公开(公告)号：WO2006092032B1

公开(公告)日：2006-12-28

申请号：PCT/BR2006000037

申请日：2006-03-03

申请人： UNIV RIO DE JANEIRO ,  DE LACERDA BARREIRO ELIEZER DE ,  MANSSOUR FRAGA CARLOS ALBERTO ,  ZAPATA SUDO GISELE ,  TAKASHI SUDO ROBERTO ,  MENEGATTI RICARDO

发明人： DE LACERDA BARREIRO ELIEZER DE ,  MANSSOUR FRAGA CARLOS ALBERTO ,  ZAPATA SUDO GISELE ,  TAKASHI SUDO ROBERTO ,  MENEGATTI RICARDO

IPC分类号： C07D471/12 ,  C07D471/14 ,  A61K31/437 ,  A61P25/00 ,  A61P25/04 ,  A61P25/28

CPC分类号： A61K31/437 ,  C07D471/14

摘要： The present invention is related to new derivatives of 1-methyl-3,6,7,8- tetrahydropirazolo[3,4-b]pirrolo[4,3-d]piridin-6,8-dione nucleus, preferably heterocyclic derivatives, acting as hypnotics and analgesic in the central nervous system, being useful in the treatment of anxiety and central hyperalgesia, including: anxiety relief, central hyperalgesia relief in mammals, preferably humans. It is also described pharmaceutical compositions containing said compounds and preparation processes.

摘要翻译： 本发明涉及1-甲基-3,6,7,8-四氢吡唑并[3,4-b]螺[4,3-d]哌啶-6,8-二酮核，优选杂环衍生物的新衍生物， 用作中枢神经系统中的催眠药和镇痛药，可用于治疗焦虑和中枢痛觉过敏，包括：在哺乳动物，优选人类中缓解焦虑，中枢痛觉过敏。 还描述了含有所述化合物和制备方法的药物组合物。

公开(公告)号：WO2005051870A2

公开(公告)日：2005-06-09

申请号：PCT/BR2004000236

申请日：2004-11-25

申请人： UNIV RIO DE JANEIRO ,  LOPES CLAUDIO CERQUEIRA ,  LOPES ROSANGELA SABATTINI CAPE ,  CARDOSO JARI NOBREGA ,  SILVA JACQUELINE ALVES DA ,  FERREIRA GOMES LETICIA

发明人： LOPES CLAUDIO CERQUEIRA ,  LOPES ROSANGELA SABATTINI CAPE ,  CARDOSO JARI NOBREGA ,  SILVA JACQUELINE ALVES DA ,  FERREIRA GOMES LETICIA

IPC分类号： A61K47/22 ,  C07C20060101 ,  C07C205/57 ,  C07C241/04 ,  C07D237/26 ,  C07D237/30 ,  C07D237/32 ,  G01N21/76 ,  C07C

CPC分类号： C07C201/14 ,  C07D237/28 ,  C07C205/57

摘要： The present invention describes a process to form hydrazides from the reaction of a hydrazine and a dicarboxylic, using a Lewis acid as a main reagent of the reaction. The reaction occurs in a safe reactional environment, utilizing smooth conditions, neither involving high temperatures nor high pressures, producing the desired products with high yields, between 90-95%. The invention also describes a kit for utilization of chemiluminescent substances, comprised of two solutions.

摘要翻译： 本发明描述了使用路易斯酸作为反应的主要试剂从肼和二羧酸的反应形成酰肼的方法。 该反应发生在安全的反应环境中，使用平稳的条件，既不涉及高温也不高压，以高产率生产所需产物，在90-95％之间。 本发明还描述了一种用于利用由两种溶液组成的化学发光物质的试剂盒。

公开(公告)号：WO2017054066A3

公开(公告)日：2017-06-08

申请号：PCT/BR2016050240

申请日：2016-09-30

申请人： BRASKEM SA ,  UNIV RIO DE JANEIRO

发明人： HABERT ALBERTO CLAUDIO ,  BORGES CRISTIANO PIACSEK ,  PEREIRA CRISTINA CARDOSO ,  GARCIA MARIA ELIZABETH FERREIRA ,  FUJIYAMA-NOVAK JANE HITOMI ,  AMARAL RAFAEL AISLAN ,  MANO BARBARA IRIA SILVA ,  GRASSI VINICIUS GALHARD ,  SAKAHARA ROGERIO MASSANORI ,  FARAH MARCELO ,  STOCKER MARIELE KAIPERS ,  BUENO MARCOS ROBERTO PAULINO

IPC分类号： C08L23/00

CPC分类号： C08L23/06 ,  C08J3/005 ,  C08J3/24 ,  C08J2323/06 ,  C08J2329/04 ,  C08J2429/04 ,  C08L23/0815 ,  C08L29/00 ,  C08L51/06 ,  C08L2201/08 ,  C08L2205/03 ,  C08L2205/22

摘要： Polymer compositions may include a polymer matrix containing a polyolefin, one or more polymer particles dispersed in the polymer matrix, wherein the one or more polymer particles include a polar polymer selectively crosslinked with a crosslinking agent, and wherein the one or more polymer particles has an average particle size of up to 200 µm. Processes of preparing a polymer composition may include mixing a polyolefin, a polar polymer, and a crosslinking agent; and selectively crosslinking the polar polymer with the crosslinking agent in the presence of the polyolefin. Methods may include increasing stress cracking resistance of a polyolefin by mixing a polar polymer with the polyolefin; and selectively crosslinking the polar polymer in the presence of the polyolefin with a crosslinking agent to form crosslinked polar polymer particles dispersed in the polyolefin.

摘要翻译： 聚合物组合物可以包括含有聚烯烃的聚合物基质，分散在聚合物基质中的一种或多种聚合物颗粒，其中所述一种或多种聚合物颗粒包括与交联剂选择性交联的极性聚合物，并且其中所述一种或多种聚合物颗粒具有 平均粒径高达200μm。 制备聚合物组合物的方法可以包括混合聚烯烃，极性聚合物和交联剂; 并在聚烯烃存在下用交联剂选择性交联极性聚合物。 方法可包括通过混合极性聚合物与聚烯烃来提高聚烯烃的抗应力开裂性; 并在聚烯烃存在下用交联剂选择性交联极性聚合物以形成分散在聚烯烃中的交联的极性聚合物颗粒。

公开(公告)号：WO2014197961A1

公开(公告)日：2014-12-18

申请号：PCT/BR2014000199

申请日：2014-06-13

申请人： UNIV RIO DE JANEIRO

发明人： TRAMBAIOLI DA ROCHA E LIMA LUIS MAURICIO ,  GUERREIRO ROSADO LUIZ HENRIQUE ,  AVILA NETTO GUTERRES MARIANA FERNANDES DE ,  MELO VIEIRA GONÇALVES FERREIRA BRUNO

IPC分类号： A61K38/22 ,  A61K47/48 ,  A61P3/10 ,  A61P5/48 ,  A61P5/50 ,  A61P9/10 ,  A61P25/28 ,  C07K1/113 ,  C07K14/575

CPC分类号： A61K38/22 ,  A61K38/00 ,  A61K38/28 ,  A61K45/06 ,  A61K47/48215 ,  A61K47/60 ,  C07K14/575

摘要： The present invention generally concerns new non-agglomerating bioconjugates of amylin-mimetic compounds with polyethylene glycol, and their use mainly in the treatment of diseases associated with extracellular amyloid deposition or accumulation that contributes to the dysfunction or failure of systemic organs such as the pancreas.

摘要翻译： 本发明一般涉及胰岛淀粉样多肽模拟化合物与聚乙二醇的新的非附聚生物缀合物，它们主要用于治疗与细胞外淀粉样蛋白沉积或积累相关的疾病，其有助于全身器官如胰腺的功能障碍或衰竭。

公开(公告)号：WO2011130815A8

公开(公告)日：2012-07-19

申请号：PCT/BR2011000119

申请日：2011-04-25

申请人： UNIV RIO DE JANEIRO ,  FERREIRA PAULO CAVALCANTI GOMES ,  HEMERLY ADRIANA SILVA ,  CARVALHO THIAGO BRETZ

发明人： FERREIRA PAULO CAVALCANTI GOMES ,  HEMERLY ADRIANA SILVA ,  CARVALHO THIAGO BRETZ

IPC分类号： C12N15/82

CPC分类号： C12N15/8261 ,  C12N9/93 ,  Y02A40/146

摘要： The invention relates to a method for promoting an exacerbated increase in vegetable biomass, in the order of 30 to 80% higher than that of non-transformed plants, by introducing a polynucleotide sequence into the genome of a plant of commercial interest. The sequence of SEQ. ID. No. 1 or the sequence of SEQ. ID. No. 2 code for a gene belonging to the anaphase-promoting complex, also called cyclosome (APC/C), and homologous, orthologous or paralogous sequences.

摘要翻译： 本发明涉及通过将多核苷酸序列引入到商业感兴趣的植物的基因组中来促进植物生物量加剧增加的方法，其比非转化植物高30-80％。 SEQ。 ID。 序列号1或SEQ.ID.No.2的序列。 ID。 用于属于后期促进复合体的基因的第2号编码，也称为环状体（APC / C），以及同源的，直向同源的或旁系同源的序列。

公开(公告)号：WO2012031342A2

公开(公告)日：2012-03-15

申请号：PCT/BR2011000316

申请日：2011-09-08

申请人： UNIV RIO DE JANEIRO ,  TRAMBAIOLI DA ROCHA E LIMA LUIS MAURICO ,  GUERREIRO ROSADO LUIZ HENRIQUE ,  MOREIRA MASCARENHAS CAMILE ,  RICCI JUNIOR EDUARDO

发明人： TRAMBAIOLI DA ROCHA E LIMA LUIS MAURICO ,  GUERREIRO ROSADO LUIZ HENRIQUE ,  MOREIRA MASCARENHAS CAMILE ,  RICCI JUNIOR EDUARDO

IPC分类号： A61K38/22

CPC分类号： A61K38/22

摘要： Diabetes mellitus is a disease which, according to the World Health Organisation, is responsible for a significant proportion of deaths throughout the world. In spite of the large number of glycemic control products aimed at diabetes, there still exist pharmacological and pharmacokinetic gaps to be filled. The present invention aims at describing a method for developing a polymer system for encapsulating amylin and agonist analogues in the form of nanoparticles and microparticles. Another object of the invention is a method of functional in vitro evaluation of amylin released from polymer encapsulation systems. The invention further describes the use of the system for producing a medicament for amylin replenishment therapy in patients, which can be used for treating or preventing metabolic diseases.

摘要翻译： 根据世界卫生组织的统计，糖尿病是一种疾病，在世界各地造成很大比例的死亡。 尽管针对糖尿病的大量血糖控制产品仍然存在药物和药代动力学缺口。 本发明的目的在于描述一种开发用于将胰岛淀粉样多肽和激动剂类似物包封成纳米颗粒和微粒形式的聚合物体系的方法。 本发明的另一个目的是从聚合物封装系统释放的胰岛淀粉样多肽的功能性体外评估方法。 本发明还描述了该系统用于生产可用于治疗或预防代谢性疾病的患者中的胰岛淀粉样多肽补充治疗药物的用途。

公开(公告)号：WO2007025360A3

公开(公告)日：2007-05-18

申请号：PCT/BR2006000174

申请日：2006-09-01

申请人： UNIV RIO DE JANEIRO ,  SUD CHEMIE DO BRASIL ,  ARANDA DONATO ALEXANDRE GOMES ,  ZHAO SHIZHONG ,  TOLLE DAVID P ,  JOAO RAFAEL RICHARD ,  SANTOS RAFAEL THOMAZ PERGENTIN

发明人： ARANDA DONATO ALEXANDRE GOMES ,  ZHAO SHIZHONG ,  TOLLE DAVID P ,  JOAO RAFAEL RICHARD ,  SANTOS RAFAEL THOMAZ PERGENTIN ,  DE SOUZA GUILHERME LUIS MONTEI

IPC分类号： C11C3/10

CPC分类号： C11C3/003 ,  C10G2300/1011 ,  C10L1/026 ,  C11D1/667 ,  Y02E50/13 ,  Y02P30/20

摘要： The present invention refers to a process of transesterification of mono-, di and triglycerides present in vegetable oils and animal fats, which are transesterified with alcohols of 1 to 3 carbon atoms making use of basic solid heterogeneous catalyzers, being the products of the reaction used as fuel or additive for fuel, as solvents, as intermediaries of tensoactives or as detergents .

摘要翻译： 本发明涉及存在于植物油和动物脂肪中的甘油单酯，甘油二酯和甘油三酯的酯交换方法，所述酯与用1-3个碳原子的醇进行酯交换，使用碱性固体非均相催化剂，其为所用反应的产物 作为燃料的燃料或添加剂，作为溶剂，作为缓蚀剂的中间体或作为洗涤剂。

公开(公告)号：WO2006128268A8

公开(公告)日：2007-04-26

申请号：PCT/BR2006000107

申请日：2006-06-01

申请人： UNIV RIO DE JANEIRO ,  LACERDA BARREIRO ELIEZER JESUS ,  MANSSOUR FRAGA CARLOS ALBERTO ,  SPERANDIO DA SILVA GILBERTO MA ,  MOREIRA LIMA LIDIA ,  MEDEIROS DE CARVALHO FATIMA ,  MENEZES QUINTAS LUIS EDUARDO ,  LEGORA MACHADO ALEXANDRE ,  GONCALVES KOATZ VERA LUCIA

发明人： LACERDA BARREIRO ELIEZER JESUS ,  MANSSOUR FRAGA CARLOS ALBERTO ,  SPERANDIO DA SILVA GILBERTO MA ,  MOREIRA LIMA LIDIA ,  MEDEIROS DE CARVALHO FATIMA ,  MENEZES QUINTAS LUIS EDUARDO ,  LEGORA MACHADO ALEXANDRE ,  GONCALVES KOATZ VERA LUCIA

IPC分类号： C07D491/056 ,  C07D491/14 ,  A61K31/4741 ,  A61P29/00 ,  C07C275/38

CPC分类号： C07D491/048

摘要： The present invention describes functionalizeds derivatives of ethyl 6-N- alkyl and/or 6-N-aryl ureas [1 ,3]dioxolo[5,4-g]quinolin-7-carboxylate (3a-z, 4a-z) and similar types (5a-z), of general formula (I, II, III and IV), useful in the treatment and/or prevention of inflammatory diseases, such as acute or chronic inflammatory conditions, different types of arthritis, asthma, Crohn's Disease and diabetes mellitus Type I, among others. These derivatives have the ability of modulate the inflammatory process, acting in mitogen activated protein kinase p-38 (MAPK-p38). Moreover, the derivatives of the present invention present expressive anti-inflammatory properties evaluated in in vivo models. The present invention also discloses processes for the production of such derivatives and harmaceutical com ositions containin the same.

摘要翻译： 本发明描述了6-N-烷基和/或6-N-芳基脲[1,3]二氧杂环戊烯并[5,4-g]喹啉-7-羧酸乙酯（3a-z，4a-z）的官能化衍生物和 可用于治疗和/或预防炎性疾病如急性或慢性炎症性疾病，不同类型的关节炎，哮喘，克罗恩病的通式（I，II，III和IV）的类似类型（5a-z） 和I型糖尿病等。 这些衍生物具有调节炎症过程的能力，作用于丝裂原活化蛋白激酶p38（MAPK-p38）。 此外，本发明的衍生物表现出在体内模型中评估的表现的抗炎特性。 本发明还公开了生产这种衍生物的方法和含有其的药物组合物。

公开(公告)号：WO2006042391A8

公开(公告)日：2006-09-08

申请号：PCT/BR2005000221

申请日：2005-10-21

申请人： UNIV RIO DE JANEIRO ,  UNIV BRASILIA FUDACAO ,  UNIAO BRASILIENSE DE EDUCACAO ,  SOARES ROMEIRO LUIS ANTONIO ,  CANDIDA DA SILVA VIVIANE ,  MARCIA MURTA MARIA ,  GOUVAN CAVALCANTE MAGALHAES ,  LIMA LOGRADO LUCIO PAULO ,  DOS SANTOS MARIA LUCILIA ,  SABIONI RESCK INES ,  DE ARAUJO MOURA EMELI ,  DELLAMORA-ORTIZ GISELA MARIA ,  DA COSTA LEITAO ALVARO AUGUSTO ,  SANTOS DA SILVA CELIA ,  FARIA DE FREITAS ZAIDA MARIA ,  PEREIRA DOS SANTOS ELISABETE ,  GARCIA SHEILA

发明人： SOARES ROMEIRO LUIS ANTONIO ,  CANDIDA DA SILVA VIVIANE ,  MARCIA MURTA MARIA ,  GOUVAN CAVALCANTE MAGALHAES ,  LIMA LOGRADO LUCIO PAULO ,  DOS SANTOS MARIA LUCILIA ,  SABIONI RESCK INES ,  DE ARAUJO MOURA EMELI ,  DELLAMORA-ORTIZ GISELA MARIA ,  DA COSTA LEITAO ALVARO AUGUSTO ,  SANTOS DA SILVA CELIA ,  FARIA DE FREITAS ZAIDA MARIA ,  PEREIRA DOS SANTOS ELISABETE ,  GARCIA SHEILA

IPC分类号： A61K36/22

CPC分类号： A61Q17/04 ,  A61K8/97

摘要： The molecules capable of absorbing ultraviolet radiation from the cashew nut shell liquid changes are the object of the present invention; it is also described the compositions responsible for protecting the surfaces and chemical processes for the referred molecules production.

公开(公告)号：WO2006081644A2

公开(公告)日：2006-08-10

申请号：PCT/BR2006000013

申请日：2006-02-02

申请人： UNIV RIO DE JANEIRO ,  ARANDA DONATO ALEXANDRE GOMES ,  ANTUNES OCTAVIO AUGUSTO CEVA

发明人： ANTUNES OCTAVIO AUGUSTO CEVA

IPC分类号： C07C67/02 ,  C07C67/03 ,  C10L1/02

CPC分类号： C11C3/003 ,  Y02E50/13

摘要： The present invention refers to a process of esterification of fatty acids, which can be obtained from vegetable oils or animal fats. Such a process that produces esters with high grade of purity that can be used in the production of biodiesel with high added value.

摘要翻译： 本发明涉及可以从植物油或动物脂肪获得的脂肪酸的酯化方法。 这种生产高纯度酯的方法可用于生产高附加值的生物柴油。