公开(公告)号：WO2012135068A1

公开(公告)日：2012-10-04

申请号：PCT/US2012/030453

申请日：2012-03-23

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  AYAZ, Hasan ,  SHEWOKIS, Patricia A. ,  BUNCE, Scott C. ,  ONARAL, Banu

发明人： AYAZ, Hasan ,  SHEWOKIS, Patricia A. ,  BUNCE, Scott C. ,  ONARAL, Banu

IPC分类号： A61B5/04 ,  A61B5/00

CPC分类号： G06F3/015 ,  A61B5/0042 ,  A61B5/0075 ,  A61B5/14553 ,  A61B5/486 ,  A61B5/6814

摘要： Described herein are fNIR-based brain computer interfaces. Training of individuals to intentionally control neural activity in specific cortical areas, thereby up-regulating and down- regulating oxygenation levels in specific locations in the brain is also provided herein. Further, continuous and/or binary control over computing environments using fNIR brain computer interfaces. Further still, a scale for brain interface index for oxygenation of a portion of the brain is provided herein.

摘要翻译： 这里描述的是基于fNIR的大脑计算机接口。 训练个人有意控制特定皮层区域的神经活动，从而上调和降低大脑特定位置的氧合水平。 此外，使用fNIR大脑计算机接口对计算环境进行连续和/或二进制控制。 此外，本文提供了脑部分的氧合的脑界面指数的标度。

公开(公告)号：WO2012018891A3

公开(公告)日：2012-02-09

申请号：PCT/US2011/046382

申请日：2011-08-03

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  FRIDMAN, Gregory ,  PARK, Sin ,  SHAINSKY, Natalie ,  DOBRYNIN, Danil ,  RABINOVICH, Alexander ,  FRIEDMAN, Gennady ,  FRIDMAN, Alexander ,  COOPER, Moogega ,  BROOKS, Ari, D. ,  JOSHI, Suresh ,  POOR, Alexander ,  ERCAN, Utku ,  INGERMAN, Mark

发明人： FRIDMAN, Gregory ,  PARK, Sin ,  SHAINSKY, Natalie ,  DOBRYNIN, Danil ,  RABINOVICH, Alexander ,  FRIEDMAN, Gennady ,  FRIDMAN, Alexander ,  COOPER, Moogega ,  BROOKS, Ari, D. ,  JOSHI, Suresh ,  POOR, Alexander ,  ERCAN, Utku ,  INGERMAN, Mark

IPC分类号： C12N5/00 ,  C12N5/02

摘要： Aspects of the present subject matter are directed to a method comprising contacting an fluid, optionally containing an added organic material, with a non-thermal plasma to form a disinfection composition, wherein the disinfection composition is a liquid, and contacting a surface with the disinfection composition, wherein the surface is at least partially disinfected upon contact with the disinfection composition. Additional aspects of the present subject matter are directed to a method comprising forming a disinfection composition by contacting an organic material with a non-thermal plasma, wherein the disinfection composition is a liquid. A further aspect of the present subject matter is directed to a disinfection composition comprising an organic material contacted by a non-thermal plasma, wherein the disinfection composition is a liquid.

公开(公告)号：WO2010009103A2

公开(公告)日：2010-01-21

申请号：PCT/US2009/050509

申请日：2009-07-14

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  FRIDMAN, Gregory ,  FRIDMAN, Alexander ,  GUTSOL, Alexander ,  FRIEDMAN, Gennady ,  STAACK, David ,  HAMILTON, Richard, Joseph

发明人： FRIDMAN, Gregory ,  FRIDMAN, Alexander ,  GUTSOL, Alexander ,  FRIEDMAN, Gennady ,  STAACK, David ,  HAMILTON, Richard, Joseph

IPC分类号： A61B18/00 ,  A61M1/00 ,  A61B1/07

CPC分类号： A61B18/042 ,  A61B2018/00982

摘要： The use of non-thermal plasma to treat mucus membrane bleeding is described herein. A non-thermal plasma is generated using an apparatus having a first electrode that receives alternating electrical potentials from a power supply. When placed in an appropriate location proximate to tissue, a non-thermal plasma is generated, the second electrode being human tissue, blood, etc. To reduce the likelihood of an arc being generated, potentially causing tissue damage or pain, the first electrode is partially encapsulated by a dielectric. The non-thermal plasma is applied to the area of bleeding for treatment.

摘要翻译： 本文描述了使用非热等离子体来治疗粘液膜出血。 使用具有从电源接收交流电位的第一电极的装置产生非热等离子体。 当放置在靠近组织的适当位置时，产生非热等离子体，第二电极是人体组织，血液等。为了减少产生电弧的可能性，可能导致组织损伤或疼痛，第一电极 被电介质部分封装。 将非热等离子体施加到出血处理区域。

公开(公告)号：WO2008048237A3

公开(公告)日：2008-04-24

申请号：PCT/US2006/035028

申请日：2006-09-08

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  GISZTER, Simon ,  KO, Frank, K. ,  UDOEKWERE, Ubong, Ime ,  YANG, Heejae

发明人： GISZTER, Simon ,  KO, Frank, K. ,  UDOEKWERE, Ubong, Ime ,  YANG, Heejae

IPC分类号： A61N5/04

摘要： Electrodes for intracorporeal and other uses are provided. The invention features sterilizable, braided electrodes which are formed of or include conductive elements in electronic communication with a plurality of sites for electrical stimulation or sensing. Other active elements may be included in the braided electrodes.

公开(公告)号：WO2009140660A2

公开(公告)日：2009-11-19

申请号：PCT/US2009/044250

申请日：2009-05-15

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  SHIH, Wan, Y. ,  SHIH, Wei-Heng ,  YEGINGIL, Hakki ,  BROOKS, Ari, D.

发明人： SHIH, Wan, Y. ,  SHIH, Wei-Heng ,  YEGINGIL, Hakki ,  BROOKS, Ari, D.

IPC分类号： G01N33/483 ,  C12Q1/02

CPC分类号： A61B5/0053 ,  A61B5/4244 ,  A61B5/4312 ,  A61B5/4381 ,  A61B5/441 ,  A61B5/442 ,  A61B8/085 ,  A61B8/403 ,  A61B8/485 ,  G01N29/0672 ,  G01N2291/02475 ,  G01N2291/02827

摘要： A sensor system for measuring an elastic modulus and a shear modulus and a method for evaluating a tissue. The invention pertains to a method for determining the presence of and/or characterizing abnormal growths, using a piezoelectric finger sensor (PEFS) system. The PEFS system may be particularly useful for screening for tumors and various forms of cancer. Additionally, the PEFS system may be useful for various dermatological applications.

摘要翻译： 用于测量弹性模量和剪切模量的传感器系统和用于评估组织的方法。 本发明涉及使用压电手指传感器（PEFS）系统确定异常生长的存在和/或表征异常生长的方法。 PEFS系统可能特别适用于筛选肿瘤和各种​​形式的癌症。 此外，PEFS系统可用于各种皮肤病学应用。

公开(公告)号：WO2014169226A2

公开(公告)日：2014-10-16

申请号：PCT/US2014/033830

申请日：2014-04-11

申请人： PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY OF MEDICINE ,  DREXEL UNIVERSITY

发明人： AJIT, Seena ,  SACAN, Ahmet ,  ALEXANDER, Guillermo ,  SCHWARTZMAN, Robert, J. ,  MCDONALD, Marguerite

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  A61K31/135 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The invention includes compositions and methods useful for the diagnosis, prognosis, treatment, assessment, and characterization of inflammation or pain (e.g., neuropathic pain) in a subject in need thereof, based upon the expression level of at least one miRNA that is associated with inflammation or pain. In one aspect, the invention relates to compositions and methods for the prediction of a subject's responsiveness of a treatment of inflammation or pain.

摘要翻译： 本发明包括可用于在有需要的受试者中诊断，预后，治疗，评估和表征炎症或疼痛（例如神经性疼痛）的组合物和方法，基于与至少一种miRNA相关的至少一种miRNA的表达水平 炎症或疼痛。 一方面，本发明涉及用于预测受试者对炎症或疼痛的治疗的反应性的组合物和方法。

公开(公告)号：WO2010059832A1

公开(公告)日：2010-05-27

申请号：PCT/US2009/065156

申请日：2009-11-19

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  GISZTER, Simon ,  KIM, Tae, Gyo ,  RAMAKRISHNAN, Arun

发明人： GISZTER, Simon ,  KIM, Tae, Gyo ,  RAMAKRISHNAN, Arun

IPC分类号： D04C3/00

CPC分类号： D04C3/42

摘要： A method and apparatus for fabricating microbraided structures is provided. A microbraiding device includes first and second carrier members that are movable with respect to each other. Each carrier includes a plurality of shelters. Spool-less strands of microfiber are retained in shuttles that are movable between the first and second shelters under magnetic forces. The microbraid structure is fabricated as the shuttles move between the first shelters, and as the first carrier member moves relative to the second carrier member.

摘要翻译： 提供了一种用于制造微阵列结构的方法和装置。 微型装置包括可相对于彼此移动的第一和第二承载构件。 每个载体包括多个收容所。 无纺布的超细纤维束被保留在可在磁力下在第一和第二收容所之间移动的梭子中。 随着梭子在第一遮蔽物之间移动，并且当第一承载构件相对于第二承载构件移动时，制作微框架结构。

公开(公告)号：WO2014138204A1

公开(公告)日：2014-09-12

申请号：PCT/US2014/020681

申请日：2014-03-05

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION d/b/a DREXEL UNIVERSITY COLLEGE OF MEDICINE

发明人： DANDEKAR, Kapil, R. ,  DION, Genevieve ,  FONTECCHIO, Adam, K. ,  KURZWEG, Timothy, P. ,  PATRON, Damiano ,  MONTGOMERY, Owen

IPC分类号： A61B5/02

CPC分类号： A61B5/6804 ,  A61B5/0002 ,  A61B5/0024 ,  A61B5/0205 ,  A61B5/04085 ,  A61B5/0476 ,  A61B5/4356 ,  A61B5/4362 ,  A61B5/4519 ,  A61B5/4818 ,  A61B5/742 ,  D04B1/12 ,  D04B1/24 ,  D04B1/243 ,  D04B35/00 ,  D10B2403/02431 ,  G06F3/016 ,  G06F3/041 ,  H05K1/038

摘要： Knitting machines are used to intermesh conductive yarns into loops resulting in knitted fabrics. The knitting machine is adapted to import different types of yarns (conductive and non- conductive) directly into the knit structure. Combining conductive yarns and knitting systems allows for integration of electrical or mechanical component designs into existing clothing fabrication processes, avoiding current limitations of attaching or gluing conductive fabrics or other components over various materials. Starting with a planar design of an antenna, RFID tag, or some other electronic structure, the layout is converted into a CAD knitting program including a grid representing stitches. The CAD specifications of the final design/product are exported to the knitting machines so that the knitting machine may make conductive fabrics in accordance with the CAD specifications. The conductive fabrics are knitted into a variety of garments that monitor the vital signs of the wearer, including the fetus of an expectant mother.

摘要翻译： 针织机用于将导电纱线互相啮合，形成针织物。 针织机适用于将不同类型的纱线（导电和非导电）直接导入编织结构中。 结合导电纱线和编织系统允许将电气或机械部件设计集成到现有的服装制造工艺中，避免了导电织物或其他部件在各种材料上附着或胶合的现有限制。 从天线，RFID标签或其他电子结构的平面设计开始，布局被转换成包括表示针迹的网格的CAD编织程序。 最终设计/产品的CAD规格出口到针织机，以便针织机根据CAD规格制作导电织物。 导电织物被编织成各种衣服，其监测佩戴者的生命体征，包括孕妇的胎儿。

公开(公告)号：WO2009135129A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042528

申请日：2009-05-01

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  LAYTON, Bradley, Edward ,  WHEATLEY, Margaret, A. ,  BROOKS, Ari

发明人： LAYTON, Bradley, Edward ,  WHEATLEY, Margaret, A. ,  BROOKS, Ari

IPC分类号： A61B17/12

CPC分类号： A61B17/11 ,  A61B17/0643 ,  A61B17/1114 ,  A61B17/320016 ,  A61B2017/00473 ,  A61B2017/00893 ,  A61B2017/0648 ,  A61B2017/1135 ,  A61B2017/320052

摘要： A tissue joining device and a surgical instrument for employing the tissue joining device are provided. The tissue joining device may be designed such that a first member may be inserted into a second member in discrete increments so that two lumen structures can properly be combined.

摘要翻译： 提供了一种用于使用组织接合装置的组织接合装置和外科器械。 组织接合装置可以设计成使得第一构件可以以离散的增量插入到第二构件中，使得可以适当地组合两个内腔结构。

公开(公告)号：WO2009131989A2

公开(公告)日：2009-10-29

申请号：PCT/US2009/041232

申请日：2009-04-21

申请人： DREXEL UNIVERSITY ,  PHILADELPHIA HEALTH & EDUCATION CORPORATION, D/B/A DREXEL UNIVERSITY COLLEGE OF MEDICINE ,  PAPAZOGLOU, Elisabeth, S. ,  WEINGARTEN, Michael, S. ,  ZUBKOV, Leonid ,  NEIDRAUER, Michael, T. ,  ZHU, Linda ,  POURREZAEI, Kambiz

发明人： PAPAZOGLOU, Elisabeth, S. ,  WEINGARTEN, Michael, S. ,  ZUBKOV, Leonid ,  NEIDRAUER, Michael, T. ,  ZHU, Linda ,  POURREZAEI, Kambiz

IPC分类号： G01N21/35 ,  G01N21/41 ,  G01N21/47 ,  A61B10/00 ,  G01N33/483

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/02007 ,  A61B5/14546 ,  A61B5/445 ,  G01N21/359 ,  G01N21/4738

摘要： Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound. The methodologies used to collect information regarding the healing state of a wound may be used to clinically assess the efficacy of wound healing agents in a patient (e.g., a diabetic) and as a non-invasive method to detect the progress of wound healing, particularly chronic wounds due to diabetes. The methodology applies to ischemic environments, impaired healing states, and emerging subsurface tissue deterioration, such as in pressure ulcers, venous ulcers, and ubiquitous ulcers.

摘要翻译： 通过近红外和漫反射光谱测量伤口愈合期间组织的光学变化显示与组织学变化相关。 近红外吸收系数与血管生长随时间相关，漫反射光谱（DRS）数据与胶原浓度相关。 伤口组织在较大深度的光学性质的变化也通过近红外波长的漫射光子密度波（DPDW）方法进行定量。 用于半无限介质的扩散方程用于基于频域或时域装置的相位和幅度测量来计算吸收和散射系数。 观察到与非伤口部位相比，吸收和散射系数的增加以及伤口的血液饱和度降低。 这些变化与伤口的愈合阶段相关。 用于收集关于伤口愈合状态的信息的方法可用于临床评估伤口愈合剂在患者（例如，糖尿病）中的功效以及用于检测伤口愈合进展的非侵入性方法，特别是 慢性创伤由于糖尿病。 该方法适用于缺血性环境，愈合状态受损，以及出现的地下组织恶化，如压力性溃疡，静脉溃疡和普遍存在的溃疡。