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    LIPOSOMAL FORMULATIONS CONTAINING RIFAMYCINS
    36.
    发明申请
    LIPOSOMAL FORMULATIONS CONTAINING RIFAMYCINS 审中-公开
    含有RIFAMYCINS的脂质制剂

    公开(公告)号：WO1993023016A1

    公开(公告)日：1993-11-25

    申请号：PCT/PT1993000002

    申请日：1993-05-14

    Applicant: INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA ... ,  BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM ,  MEIRINHOS DA CRUZ, Maria Eugénia ,  CONSTANTINO, Luís, Vicente ,  GASPAR DE JESUS GUILHERME, Maria, Manuela ,  BERESTEIN-LOPEZ, Gabriel ,  MEHTA, Reeta, Taneja

    Inventor： INSTITUTO NACIONAL DE ENGENHARIA E TECNOLOGIA ... ,  BOARD OF REGENTS UNIVERSITY OF TEXAS SYSTEM

    IPC: A61K09/127

    CPC classification number: A61K9/127 ,  A61K31/395 ,  A61K31/495

    Abstract: The invention relates to liposomal formulations containing a rifamycin and/or a hydrophobic derivative as a pharmacological active substance, for clinical use, comprising pharmacological active substance/lipid ratios of 1 mole per 10 to 40 moles, lipidic compositions made by mixtures of glycerophospholipids of saturated or unsaturated acyl chains, with cholesterol and charged molecules of lipidic nature or not. The liposomal rifamycin presents a stability in saline and in human serum higher than 50 %, incorporation efficiencies up to 95 %, intraliposomal concentration of at least 1 mg/ml and toxicity lower compared to the free pharmacological active substance. The invention also refers to a process for the preparation of liposomal formulations comprising solving the pharmacological active substance and the other components in appropriate solvents, lyophilization or not and rehydration of the lyophilized or resulting mixture.

    Abstract translation: 本发明涉及用于临床应用的含有利福霉素和/或疏水衍生物作为药理学活性物质的脂质体制剂，其包含每10至40摩尔1摩尔的药物活性物质/脂质比例，由饱和脂肪酸甘油磷脂的混合物制成的脂质组合物 或不饱和酰基链，具有胆固醇和带脂分子的脂质性质。 脂质体利福霉素在盐水中和人血清中的稳定性高于50％，引入效率高达95％，体内脂质体浓度至少为1mg / ml，并且与游离药物活性物质相比毒性较低。 本发明还涉及制备脂质体制剂的方法，包括在合适的溶剂中解决药物活性物质和其它成分，冻干或不冻干和再水化冻干的或得到的混合物。

    DEEP LEARNING BASED DOSED PREDICTION FOR TREATMENT PLANNING AND QUALITY ASSURANCE IN RADIATION THERAPY
    37.
    发明申请
    DEEP LEARNING BASED DOSED PREDICTION FOR TREATMENT PLANNING AND QUALITY ASSURANCE IN RADIATION THERAPY 审中-公开

    公开(公告)号：WO2020047536A1

    公开(公告)日：2020-03-05

    申请号：PCT/US2019/049302

    申请日：2019-09-03

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

    Inventor： NGUYEN, Dan ,  JIANG, Steve

    IPC: A61N5/10 ,  G16H50/20

    Abstract: A method and system for generating a treatment plan are disclosed herein. A computing system receives a plurality of dose volume histograms for a plurality of patients and a plurality of volumetric dose distributions corresponding to the plurality of dose volume histograms. The computing system generates a volumetric dose prediction model using a neural network by learning, by the neural network, a relationship between a plurality of dose volume histograms for the plurality of patients and the corresponding plurality of volumetric dose distributions. The computing system receives a candidate dose volume histogram for a target patient. The computing system infers, via the volumetric dose prediction module, a volumetric dose prediction distribution matching the candidate dose volume histogram. The computing system generates a recommendation based on the inferred volumetric dose prediction distribution.

    FUNCTIONALIZED POLYOLEFIN CAPILLARIES FOR OPEN TUBULAR ION CHROMATOGRAPHY
    39.
    发明申请
    FUNCTIONALIZED POLYOLEFIN CAPILLARIES FOR OPEN TUBULAR ION CHROMATOGRAPHY 审中-公开
    用于开放式管式离子色谱的功能化聚烯烃毛细管

    公开(公告)号：WO2018064017A1

    公开(公告)日：2018-04-05

    申请号：PCT/US2017/053382

    申请日：2017-09-26

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM ,  DIONEX CORPORATION

    Inventor： DASGUPTA, Purnendu, K. ,  HUANG, Weixiong ,  POHL, Christopher, A.

    IPC: B01D15/22 ,  B01D15/36 ,  B01J20/286 ,  B01J20/32 ,  G01N30/60

    Abstract: Open tubular capillary columns for liquid and ion chromatography, based upon an ionically impermeable polyolefin capillary having a bore with a sulfonate-group- or amine- group-functionalized internal surface. The capillary columns may include a coating of ion exchanging nanoparticles electrostatically bound to the functionalized internal surface. The capillary columns may be made by exposing the interior surface to a sulfonating reagent comprising chlorosulfonic acid (CIS03H), preferably from 85 wt% to 95 wt% chlorosulfonic acid at a process temperature of 20 to 25 °C. The interior surface may be subsequently exposed to an asymmetrical diamine to form a sulfonic mid-linkage to the diamine, i.e., to form a sulfonamide-linked, amine-group-functionalized internal surface. The coating may be provided by subsequently exposing the interior surface to an aqueous suspension of ion exchanging nanoparticles to electrostatically bond the ion exchanging nanoparticles to the functionalized internal surface.

    Abstract translation: 基于具有带磺酸盐基团或胺基团官能化内表面的孔的离子不可渗透的聚烯烃毛细管，打开用于液体和离子色谱的管式毛细管柱。 毛细管柱可以包括静电结合到官能化内表面的离子交换纳米颗粒的涂层。 毛细管柱可以通过将内表面暴露于包含氯磺酸（CISO 3 H）的磺化剂，优选85重量％至95重量％的氯磺酸，在20至25℃的处理温度下进行制备。 内表面可随后暴露于不对称二胺以形成与二胺的磺酸中间键，即形成磺酰胺连接的胺基官能化的内表面。 可通过随后将内表面暴露于离子交换纳米颗粒的含水悬浮液以将离子交换纳米颗粒静电结合至功能化内表面来提供涂层。

    DOWNHOLE INDUCTION HEATER AND COUPLING SYSTEM FOR OIL AND GAS WELLS
    40.
    发明申请
    DOWNHOLE INDUCTION HEATER AND COUPLING SYSTEM FOR OIL AND GAS WELLS 审中-公开
    井下感应加热器和油气井耦合系统

    公开(公告)号：WO2017205761A1

    公开(公告)日：2017-11-30

    申请号：PCT/US2017/034716

    申请日：2017-05-26

    Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM

    Inventor： ZOWARKA, Raymond C. ,  SHARMA, Mukul M. ,  WERST, Michael D. ,  HEARN, Clay ,  WORTHINGTON, Michael ,  HAHNE, Jon ,  LIU, Hsing-Pang ,  BUNKOWSKI, Bryan ,  PRATAP, Siddharth

    IPC: H05B6/10 ,  E21B36/04 ,  E21B41/00 ,  E21B43/24 ,  F16L53/00 ,  C02F1/48

    CPC classification number: E21B43/2401 ,  E21B36/04 ,  E21B43/127 ,  F16H2025/2028 ,  F16L53/34 ,  H05B6/10 ,  H05B6/108

    Abstract: Described herein are methods and system that use electromagnetic heating to heat wellbores and the fluids therein. The heating is achieved by placing one or more permanent magnets in the wellbore and moving a metallic component and/or the one or more permanent magnets relative to each other. This generates eddy currents in the metallic component, which heat the metallic component. This heat is transferred to the fluids in the wellbore from the metallic component by convection. In some embodiments, permanent magnets are installed in the tubing to induce eddy current heating in a well by converting the linear motion of a sucker rod to rotary motion of a conducting tube using a lead or ball screw. The heater may directly integrate with existing pump jack equipment with little or no additional infrastructure required.

    Abstract translation: 这里描述的是使用电磁加热来加热井筒及其中的流体的方法和系统。 通过将一个或多个永磁体放置在井筒中并且使金属部件和/或一个或多个永磁体相对于彼此移动来实现加热。 这会在金属部件中产生涡流，从而加热金属部件。 这种热量通过对流从金属部件传递到井筒中的流体。 在一些实施例中，永磁体被安装在管中以通过使用引导或滚珠螺杆将抽油杆的线性运动转换为导管的旋转运动来引起井中的涡电流加热。 加热器可以直接与现有的泵插孔设备集成，几乎不需要额外的基础设施。

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