHERLEY, James, L. ,  NOH, Min-soo

    Inventor： SHERLEY, James, L. ,  NOH, Min-soo

    CPC classification number: C12Q1/6883 ,  C12Q2600/158

    Abstract: The present invention is directed to nucleic acid sequences whose expression is associated with different cell states, including nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting asymmetric self-renewal relative to other cells. The invention is also directed to nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting symmetric self-renewal relative to other cells.

    Abstract translation: 本发明涉及其表达与不同细胞状态相关的核酸序列，包括在其相对于其他细胞显示不对称自我更新的细胞中，其表达被诱导至少100倍或可选地上调的核酸序列。 本发明还涉及其表达在相对于其他细胞显示对称自我更新的细胞中被诱导至少100倍或者可选地上调的核酸序列。

    METHOD OF TREATING DISEASES AND DISORDERS
    29.
    发明申请
    METHOD OF TREATING DISEASES AND DISORDERS 审中-公开
    治疗疾病和疾病的方法

    公开(公告)号：WO2006055974A2

    公开(公告)日：2006-05-26

    申请号：PCT/US2005/042597

    申请日：2005-11-22

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  HARN, Donald

    Inventor： HARN, Donald

    CPC classification number: C07K16/20 ,  A61K2039/505 ,  C07K16/1045 ,  C07K2317/34 ,  C07K2317/76

    Abstract: We have discovered that targeting carbohydrates on cell, or viral particle surfaces, such as using antibodies against such carbohydrates also called glycans provide a new tool to treat diseases and disorders, such as viral diseases and malignant tumors. Therefore, the present invention provides methods for treating individuals affected with diseases and disorders, for example viral infections, such as lentiviral infections, and malignant tumors, using molecules that bind carbohydrates that are expressed on the surface of the viral particle or a cell, for example antibodies against Lewis X-antigen.

    Abstract translation: 我们已经发现，靶向细胞或病毒颗粒表面上的碳水化合物，例如使用针对这种碳水化合物的抗体也称为聚糖，提供了治疗诸如病毒性疾病和恶性肿瘤之类的疾病和病症的新工具。 因此，本发明提供用于治疗患有疾病和病症的个体的方法，例如病毒感染，例如慢病毒感染和恶性肿瘤，使用结合在病毒颗粒或细胞表面上表达的碳水化合物的分子，用于 示例性针对Lewis X抗原的抗体。

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