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1.发明申请
公开(公告)号：WO2023092040A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/080086
申请日：2022-11-17
发明人： STEGH, Alexander, H. , MIRKIN, Chad, A. , MAHAJAN, Akanksha, Sanjay , TEPLENSKY, Michelle, Hope , PARK, Jungsoo , VASHER, Matthew Kuo , SINEGRA, Andrew Joseph
IPC分类号： C12N15/117 , A61P35/00 , A61P37/04 , A61P37/02
摘要： The disclosure is generally directed to spherical nucleic acids (SNAs), nanostructures with a core surrounded by a radial presentation of oligonucleotides, that can activate a cytoplasmic DNA sensor including but not limited to cyclic GMP-AMP synthase (cGAS). In some embodiments, the SNAs also inactivate a transcription factor including but not limited to signal transducer and activator of transcription 3 (STATS). Methods of making and using the SNAs are also provided herein. In some aspects, the present disclosure provides a spherical nucleic acid (SNA) comprising (a) a nanoparticle core; and (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising a double-stranded or single-stranded stem loop DNA oligonucleotide that activates cyclic GMP-AMP synthase (cGAS) and is at least 15 base pairs in length.
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公开(公告)号：WO2022212564A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/022626
申请日：2022-03-30
IPC分类号： A61K47/64 , A61K47/69 , A61K39/385 , A61K9/51 , A61P35/00
摘要： The disclosure is generally related to spherical nucleic acids (SNAs), nanostructures with a core surrounded by a radial presentation of oligonucleotides, that can target multiple classes of immune cells. Methods of making and using the nanoparticles are also provided herein. In some aspects, the disclosure provides a spherical nucleic acid (SNA) comprising: (a) a nanoparticle core; (b) a shell of oligonucleotides attached to the external surface of the nanoparticle core, the shell of oligonucleotides comprising one or more immunostimulatory oligonucleotides; and (c) a first antigen that is a major histocompatibility complex type I (MHC-I) antigen, and a second antigen that is a major histocompatibility complex type II (MHC-I I) antigen.
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公开(公告)号：WO2020056341A9
公开(公告)日：2020-03-19
申请号：PCT/US2019/051131
申请日：2019-09-13
摘要： The present disclosure is generally directed to methods for making protein polymers. The methods comprise utilizing oligonucleotides for controlling the association pathway of oligonucleotide-functionalized proteins into oligomeric/polymeric materials.
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公开(公告)号：WO2019070817A1
公开(公告)日：2019-04-11
申请号：PCT/US2018/054115
申请日：2018-10-03
发明人： MIRKIN, Chad, A. , KANG, Yijin , HUANG, Liliang
IPC分类号： B01J23/52
CPC分类号： B01J35/0013 , B01J23/892 , B01J23/8926 , B01J35/006
摘要： Disclosed herein are trimetallic PtAu-based nanocatalysts for electrochemical hydrogen production and screening methods thereof. Nanocatalysts are produced through a polymer pen lithography (PPL) technique, which enables large-scale fabrication of nanoparticle arrays with programmable specifications such as size, shape, and composition, providing a route to the high- throughput screening and discovery of new catalysts.
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公开(公告)号：WO2018213585A8
公开(公告)日：2018-11-22
申请号：PCT/US2018/033200
申请日：2018-05-17
发明人： MIRKIN, Chad, A. , SKAKUJ, Kacper , WANG, Shuya
IPC分类号： C12N15/113
摘要： The present disclosure provides compositions and methods directed to combining spherical nucleic acid (SNA) components that are required for T-cell activation and proliferation.
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6.发明申请
公开(公告)号：WO2018152327A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018372
申请日：2018-02-15
IPC分类号： A61K9/127 , A61K31/7088 , A61K31/7105 , A61K47/54 , C12N15/113
CPC分类号： C12N15/111 , A61K9/0019 , A61K9/1272 , A61K31/7105 , A61K31/713 , A61K47/543 , A61K47/544 , A61K47/549 , A61K47/554 , A61K47/6911 , C12N2310/17 , C12N2310/3515 , C12N2320/32
摘要： The present disclosure is directed to liposomal spherical nucleic acids synthesized by directly functionalizing DNA to lipids on the surface of a liposome. This leads to a higher DNA shell density, increased serum stability. These attributes provide markedly increased cellular uptake and enhanced sequence-specific immunostimulation.
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7.发明申请QUANTIFICATION AND SPATIO-TEMPORAL TRACKING OF A TARGET USING A SPHERICAL NUCLEIC ACID (SNA) 审中-公开使用球状核酸（SNA）的目标的定量和时空跟踪
公开(公告)号：WO2015066708A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/063921
申请日：2014-11-04
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/3517 , C12Q1/6823 , C12Q2563/155 , C12Q2563/179 , C12Q2565/519
摘要： The present invention relates to methods of detecting and tracking a target molecule using a nanoparticle wherein the nanoparticle comprises a polynucleotide that can specifically associate with the target molecule, and wherein the association results in a change in a detectable marker that can be measured after association with the target molecule.
摘要翻译： 本发明涉及使用纳米颗粒检测和追踪靶分子的方法，其中所述纳米颗粒包含可与靶分子特异性结合的多核苷酸，并且其中所述缔合导致可检测标记的变化，所述可检测标记可在与 目标分子。
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8.发明申请
公开(公告)号：WO2015012912A2
公开(公告)日：2015-01-29
申请号：PCT/US2014/034947
申请日：2014-04-22
发明人： LEE, Andrew , MIRKIN, Chad, A. , CALABRESE, Colin, Michael , CHERNYAK, Natalia , AUYEUNG, Evelyn
CPC分类号： C07F9/2408 , A61K9/14 , A61K9/5115 , C07F9/2412 , C07F9/2458 , C07F9/65586 , C07H19/073 , C07H19/10 , C07H21/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N15/87 , C12N2310/3515 , C12N2310/3519
摘要： The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.
摘要翻译： 本公开涉及包含炔烃寡核苷酸，由其制备的纳结合物及其使用方法的组合物。
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9.发明申请METHOD OF ANALYZING AN ANALYTE USING COMBINATORIAL ARRAYS AND UNIFORM PATTERNS 审中-公开使用组合阵列和均匀图案分析分析的方法
公开(公告)号：WO2012125986A1
公开(公告)日：2012-09-20
申请号：PCT/US2012/029569
申请日：2012-03-17
CPC分类号： B01J19/0046 , B01J2219/00387 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00612 , B01J2219/0063 , B01J2219/00637 , B01J2219/00659 , B01J2219/0072 , B01J2219/00743 , B82Y10/00 , B82Y40/00 , G03F7/0002
摘要： The disclosure relates to a method of analyzing an analyte that includes forming a combinatorial pattern comprising pattern elements with a plurality of sizes and/or structures on a substrate surface with a tilted pen array, applying an analyte to the combinatorial pattern, and identifying a pattern element size and/or structure having a desired effect on an analyte parameter using the combinatorial pattern. The method further includes forming a uniform pattern comprising pattern elements each having substantially the same size and/or structure corresponding to the identified pattern element size and/or structure, and analyzing the effect of pattern element size and/or structure on the analyte parameter using the uniform pattern.
摘要翻译： 本公开涉及一种分析分析物的方法，其包括用倾斜的笔阵列在基底表面上形成包括多个尺寸和/或结构的图案元素的组合图案，将分析物施加到组合图案，以及识别图案 使用组合图案对分析物参数具有期望效果的元件尺寸和/或结构。 该方法还包括形成包含图案元素的均匀图案，每个图案元素具有与所识别的图案元素尺寸和/或结构相对应的基本相同的尺寸和/或结构，并且使用以下方式分析图案元素尺寸和/或结构对分析物参数的影响 均匀图案。
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10.发明申请PLASMONIC-DRIVEN SYNTHESIS OF NANOPRISMS FROM ISOTROPIC AND ANISOTROPIC GOLD CORES 审中-公开等离子体和多相金黄色金属纳米粒子的合成驱动合成
公开(公告)号：WO2009015381A1
公开(公告)日：2009-01-29
申请号：PCT/US2008/071296
申请日：2008-07-28
发明人： MIRKIN, Chad, A. , XUE, Can , MILLSTONE, Jill, E.
CPC分类号： B22F1/025 , B22F1/0018 , B22F2001/0037 , B22F2998/00 , B22F2999/00 , B82Y30/00 , Y10T428/12181 , B22F9/24 , B22F2201/11
摘要： A nanoprism having a prismatic silver shell formed about a gold core and a process of forming the same are disclosed. The process includes irradiating a mixture of gold and silver nanoparticles with a narrow band of wavelengths capable of exciting the surface plasmon resonance of the gold.
摘要翻译： 公开了一种具有围绕金芯形成的方形银壳的纳米棱镜及其形成方法。 该方法包括用能够激发金的表面等离子体共振的窄波长波段照射金和银纳米颗粒的混合物。
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