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    METHODS AND COMPOSITIONS FOR TREATING COMMON COLD SYMPTOMS
    24.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING COMMON COLD SYMPTOMS 审中-公开
    治疗常见症状的方法和组合

    公开(公告)号：WO00027423A2

    公开(公告)日：2000-05-18

    申请号：PCT/US1999/027003

    申请日：1999-11-12

    IPC: A61K31/00 ,  A61K31/285 ,  A61K31/33 ,  A61K38/41 ,  A61P11/00 ,  C12Q1/18 ,  G01N33/50 ,  G01N33/68 ,  A61K38/17 ,  A61K39/395 ,  C07K16/28

    CPC classification number: G01N33/5044 ,  A61K31/00 ,  A61K31/285 ,  A61K31/33 ,  A61K38/415 ,  A61K2039/505 ,  C12Q1/18 ,  G01N33/5008 ,  G01N33/6869

    Abstract: The present invention provides methods of inhibiting replication of cold-causing viruses in respiratory epithelium cells and elaboration of IL-8 in the cells of subjects exposed to the viruses, by interfering with the virus binding to the cell membrane receptor that stimulates elaboration of IL-8 and viral replication. A polypeptide that binds to a virus and interferes with the binding of the virus to the cell is provided. An antibody that binds to a cell membrane-bound cytochrome and interferes with the virus binding to the cytochrome is also provided. Further, a chemical inhibitor of a membrane-bound cytochrome, that inhibitis viral replication in and elaboration of IL-8 by the cell, is provided. Moreover, the present invention provides methods of treating and reducing cold symptoms in a subject comprising administering to a subject any of the compositions of this invention. Further, the invention provides methods of screening for a compound which inhibits the interaction of a cold-causing virus and a respiratory epithelium cell.

    Abstract translation: 本发明提供了抑制呼吸道上皮细胞中冷引起病毒复制的方法，以及通过干扰结合细胞膜受体来刺激IL- 8和病毒复制。 提供了结合病毒并干扰病毒与细胞结合的多肽。 还提供了结合细胞膜结合细胞色素并干扰与细胞色素结合的病毒的抗体。 此外，提供了膜结合细胞色素的化学抑制剂，其抑制细胞病毒复制和细胞中IL-8的制备。 此外，本发明提供了治疗和减轻受试者感冒症状的方法，包括向受试者施用本发明的任何组合物。 此外，本发明提供了筛选抑制冷引起病毒与呼吸上皮细胞相互作用的化合物的方法。

    ARSENIC MEDICAMENTS FOR THE TREATMENT OF CHRONIC FATIGUE SYNDROME
    25.
    发明申请
    ARSENIC MEDICAMENTS FOR THE TREATMENT OF CHRONIC FATIGUE SYNDROME 审中-公开
    用于治疗慢性疲劳综合征的ARSENIC药物

    公开(公告)号：WO1995001789A1

    公开(公告)日：1995-01-19

    申请号：PCT/IT1993000094

    申请日：1993-09-08

    Applicant: TARELLO, Walter ,  SANTAMARIA, Anna

    IPC: A61K31/285

    CPC classification number: A61K31/285 ,  A61K33/36

    Abstract: The object of my invention is to provide a very safe and active drug against the new infectious disease called Chronic Fatigue Syndrome (CFS). This illness is characterized by chronic debilitation and fatigue. Other symptoms include malaise, muscle and joint pain, muscle weakness, mild fever, recurrent sore throats, swollen or tender lymph nodes, headaches and a variety of neuropsychological complaints that include dizziness, visual disturbance, irritability, cognitive dysfunction, sleep disturbances. All Arsenic compounds, organic and inorganic, work as very good and efficacious drugs against the Chronic Fatigue Syndrome. Oral treatment: 2 milligrams of Arsenic trioxide/10 kilograms of body weight every day and for a period of 10-15 days. A second cycle can be made after 40 days. By intravenous injection of 2 milligrams of pure Arsenic/10 kilograms of body weight, for 2-4 consecutive days, we can resolve all the symptoms of Chronic Fatigue Syndrome.

    Abstract translation: 我的发明的目的是提供一种非常安全和有效的药物抗新型传染病称为慢性疲劳综合征（CFS）。 这种疾病的特征是慢性衰弱和疲劳。 其他症状包括不适，肌肉和关节疼痛，肌肉无力，轻度发烧，复发性喉咙痛，肿胀或淋巴结肿大，头痛，以及各种神经心理投诉，包括头晕，视力障碍，烦躁，认知功能障碍，睡眠障碍。 所有有机和无机砷化合物都能作为抗慢性疲劳综合征的非常好的有效药物。 口服治疗：每天2毫克三氧化二砷/ 10公斤体重，持续10-15天。 40天后可以进行第二个循环。 通过静脉注射2毫克纯砷/ 10公斤体重，连续2-4天，我们可以解决慢性疲劳综合征的所有症状。

    ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER
    29.
    发明申请
    ORGANOARSENIC COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
    有机化合物和治疗癌症的方法

    公开(公告)号：WO2010021928A1

    公开(公告)日：2010-02-25

    申请号：PCT/US2009/053858

    申请日：2009-08-14

    Applicant: ZIOPHARM ONCOLOGY, INC. ,  SCHWARTZ, Brian, Eric ,  LEWIS, Jonathan ,  KOMARNITSKY, Philip, B.

    Inventor： SCHWARTZ, Brian, Eric ,  LEWIS, Jonathan ,  KOMARNITSKY, Philip, B.

    IPC: A61P35/00 ,  A61K31/455 ,  A61K38/06 ,  A61K31/285 ,  A61K31/60

    CPC classification number: A61K31/285 ,  A61K31/455 ,  A61K31/60

    Abstract: A method for treating a lymphoma selected from non-Hodgkin's and Hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (I) wherein X is S or Se and R 1 and R 2 are independently C 1-30 alkyl (R 3 , R 3' , R 4 , R 5 , W and "n" are as defined in claim 1 ) in particular where the compound is S-dimethylarsinoglutathione, N-(2-S-dimethylarsinothiopropionyl)glycine, 2- amino-3-(dimethylarsino)thio-3-methylbutanoic acid, S-dimethylarsino-thiosuccinic acid or S-dipropylarsino-l - thioglycerol.

    Abstract translation: 一种治疗选自非霍奇金淋巴瘤和霍奇金淋巴瘤的淋巴瘤的方法，包括给予具有式（I）结构的有机砷化合物，其中X为S或Se，R 1和R 2独立地为C 1-3烷基（R 3，R 3'，R 4 ，R 5，W和“n”如权利要求1所定义），特别是当化合物为S-二甲基胂基谷胱甘肽，N-（2-S-二甲基胂基硫丙酰）甘氨酸，2-氨基-3-（二甲基胂基）硫代-3-甲基丁酸 酸，S-二甲基胂基 - 硫代琥珀酸或S-二丙基胂基-1-硫代甘油。

    TREATMENT OF INFLAMMATORY CONDITIONS AND DISEASES WITH METAL-THIOLS
    30.
    发明申请
    TREATMENT OF INFLAMMATORY CONDITIONS AND DISEASES WITH METAL-THIOLS 审中-公开
    用金属硫醇治疗炎症病症和疾病

    公开(公告)号：WO2009154819A3

    公开(公告)日：2010-02-18

    申请号：PCT/US2009036609

    申请日：2009-03-10

    Applicant: CHARLOTTE MECKLENBURG HOSPITAL ,  SAHA DHANONJOY ,  DOMENICO PHILIP

    Inventor： SAHA DHANONJOY ,  DOMENICO PHILIP

    IPC: A61K31/095 ,  A61K31/285 ,  A61K31/29 ,  A61K33/24 ,  A61P29/00

    CPC classification number: A61K31/29 ,  A61K31/095 ,  A61K31/285 ,  A61K33/24 ,  A61K33/245 ,  A61K33/36 ,  A61K45/06 ,  A61K2300/00

    Abstract: The present invention provides a method for the treatment of a disease or disorder related to an inflammatory condition comprising administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a metal and a thiol. In particular, embodiments of the present invention are directed towards methods of treating inflammatory conditions that are associated with elevated levels of free TNFa. In one embodiment, the present invention can be used to treat and/or ameliorate the effects of a wide variety of diseases or disorders related to an inflammatory condition including one or more of the following inflammation related diseases/disorders: arthritis, rheumatoid arthritis, asthma, psoriasis, systemic lupus erythematosus, inflammatory bowel syndrome, chronic obstructive respiratory diseases (COPD), fibromyalgia and the neurological diseases and disorders multiple sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, vascular dementia, epilepsy, migraines, stroke and trauma.

    Abstract translation: 本发明提供了治疗与炎性病症有关的疾病或病症的方法，包括向有需要的患者施用治疗有效量的包含金属和硫醇的药物组合物。 特别地，本发明的实施方案涉及治疗与升高的游离TNFα水平相关的炎性病症的方法。 在一个实施方案中，本发明可用于治疗和/或改善与炎性病症相关的多种疾病或病症的影响，包括以下与炎症相关的疾病/病症中的一种或多种：关节炎，类风湿性关节炎，哮喘 ，银屑病，系统性红斑狼疮，炎性肠综合征，慢性阻塞性呼吸系统疾病（COPD），纤维肌痛和神经系统疾病和病症多发性硬化，阿尔茨海默氏病，帕金森病，亨廷顿病，血管性痴呆，癫痫，偏头痛，中风和创伤。

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