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    PRODUCING AND ALTERING MICROBIAL FERMENTATION PRODUCTS USING NON-COMMONLY USED LIGNOCELLULOSIC HYDROLYSATES
    8.
    发明申请
    PRODUCING AND ALTERING MICROBIAL FERMENTATION PRODUCTS USING NON-COMMONLY USED LIGNOCELLULOSIC HYDROLYSATES 审中-公开
    使用非共同使用的木质纤维素水解产物生产和改变微生物发酵产品

    公开(公告)号：WO2018027181A1

    公开(公告)日：2018-02-08

    申请号：PCT/US2017/045595

    申请日：2017-08-04

    申请人： KUEHNLE AGROSYSTEMS, INC.

    发明人： NOLASCO, Norie Anne, B. ,  VASAVADA, Amit ,  KUEHNLE, Adelheid, R. ,  SCHURR, Robert, J.

    IPC分类号： C12N1/22 ,  C12N1/12 ,  C12P19/02 ,  C12P19/14 ,  C12P7/64

    CPC分类号： C12P7/065 ,  C08H8/00 ,  C12N1/12 ,  C12N1/22 ,  C12P1/00 ,  C12P7/04 ,  C12P7/6409 ,  C12P7/6427 ,  C12P19/02 ,  C12P19/14 ,  C12P21/02 ,  C12P23/00 ,  C12P39/00 ,  C12P2203/00 ,  Y02E50/17

    摘要： The invention pertains to a method for synthesizing a product of interest by culturing a microbe that produces the product of interest, the method comprising culturing the microbe in a culture medium, wherein the culture medium is produced by a method comprising the steps of: a) providing a lignocellulosic biomass, b) hydrolyzing the lignocellulosic biomass to produce a lignocellulosic hydrolysate comprising a simplified sugar produced from at least a portion of the lignocellulosic compound, c) optionally, treating a portion of the lignocellulosic hydrolysate to convert a portion of the lignocellulosic compound and/or the simplified sugar to a non-sugar agent; d) optionally, mixing the treated portion of the lignocellulosic hydrolysate, if produced, with the untreated portion of the lignocellulosic hydrolysate, e) producing a culture medium comprising the lignocellulosic hydrolysate obtained after step b) or comprising the mixture obtained after steps c) and d).

    摘要翻译： 本发明涉及通过培养产生感兴趣产物的微生物来合成感兴趣产物的方法，所述方法包括在培养基中培养微生物，其中所述培养基由 方法，所述方法包括以下步骤：a）提供木质纤维素生物质，b）水解木质纤维素生物质以产生包含由至少一部分木质纤维素化合物产生的简化糖的木质纤维素水解产物，c）任选地， 将一部分木质纤维素化合物和/或简化糖转化为非糖剂; d）任选地，将木质纤维素水解产物的处理部分（如果产生）与木质纤维素水解产物的未处理部分混合，e）产生培养基，其包含步骤b）之后获得的木质纤维素水解产物或包含步骤c）和 d）。

    SYSTEMS AND METHODS FOR CONTINUOUSLY FERMENTING C5 AND C6 SACCHARIDES
    10.
    发明申请
    SYSTEMS AND METHODS FOR CONTINUOUSLY FERMENTING C5 AND C6 SACCHARIDES 审中-公开
    用于连续引发C5和C6糖链的系统和方法

    公开(公告)号：WO2017205705A1

    公开(公告)日：2017-11-30

    申请号：PCT/US2017/034596

    申请日：2017-05-26

    申请人： API INTELLECTUAL PROPERTY HOLDINGS, LLC

    发明人： SURVASE, Shrinkant ,  ZEBROSKI, Ryan ,  ADAMOS, Georgios ,  PYLKKANEN, Vesa

    IPC分类号： C12P7/04 ,  C12P7/06 ,  C12P7/14 ,  C12P7/16 ,  C12P7/28 ,  C12Q3/00

    CPC分类号： C12P7/10 ,  C12P7/04 ,  C12P7/16 ,  C12P7/28 ,  C12P7/52 ,  C12P7/54 ,  C12P19/02 ,  C12P19/14 ,  C12P2201/00 ,  C12P2203/00 ,  Y02E50/10 ,  Y02E50/16 ,  Y02E50/17

    摘要： This invention provides optimized fermentation of cellulosic and hemicellulosic sugars. Biomass-derived hemicellulosic and cellulosic sugars are independently conditioned and separately fermented, utilizing reuse and recycle of microorganisms, metabolic intermediates, and nutrients. Conditioned sugars can be fermented in separate vessels, where excess cells from glucose fermentation are conveyed to hemicellulose sugar fermentation along with raffinate from solvent recovery, to enhance productivity and product yield. Some variations provide a method of fermenting C 5 and C 6 sugars to fermentation products, the method comprising: fermenting a C 6 -rich sugar feed to a first fermentation product; fermenting a C 5 -rich sugar feed to a second fermentation product; removing microorganism cells from the first fermentor, to maintain a cell concentration within a selected range; conveying microorganism cells to a second fermentor; and removing microorganism cells from the second fermentor, to maintain a microorganism cell concentration that is greater than that in the C 6 -rich fermentor.

    摘要翻译： 本发明提供了纤维素和半纤维素糖的优化发酵。 利用微生物，代谢中间体和营养物质的再利用和再循环，将生物质衍生的半纤维素和纤维素糖独立调节并分别发酵。 条件糖可以在单独的容器中发酵，其中来自葡萄糖发酵的过量细胞与来自溶剂回收的提余液一起被输送到半纤维素糖发酵，以提高生产率和产品产量。 一些变化提供了将C 5和C 6糖发酵成发酵产物的方法，所述方法包括：发酵富含C 6的糖进料 到第一发酵产物; 将第C 5高丰度糖原料发酵成第二发酵产物; 从第一发酵罐中除去微生物细胞，以将细胞浓度保持在选定范围内; 将微生物细胞输送至第二发酵罐; 并从第二发酵罐中除去微生物细胞，以保持比富含Cys6的发酵罐更高的微生物细胞浓度。