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    CONTACT LENS PACKAGE SOLUTION
    2.
    发明申请
    CONTACT LENS PACKAGE SOLUTION 审中-公开
    联系镜头包装解决方案

    公开(公告)号：WO2006038080A8

    公开(公告)日：2006-07-27

    申请号：PCT/IB2005002912

    申请日：2005-09-30

    Applicant: CLEARLAB INTERNAT PTE LTD ,  NEWMAN STEPHEN D ,  GLASBEY TREVOR O

    Inventor： NEWMAN STEPHEN D ,  GLASBEY TREVOR O

    IPC: A61L12/08 ,  A61K9/00 ,  A61L12/14 ,  C11D3/00

    CPC classification number: C11D3/0078 ,  A61L12/04 ,  C11D17/003

    Abstract: An aqueous contact lens storage solution comprises a viscoelastic rheology modifier; and not more than 0.3% w/v of an alkali metal salt; the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg, and the solution has viscoelastic properties, even if heat sterilized at 121°C for at least 15 minutes. The viscoelastic rheology modifier may be selected from the following acids or their alkali metal salts: hyaluronic acid, poly(acrylic acid), crosslinked poly(acrylic acid), poly(methacrylic acid), carboxymethyl cellulose, alginic acid and mixtures thereof. The alkali metal salt may be present in an amount of from 0.01% to 0.3% w/v, and be selected from sodium chloride, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium tetraborate, sodium citrate, sodium acetate, sodium lactate, potassium chloride, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, potassium tetraborate, potassium citrate, potassium acetate, potassium lactate and mixtures thereof. The solution may be an inhomogeneous combination of a gel component and an additional liquid component. If so, the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg when in a homogeneous form.

    Abstract translation: 水溶性隐形眼镜储存溶液包含粘弹性流变改性剂; 和不超过0.3％w / v的碱金属盐; 该溶液具有6.0至8.0的渗透压和100至400mOsm / kg的重量摩尔渗透压浓度，并且该溶液具有粘弹性，即使在121℃下加热灭菌至少15分钟。 粘弹性流变改性剂可以选自以下酸或其碱金属盐：透明质酸，聚（丙烯酸），交联聚（丙烯酸），聚（甲基丙烯酸），羧甲基纤维素，海藻酸及其混合物。 碱金属盐的存在量可以为0.01〜0.3％w / v，选自氯化钠，碳酸氢钠，磷酸二氢钠，磷酸氢二钠，磷酸三钠，四硼酸钠，柠檬酸钠，乙酸钠 ，乳酸钠，氯化钾，碳酸氢钾，磷酸二氢钾，磷酸氢二钾，磷酸三钾，四硼酸钾，柠檬酸钾，乙酸钾，乳酸钾及其混合物。 溶液可以是凝胶组分和另外的液体组分的不均匀组合。 如果是这样，当均匀形式时，溶液的pH值在6.0和8.0之间，重量摩尔渗透压浓度在100和400mOsm / kg之间。

    SYSTEM AND METHOD FOR TRANSFERRING HYDRATED LENSES ON AN AUTOMATED LINE
    7.
    发明申请
    SYSTEM AND METHOD FOR TRANSFERRING HYDRATED LENSES ON AN AUTOMATED LINE 审中-公开
    在自动化线路上传输水力透镜的系统和方法

    公开(公告)号：WO2008053587A1

    公开(公告)日：2008-05-08

    申请号：PCT/JP2007/001175

    申请日：2007-10-26

    Applicant: MENICON CO., LTD. ,  NEWMAN, Stephen, D.

    Inventor： NEWMAN, Stephen, D.

    IPC: B29D11/00

    CPC classification number: B29D11/0024

    Abstract: A method of transferring a contact lens (310) from a first location to a primary package (330) includes transferring the contact lens (310) with an intermediate transfer member (300) to the primary package (330), wherein the transfer member (300) is sealed in the primary package (330) with the contact lens (310). Additionally, according to another of many exemplary embodiments, a system for transferring a contact lens (310) to a primary package (330) includes a contact lens (310) and a transfer member (300) associated with the contact lens (310), wherein an automated lens transfer device (258) is configured to couple the contact lens (310) and the lens transfer member (300).

    Abstract translation: 将隐形眼镜（310）从第一位置转移到初级包装（330）的方法包括将隐形眼镜（310）与中间转印部件（300）转移到初级包装（330），其中转印部件 300）用隐形眼镜（310）密封在初级包装（330）中。 另外，根据许多示例性实施例中的另一个，用于将隐形眼镜（310）传送到初级包装（330）的系统包括与隐形眼镜（310）相关联的隐形眼镜（310）和传送构件（300） 其中自动透镜转移装置（258）被配置为联接所述隐形眼镜（310）和所述透镜传送构件（300）。

    PROCESSES FOR MAKING LACTOSE UTILIZING PRE-CLASSIFICATION TECHNIQUES AND PHARMACEUTICAL FORMULATIONS FORMED THEREFROM
    8.
    发明申请
    PROCESSES FOR MAKING LACTOSE UTILIZING PRE-CLASSIFICATION TECHNIQUES AND PHARMACEUTICAL FORMULATIONS FORMED THEREFROM 审中-公开
    使用预分类技术制造乳糖的方法和其形成的药物制剂

    公开(公告)号：WO2006086270A1

    公开(公告)日：2006-08-17

    申请号：PCT/US2006/004032

    申请日：2006-02-06

    Applicant: GLAXO GROUP LIMITED ,  SMITHKLINE BEECHAM CORPORATION ,  NEWMAN, Stephen

    Inventor： NEWMAN, Stephen

    IPC: A61K31/7016 ,  A61K31/715 ,  C07H3/00 ,  C13K5/00

    CPC classification number: C13K5/00 ,  A61K9/0075 ,  A61K9/145 ,  A61K31/7016 ,  A61K31/715 ,  C07H3/00

    Abstract: A process for forming lactose suitable for use in a pharmaceutical formulation comprises providing a plurality of lactose particles containing no more than 10% w/w of lactose particles having a volume average particle size of about 70 microns or less; milling the plurality of lactose particles to yield a plurality of milled lactose particles with an average particle size, (D50), ranging from about 50 microns to about 100 microns; and classifying the plurality of milled lactose particles into at least two fractions comprising a fine fraction and a coarse fraction wherein the fine fraction has an average particle size, (D50), ranging from about 3 microns to about 50 microns, and the coarse fraction has an average particle size, (D50), ranging from about 40 microns to about 250 microns.

    Abstract translation: 形成适用于药物制剂的乳糖的方法包括提供多种含有不超过10％w / w的体积平均粒径为约70微米或更小的乳糖颗粒的乳糖颗粒; 研磨多个乳糖颗粒以产生平均粒度（D50）的多个研磨的乳糖颗粒，范围为约50微米至约100微米; 以及将所述多个研磨的乳糖颗粒分成至少两个级分，所述级分包含细级分和粗级分，其中所述细级分具有约3微米至约50微米的平均粒度（D50），粗级分具有 平均粒径（D50）为约40微米至约250微米。

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