Abstract:
이건 발명은 열민감성 하이드로겔과 이온 용액 및 세포를 포함하는 액적을 이온가교형 하이드로겔에 디스펜싱하여 in-situ로 코어-쉘 구조체를 형성하여, 구조체 내부에서 세포 응집체를 제조하는 방법 및 이러한 방법으로 제조되는 세포 응집체에 관한 것으로, 반복 재현성이 우수하여 품질 관리 및 신속한 대량 생산이 가능한 장점이 존재한다.
Abstract:
A method of bioprinting a bioink printed structure and a bioprinted composition resulting from this method is provided. Biological cells are mixed with biomaterial inks. These biomaterial inks have a biopolymer backbone with grafted thereto a first bio-orthogonal chemical group. The mixed biological cells and biomaterial inks are extruded into a support bath. The next step is diffusing crosslinking molecules which have a second (complementary to the first) bio-orthogonal chemical group, in the support bath, whereby the diffusing crosslinking molecules react via bioorthogonal click-chemistry between the first and second bio-orthogonal chemical groups resulting in covalently crosslinking the biomaterial ink into a printed structure. Embodiments of this invention can be directed towards personalized medicine and printed tissue engineering constructs, as well as drug discovery by printing complex tissue mimics or printing model vasculature for studying cardiovascular disease.
Abstract:
Silkworm silk, has been processed into a variety of new material formats including, hydrogels, ultrathin films, thick films, conformal coatings, 3D porous or solid matrices, fibers and many related material formats. Silk is processed in an all water-based, room temperature, neutral pH environment, is mechanically stable, edible, and biocompatible. Given the favorable material properties, the use of silk-based inks have been used in a variety of controlled chemical and biological material fabrication on the micro-and nano- scale. Tuning of the properties of silk -based inks has led to the utilization of more diverse printing techniques and has expanded the scale and function of the printed substrates.
Abstract:
The present invention relates to a gelatin having improved properties, in particular improved dispensing properties, more particularly improved printing properties. The present invention further relates to a construct produced with the gelatin of the present invention and to a process to produce said construct. Further the present invention relates to the use of the gelatin of the present invention to solve existing problems encountered with dispensing systems, in particular with 3D printing and more particularly for applications in the medical field. The gelatin of the present invention is particularly suitable for bio-printing in the medical field and may also be used in cosmetic and in food applications.
Abstract:
This application relates to biologically compatible porous cartilage templates for in vitro and in vivo generation of bone with enhanced structural characteristics. Provided herein are compositions having an internal structure desirable for the generation and regeneration of bone, along with methods of preparation and use.
Abstract:
The invention relates to a printable hydrogel comprising a plurality of microstrands comprising or consisting of a polymer, wherein the microstrands have a diameter of 1 µm to 500 µm and an aspect ratio of at least 100:1, and wherein said microstrands are entangled with each other. A further aspect of the invention is a lyophilizate comprising a plurality of microstrands comprising or consisting of a polymer, wherein the microstrands have a diameter of 1 µm to 500 µm and an aspect ratio of at least 100:1, and wherein said microstrands are entangled with each other. Furthermore, a method for generating a printable hydrogel comprising the step of providing a cross-linked hydrogel, passing said cross-linked hydrogel through a sieve comprising a plurality of openings, such that a plurality of microstrands having a diameter of 1 µm to 500 µm and an aspect ratio of at least 100:1 are generated, and passing said microstrands through a volume, such that the microstrands are entangled with each other, is provided. The invention further relates to a 3D printed product and a 3D printing method using the hydrogel.
Abstract:
3D printing of biopolymer-based inks provides for manufacturing a broad range of products with desirable properties. A print nozzle may be charged to form a cone-shaped ink droplet to result in increased resolution, more reliable contact with irregular surfaces, and a mechanism to control contacting the ink to the print surface.
Abstract:
A method of micropatterning a substrate is provided. The method comprises providing a template substrate having a patterned surface inked with a composition of interest; contacting the patterned surface with an intermediate substrate, thereby transferring the composition to the surface of the intermediate substrate; contacting the surface of the intermediate substrate comprising the composition with the substrate; and removing the intermediate substrate by dissolution using a solvent. A patterned substrate formed using the method, as well as a biosensor comprising the patterned substrate is also provided.
Abstract:
The present invention is in respect of a device that produces cyphers specific for the persons or establishments and then produces mixtures that are appropriate for the said cyphers and then analyses these mixtures by way of atomic absorption method and then determines to whom or to which company the relevant mixture belongs to. The device determining the characteristic colors and produces mixtures takes the eye retina or the finger print or the tone of voice of the person consist of a sensor that either creates a cypher that is specific for the person or the company or that recognizes the cyphers that have been created by the said persons or companies, a processor that determines the amounts of the mixtures to be obtained from the major colors depending on the cypher that had been produced or the color that had been selected by the relevant person, color chambers that contain seven major colors, a mixer in which the colors are being mixed, an outlet in which the colors that had been created are filled in the tubes, a cash entry inlet for the person to be able to make the payment, a color reader that defines the relevant color in terms of to whom or to which company the relevant color belongs to and a server that has been connected to a processor in which all of the cyphers and all of the information is retained.
Abstract:
A radioluminescent ink composition including a dye having a fluorescent moiety, a radioactive source selected to have an emission capable of exciting said fluorescent moiety, and a liquid carrier.