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    METHOD FOR PREPARING (S)-3-HYDROXY-GAMMA-BUTYROLACTONE USING HYDROLASE
    41.
    发明申请
    METHOD FOR PREPARING (S)-3-HYDROXY-GAMMA-BUTYROLACTONE USING HYDROLASE 审中-公开
    使用水解制备（S）-3-羟基 - 恶唑基 - 丁酮的方法

    公开(公告)号：WO2007100227A1

    公开(公告)日：2007-09-07

    申请号：PCT/KR2007/001052

    申请日：2007-03-02

    Applicant: LG CHEM, LTD. ,  LG Life Sciences Ltd. ,  PARK, Oh-Jin ,  LEE, Sang-Hyun ,  LEE, Sang-Who ,  JOE, Goon-Ho ,  UH, Hong-Sun

    Inventor： PARK, Oh-Jin ,  LEE, Sang-Hyun ,  LEE, Sang-Who ,  JOE, Goon-Ho ,  UH, Hong-Sun

    IPC: C07D307/32

    CPC classification number: C07D307/32

    Abstract: The present invention relates to a method for preparing S-HGB ((S)-3-hydroxy-γ-butyrolactone) using hydrolase, and more particularly to a method for preparing S-HGB in a high purity by hydrolyzing S-BBL ((S)-β-benzoyloxy-γ-butyrolactone) in the presence of hydrolase. According to the present invention, the S-HGB having an optical purity can be obtained in a high yield under simple process conditions without requiring reaction conditions of high pressure and high temperature or complex operation conditions by hydrolyzing S-BBL with hydrolase.

    Abstract translation: 本发明涉及使用水解酶制备S-HGB（（S）-3-羟基-γ-丁内酯）的方法，更具体地说，涉及一种通过水解S-BBL（（ S）-β-苯甲酰氧基-β-丁内酯）。 根据本发明，通过水解酶水解S-BBL，可以在简单的工艺条件下以高产率获得具有光学纯度的S-HGB，而不需要高压和高温或复杂操作条件的反应条件。

    A PROCESS FOR PREPARING BETA-KETOESTER COMPOUNDS
    42.
    发明申请
    A PROCESS FOR PREPARING BETA-KETOESTER COMPOUNDS 审中-公开
    一种制备BET-KETOESTER化合物的方法

    公开(公告)号：WO2007064077A1

    公开(公告)日：2007-06-07

    申请号：PCT/KR2006/003683

    申请日：2006-09-15

    Applicant: LG LIFE SCIENCES LTD. ,  SHIN, Hyun Ik ,  CHOI, Bo Seung ,  LEE, Jae Hoon

    Inventor： SHIN, Hyun Ik ,  CHOI, Bo Seung ,  LEE, Jae Hoon

    IPC: C07C67/20

    CPC classification number: C07D213/61 ,  C07C67/343 ,  C07C69/738

    Abstract: The present invention relates to a process for preparing a beta-keto ester compound of formula (1) , which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).

    Abstract translation: 本发明涉及一种制备式（1）的β-酮酯化合物的方法，其是用于合成喹诺酮抗生素的中间体。 特别地，本发明的特征在于在金属盐存在下有机腈化合物与单烷基丙二酸盐的反应，因此由于其吸热性质，反应易于控制，并且没有氯仿试剂 具有极好的重复性。 在酸性水溶液存在下进行原位水解，得到式（1）化合物。

    SYNERGISTIC HERBICIDAL COMPOSITIONS
    43.
    发明申请
    SYNERGISTIC HERBICIDAL COMPOSITIONS 审中-公开
    协同除草剂组合物

    公开(公告)号：WO2006065094A1

    公开(公告)日：2006-06-22

    申请号：PCT/KR2005/004337

    申请日：2005-12-16

    Applicant: LG LIFE SCIENCES LTD. ,  KIM, Do, Soon ,  LEE, Jong, Nam ,  HWANG, Ki, Hwan ,  KOO, Suk, Jin

    Inventor： KIM, Do, Soon ,  LEE, Jong, Nam ,  HWANG, Ki, Hwan ,  KOO, Suk, Jin

    IPC: A01N41/06 ,  A01P13/00

    CPC classification number: A01N47/36 ,  A01N37/26 ,  A01N39/02 ,  A01N39/04 ,  A01N43/40 ,  A01N43/56 ,  A01N43/653 ,  A01N43/70 ,  A01N43/76 ,  A01N43/88 ,  A01N47/12 ,  A01N2300/00

    Abstract: The present invention relates to a synergistic herbicidal composition comprising N- [ [(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl] -2- [2-fluoro- 1 -(methoxymethylcarbony loxy)propyl] -3 -pyridine sulfonamide or N-[[(4,6-dimethoxy-2-pyrimidinyl)amino] carbonyl]-2-[2-fluoro-l-(hydroxy)propyl]-3-pyridine sulfonamide and other herbicidal active materials as active ingredient. The herbicidal composition of the present invention can increase the herbicidal efficacy against major weeds, and can reduce the use amount of active ingredients per unit area, due to the synergistic effect by mixing two herbicidal active ingredient having different physiological functions or different herbicidal activities.

    Abstract translation: 本发明涉及包含N - [[（4,6-二甲氧基-2-嘧啶基）氨基]羰基] -2- [2-氟-1-（甲氧基甲基羰基）丙基] -3-吡啶磺酰胺的协同除草组合物 或N - [[（4,6-二甲氧基-2-嘧啶基）氨基]羰基] -2- [2-氟-1-（羟基）丙基] -3-吡啶磺酰胺和其它除草活性物质作为活性成分。 由于通过混合具有不同生理功能或不同除草活性的两种除草活性成分的协同作用，本发明的除草组合物可以提高对主要杂草的除草效力，并且可以减少每单位面积活性成分的使用量。

    PROCESS FOR PREPARING 4-CHLORO-3-HYDROXYBUTANOIC ACID ESTER
    46.
    发明申请
    PROCESS FOR PREPARING 4-CHLORO-3-HYDROXYBUTANOIC ACID ESTER 审中-公开
    制备4-氯-3-羟基丁酸的方法

    公开(公告)号：WO2004092114A1

    公开(公告)日：2004-10-28

    申请号：PCT/KR2004/000869

    申请日：2004-04-14

    Applicant: LG LIFE SCIENCES LTD. ,  CHO, Sung-Wook ,  CHANG, Jay-Hyok ,  LEE, Kyu-Woong ,  LEE, Ki-Kon ,  SO, Byung-Ran ,  SHIN, Hyun-Ik

    Inventor： CHO, Sung-Wook ,  CHANG, Jay-Hyok ,  LEE, Kyu-Woong ,  LEE, Ki-Kon ,  SO, Byung-Ran ,  SHIN, Hyun-Ik

    IPC: C07C253/04

    CPC classification number: C07C253/00 ,  C07B2200/07 ,  C07C67/22 ,  C07C253/16 ,  C07C69/675 ,  C07C255/12 ,  C07C255/15

    Abstract: The present invention relates to a process for preparing 4-chloro-3-hydroxybutanoic acid ester, an intermediate for preparing atorvastatin, in high purity and yield, by comprising the steps of 1) reacting epichlorohydrin of formula (2) with cyanide of formula (3) under the condition of pH ranging from 7 to 8, to form the 4-chloro-3-hydroxybutyronitrile of formula (4) and 2a) dissolving the 4-chloro-3-hydroxybutyronitrile of formula (4) in an alcoholic solvent and reacting it with hydrogen chloride, or 2b) reacting the 4-chloro-3-hydroxybutyronitrile of formula (4) in an alcoholic solvent saturated with hydrogen chloride, to form the 4-chloro-3-hydroxybutyronitrile acid ester of formula (I).

    Abstract translation: 本发明涉及一种制备4-氯-3-羟基丁酸酯的方法，该方法是高纯度和高收率制备阿托伐他汀的中间体，包括以下步骤：1）使式（2）的表氯醇与式（2）的氰化物反应， 3）在pH为7至8的条件下，形成式（4）的4-氯-3-羟基丁腈和2a）将式（4）的4-氯-3-羟基丁腈溶解在醇溶剂中， 使其与氯化氢反应，或2b）使式（4）的4-氯-3-羟基丁腈在饱和氯化氢的醇溶剂中反应，形成式（I）的4-氯-3-羟基丁腈酸酯。

    METHOD AND PHARMACEUTICAL COMPOSITION FOR INDUCING CANCER CELL-SPECIFIC APOPTOSIS BY COMBINATION WITH TNF FAMILY PROTEINS AND FLAVOPIRIDOL
    48.
    发明申请
    METHOD AND PHARMACEUTICAL COMPOSITION FOR INDUCING CANCER CELL-SPECIFIC APOPTOSIS BY COMBINATION WITH TNF FAMILY PROTEINS AND FLAVOPIRIDOL 审中-公开
    通过与TNF家族蛋白和氟维铁二烯组合诱导癌细胞特异性凋亡的方法和药物组合物

    公开(公告)号：WO03028001A3

    公开(公告)日：2003-12-04

    申请号：PCT/KR0201780

    申请日：2002-09-19

    Applicant: LG LIFE SCIENCES LTD ,  JEONG SHIN-WU ,  KIM DONG-MYUNG ,  KOO SUNG-YOUNG ,  LEE JIN-HO ,  HONG CHANG-YONG

    Inventor： JEONG SHIN-WU ,  KIM DONG-MYUNG ,  KOO SUNG-YOUNG ,  LEE JIN-HO ,  HONG CHANG-YONG

    IPC: C07K14/525 ,  A61K31/453 ,  A61K38/17 ,  A61K38/19

    CPC classification number: A61K31/453 ,  A61K38/177 ,  A61K38/191 ,  A61K2300/00

    Abstract: The present invention relates to a cancer cell- specific apoptosis inducing composition. The TNF (tumor necrosis factor; hereinafter, referred to as " TNF ") family proteins and flavopiridol (also its salts) and the like are individually disadvantageous to provoke a serious side effect such as toxicity against an excessive dose, although they have excellent anti-cancer effects respectively. The composition of the present invention is prepared by combining the TNF family protein and flavopiridol, which reduces the toxicity or the side effect induced during the independent treatment at an high concentration, since the TNF family protein and flavopiridol are blended at an low concentration. Also, the composition has a specific action for cancer cells and a synergistic efficacy pharmaceutically.

    Abstract translation: 本发明涉及癌细胞特异性凋亡诱导组合物。 TNF（肿瘤坏死因子;以下称为“TNF”）家族蛋白质和flavopiridol（以及其盐）等单独地不利地引起严重的副作用，例如对过量剂量的毒性，尽管它们具有优异的抗 - 癌症分别。 通过组合TNF家族蛋白和flavopiridol来制备本发明的组合物，因为TNF家族蛋白质和flavopiridol以低浓度混合，因此降低了在独立治疗期间以高浓度诱导的毒性或副作用。 此外，组合物对癌细胞具有特异性作用，并且在药学上具有协同作用。

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