公开(公告)号：WO2020181144A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/021275

申请日：2020-03-05

Applicant: NORTHWESTERN UNIVERSITY

Inventor： MIRKIN, Chad, A. ,  YAMANKURT, Gokay ,  VASHER, Matthew, K.

IPC: C12N15/113 ,  A61K47/69 ,  A61K31/713 ,  C12N15/87 ,  B82Y5/00

Abstract: The disclosure is generally related to oligonucleotides having a hairpin-like structure, nanoparticles comprising the same, and methods of using the same.

公开(公告)号：WO2018209270A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/032372

申请日：2018-05-11

Applicant: NORTHWESTERN UNIVERSITY

Inventor： MIRKIN, Chad, A. ,  LEE, Andrew ,  ZHANG, Bin ,  DOMINGUEZ, Donye

IPC: C12Q1/68

Abstract: The disclosure is related to compositions comprising a cell and a spherical nucleic acid (SNA) comprising a nanoparticle, an oligonucleotide on the surface of the nanoparticle, and an antigen; and to methods for production of such compositions and their applications, including but not limited to adoptive cell therapy.

公开(公告)号：WO2018175445A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/023367

申请日：2018-03-20

Applicant: NORTHWESTERN UNIVERSITY

Inventor： MIRKIN, Chad, A. ,  ZHU, Shengshuang ,  XING, Hang ,  PARK, Jungsoo

IPC: A61K47/48 ,  A61K48/00 ,  A61K9/127

CPC classification number: A61K47/6937 ,  A61K38/00 ,  C12N15/88

Abstract: The present disclosure generally relates to poly (lactic-co-glycolic acid)(PLGA) spherical nucleic acids (SNAs) having enhanced stability, methods of making the same, and uses thereof. PLGA-SNAs are useful in gene regulation and drug delivery.

公开(公告)号：WO2018039629A2

公开(公告)日：2018-03-01

申请号：PCT/US2017/048726

申请日：2017-08-25

Applicant: NORTHWESTERN UNIVERSITY

Inventor： MIRKIN, Chad, A. ,  NGUYEN, Sonbinh, T. ,  BANGA, Resham, J.

IPC: A61K48/00 ,  C07H21/04

Abstract: Methods of preparing spherical nucleic acids using thermoresponsive traceless templates, such as PEO-PPO-PEO block copolymers.

Abstract translation: 使用热响应无痕模板（例如PEO-PPO-PEO嵌段共聚物）制备球形核酸的方法。

公开(公告)号：WO2011079290A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/062047

申请日：2010-12-23

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  GILJOHANN, David, A.

Inventor： MIRKIN, Chad, A. ,  GILJOHANN, David, A.

IPC: B82B1/00 ,  B82Y5/00

CPC classification number: C12N15/113 ,  A61K47/6923 ,  B82Y5/00 ,  C07H1/00 ,  C07H21/00 ,  C12N2310/11 ,  C12N2310/351

Abstract: Disclosed are nanoparticles functionalized with an oligonucleotide and a domain, wherein the domain increases cellular uptake of the nanoparticles. The domain is a sequence of nucleobases or phosphate groups, such as a poly thymidine (polyT) sequence or a phosphate polymer (C3 residue) and may be located 5' to the oligonucleotide, 3' to the oligonucleotide, within, or colinear with the oligonucleotide. Usage of the nanoparticles including modulating gene regulation is contemplated.

Abstract translation: 公开了用寡核苷酸和结构域功能化的纳米颗粒，其中该结构域增加纳米颗粒的细胞摄取。 该结构域是核碱基或磷酸基团的序列，例如多胸苷（polyT）序列或磷酸酯聚合物（C3残基），并且可以位于寡核苷酸的5'，寡核苷酸的3'，或者与 寡核苷酸。 预期使用纳米颗粒，包括调节基因调控。

公开(公告)号：WO2011071753A2

公开(公告)日：2011-06-16

申请号：PCT/US2010/058773

申请日：2010-12-02

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  BRAUNSCHWEIG, Adam, B. ,  CHAI, Jinan ,  EICHELSDOERFER, Dan, J. ,  GIAM, Louise, R. ,  LIAO, Xing ,  WONG, Lu, Shin

Inventor： MIRKIN, Chad, A. ,  BRAUNSCHWEIG, Adam, B. ,  CHAI, Jinan ,  EICHELSDOERFER, Dan, J. ,  GIAM, Louise, R. ,  LIAO, Xing ,  WONG, Lu, Shin

IPC: G03F7/00 ,  B29C33/38 ,  B41M1/26

CPC classification number: G03F7/0002 ,  B01J2219/00387 ,  B82Y10/00 ,  B82Y40/00

Abstract: The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.

Abstract translation: 本公开涉及一种在衬底表面上形成具有多个尺寸的图案元件的图案的方法，该倾斜笔阵列包括相对于衬底选择笔阵列的倾斜几何形状，从而引起笔之间的倾斜几何形状 阵列和衬底表面，并且用标称笔阵列在衬底表面上形成具有图形元素的图案，由此形成的图案元素的尺寸沿着倾斜的轴线或轴线跨越衬底表面变化。 例如，倾斜几何形状参考衬底表面并且包括相对于衬底的第一轴线的第一角度和相对于衬底的第二轴线的第二角度，第二轴线垂直于第一轴线 并且第一和第二角度中的至少一个是非零。

公开(公告)号：WO2011068960A3

公开(公告)日：2011-06-09

申请号：PCT/US2010/058715

申请日：2010-12-02

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  CHAI, Jinan ,  HUO, Fengwei ,  ZHENG, Zijian ,  GIAM, Louise, R.

Inventor： MIRKIN, Chad, A. ,  CHAI, Jinan ,  HUO, Fengwei ,  ZHENG, Zijian ,  GIAM, Louise, R.

IPC: G03F7/00

Abstract: In accordance with an embodiment of the disclosure, a method for forming sub- micron size nanostructures on a substrate surface includes contacting a substrate with a tip coated with an ink comprising a block copolymer matrix and a nanostructure precursor to form a printed feature comprising the block copolymer matrix and the nanostructure precursor on the substrate, and reducing the nanostructure precursor of the printed feature to form a nanostructure having a diameter (or line width) of less than 1μm.

公开(公告)号：WO2011028850A1

公开(公告)日：2011-03-10

申请号：PCT/US2010/047594

申请日：2010-09-01

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  GILJOHANN, David, A. ,  DANIEL, Weston, L.

Inventor： MIRKIN, Chad, A. ,  GILJOHANN, David, A. ,  DANIEL, Weston, L.

IPC: A61K9/16

CPC classification number: A61K47/26 ,  A61K31/337 ,  A61K47/6923

Abstract: Disclosed are drug delivery compositions comprising an oligonucleotide-modified nanoparticle and a therapeutic agent. Specifically, disclosed are compositions comprising a number of oligonucleotide molecules in a ratio to therapeutic agent molecules to allow a sufficient transportation of the therapeutic agent molecules into a cell. The therapeutic agents include both hydrophobic and hydrophilic. Different attachments of therapeutic agents in a composition are also described.

Abstract translation: 公开了包含寡核苷酸修饰的纳米颗粒和治疗剂的药物递送组合物。 具体地，公开了包含与治疗剂分子成比例的多个寡核苷酸分子的组合物，以允许将治疗剂分子充分输送到细胞中。 治疗剂包括疏水和亲水的。 也描述了组合物中治疗剂的不同附着物。

公开(公告)号：WO2011017691A2

公开(公告)日：2011-02-10

申请号：PCT/US2010/044847

申请日：2010-08-09

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  MCMAHON, Kaylin ,  THAXTON, C., Shad ,  PRIGODICH, Andrew, E.

Inventor： MIRKIN, Chad, A. ,  MCMAHON, Kaylin ,  THAXTON, C., Shad ,  PRIGODICH, Andrew, E.

IPC: C12N15/63 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/52

CPC classification number: C12Q1/6886 ,  C12Q1/6841 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2565/626 ,  C12Q2565/107 ,  C12Q2563/155

Abstract: The present invention is directed to compositions and methods for enhanced molecular detection of targeted intracellular mRNA transcription using a polynucleotide functionalized nanoparticle (PN-NP).

Abstract translation: 本发明涉及用于使用多核苷酸功能化纳米颗粒（PN-NP）增强靶向细胞内mRNA转录的分子检测的组合物和方法。

公开(公告)号：WO2011017690A3

公开(公告)日：2011-02-10

申请号：PCT/US2010/044844

申请日：2010-08-09

Applicant: NORTHWESTERN UNIVERSITY ,  MIRKIN, Chad, A. ,  MEADE, Thomas, J. ,  SONG, Ying ,  XU, Xiaoyang

Inventor： MIRKIN, Chad, A. ,  MEADE, Thomas, J. ,  SONG, Ying ,  XU, Xiaoyang

IPC: A61K49/14 ,  A61K49/10 ,  A61K49/06

Abstract: The present invention is directed to compositions and methods for intracellular delivery of a contrast agent with a functionalized nanoparticle.