公开(公告)号：WO2009137709A1

公开(公告)日：2009-11-12

申请号：PCT/US2009/043190

申请日：2009-05-07

Applicant: RHODE ISLAND BOARD OF GOVERNORS FOR HIGHER EDUCATION ,  LUCHT, Brett, L. ,  EULER, William, B.

Inventor： LUCHT, Brett, L. ,  EULER, William, B.

IPC: C08G61/00 ,  G01N31/22

CPC classification number: G01N25/00 ,  B41M5/284 ,  C08F28/06 ,  C08G61/126 ,  C09D11/50 ,  C09K9/02 ,  C09K2211/1425 ,  C09K2211/1458

Abstract: Provided herein are novel polythiophene compounds having polyalkoxyl sidechains and low temperature irreversible upon activation (I UA) thermochromic compounds/compositions thereof The IUA thermochromic compounds or compositions are activated and exhibit an IUA color by heating to or above a reversible thermochromic transition temperature (RTTT) and cooling to or below an irreversible thermochromic transition temperature (IRTTT) in less than 2 seconds The activated IUA thermochromic compounds or compositions will retain their IUA color as long as the compounds or compositions are kept at or below about 5 degreeC below the IRTTT The IUA thermochromic compounds/composition can be used to prepare IUA thermochromic indicators which can monitor subjects stored below a pre-determined temperature and detect the subjects that have been exposed to a temperature above the pre-determined temperature.

Abstract translation: 本文提供了具有聚烷氧基侧链和活化后低温不可逆（I UA）热变色化合物/组合物的新型聚噻吩化合物。IUA热致变色化合物或组合物被活化并通过加热至或高于可逆热变色转变温度（RTTT）而呈现IUA颜色， 并在少于2秒内冷却至或低于不可逆的热变色转变温度（IRTTT）。活化的IUA热变色化合物或组合物将保持其IUA颜色，只要化合物或组合物保持在低于IRTTT低于或低于5℃的IUA 热变色化合物/组合物可用于制备IUA热变色指示剂，其可以监测存储在预定温度以下的受试者，并检测已经暴露于高于预定温度的温度的受试者。

公开(公告)号：WO2006066253A2

公开(公告)日：2006-06-22

申请号：PCT/US2005/046150

申请日：2005-12-15

Applicant: CARGILL, INCORPORATED ,  KOEFOD, Robert, Scott

Inventor： KOEFOD, Robert, Scott

IPC: C02F1/42

CPC classification number: C02F1/42 ,  B01J49/53 ,  B01J49/60

Abstract: One embodiment of the present invention is a method of regenerating an ion exchange medium having a bacterial population, comprising dissolving a salt formulation in water to create a brine and passing the brine through the ion exchange medium during a regenerating cycle, wherein the salt formulation comprises a food-grade acid, at least about 100 ppm of a food-grade surfactant, and at least about 90 wt. % of an inorganic, water-soluble salt of sodium, potassium, or sodium and potassium and wherein the acid and the surfactant are present in the brine in an amount efficacious to kill at least about 65% of gram negative bacteria in the bacterial population as a result of the regenerating cycle.

Abstract translation: 本发明的一个实施方案是再生具有细菌群体的离子交换介质的方法，包括将盐制剂溶解在水中以产生盐水并在再生循环期间使盐水通过离子交换介质，其中盐制剂包含 食品级酸，至少约100ppm的食品级表面活性剂，和至少约90wt。 ％的钠，钾或钠和钾的无机水溶性盐，其中酸和表面活性剂以有效杀死细菌群体中至少约65％的革兰氏阴性细菌的量存在于盐水中， 是再生循环的结果。

公开(公告)号：WO2005018323A1

公开(公告)日：2005-03-03

申请号：PCT/US2004/027152

申请日：2004-08-19

Applicant: ZENGEN, INC. ,  DAVIDSON, R., Steven

Inventor： DAVIDSON, R., Steven

IPC: A01N25/34

CPC classification number: A61K9/10 ,  A61K9/0019

Abstract: A medicament composition for the administration to pets is provided. The composition generally includes a film, a medicament and a flavoring composition that renders the film palatable to a pet.

Abstract translation: 提供了一种用于给宠物的药物组合物。 组合物通常包括使膜能够适合宠物的薄膜，药物和调味组合物。

公开(公告)号：WO2005016136A1

公开(公告)日：2005-02-24

申请号：PCT/US2003/024203

申请日：2003-07-31

Applicant: MATLOCK, David, L.

Inventor： MATLOCK, David, L.

IPC: A61B1/32

CPC classification number: A61B1/32

Abstract: Disclosed is a specially designed speculum for use in retraction of anatomical structures. The speculum contains an opening (1) with in a first dilatory blade. In an additional embodiment, the speculum contains a bifurcation in a first dilatory blade. Said bifurcation creating an opening (1) between a first and second arm (20). In an additional embodiment, graduations exist on a convex surface of a first dilatory blade. Also disclosed is a kit containing a speculum of the invention. Also disclosed is a method of using the speculum.

Abstract translation: 公开了一种专门设计的窥器，用于解剖结构的缩回。 窥器包含在第一扩张刀片中的开口（1）。 在另外的实施例中，窥器包含在第一扩张刀片中的分叉。 所述分叉在第一和第二臂（20）之间产生开口（1）。 在另外的实施例中，刻度存在于第一扩张刀片的凸表面上。 还公开了包含本发明的窥器的试剂盒。 还公开了使用窥器的方法。

公开(公告)号：WO2003020223A2

公开(公告)日：2003-03-13

申请号：PCT/US2002/028257

申请日：2002-09-05

Applicant: LIPTON, James ,  CATANIA, Anna, P.

Inventor： LIPTON, James ,  CATANIA, Anna, P.

IPC: A61K

CPC classification number: C07K5/1013 ,  A61K38/34 ,  A61K48/00 ,  C07K14/48

Abstract: An invention is disclosed for the combating cancer. In vitro studies have shown that α-MSH inhibits the proliferation of various mesothelioma cell lines. The invention is directed to a system and method for combating cancer and, in a specific embodiment, mesothelioma . Use of a therapeutic composition containing α-MSH and/or derivatives of α-MSH is disclosed for treatments including but not limited to parenteral administrations, direct targeting of cancer cells, gene therapy and local administrations using a cannula. Certain derivatives of α-MSH, NDP-α-MSH for example, are particularly effective in combating growth in mesothelioma cell lines.

Abstract translation: 公开了一种针对对抗癌症的发明。 体外研究显示α-MSH抑制各种间皮瘤细胞系的增殖。 本发明涉及用于对抗癌症的系统和方法，并且在一个具体的实施方案中，涉及间皮瘤。 公开了包含α-MSH和/或α-MSH衍生物的治疗组合物用于治疗，包括但不限于肠胃外施用，直接靶向癌细胞，基因治疗和使用套管的局部施用。 α-MSH的某些衍生物，例如NDP-α-MSH，对于抑制间皮瘤细胞系中的生长特别有效。

公开(公告)号：WO2002059369A2

公开(公告)日：2002-08-01

申请号：PCT/US2001/047962

申请日：2001-11-01

Applicant: UNIVERSITY OF MEDICINE AND DENTISTRY NEW JERSEY MEDICAL SCHOOL

Inventor： LOBEL, Peter

IPC: C12Q1/68

CPC classification number: A61K38/1709 ,  A61K31/70 ,  C07K14/47 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/92

Abstract: Niemann-Pick type C2 (NP-C2) disease is a fatal lipid storage disorder characterized by massive lysosomal accumulation of cholesterol. The present invention identifies HE1 as the gene responsible for NP-C2. Treatment of NP-C2 fibroblasts with an exogenous HE1 genetic element ameliorated the cholesterol accumulation phenotype. HE1 functions in intracellular cholesterol transport. The present invention provides therapeutic compositions consisting of HE1 polynucleotide and polypeptide sequences, as well as an expression system for expressing HE1 in target cells. These therapeutic compositions can be used to target diseases involving faulty cholesterol transport and regulation, including NP-C2, atherosclerosis, Alzheimer's, diabetes, and cardiovascular disease. In addition, the present invention provides methods of diagnosing both NP-C2 and the ability of a subject to genetically transmit the disease by detecting mutations in the HE1 gene sequence.

Abstract translation: Niemann-Pick型C2（NP-C2）疾病是以胆固醇的大量溶酶体积累为特征的致命脂质储存障碍。 本发明鉴定HE1为负责NP-C2的基因。 用外源HE1遗传元件处理NP-C2成纤维细胞，改善胆固醇积累表型。 HE1在细胞内胆固醇转运中起作用。 本发明提供由HE1多核苷酸和多肽序列组成的治疗组合物，以及用于在靶细胞中表达HE1的表达系统。 这些治疗组合物可用于靶向包括缺陷胆固醇转运和调节的疾病，包括NP-C2，动脉粥样硬化，阿尔茨海默病，糖尿病和心血管疾病。 此外，本发明提供了通过检测HE1基因序列中的突变来诊断NP-C2和受试者遗传性传播疾病的能力的方法。

公开(公告)号：WO2001065911A2

公开(公告)日：2001-09-13

申请号：PCT/US2001/006831

申请日：2001-03-02

Applicant: VALENTIS, INC. ,  NICOL, François ,  WANG, Jijun ,  COLEMAN, Michael ,  MACLAUGHLIN, Fiona ,  ROLLAND, Alain

Inventor： NICOL, François ,  WANG, Jijun ,  COLEMAN, Michael ,  MACLAUGHLIN, Fiona ,  ROLLAND, Alain

IPC: A61K48/00

CPC classification number: C12N15/87 ,  A61K38/00 ,  A61K38/208 ,  A61K39/00 ,  A61K47/34 ,  A61K48/00 ,  A61K48/0008 ,  A61K48/0075 ,  A61K2039/53 ,  C07K14/475

公开(公告)号：WO2015120096A2

公开(公告)日：2015-08-13

申请号：PCT/US2015/014520

申请日：2015-02-04

Applicant: BETTER, Marc ,  FELDMAN, Steven, A. ,  ROSENBERG, Steven, A.

Inventor： BETTER, Marc ,  FELDMAN, Steven, A. ,  ROSENBERG, Steven, A.

IPC: A61K31/549

CPC classification number: C12N5/0636 ,  A61K35/17 ,  A61K38/1774 ,  A61K39/0011 ,  A61K39/39558 ,  A61K2039/5156 ,  A61K2039/5158 ,  C07K14/7051 ,  C07K16/2896 ,  C07K2319/74 ,  C12N2500/90 ,  C12N2501/2302 ,  C12N2501/515 ,  C12N2510/00

Abstract: Provided herein are methods for manufacturing T cells. In certain embodiments, methods for manufacturing T cells which express a cell surface receptor that recognizes a specific antigenic moiety on the surface of a target cell are provided. Such methods may include, but are not limited to, steps of (1 ) enriching a population of lymphocytes obtained from a donor subject; (2) stimulating the population of lymphocytes with one or more T-cell stimulating agents to produce a population of activated T cells, wherein the stimulation is performed in a closed system using serum-free culture medium; (3) transducing the population of activated T cells with a viral vector comprising a nucleic acid molecule which encodes the cell surface receptor, using a single cycle transduction to produce a population of transduced T cells, wherein the transduction is performed in a closed system using serum-free culture medium; and (4) expanding the population of transduced T cells for a predetermined time to produce a population of engineered T cells, wherein the expansion is performed in a closed system using serum-free culture medium. Also provided herein are populations of engineered T cells produced by the methods described herein and pharmaceutical compositions thereof.

Abstract translation: 本文提供了制造T细胞的方法。 在某些实施方案中，提供了用于制造表达识别靶细胞表面上的特定抗原部分的细胞表面受体的T细胞的方法。 这样的方法可以包括但不限于以下步骤：（1）富集从供体受试者获得的淋巴细胞群; （2）用一种或多种T细胞刺激剂刺激淋巴细胞群以产生一群活化的T细胞，其中所述刺激在使用无血清培养基的封闭系统中进行; （3）使用包含编码细胞表面受体的核酸分子的病毒载体转导活化的T细胞群，使用单循环转导产生转导的T细胞群，其中转导在封闭系统中进行，使用 无血清培养基; 和（4）扩增转导的T细胞群体预定的时间以产生一组工程化T细胞，其中使用无血清培养基在封闭系统中进行扩增。 本文还提供了通过本文所述的方法生产的工程化T细胞群及其药物组合物。

公开(公告)号：WO2011056903A1

公开(公告)日：2011-05-12

申请号：PCT/US2010/055339

申请日：2010-11-03

Applicant: TRAN, Henry ,  WANG, Yue

Inventor： TRAN, Henry ,  WANG, Yue

IPC: G03F1/00

CPC classification number: H01B1/127 ,  C08G61/126 ,  C08G2261/1424 ,  C08G2261/226 ,  C08G2261/3223 ,  C08G2261/51 ,  C08G2261/792 ,  H01B1/128

Abstract: In one embodiment a conductive film or coating is provided comprising a conductive oligomer and a dopant, wherein the conductivity of the conductive film is about 1 S/cm or greater, and, in another embodiment, a method of preparing the conductive film or coating is provided.

Abstract translation: 在一个实施方案中，提供了包括导电低聚物和掺杂剂的导电膜或涂层，其中导电膜的导电率为约1S / cm或更大，并且在另一个实施方案中，制备导电膜或涂层的方法为 提供。

公开(公告)号：WO2007061592A1

公开(公告)日：2007-05-31

申请号：PCT/US2006/042800

申请日：2006-11-01

Applicant: BIOSPHERE INDUSTRIES CORPORATION ,  HELOU, Elie, Jr. ,  DELLINGER, David

Inventor： HELOU, Elie, Jr. ,  DELLINGER, David

IPC: A21D13/00

CPC classification number: A23K20/20 ,  A21D13/33 ,  A21D13/48 ,  A23G9/506 ,  A23K20/147 ,  A23K20/163 ,  A23K40/20 ,  A23K40/30

Abstract: One embodiment of the present invention is a composition for use in making edible biodegradable containers comprising water, pregelatinized and native starch, a first protein or natural polymeric compound, natural fibers, a wax emulsion, a mold release agent, a flavoring agent, and a coloring agent, wherein the composing consisting essentially of food grade materials.

Abstract translation: 本发明的一个实施方案是用于制备包含水，预胶化和天然淀粉，第一种蛋白质或天然聚合物，天然纤维，蜡乳液，脱模剂，调味剂和 着色剂，其中组合基本上由食品级材料组成。