公开(公告)号：WO1994005627A1

公开(公告)日：1994-03-17

申请号：PCT/US1993008401

申请日：1993-09-07

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  SAFAVY, Ahmad ,  BUCHSBAUM, Donald, J. ,  KHAZAELI, M., B.

IPC: C07C271/02

CPC classification number: C07C259/06 ,  A61K51/1093 ,  A61K2121/00 ,  A61K2123/00 ,  C07K5/022

Abstract: The present disclosure details the preparation of hydroxamic-acid based bifunctional chelators and their use in conjugating metal ions to proteins and nucleic acids for tumor or tissue imaging or therapy purposes. Some preferred aspects of the disclosure involve the preparation of trisuccin, chemical name N-((tris)(2-N-benzyloxyaminocarbonylethyl)) methylsuccinamic acid, which is a hydroxamic acid/succinate based structure that is particularly useful for binding radionuclides such as 99mTc, 186Re and 67Cu.

Abstract translation: 本公开详细描述了基于异羟肟酸的双功能螯合剂的制备及其在将金属离子与用于肿瘤或组织成像或治疗目的的蛋白质和核酸结合的用途。 本公开的一些优选方面涉及制备三羟色胺，化学名称N - （（三（（三（（（N） - 三苄基氧基氨基羰基乙基））甲基琥珀酸，其是特别可用于结合放射性核素如99mTc的异羟肟酸/ ，186Re和67Cu。

公开(公告)号：WO1992014488A1

公开(公告)日：1992-09-03

申请号：PCT/US1992000857

申请日：1992-02-12

Applicant: UAB RESEARCH FOUNDATION ,  BRILES, David, E. ,  YOTHER, Janet, L. ,  McDANIEL, Larry, S.

Inventor： UAB RESEARCH FOUNDATION

IPC: A61K39/12

CPC classification number: C12N15/74 ,  A61K39/00 ,  C07K14/28 ,  C07K14/3156 ,  C07K14/7151 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/746 ,  Y02A50/472

Abstract: A purified pneumococcal surface protein A (PspA) comprises a truncated form of the PspA protein which is immunoprotective and contains the protective epitopes of PspA. The PspA protein is soluble in physiologic solution and lacks at least the cell membrane anchor region of the whole protein. The protein is formed by insertion-duplication of mutagenesis of S. pneumoniae with pspA gene and expression of the truncated protein into the growth medium.

Abstract translation: 纯化的肺炎球菌表面蛋白A（PspA）包含免疫保护的PspA蛋白的截短形式，并含有PspA的保护性表位。 PspA蛋白可溶于生理溶液，至少缺乏整个蛋白质的细胞膜锚定区域。 该蛋白质通过使用pspA基因的插入重复的肺炎链球菌的突变和截短的蛋白质的表达插入到生长培养基中而形成。

公开(公告)号：WO1991016063A1

公开(公告)日：1991-10-31

申请号：PCT/US1991002826

申请日：1991-04-25

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  HUANG, Shu, T. ,  HOOK, Magnus

IPC: A61K35/14

CPC classification number: C07K14/75

Abstract: A cryoprecipitation method for concentrating fibrinogen and the fibrinogen product prepared thereby, wherein plasma is separated from whole blood, the plasma is subjected to two freeze-thaw cycles in a closed-bag system, the plasma is centrifuged and the concentrated fibrinogen product is separated from the plasma. In the freeze-thaw cycles, the plasma is preferably slow-frozen in an immersion freezer at a temperature of about -18 DEG C or below and quick-thawed at a temperature of about 4 DEG C. The method increases product yield and fibrinogen concentration. The tensile strength of the fibrinogen concentrate is improved. The fibrinogen product can be used to prepare fibrin glue from random single-donor or autologous plasma. The fibrinogen concentrate has a concentration of about 2,000-6,000 mg/dl and a volume of about 3-5 ml.

Abstract translation: 一种用于浓缩纤维蛋白原和由此制备的纤维蛋白原产物的冷沉淀法，其中血浆与全血分离，血浆在封闭袋系统中进行两次冻融循环，将血浆离心，将浓缩的纤维蛋白原产物从 等离子体。 在冷冻 - 融化循环中，优选在约-18℃或更低的温度下在浸没式冷冻机中缓慢冷冻等离子体，并在约4℃的温度下快速解冻。该方法提高产物产率和纤维蛋白原浓度 。 纤维蛋白原浓缩物的拉伸强度提高。 纤维蛋白原产物可用于从随机单供体或自体血浆制备纤维蛋白胶。 纤维蛋白原浓缩物的浓度为约2,000-6,000mg / dl，体积为约3-5ml。

公开(公告)号：WO1990009442A1

公开(公告)日：1990-08-23

申请号：PCT/US1990000745

申请日：1990-02-07

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  LEBOEUF, Robert, D. ,  BLALOCK, J., Edwin ,  BOST, Kenneth, L.

IPC: C12N15/00

CPC classification number: C07K16/22 ,  A61K38/00 ,  C07K14/475 ,  C07K2317/74 ,  Y10S530/854

Abstract: Mammalian pituitary tissues contain newly discovered antiproliferation factor that inhibits in vitro cellular proliferation of lymphoid, neuroendocrine and neural cells but not of fibroblast or endothelial cells. The present invention is directed to this antiproliferation factor which has been named suppressin and is a protein of Mr 63,000, sensitive to reduction and has a pI of 8.1. Suppressin is provided as a cell free preparation or in homogeneous form. The invention provides methods to purify suppressin, antibodies against suppressin and their use in recombinant DNA molecules encoding suppressin, and pharmaceutical compositions for inducing regression or inhibiting growth of tumor or cancer cells and autoimmune diseases.

Abstract translation: 哺乳动物垂体组织含有新发现的抗增殖因子，其抑制淋巴，神经内分泌和神经细胞的体外细胞增殖，但不抑制成纤维细胞或内皮细胞。 本发明涉及这种抗增殖因子，其被称为抑制蛋白，并且是63,000的蛋白质，对还原敏感并具有8.1的pI。 抑制素作为无细胞制剂或均匀形式提供。 本发明提供了抑制抑制抗体，抗抑制抗体及其在编码抑制蛋白的重组DNA分子中的应用的方法，以及用于诱导肿瘤或癌细胞和自身免疫性疾病生长退化或抑制的药物组合物。

公开(公告)号：WO1989010099A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001482

申请日：1989-04-14

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  URRY, Dan, W.

IPC: A61F02/02

CPC classification number: A61L24/106 ,  A61B17/00491 ,  A61B17/11 ,  A61B17/1114 ,  A61B2090/0816 ,  A61F2/0063 ,  A61L31/047

Abstract: An elastomeric material, capable of reversibly contracting and relaxing by an inverse temperature transition, in a form suitable for use as a protective layer between a mammalian repair site and a second tissue site whereby adhesion involving said repair site and said second tissue site is substantially prevented.

Abstract translation: 弹性体材料，其能够以适合用作哺乳动物修复部位和第二组织部位之间的保护层的形式通过反向温度转变可逆地收缩和松弛，从而基本上防止了涉及所述修复部位和所述第二组织部位的粘附 。

公开(公告)号：WO1989010098A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001321

申请日：1989-04-05

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  URRY, Dan, W. ,  LONG, Marianna

IPC: A61F02/02

CPC classification number: A61L27/54 ,  A61K38/00 ,  A61L27/227 ,  A61L2300/25 ,  C07K7/06 ,  C07K14/78

Abstract: A method of stimulating chemotaxis toward a prosthetic device is disclosed, which method comprises incorporating a chemotactic peptide of the formula B -X-(AGVPGLGVG)n-(AGVPGFGVG)m-Y-B , wherein B is H or a biocompatible N-terminal group; B is OH, OB where B is a non-toxic metal ion, or a biocompatible C-terminal group; X is GVPGFGVG, GVPGLGVG, VPGFGVG, VPGLGVG, PGFGVG, PGLGVG, GFGVG, GLGVG, FGVG, LGVG, GVG, VG, G or a covalent bond; Y is AGVPGFGV, AGVPGLGV, AGVPGFG, AGVPGLG, AGVPGF, AGVPGL, AGVPG, AGVP, AGV, AG, A or a covalent bond; n is an integer from 0 to 50; m is an integer from 0 to 50; with the proviso that when both n and m are 0, X and Y are selected so that the chemotactic peptide has at least 3 amino acid residues in the X and Y positions combined; into a surface of a prosthetic device.

Abstract translation: 公开了一种刺激朝向假体装置的趋化性的方法，该方法包括掺入式B 1 -X-（AGVPGLGVG）n-（AGVPGFGVG）mYB 2的趋化性肽，其中B 1为H或 生物相容性N-末端基团; B 2是OH，OB 3，其中B 3是无毒金属离子或生物相容性C端基; X是GVPGFGVG，GVPGLGVG，VPGFGVG，VPGLGVG，PGFGVG，PGLGVG，GFGVG，GLGVG，FGVG，LGVG，GVG，VG，G或共价键; Y是AGVPGFGV，AGVPGLGV，AGVPGFG，AGVPGLG，AGVPGF，AGVPGL，AGVPG，AGVP，AGV，AG，A或共价键; n为0〜50的整数， m为0〜50的整数; 条件是当n和m都为0时，选择X和Y，使得趋化肽在X和Y位置的组合中具有至少3个氨基酸残基; 进入假体装置的表面。

公开(公告)号：WO1989007970A1

公开(公告)日：1989-09-08

申请号：PCT/US1989000541

申请日：1989-02-15

Applicant: UAB RESEARCH FOUNDATION

Inventor： UAB RESEARCH FOUNDATION ,  URRY, Dan, W.

IPC: B01D13/00

CPC classification number: B01D71/74 ,  B01D61/00 ,  C02F1/265 ,  C02F1/44 ,  F03G7/005 ,  F03G7/065 ,  Y02A20/131

Abstract: A mechanochemical engine capable of desalinating sea water or brackish water by the conversion of mechanical work to chemical work, which comprises: a) a housing containing an elastomeric material capable of being stretched, to thereby allow salt-diminished water to move into the elastomeric material, while substantially repelling solvated salt ions from entry thereto, b) means for stretching and relaxing said elastomeric material in said housing, in connection with said elastomeric material; and c) means for uptake of sea water or brackish water into said housing, means for draining concentrated salt water from said housing, and means for draining desalinated water from said housing.

Abstract translation: 一种机械化学发动机，其能够通过将机械作业转化为化学作业使海水或微咸水脱海，其包括：a）包含能够被拉伸的弹性体材料的壳体，从而允许盐减少的水移动到弹性材料中 ，同时基本上排斥溶剂化的盐离子进入其中，b）与所述弹性体材料结合的用于在所述壳体中拉伸和松弛所述弹性体材料的装置; 以及c）用于将海水或微咸水吸收到所述壳体中的装置，用于从所述壳体排出浓缩盐水的装置，以及用于从所述壳体排放脱盐水的装置。