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公开(公告)号：WO2019027650A1
公开(公告)日：2019-02-07
申请号：PCT/US2018/041786
申请日：2018-07-12
摘要： The present disclosure is directed to methods for scrubbing low levels of urea from aqueous solutions such as a dialysate from dialysis, and including blood and blood products, and devices capable of employing these methods.
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公开(公告)号：WO2018132796A1
公开(公告)日：2018-07-19
申请号：PCT/US2018/013728
申请日：2018-01-15
申请人： DREXEL UNIVERSITY
发明人： CHACKO, James, J. , DANDEKAR, Kapil, R. , JACOVIC, Marko , JURETUS, Kyle , KANDASAMY, Nagarajan , SAHIN, Cem , SAVIDIS, Ioannis
摘要： A physical layer based technique secures wireless communication between a transmitter and receiver. The technique involves obfuscating the preamble data of the baseband signal through unique keys that are generated at the transmitter and the receiver based on channel characteristics known only to them.
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公开(公告)号：WO2018053013A1
公开(公告)日：2018-03-22
申请号：PCT/US2017/051380
申请日：2017-09-13
摘要： The present invention includes novel cyclic peptides of formula (I). The present invention further includes novel cyclic peptides conjugated with a gold nanoparticle, and methods of using the same. The invention further provides a pharmaceutical composition comprising at least one pharmaceutically acceptable carrier and at least one cyclic compound of the invention. The invention further provides a method of treating, reducing, or preventing HIV-1 infection in a mammal in need thereof, the method comprising administering to the mammal a therapeutically effective amount of at least one cyclic compound of the invention.
摘要翻译： 本发明包括式（I）的新型环肽。 本发明还包括与金纳米颗粒结合的新型环状肽及其使用方法。 本发明还提供了包含至少一种药学上可接受的载体和至少一种本发明的环状化合物的药物组合物。 本发明还提供了治疗，减少或预防有此需要的哺乳动物中HIV-1感染的方法，所述方法包括给哺乳动物施用治疗有效量的至少一种本发明的环状化合物。
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公开(公告)号：WO2017223297A1
公开(公告)日：2017-12-28
申请号：PCT/US2017/038718
申请日：2017-06-22
摘要： This application relates to biologically compatible porous cartilage templates for in vitro and in vivo generation of bone with enhanced structural characteristics. Provided herein are compositions having an internal structure desirable for the generation and regeneration of bone, along with methods of preparation and use.
摘要翻译： 本申请涉及用于体外和体内生成具有增强的结构特征的骨的生物相容性多孔软骨模板。 本文提供的是具有期望用于骨的产生和再生的内部结构以及制备和使用方法的组合物。
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公开(公告)号：WO2017106334A1
公开(公告)日：2017-06-22
申请号：PCT/US2016/066641
申请日：2016-12-14
IPC分类号： G01N33/49
CPC分类号： G01N33/721 , G01N11/04 , G01N11/06 , G01N2800/22
摘要： One aspect of the invention provides a method of screening for sickle-cell disease. The method includes: contacting an end of a capillary tube with deoxygenated blood; observing a flow rate of the deoxygenated blood within the capillary tube; and performing one or more steps selected from the group consisting of: comparing the flow rate to a predetermined flow-rate threshold for the capillary tube indicative of sickle-cell disease; calculating viscosity based on the flow rate and comparing the viscosity to a predetermined viscosity threshold for the capillary tube indicative of sickle-cell disease; and comparing the flow rate to a second flow rate for oxygenated blood from a same subject within a substantially identical capillary tube.
摘要翻译： 本发明的一个方面提供了筛选镰状细胞疾病的方法。 该方法包括：使毛细管的一端与脱氧血液接触; 观察毛细管内的脱氧血液的流速; 以及执行选自以下的一个或多个步骤：将所述流速与指示镰状细胞疾病的所述毛细管的预定流速阈值进行比较; 基于所述流量计算粘度并将所述粘度与指示镰状细胞病的所述毛细管的预定粘度阈值进行比较; 并且将流速与来自同一对象的含氧血液的第二流速相比较，所述血液来自基本相同的毛细管内的同一受试者。
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公开(公告)号：WO2017087749A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062674
申请日：2016-11-18
申请人： DREXEL UNIVERSITY , SHIH, Wan Y. , SHIH, Wei-Heng , XU, Xin , EMERY, Christopher , JOSHI, Suresh , WU, Wei
发明人： SHIH, Wan Y. , SHIH, Wei-Heng , XU, Xin , EMERY, Christopher , JOSHI, Suresh , WU, Wei
CPC分类号： G01N29/022 , G01N29/036 , G01N2291/012 , G01N2291/02466 , G01N2291/0256 , G01N2291/0422 , G01N2291/0426 , G01N2291/0427
摘要： A system for and method of antimicrobial susceptibility testing includes detecting a resonance peak of a sensor provided with live microbes on a surface thereof; applying a substance to the live microbes; detecting a resonance peak of said sensor after application of said substance; determining a width of a top of each of said resonance peaks before and after application of the substance from one of: (1) a phase angle versus frequency plot where the phase angle is the phase angle of the electrical impedance of said sensor, (2) a real part of a plot of an electrical impedance versus frequency of said sensor, (3) a plot of a magnitude of electrical impedance versus frequency of said sensor, and (4) a phase angle versus frequency plot where the phase angle is the phase angle between an output voltage and an input voltage of said sensor, and comparing the determined widths of tops of said resonance peaks or standard deviations of the frequency of said resonance peaks to determine antimicrobial susceptibility including the minimum inhibitory concentration (MIC).
摘要翻译： 用于抗微生物敏感性测试的系统和方法包括：检测在其表面上提供有活微生物的传感器的共振峰; 将一种物质应用于活的微生物; 在施加所述物质之后检测所述传感器的谐振峰值; （1）相位角对频率曲线，其中相位角是所述传感器的电阻抗的相位角，（2）相位角对频率曲线， ）所述传感器的电阻抗对频率的曲线的实部;（3）电阻抗的量值与所述传感器的频率的曲线图;以及（4）相角对频率曲线，其中相位角是 以及比较所确定的所述共振峰的顶部宽度或所述共振峰的频率的标准偏差以确定包括最小抑制浓度（MIC）在内的抗微生物剂敏感性。 p>
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公开(公告)号：WO2017066605A1
公开(公告)日：2017-04-20
申请号：PCT/US2016/057092
申请日：2016-10-14
申请人： DREXEL UNIVERSITY
IPC分类号： A61K35/15 , A61L26/00 , A61P17/02 , C12N5/0786
CPC分类号： A61K35/15 , C12N5/0645
摘要： The application relates to the healing of wounds. Provided herein are methods directed to treatment of hard-to-heal or chronic wounds by sequential administration of M1 and M2 macrophages to the wound site.
摘要翻译：
该申请涉及伤口愈合。 本文提供了通过将M1和M2巨噬细胞依次施用于伤口部位来治疗难以愈合或慢性伤口的方法。
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28.发明申请DIRECT INTEGRATON OF INDIVIDUALLY CONTROLLED PIXELS INTO A KNITTED FABRIC MATRIX 审中-公开独立控制像素直接集成到针织织物矩阵
公开(公告)号：WO2017031484A1
公开(公告)日：2017-02-23
申请号：PCT/US2016/047940
申请日：2016-08-22
申请人： DREXEL UNIVERSITY
CPC分类号： G09F9/30 , D04B1/14 , D10B2401/16 , G09F9/305 , G09G3/12
摘要： A flexible and scalable emissive fabric display with individually controllable pixels disposed within a fabric matrix. The pixels may include areas where electroluminescent thread contact conductive threads, and take the form of either individual stitches, or contact points between perpendicularly inlayed conductive threads and electroluminescent threads. Alternatively, the pixels may include individual electroluminescent segments disposed along a conductive thread.
摘要翻译： 灵活和可扩展的发射结构显示器，其具有布置在织物矩阵内的独立可控像素。 像素可以包括电致发光线接触导电丝线并且采取单独针迹或垂直嵌入的导电线和电致发光线之间的接触点的形式。 或者，像素可以包括沿着导电线设置的单个电致发光段。
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29.发明申请COMPOSITIONS AND METHODS FOR HIV QUASI-SPECIES EXCISION FROM HIV-1-INFECTED PATIENTS 审中-公开艾滋病毒感染艾滋病病毒感染者的组成和方法
公开(公告)号：WO2016086177A2
公开(公告)日：2016-06-02
申请号：PCT/US2015/062755
申请日：2015-11-25
申请人： DREXEL UNIVERSITY
CPC分类号： C12Q1/6809 , C12Q1/6876 , C12Q1/703
摘要： The invention relates to the compositions and methods for complete excision of HIV-1 proviral genomes including viral quasi-species (vQS) from an HIV-1-infected human. The invention includes a composition of guide RNAs (gRNAs) designed to specifically target the HIV-1 LTR region or any other region of the HIV-1 genome. The invention further includes a method for treating an HIV-1-infected human using the clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated (Cas) 9 system and the compositions of the present invention.
摘要翻译： 本发明涉及完全切除HIV-1前病毒基因组的组合物和方法，包括来自HIV-1感染的人的病毒准物种（vQS）。 本发明包括设计用于特异性靶向HIV-1 LTR区域或HIV-1基因组的任何其它区域的引导RNA（gRNA）的组合物。 本发明进一步包括使用聚簇规则间隔的短回文重复（CRISPR）/ CRISPR相关（Cas）9系统和本发明的组合物来治疗HIV-1感染的人的方法。
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公开(公告)号：WO2016033095A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046768
申请日：2015-08-25
申请人： DREXEL UNIVERSITY
CPC分类号： A61K31/78 , A61K38/00 , A61K45/06 , A61K47/58 , C07K17/08 , C08F120/02 , A61K2300/00
摘要： The present invention novel methods of preparing biomimetic proteoglycans, such as bottle-brush, chondroitin sulfate-containing, biomimetic proteoglycans. In certain embodiments, the methods of the invention comprise contacting a core polymer comprising at least one acyl chloride group and a GAG comprising a terminal primary amine.
摘要翻译： 本发明制备仿生蛋白多糖的新颖方法，如瓶刷，硫酸软骨素，仿生蛋白聚糖。 在某些实施方案中，本发明的方法包括使包含至少一个酰氯基团的核聚合物和包含末端伯胺的GAG接触。
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