公开(公告)号：WO99004903A1

公开(公告)日：1999-02-04

申请号：PCT/AU1998/000588

申请日：1998-07-24

IPC: A23C9/142 ,  A23C9/146 ,  A23L1/29 ,  A23L1/30 ,  A23L1/307 ,  B01J39/04 ,  B01J49/00 ,  C02F1/44 ,  C13B20/14 ,  C13B20/16 ,  C13K5/00 ,  C13D3/14

CPC classification number: C13B20/14 ,  A23C9/1425 ,  A23C9/146 ,  C13B20/165 ,  C13K5/00

Abstract: A separation process for isolation and purification of useful nutrients from food process streams is described. The process includes the steps of contacting an aqueous solution including a nutrient and divalent ions with an ion exchange resin including monovalent ions. The eluate which is depleted of divalent ions is collected and subjected to a process capable of separating monovalent ions to obtain a permeate fraction including monovalent ions and a retentate fraction including said nutrient. The retentate is separated into fractions, wherein at least one of said fractions includes the major portion of said nutrient, which may then be further purified. The ion-exchange resin can be regenerated by contacting the ion-exchange resin with a solution including the permeate fraction until a major portion of divalent ions in the ion exchange resin have been replaced by monovalent ions.

Abstract translation: 描述了从食品工艺流中分离和纯化有用营养物质的分离过程。 该方法包括使包含营养物和二价离子的水溶液与包含一价离子的离子交换树脂接触的步骤。 收集耗尽二价离子的洗脱液，并进行能够分离一价离子以获得包含一价离子的渗透物部分和包含所述营养物的滞留物部分的方法。 将渗余物分离成级分，其中至少一种所述馏分包括所述营养物的主要部分，然后可以进一步纯化。 离子交换树脂可以通过使离子交换树脂与包含渗透物部分的溶液接触直到离子交换树脂中的大部分二价离子被一价离子代替来再生。

公开(公告)号：WO2017098058A1

公开(公告)日：2017-06-15

申请号：PCT/EP2016/080703

申请日：2016-12-12

Applicant: O'REILLY, Dominick

Inventor： O'REILLY, Dominick

IPC: A23C9/142 ,  A23C21/00 ,  C07H1/08 ,  C13K5/00

CPC classification number: A23C9/1422 ,  A23C9/1425 ,  A23C21/00 ,  A23C2210/20 ,  C07H1/08 ,  C07H3/04 ,  C13K5/00

Abstract: Methods of extracting lactose from whey are disclosed herein. Such methods can include removing water from the whey, thereby causing precipitation of lactose from the whey. The resulting heterogeneous mixture may be passed through one or more vibrating filters to separate the solid lactose from the liquid portion of the whey. Related products, such as the lactose-enriched retentate and the lactose-depleted filtrate obtained from such processes, are also disclosed herein.

Abstract translation: 本文公开了从乳清提取乳糖的方法。 这些方法可以包括从乳清中除去水分，从而导致乳清从乳清中沉淀。 所得不均匀混合物可以通过一个或多个振动过滤器以从乳清的液体部分分离固体乳糖。 本文还公开了相关产品，例如从这些方法获得的富含乳糖的保留物和消耗乳糖的滤液。

公开(公告)号：WO2015034356A1

公开(公告)日：2015-03-12

申请号：PCT/NL2014/050604

申请日：2014-09-04

Applicant: FRIESLAND BRANDS B.V. ,  RIJKSUNIVERSITEIT GRONINGEN

Inventor： BENJAMINS, Frédéric ,  CAO, Linqiu ,  BROEKHUIS, Antonius Augustinus

IPC: C12P19/14 ,  A61K31/702 ,  C13K5/00

CPC classification number: C12P19/04 ,  C07H1/00 ,  C07H3/06 ,  C12N9/2471 ,  C12N11/08 ,  C12P19/00 ,  C12P19/14 ,  C12Y302/01023 ,  C13K5/00

Abstract: The invention relates to the enzymatic preparation of galacto-oligosaccharides (GOS). Provided is a method for preparing GOS from lactose, comprising (i) contacting a lactose feed with immobilized beta- galactosidase (EC 3.2.1.23) and (ii) allowing for GOS synthesis, wherein said lactose feed is an aqueous slurry of crystalline lactose.

Abstract translation: 本发明涉及低聚半乳糖（GOS）的酶制剂。 提供了一种从乳糖制备GOS的方法，其包括（i）使乳糖进料与固定的β-半乳糖苷酶（EC 3.2.1.23）接触，和（ii）允许GOS合成，其中所述乳糖进料是结晶乳糖的水性浆液。

公开(公告)号：WO2014141164A1

公开(公告)日：2014-09-18

申请号：PCT/IB2014/059773

申请日：2014-03-14

Applicant: STEPHENSON, Paul ,  STEVENS, Geoffrey Shaun ,  BERRIDGE, Ian Stuart

Inventor： STEPHENSON, Paul ,  STEVENS, Geoffrey Shaun ,  BERRIDGE, Ian Stuart

IPC: C13K5/00 ,  A23C23/00 ,  C07H1/08

CPC classification number: C13K5/00 ,  A23C9/1422 ,  A23C9/1425 ,  A23C2210/206 ,  C07H1/08 ,  C07H3/04

Abstract: The present invention relates to a method of recovering lactose from a lactose- containing liquid source comprising providing a lactose-containing liquid source, crystallising the lactose in the lactose-containing liquid source to generate one or more lactose-containing liquid streams, recovering a lactose-containing extract from the one or more lactose-containing liquid streams by subjecting the one or more lactose-containing liquid streams to filtration to remove cells, proteins, polypeptides, polysaccharides, lipid, ions or salts. The method also includes processing the lactose-containing liquid streams using at least nanofiltration, ultrafiltration and/or centrifugal separation and recycling the lactose-containing extract into the lactose-containing liquid source.

Abstract translation: 本发明涉及一种从含乳糖的液体源中回收乳糖的方法，包括提供含乳糖的液体源，使含乳糖的液体源中的乳糖结晶以产生一种或多种含乳糖的液体流，回收乳糖 通过使一种或多种含乳糖的液体流过滤以除去细胞，蛋白质，多肽，多糖，脂质，离子或盐，从一种或多种含乳糖的液体流中提取。 该方法还包括使用至少纳米过滤，超滤和/或离心分离和将含乳糖的提取物再循环到含乳糖的液体源中来处理含乳糖的液体流。

公开(公告)号：WO2012047122A1

公开(公告)日：2012-04-12

申请号：PCT/NZ2011/000212

申请日：2011-10-10

Applicant: STYLES, Anthony James ,  STEPHENSON, Paul

Inventor： STYLES, Anthony James ,  STEPHENSON, Paul

IPC: A23C1/12 ,  C13K5/00

CPC classification number: C07H1/06 ,  A23C1/12 ,  A23V2002/00 ,  C13K5/00 ,  A23V2250/612

Abstract: The invention relates to a method of crystallising lactose from a lactose-containing liquid comprising the steps of providing a lactose-containing liquid comprising less than 80% by weight total solids, providing an evaporator system that comprises a heat exchanger and an evaporation vessel, the heat exchanger comprising a tube or tubes that define a flowpath having an inlet and an outlet, heating the lactose-containing liquid in the heat exchanger to about 50 to about 90° C such that the lactose-containing liquid passes along the flowpath by forced circulation or thermo-siphoning, concentrating the lactose-containing liquid in the evaporation vessel, to generate crystallised lactose in the lactose-containing liquid in the evaporator system.

Abstract translation: 本发明涉及一种从含乳糖的液体中结晶乳糖的方法，包括以下步骤：提供含有小于80重量％的总固体的含乳糖的液体，提供包括热交换器和蒸发容器的蒸发器系统， 热交换器，其包括限定具有入口和出口的流路的管或管，将热交换器中的含乳糖的液体加热至约50至约90℃，使得含乳糖的液体通过强制循环 或热虹吸，将含乳糖的液体浓缩在蒸发容器中，以在蒸发器系统中的含乳糖的液体中产生结晶的乳糖。

公开(公告)号：WO2008052076B1

公开(公告)日：2008-09-12

申请号：PCT/US2007082422

申请日：2007-10-24

Applicant: MAMTEK INT LTD ,  HO DAVID LOSAN ,  WANG ZHENGHAO

Inventor： HO DAVID LOSAN ,  WANG ZHENGHAO

IPC: C13K5/00 ,  A23L27/30 ,  C13K7/00

CPC classification number: C07H1/00 ,  C07H5/02

Abstract: In one embodiment of the invention a method to prepare sucralose-6-acylate through chlorinating sucrose-6-acylater by BTC in the process of sucralose preparation is disclosed. In this embnodiment a Vilsmeier reagent is firstly prepared belowe 0 °C by dissolving BTC in DMF or in component solvent, containing DMF, toluene, dichloroethane, chloroform and carbon tetrachloride. Consequently, sucrose-6-ester was chlorinated by Vilsmeier reagent. BTC can also be dissolved in one or several organic solvent such as toluene, dichloroethane, chloroform and carbon tetrachloride, and added to a DMF solution of sucrose-6-acylate for chlorination. Sucralose was prepared through de-esterifying the obtained sucralosed 6-ester using sodium methoxide/methanol or sodium ethoxide/ethanol.

公开(公告)号：WO2008021858A3

公开(公告)日：2008-02-21

申请号：PCT/US2007/075432

申请日：2007-08-08

Applicant: GLAXO GROUP LIMITED ,  ROCHE, Trevor Charles ,  TAI, Xiang ,  VAN OORT, Michiel, M ,  WOOD-KACZMAR, Marian, Wladyslaw

Inventor： ROCHE, Trevor Charles ,  TAI, Xiang ,  VAN OORT, Michiel, M ,  WOOD-KACZMAR, Marian, Wladyslaw

IPC: C13K5/00 ,  C07H1/00

Abstract: A process for forming crystalline lactose suitable for use in a pharmaceutical formulation comprises subjecting a solution comprising a plurality of nanosized lactose particles to conditions sufficient to cause crystallization to occur on the nanosized lactose particles such that a plurality of lactose particles are formed therefrom having a median diameter ranging from about 4 μm to about 20 μm.

公开(公告)号：WO2006086270A1

公开(公告)日：2006-08-17

申请号：PCT/US2006/004032

申请日：2006-02-06

Applicant: GLAXO GROUP LIMITED ,  SMITHKLINE BEECHAM CORPORATION ,  NEWMAN, Stephen

Inventor： NEWMAN, Stephen

IPC: A61K31/7016 ,  A61K31/715 ,  C07H3/00 ,  C13K5/00

CPC classification number: C13K5/00 ,  A61K9/0075 ,  A61K9/145 ,  A61K31/7016 ,  A61K31/715 ,  C07H3/00

Abstract: A process for forming lactose suitable for use in a pharmaceutical formulation comprises providing a plurality of lactose particles containing no more than 10% w/w of lactose particles having a volume average particle size of about 70 microns or less; milling the plurality of lactose particles to yield a plurality of milled lactose particles with an average particle size, (D50), ranging from about 50 microns to about 100 microns; and classifying the plurality of milled lactose particles into at least two fractions comprising a fine fraction and a coarse fraction wherein the fine fraction has an average particle size, (D50), ranging from about 3 microns to about 50 microns, and the coarse fraction has an average particle size, (D50), ranging from about 40 microns to about 250 microns.

Abstract translation: 形成适用于药物制剂的乳糖的方法包括提供多种含有不超过10％w / w的体积平均粒径为约70微米或更小的乳糖颗粒的乳糖颗粒; 研磨多个乳糖颗粒以产生平均粒度（D50）的多个研磨的乳糖颗粒，范围为约50微米至约100微米; 以及将所述多个研磨的乳糖颗粒分成至少两个级分，所述级分包含细级分和粗级分，其中所述细级分具有约3微米至约50微米的平均粒度（D50），粗级分具有 平均粒径（D50）为约40微米至约250微米。

公开(公告)号：WO2005002499A3

公开(公告)日：2005-11-24

申请号：PCT/US0337922

申请日：2003-11-28

Applicant: UNIV CALIFORNIA ,  CROWE JOHN H ,  TABLIN FERN ,  WOLKERS WILLEM ,  WALKER NAOMI J ,  LOOPER SHERI ,  TSVETKOVA NELLY M ,  TOROK ZSOLT

Inventor： CROWE JOHN H ,  TABLIN FERN ,  WOLKERS WILLEM ,  WALKER NAOMI J ,  LOOPER SHERI ,  TSVETKOVA NELLY M ,  TOROK ZSOLT

IPC: A01N1/02 ,  A61K20060101 ,  A61K35/14 ,  C12N5/00 ,  C12N5/02 ,  C12N5/08 ,  C13K5/00

CPC classification number: A01N1/0221 ,  A01N1/0226 ,  A61K35/19

Abstract: A process for preparing a dehydrated biological sample comprising providing a biological sample selected from a mammalian species, loading with a solute the biological sample having an alcohol by fluid phase endocytosis to produce an internally loaded biological sample, and drying the loaded biological sample to produce a dehydrated biological sample.

Abstract translation: 一种制备脱水生物样品的方法，包括提供选自哺乳动物物种的生物样品，通过液相内吞作用将含有醇的生物样品加载到溶质中以产生内部装载的生物样品，并干燥装载的生物样品以产生 脱水的生物样品。

公开(公告)号：WO2004022789A1

公开(公告)日：2004-03-18

申请号：PCT/FR2003/002574

申请日：2003-08-25

Applicant: APPLEXION ,  THEOLEYRE, Marc-André

Inventor： THEOLEYRE, Marc-André

IPC: C13K5/00

CPC classification number: C13B20/142 ,  A23C9/146 ,  C13B20/144 ,  C13K5/00

Abstract: La présente invention concerne un procédé de production de lactose partir de lactosérum ou d'un perméat résultant de l'ultrafiltration de lactosérum. Il comprend les opérations : (a) de substitution d'une partie au moins des cations polyvalents du lactosérum ou perméat par des cations métalliques monovalents, pour obtenir un lactosérum ou un perméat appauvri en cations polyvalents, (b) de substitution d'une partie au moins des anions polyvalents minéraux et anions d'acides organiques du lactosérum ou perméat, par des anions monovalents non aptes à former des complexes avec les cations polyvalents, cette opération (b) étant effectuée avant ou simultanément à l'opération (a), et (c) de cristallisation du lactosérum ou perméat résultant des opérations (a) et (b), pour obtenir du lactose cristallisé et des eaux-mères enrichies en cations métalliques monovalents.

Abstract translation: 本发明涉及从乳糖或源于乳糖超滤的渗透物中产生乳糖的方法，包括以下步骤：（a）用一价金属阳离子代替乳糖或渗透物的至少一部分多价阳离子，以获得乳糖或 贫化多价阳离子的渗透物，（b）用不能与多价阳离子形成络合物的单价阴离子代替乳糖或渗透物的至少一部分多价矿物阴离子和有机酸阴离子，所述步骤（b）在之前进行 步骤（a）中或同时进行，和（c）使来自步骤（a）和（b）的乳糖或渗透物结晶，得到结晶的乳糖和富含一价金属阳离子的滤液。