Abstract:
본 발명은 면역이 저하된 만성 감기, 만성 피로증후군 환자뿐만 아니라 암환자의 면역기능을 증가시키기 위한 법제된 비상을 함유하는 약학적 조성물, 더더욱 이 법제된 비상을 정제수, 프로폴리스액, 발효 프로폴리스액, 인삼 추출액, 발효 인삼 추출액, 산양삼 추출액, 산양산삼 추출액, 발효 산양삼 추출액, 발효 산양산삼 추출액, 수소수 및 알칼리환원수로 이루어진 군에서 선택되는 어느 하나 이상에 용해시켜 제조되는 면역 증강을 위한 약학적 조성물에 관한 것이다. 본 발명에 따른 약학적 조성물을 항암치료 시 면역증강제로서의 효과가 뛰어나며, 또한 만성감기환자와 같은 상대적으로 면역력이 낮은 정상인에게도 안정성이 확보된 고효율의 면역증강제로서 우수한 효과를 보인다.
Abstract:
Disclosed are compound having the structure of formula (I): wherein M is Pt, Pd or Ni; Q is As, Sb or Bi; Z 1 is N; Z 2 is O or S; L 1 and L 2 are independently C(O), C-R 1 or C-R 2 ; X is a Lewis base and Y 1 and Y 2 are independently oxygen- or sulfur-containing substituents, conjugates containing compounds of formula (I) and their use as chemotherapy agents.
Abstract:
A multiphasic method of contraception comprising the steps of sequentially administering to a female of child bearing age a Phase I composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg norethiiidrpne acetate and an estrogen in an amount equivalent to about 5 to aboµt 15 mcg of ethinyl estradiol for about 7 to about 14 days; a Phase II composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 10 to about 25 meg of ethinyl estradiol for about 14 to about 22 days; a Phase m composition containing a progestogen in an amount equivalent to about 0.3 to about 1.5 mg of norethindrone acetate and an estrogen in an amount equivalent to about 15 to about 35 meg of ethinyl estradiol for about 20 to about 31 days; and an optional Phase IV composition containing (i) an estrogen in an amount equivalent to about 5 to about 20 meg of ethinyl estradiol, or (ii) a placebo or a non-steroidal component, or (iii) a combination of (i) and (ii), for about 2 to about 8 days. The ethinyl estradiol equivalent amount of estrogen in each of the successive Phases II and III is at least 5 meg greater than the ethinyl estradiol equivalent amount of estrogen in the immediately-preceding phase.
Abstract:
La composition pharmaceutique ou nutraceutique à libération prolongée d'un principe actif selon la présente invention comprend au moins un granulé enrobé; ledit granulé enrobé étant composé d'une particule comprenant ledit principe actif enrobée d'au moins deux enveloppes comprenant une combinaison d'excipients. La présente invention concerne également un procédé de préparation de ladite composition.
Abstract:
La présente invention est relative à l’utilisation d’au moins un composé organoarsénié ou organostibique de formule (I) telle que définie ci-après pour la préparation d’un médicament destiné au traitement des cancers et en particulier des leucémies, à l’utilisation de certains de ces dérivés de formule (I) à titre de médicament, ainsi qu’à des formulations pharmaceutiques des dérivés de formule (I) sous forme de nanovecteurs.
Abstract:
The invention concerns the use of novel agents inducing cell death, and in particular, an agent for overexpression of the PML protein on nuclear bodies, combined with interferons, to induce the death of undesirable cells and stimulate an immune reaction.
Abstract:
The present invention relates to synergistic pharmaceutical combinations comprising organic arsenoxide compounds and mTOR inhibitors. Further, the present invention relates to the use of these pharmaceutical combinations in therapy, in particular, treatment of proliferative diseases.
Abstract:
The present invention relates to a pharmaceutical composition comprising at least one inhibitor of SHP-2, optionally together with pharmaceutically acceptable carriers, adjuvants, diluents and/or additives. The present invention also relates to screening methods for identification of a compound suitable as inhibitor of SHP-2.
Abstract:
Inhibitors of the phosphatase activity of soluble epoxide hydrolase (sEH) are provided and are useful for in the treatment of diseases. These Inhibitors are based on derivatives of various epoxide hydrolase substrates that mimic the enzyme substrate so that there Is stable Interaction with the enzyme catalytic site. These inhibitors are potentially useful for the treatment of hypertension, vascular inflammation, renal inflammation, and lung disease.