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公开(公告)号：WO2023087230A1
公开(公告)日：2023-05-25
申请号：PCT/CN2021/131606
申请日：2021-11-19
Applicant: 深圳先进技术研究院
Abstract: 本申请提供了一种织物中塑料微粒的提取方法，包括以下步骤：采用包埋液体包埋织物，冷冻至凝固，得到待切取固体；将所述待切取固体进行切割，并收集切割得到的固体薄片；待所述固体薄片融化后离心，烘干，得到所述塑料微粒。采用该提取方法可获得尺寸小且纯度高的塑料微粒，有利于为塑料微粒对生态环境的污染和生物健康的危害的深入研究提供技术基础。本申请还提供了一种塑料微粒的切取装置。
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公开(公告)号：WO2023086874A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/079619
申请日：2022-11-10
Inventor： ANAND, Kanwaljeet S. , ROVNAGHI, Cynthia , LEIB, Ryan
Abstract: Compositions and methods are provided for identifying and measuring biomarkers in hair. In particular, methods for extracting proteins and RNA species from hair, and for identifying and measuring hair biomarkers are disclosed. Serial segmentation of a hair sample can be used to assess sequential epochs of protein expression, metabolic regulation, and gene expression in the body across different time periods. Use of hair biomarkers provides a non-invasive, pain-free method for diagnosing diseases and identifying individuals at risk for poor health outcomes.
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公开(公告)号：WO2023077166A1
公开(公告)日：2023-05-04
申请号：PCT/US2022/079082
申请日：2022-11-01
Applicant: MATTERWORKS INC
Inventor： KASSIS, Timothy , PRUYNE, Jefferson , SIMON, Mark D. , CADOSCH DELMAR AKERMAN, Mimoun , CAMPBELL, Jennifer , HENRIQUES DA COSTA, Ana , KOLINSKY, Laura , GEREMIA, John M.
Abstract: Disclosed are methods, libraries, and samples for quantifying a target analyte in a laboratory sample including the target analyte. The methods typically include the step of estimating the amount of the target analyte in the laboratory sample from mass spectrometric data including signal intensities for the target analyte and one or more internal standards, where the mass spectrometric data are an output of a mass spectrometric analysis of a target sample produced from the laboratory sample and a predetermined amount of the one or more internal standards. The present disclosure also provides a method for analyte quantification. The method comprises adding one or more calibrators to a sample comprising one or more analytes; applying mass spectrometry (MS) to the sample; and using a trained machine learning model to determine an absolute concentration of the one or more analytes.
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4.发明申请
公开(公告)号：WO2023069663A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047339
申请日：2022-10-21
Applicant: TEXAS TECH UNIVERSITY SYSTEM
Inventor： KELLY, Brendan
IPC: D01G31/00 , D01G99/00 , D04H1/74 , G01N1/28 , G01N33/36 , G01N1/34 , G01N21/84 , G01N1/04 , G01N1/286 , G01N21/8915 , G01N2203/028 , G01N33/362 , G01N33/365
Abstract: The present disclosure provides a system, apparatus, and method for generating randomly aligned fiber beards for evaluation. The system (20) comprises a base (22) and an x-axis frame member coupled to and positioned parallel to the base (22). A y-axis frame member is coupled to and positioned perpendicular to the base (22). A sample plate is removably coupled to the y-axis frame member and defines one or more holes. A fiber clamp couples to and is movable by the x- axis frame member perpendicularly to the sample plate.
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公开(公告)号：WO2023069648A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047318
申请日：2022-10-20
Applicant: ULTIMA GENOMICS, INC.
Inventor： ONO, Robert , WORKU, Aklilu , KUBECKA, Stephanie , OBERSTRASS, Florian , ALMOGY, Gilad
IPC: G01N21/75 , G01N1/28 , G01N1/36 , G01N1/10 , G01N33/543
Abstract: Disclosed herein are buffer solutions for decreasing the size of particles during imaging. The buffer solutions may comprise polymers, ions, or a combination thereof. The buffer solutions may decrease the sizes of particles. Decreasing the sizes of the particles during imaging can improve the resolution of individual particle imaged, and may reduce particle aggregation and/or increase substrate loading efficiency. In some cases, decreasing the sizes of the particles can improve the resolution of individual reads of sequencing. Also provided herein are methods and systems of using the same.
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Patent Agency Ranking
公开(公告)号：WO2023062309A1
公开(公告)日：2023-04-20
申请号：PCT/FR2022/051903
申请日：2022-10-10
Applicant: SAFRAN HELICOPTER ENGINES
Inventor： VERNAULT, Cyril Roger , ANSSEMS, Lucie , BESOMBES, Mariane Erika Michèle , GAULHET, Manon Paule Jeanne
Abstract: L'invention concerne un procédé de mesure quantitatif d'un élément (4) dans une pièce témoin (1) en métal ayant reçu un traitement thermochimique de surface, caractérisé en ce qu'il comprend les étapes suivantes : • - a- réalisation d'une coupe dans la pièce témoin, • - b- prise d'une photographie par un microscope optique de ladite coupe sur une surface S avec un grossissement, • - c- calcul du rapport des surfaces s occupées par l'élément par rapport à la surface S sur la photographie par un outil de traitement de l'image, • - d- obtention de la teneur de l'élément dans la surface S de la pièce témoin. On peut ainsi obtenir un profil de teneur en éléments indésirables en s'affranchissant de l'aspect subjectif du contrôle par un humain et qui est représentatif d'une teneur obtenue par acquisition de diffraction des rayons X réalisées à l'aide d'un synchrotron.
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公开(公告)号：WO2023030460A1
公开(公告)日：2023-03-09
申请号：PCT/CN2022/116587
申请日：2022-09-01
Applicant: 深圳市瑞图生物技术有限公司
Abstract: 本申请提供了一种推片染色机及推片染色方法，推片染色机包括：网织红细胞染色装置，用于对网织红细胞样本进行染色；加样装置，用于将染色后的网织红细胞样本添加至网织红细胞玻片上；推片装置，用于将添加至网织红细胞玻片上的网织红细胞样本涂布于网织红细胞玻片上，能够实现对网织红细胞样本的制片。
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公开(公告)号：WO2023019086A1
公开(公告)日：2023-02-16
申请号：PCT/US2022/074578
申请日：2022-08-05
Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.
Inventor： COX, Janine , DESILVA, Justin
Abstract: An apparatus and method for removing bubbles from a fluid sample. The apparatus has a barrel and a filter member. The barrel has a first end, a second end, a sidewall, and an inner surface defining an internal chamber. The first side has an inlet opening and the second side has an outlet opening. The filter member is slidably disposed within the internal chamber and defines an inlet side and an outlet side of the internal chamber. The filter member has a gas-permeable, liquid-impermeable membrane which permits the gas portion of the fluid sample to pass across the filter member. The barrel has a second gas-permeable, liquid-impermeable membrane which provides a fluid-tight seal across the outlet opening.
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公开(公告)号：WO2023014700A1
公开(公告)日：2023-02-09
申请号：PCT/US2022/039146
申请日：2022-08-02
Inventor： VUNJAK-NOVAKOVIC, Gordana , FLEISHER, Sharon , TAMARGO, Manuel , NASH, Trevor, Ray , WINCHESTER, Robert , GERALDINO-PARDILLA, Laura
IPC: C12M3/02 , A61K35/34 , A61K35/545 , G01N21/00 , G01N1/28
Abstract: Provided are a system and method to culture human cardiac muscle tissues in a bioreactor comprising a plurality of culture wells arranged linearly between two carbon electrodes that are exposed within each well; and two horizontal parallel flexible pillars extending from each well wherein the pillars in each well are configured to suspend an engineered tissue. Also provided is method for diagnosing myocarditis in a subject by analyzing human cardiac muscle tissues cultured in the bioreactor in the presence of blood serum or antibodies from the subject.
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公开(公告)号：WO2023003674A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/035227
申请日：2022-06-28
Applicant: APPLIED MATERIALS ISREAL LTD. , APPLIED MATERIALS, INC.
Inventor： MAIROV, Alexander , BURNER, Gal , ZUR, Yehuda
IPC: G01B15/02 , G01N23/2251 , G01N1/28 , H01J37/26 , H01J37/30
Abstract: Analyzing a buried layer on a sample includes milling a spot on the sample using a charged particle beam of a focused ion beam (FIB) column to expose the buried layer along a sidewall of the spot. From a first perspective a first distance is measured between a first point on the sidewall corresponding to an upper surface of the buried layer and a second point on the sidewall corresponding to a lower surface of the buried layer. From a second perspective a second distance is measured between the first point on the sidewall corresponding to the upper surface of the buried layer and the second point on the sidewall corresponding to the lower surface of the buried layer. A thickness of the buried layer is determined using the first distance and the second distance.
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