公开(公告)号：WO2019033104A1

公开(公告)日：2019-02-14

申请号：PCT/US2018/046510

申请日：2018-08-13

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： MIRICA, Catherine, A. ,  MENDECKI, Lukasz

IPC分类号： G01N27/00 ,  G01N27/327 ,  G01N27/333

CPC分类号： G01N27/3335 ,  G01N27/308

摘要： Embodiments of the present disclosure pertain to ion-selective electrodes that include a metal-organic framework and an electrode surface. The metal-organic framework is associated with the electrode surface in a manner that forms an interface between the metal-organic framework and the electrode surface. Additional embodiments pertain to methods of detecting an ion in a sample by associating the sample with the ion- selective electrodes of the present disclosure. The metal-organic frameworks of the ion-selective electrodes mediate ion-to- electron transduction through the interface between the metal-organic frameworks and the electrode surface. Thereafter, the presence or absence of the ion in the sample is detected by detecting a change in potential of the ion-selective electrode and correlating the change in the potential to the presence or absence of the ion. The metal organic frameworks may simultaneously mediate ion sensing and ion-to-electron transduction through the interface between the metal-organic frameworks and the electrode surface.

公开(公告)号：WO2018232370A1

公开(公告)日：2018-12-20

申请号：PCT/US2018/037939

申请日：2018-06-15

申请人： VAREX IMAGING CORPORATION ,  THE TRUSTEES OF DARTMOUTH COLLEGE ,  HONDONGWA, Donald, B. ,  FOSSUM, Eric, R.

发明人： HONDONGWA, Donald, B. ,  FOSSUM, Eric, R.

IPC分类号： G01T1/24 ,  G01T1/20

摘要： Embodiments include a device, comprising: a column line; a plurality of pixels; each pixel coupled to the column line; a comparator having an input coupled to the column line and configured to compare a signal from the column line to a threshold; and control logic coupled to the pixels and configured to selectively couple each pixel to the column line after a sampling period for each pixel.

公开(公告)号：WO2018165331A1

公开(公告)日：2018-09-13

申请号：PCT/US2018/021392

申请日：2018-03-07

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： TADIMETY, Amogha ,  ZHANG, John X.J.

IPC分类号： G01N21/552 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G01N33/553 ,  G01N33/574 ,  B82Y15/00

CPC分类号： G01N21/554 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/552 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54346 ,  G01N33/54373 ,  G01N33/553 ,  G01N33/574

摘要： A method of making a plasmon-resonance biosensor includes conjugating precious metal nanorods with form factor at least 1.5 with a biological probe material. Microfluidic chambers of volume under 0.025 microliter are formed over a substrate, and an aqueous suspension of the conjugated nanorods is injected into the chambers. The nanorods are organized in rows and aligned in long dimension along the rows. The biosensor is configured to be read by obtaining an optical absorption spectrum upon exposure to the analyte. The biosensor includes precious metal nanorods organized in rows with long dimension approximately parallel to the rows. The nanorods are conjugated with biological probes capable of binding to an analyte, the probes may be an aptamer, an antibody, a protein-nucleic acid (PNA), a complimentary DNA, or an enzyme having a binding site.

公开(公告)号：WO2018129205A1

公开(公告)日：2018-07-12

申请号：PCT/US2018/012411

申请日：2018-01-04

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  WU, Jimmy ,  FAZIO, Sergio ,  TAVORI, Hagai

发明人： WU, Jimmy ,  FAZIO, Sergio ,  TAVORI, Hagai

IPC分类号： A61K31/403 ,  C07D209/80 ,  C07D209/94 ,  A61P3/06

摘要： Provided herein are methods for inhibiting PCSK9, reducing PCSK9 levels, and for treating or preventing related conditions and disorders, in a subject, which includes administering to a subject an effective amount of a compound which includes derivatized cycloalkyl[i b ]indoles, e.g., cyclopenta-, cyclohexa- and cyclohepta[ b ]indoles.

公开(公告)号：WO2017176830A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/026056

申请日：2017-04-05

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE ,  CHAI, Ziyi

发明人： CHAI, Ziyi ,  BELBRUNO, Joseph, J.

IPC分类号： B82Y30/00 ,  B82Y15/00 ,  G01N33/50 ,  G01N33/00 ,  G01N27/26 ,  G01N27/00 ,  G01N27/30

CPC分类号： G01N33/94 ,  B82Y15/00 ,  G01N27/127 ,  G01N33/493 ,  G01N2600/00

摘要： A device for detecting cotinine includes (a) a film that includes a plurality of molecularly-imprinted-polymer (MIP) coated conductive nanoparticles having specific affinity for binding with cotinine, and (b) two electrodes in contact with the film for passing electrical current through the film to detect binding with cotinine as a change in electrical conductivity of the film. A MIP coated conductive nanoparticle for detecting cotinine includes (a) a conductive nanoparticle, (b) a silicon dioxide coating formed on the conductive nanoparticle and forming a first shell around the conductive nanoparticle, and (c) an MIP coating formed on the silicon dioxide coating and forming the second shell, wherein the MIP coating includes a polymer molecularly imprinted with cotinine to provide specific affinity for binding of cotinine to the MIP coated conductive nanoparticle such that the cotinine is detectable as a change in electrical conductivity of the MIP coated conductive nanoparticle.

摘要翻译： 用于检测可替宁的装置包括（a）包含多个具有与可替宁结合的特异性亲和力的分子印迹聚合物（MIP）涂布的导电纳米颗粒的薄膜，和（b） 与膜接触以使电流通过膜以检测与可替宁的结合，作为膜的电导率的变化。 （a）导电纳米颗粒，（b）形成在导电纳米颗粒上并在导电纳米颗粒周围形成第一壳的二氧化硅涂层，和（c）在二氧化硅上形成的MIP涂层 涂覆并形成第二壳，其中所述MIP涂层包括分子印迹有可替宁的聚合物，以提供对可替宁结合到MIP涂覆的导电纳米粒子的特异性亲和力，使得可替宁可作为MIP涂覆的导电纳米粒子的电导率变化

公开(公告)号：WO2017058753A1

公开(公告)日：2017-04-06

申请号：PCT/US2016/053896

申请日：2016-09-27

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： SENTMAN, Charles, L. ,  ARELLANO, Benjamine, H.

IPC分类号： A61K31/7088 ,  A61K35/17 ,  A61K48/00 ,  A61P37/06 ,  A61P37/08

CPC分类号： A61K31/7088 ,  A61K35/17 ,  A61K48/00 ,  A61K2039/5156 ,  A61K2039/5158 ,  C12N5/0636 ,  C12N2510/00

摘要： A chimeric antigen receptor including a co-inhibitory receptor signaling domain, as well as a nucleic acid construct and immune cells expressing the same are described. Kits and methods of using the immune cells in the treatment or amelioration of chronic inflammation or immune-mediated autoimmunity are also provided.

摘要翻译： 描述了包含共抑制受体信号结构域的嵌合抗原受体以及表达其的核酸构建体和免疫细胞。 还提供了使用免疫细胞治疗或改善慢性炎症或免疫介导的自身免疫的试剂盒和方法。

公开(公告)号：WO2016186987A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/032275

申请日：2016-05-13

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： GAUR, Arti B.

IPC分类号： A61K31/7105 ,  A61K48/00 ,  A61P35/04 ,  C07H21/02 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  C12Q2600/178

摘要： Methods for determining tumor burden, treatment toxicity and treatment efficacy using a panel of microRNAs as biomarkers in biological samples are described.

摘要翻译： 描述了使用一组微小RNA作为生物样品中生物标志物来确定肿瘤负荷，治疗毒性和治疗功效的方法。

公开(公告)号：WO2016130297A2

公开(公告)日：2016-08-18

申请号：PCT/US2016/014400

申请日：2016-01-21

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER ,  THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： BAKHOUM, Samuel, F. ,  BASSEM, Zaki, I. ,  COMPTON, Duane, A.

IPC分类号： A61K48/00 ,  A61K41/00 ,  A61P35/00

CPC分类号： A61K41/0038 ,  A61N5/10 ,  A61N2005/1098

公开(公告)号：WO2016018524A1

公开(公告)日：2016-02-04

申请号：PCT/US2015/036567

申请日：2015-06-19

申请人： TRUSTEES OF DARTMOUTH COLLEGE

发明人： CHENG, Chao

IPC分类号： C12N5/09

CPC分类号： C12Q1/6886 ,  A61K39/04 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Methods for treating breast and bladder cancer patients based upon E2F4 regulatory activity as a predictor of relapse of a patient with estrogen receptor positive breast cancer and in bladder cancer stratification are provided. This invention is a method of administering an aggressive breast cancer treatment (a) providing a ER+ breast tumor tissue sample from a patient; (b) measuring the expression of genes regulated by transcription factor E2F4 in the ER+ breast tumor tissue sample; (c) inferring changes in transcription factor E2F4 activity in the ER+ breast tumor tissue sample using the measured expression in (b); (d) comparing the inferred changes in transcription factor. E2F4 activity in the ER+ breast tumor tissue sample to transcription factor E2F4 activity in a reference sample; and (e) administering an aggressive breast cancer treatment to the patient when the ER+ breast tumor tissue sample has higher transcription factor E2F4 activity than in the reference sample.

摘要翻译： 提供了基于E2F4调节活性作为雌激素受体阳性乳腺癌和膀胱癌分层患者复发的预测因子的乳腺癌和膀胱癌患者的治疗方法。 本发明是一种施用侵袭性乳腺癌治疗（a）从患者提供ER +乳腺肿瘤组织样品的方法; （b）测量ER +乳腺肿瘤组织样本中转录因子E2F4调控基因的表达; （c）使用（b）中的测量表达推断ER +乳腺肿瘤组织样品中转录因子E2F4活性的变化; （d）比较推断的转录因子变化。 E2F4活性在ER +乳腺肿瘤组织样本中转录因子E2F4活性参考样品中; 和（e）当ER +乳腺肿瘤组织样品具有比参照样品更高的转录因子E2F4活性时，对患者进行侵袭性乳腺癌治疗。

公开(公告)号：WO2015175868A1

公开(公告)日：2015-11-19

申请号：PCT/US2015/030954

申请日：2015-05-15

申请人： TRUSTEES OF DARTMOUTH COLLEGE ,  CORNELL UNIVERSITY

发明人： O'TOOLE, George, Jr. ,  DAHLSTROM, Kurt ,  SONDERMANN, Holger ,  GIGLIO, Krista

IPC分类号： A61K31/10

CPC分类号： A61K31/7084 ,  A61K38/005 ,  C12N9/1241 ,  C12N9/16

摘要： Methods for inhibiting the physical interaction between a guanylate cyclase a cognate effector protein or phosphodiesterase, and modulating biofilm formation are provided. The present invention provides a method for inhibiting the physical interaction between a guanylate cyclase a cognate effector protein or phosphodiesterase, and a method for modulating biofilm formation by contacting a bacterial cell expressing a guanylate cyclase and a cognate effector protein or phosphodiesterase with an effective amount of a agent that modulates the physical and specific interaction between the guanylate cyclase and cognate effector protein or phosphodiesterase. In some embodiments, the agent is a peptide or peptidomimetic.

摘要翻译： 提供了抑制鸟苷酸环化酶与同源效应蛋白或磷酸二酯酶之间的物理相互作用以及调节生物膜形成的方法。 本发明提供了抑制鸟苷酸环化酶与同源效应蛋白或磷酸二酯酶之间的物理相互作用的方法，以及通过使表达鸟苷酸环化酶的细菌细胞和同源效应子蛋白或磷酸二酯酶与有效量的 调节鸟苷酸环化酶和同源效应蛋白或磷酸二酯酶之间的物理和特异性相互作用的试剂。 在一些实施方案中，所述试剂是肽或肽模拟物。