公开(公告)号：WO2008103790A3

公开(公告)日：2008-08-28

申请号：PCT/US2008/054520

申请日：2008-02-21

Applicant: MIDWEST RESEARCH INSTITUTE ,  ALLAN, Cindy ,  CASSLER, Michael ,  COFFIN, Jeanette ,  DAVID, John ,  KROEHL, Meredith ,  O'SHEA, Robert

Inventor： ALLAN, Cindy ,  CASSLER, Michael ,  COFFIN, Jeanette ,  DAVID, John ,  KROEHL, Meredith ,  O'SHEA, Robert

IPC: C12N1/20

Abstract: An improved medium for selectively culturing and detecting B. anthracis is provided. The medium comprises at least one polymyxin antibiotic, typically colistin, in combination with at least one dihydrofolate reductase inhibitor, typically trimethoprim, to provide the selectivity necessary to differentially culture B. anthracis from complex environmental samples. Methods for making the improved medium, as well as methods for utilizing the improved medium to selectively culture B. anthracis are also provided.

公开(公告)号：WO2008051348A2

公开(公告)日：2008-05-02

申请号：PCT/US2007/020945

申请日：2007-09-28

Applicant: E. I. DU PONT DE NEMOURS AND COMPANY ,  MIDWEST RESEARCH INSTITUTE ,  VIITANEN, Paul, V. ,  MCCUTCHEN, Carol, M. ,  EMPTAGE, Mark ,  CAIMI, Perry, G. ,  ZHANG, Min ,  CHOU, Yat-Chen

Inventor： VIITANEN, Paul, V. ,  MCCUTCHEN, Carol, M. ,  EMPTAGE, Mark ,  CAIMI, Perry, G. ,  ZHANG, Min ,  CHOU, Yat-Chen

CPC classification number: C12P7/065 ,  Y02E50/16 ,  Y02E50/17

Abstract: Production of ethanol using a strain of xylose-utilizing Z ymomonas with a genetic modification of the glucose-fructose oxidoreductase gene was found to be improved due to greatly reduced production of xylitol, a detrimental by-product of xylose metabolism synthesized during fermentation.

Abstract translation: 发现使用具有葡萄糖 - 果糖氧化还原酶基因的遗传修饰的具有木糖利用的酵母菌菌株的乙醇的生产由于发酵期间合成的木糖代谢的有害副产物木糖醇的产生大大降低而得到改善。

公开(公告)号：WO2007143247A2

公开(公告)日：2007-12-13

申请号：PCT/US2007/064418

申请日：2007-03-20

Applicant: MIDWEST RESEARCH INSTITUTE ,  KNOSHAUG, Eric ,  JARVIS, Eric ,  SINGH, Arjun ,  FRANDEN, Mary Ann ,  ZHANG, Min

Inventor： KNOSHAUG, Eric ,  JARVIS, Eric ,  SINGH, Arjun ,  FRANDEN, Mary Ann ,  ZHANG, Min

IPC: C12N1/18

CPC classification number: C12P7/08 ,  C07K14/39

Abstract: Two genes from non-conventional yeast encode arabinose transporters. These arabinose transporters are capable of transporting arabinose across the cell membrane. These genes may be expressed heterologously in a host that is not otherwise capable of taking up significant amounts of arabinose from the environment of use. Methods are disclosed to use such genetically engineered hosts to ferment pentose such as arabinose, to produce ethanol.

Abstract translation: 来自非常规酵母的两个基因编码阿拉伯糖转运蛋白。 这些阿拉伯糖转运蛋白能够将阿拉伯糖输送到细胞膜上。 这些基因可能在不能从使用环境中占据大量阿拉伯糖的宿主中异源表达。 公开了使用这种基因工程的宿主来发酵戊糖如阿拉伯糖的方法以产生乙醇。

公开(公告)号：WO2005105944A1

公开(公告)日：2005-11-10

申请号：PCT/US2004/010415

申请日：2004-04-02

Applicant: MIDWEST RESEARCH INSTITUTE ,  BHATTACHARYA, Raghu, N.

Inventor： BHATTACHARYA, Raghu, N.

IPC: C09K3/00

CPC classification number: H01L31/0749 ,  H01L31/0296 ,  Y02E10/541

Abstract: The invention provides CBD ZnS/Zn(O,OH)S and spray deposited ZnS/Zn(O,OH)S buffer layers prepared from a solution of zinc salt, thiourea and ammonium hydroxide dissolved in a non-aqueous/aqueous solvent mixture or in 100% non-aqueous solvent. Non-aqueous solvents useful in the invention include methanol, isopropanol and triethyl-amine. One-step deposition procedures are described for CIS, CIGS and other solar cell devices.

Abstract translation: 本发明提供了由溶解在非水/水溶剂混合物中的锌盐，硫脲和氢氧化铵溶液制备的CBD ZnS / Zn（O，OH）S和喷镀ZnS / Zn（O，OH）S缓冲层， 在100％非水溶剂中。 可用于本发明的非水溶剂包括甲醇，异丙醇和三乙胺。 针对CIS，CIGS和其他太阳能电池器件描述了一步沉积工艺。

公开(公告)号：WO2005042694A2

公开(公告)日：2005-05-12

申请号：PCT/US2003/030992

申请日：2003-10-01

Applicant: MIDWEST RESEARCH INSTITUTE ,  KOSOUROV, Sergey ,  GHIRARDI, Maria, L. ,  SEIBERT, Michael

Inventor： KOSOUROV, Sergey ,  GHIRARDI, Maria, L. ,  SEIBERT, Michael

IPC: C12N

CPC classification number: C12M21/04 ,  C12M21/02 ,  C12M41/48 ,  C12P3/00

Abstract: A method of using sequential chemostat culture vessels to provide continuous H 2 production, in which photosynthestic O 2 evolution and H 2 photoproduction are separated physically into two separate bioreactors, comprising: a) growing a microorganism culture able to continuously generate H 2 by photosynthetically producing cells at about the early-to-late log state in a first photobioreactor operating as a sulfur chemostat under aerobic and/or conditions; b) continuously feeding cells from the first photobioreactor to a second photobioreactor operating under anaerobic conditions and sulfur deprivation conditions resulting from constant uptake of sulfate in the first bioreactor and a low rate of culture flow between the first and second bioreactors, for induction of hydrogenase and H 2 photoproduction to allow for continuous cultivation of the microorganism's cells in the first photobioreactor and constant H 2 production in the second photobioreactor; and c) H 2 gas from the second photobioreactor.

Abstract translation: 使用顺序恒化器培养容器提供连续的H 2生成的方法，其中光合作用O 2进化和H 2 S 2进化， 其包括：a）在大约从早期到晚期的对数状态下，通过光合合产生细胞，在第一个时间生长能够连续产生H 2 O的微生物培养物，所述第一个生物反应器在第一个 在需氧和/或条件下作为硫化物恒化器运行的光生物反应器; b）将细胞从第一光生物反应器连续进料到第二光生物反应器，所述第二光生物反应器在厌氧条件和第一生物反应器中的硫酸盐的不断吸收和第一和第二生物反应器之间的低速培养物流动导致的脱硫条件下运行，用于诱导氢化酶和 H 2光生产以允许在第一光生物反应器中连续培养微生物细胞，并在第二光生物反应器中产生恒定的H 2： 和c）来自第二光生物反应器的H 2气体。

公开(公告)号：WO2005040170A2

公开(公告)日：2005-05-06

申请号：PCT/US2004/035050

申请日：2004-10-22

Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  SPIROGEN, LTD. ,  STARKS ASSOCIATES, INC. ,  MIDWEST RESEARCH INSTITUTE ,  HSIAO, Luke, Y. ,  VISHNUVAJJALA, B., Rao ,  LIU, Paul, S. ,  SNADER, Kenneth, M. ,  THURSTON, David ,  HOWARD, Philip, W. ,  TURNER, Gregory

Inventor： VISHNUVAJJALA, B., Rao ,  LIU, Paul, S. ,  SNADER, Kenneth, M. ,  THURSTON, David ,  HOWARD, Philip, W. ,  TURNER, Gregory

IPC: C07D487/00

CPC classification number: C07D487/04

Abstract: Disclosed are compounds of Formula (I) wherein X, Y, R 1 -R 7 , T 1 , T 2 , Z, and p are as described herein; a pharmaceutical composition comprising a compound of Formula (I) and a carrier; a method of inhibiting growth of a cell, which method comprises administering in an amount effective to inhibit growth a compound of Formula (I); a method of treating cancer in a mammal, which method comprises administering in an amount effective to treat cancer a compound of Formula (I); a method of treating a viral, parasitic, or bacterial infection of a cell, which method comprises administering in an amount effective to treat a viral, parasitic, or bacterial infection a compound of Formula (I); and a method of preparing a compound of Formula (I) as described herein.

Abstract translation: 公开了式（I）的化合物，其中X，Y，R 1 -R 7，T 1，T 2，Z和p如本文所述; 包含式（I）化合物和载体的药物组合物; 抑制细胞生长的方法，该方法包括以有效抑制生长的量施用式（I）化合物; 一种治疗哺乳动物癌症的方法，该方法包括以有效治疗癌症的量施用式（I）化合物; 治疗细胞的病毒，寄生或细菌感染的方法，所述方法包括以有效治疗病毒，寄生或细菌感染的量施用式（I）化合物; 和制备本文所述的式（I）化合物的方法。

公开(公告)号：WO2005036601A3

公开(公告)日：2005-04-21

申请号：PCT/US2004/032899

申请日：2004-10-06

Applicant: MIDWEST RESEARCH INSTITUTE ,  SOPORI, Bhushan, L.

Inventor： SOPORI, Bhushan, L.

IPC: B23K26/38

Abstract: A system for laser cutting or monitoring a thin film deposition process includes a reflectometer with a substantially spherical chamber (1204) with multiple radiation sources or a single annular radiation source that illuminate a workpiece, such as a silicon wafer (1218). The illuminated workpiece reflects radiation to a collector (1234) to determine the thickness of the workpiece. The rate of speed of the laser cutting apparatus is controlled based upon this measurement.

公开(公告)号：WO2005026393A2

公开(公告)日：2005-03-24

申请号：PCT/US2004/003699

申请日：2004-02-09

Applicant: MIDWEST RESEARCH INSTITUTE, INC. ,  PAGE, Andrew, E. ,  BROWN, Kelly, L. ,  ALBURTY, David, S. ,  HUEBNER, Robert, C.

Inventor： PAGE, Andrew, E. ,  BROWN, Kelly, L. ,  ALBURTY, David, S. ,  HUEBNER, Robert, C.

IPC: C12Q1/68

CPC classification number: G01N33/543 ,  C12Q1/04 ,  C12Q1/6813 ,  C12Q1/6851 ,  C12Q2545/113 ,  C12Q2563/155

Abstract: The present invention provides a biological particle analogue, or biological analogue, that simulates a chosen biological organism or compound. The biological analogue includes a first portion that is not, in and of itself, recognized by the biological detection system, and a second portion, which provides the properties necessary for recognition by the detection system, carried by the first portion. The biological analogue is constructed in such a way as to include some important characteristics of the chosen biological organism or compound, while excluding other undesirable characteristics of the chosen biological organism or compound. The present invention is useful in testing a variety of biological detection systems.

Abstract translation: 本发明提供了模拟所选择的生物有机体或化合物的生物颗粒类似物或生物类似物。 生物类似物包括第一部分和第二部分，第一部分本身不被生物检测系统识别，第二部分提供由检测系统识别所必需的特性，第一部分携带第二部分。 生物类似物以这样的方式构建，即包括所选生物有机体或化合物的一些重要特征，同时排除所选生物有机体或化合物的其他不良特征。 本发明可用于测试各种生物检测系统。

公开(公告)号：WO2003100654A1

公开(公告)日：2003-12-04

申请号：PCT/US2002/016271

申请日：2002-05-22

Applicant: MIDWEST RESEARCH INSTITUTE ,  WENDELIN, Timothy, J. ,  JORGENSEN, Gary, J.

Inventor： WENDELIN, Timothy, J. ,  JORGENSEN, Gary, J.

IPC: G06F17/10

CPC classification number: G06F17/50 ,  G06F2217/10

Abstract: System and method of modeling optical systems (339). Experimental data representative of exisitng systems may be used for ray-tracing exisitng optical system. Generalized models may be developed to model multiple stages having multiple elements in an optical system. Graphical user interfaces enable generalized model parameter entry, model execution (420), model editing, and graphical output (400) of ray-tracing results.

Abstract translation: 光学系统建模系统和方法（339）。 代表现有系统的实验数据可用于光线追踪光学系统。 可以开发广义模型来模拟在光学系统中具有多个元件的多个阶段。 图形用户界面支持光线跟踪结果的广义模型参数输入，模型执行（420），模型编辑和图形输出（400）。

公开(公告)号：WO2003088736A1

公开(公告)日：2003-10-30

申请号：PCT/US2002/012576

申请日：2002-04-19

Applicant: MIDWEST RESEARCH INSTITUTE ,  SEIBERT, Michael ,  MAKAROVA, Valeriya ,  TSYGANKOV, Anatoly, A. ,  RUBIN, Andrew, B.

Inventor： SEIBERT, Michael ,  MAKAROVA, Valeriya ,  TSYGANKOV, Anatoly, A. ,  RUBIN, Andrew, B.

IPC: A01G7/00

CPC classification number: G01N33/5097 ,  C12M21/02 ,  C12M21/04 ,  C12M41/34 ,  C12M41/46

Abstract: In situ fluorescence method to monitor state of sulfur-deprived algal culture's ability to produce H 2 under sulfur depletion, comprising: a) providing sulfur-deprived algal culture; b) illuminating culture; c) measuring onset of H 2 percentage in produced gas phase at multiple times to ascertain point immediately after anerobiosis to obtain H 2 data as function of time; and d) determining any abrupt change in three in situ fluorescence parameters; i) increase in F t (steady-state level of chlorophyll fluorescence in light adapted cells); ii) decrease in F m' (maximal saturating light induced fluorescence level in light adapted cells); and iii) decrease in Δ F/F m ' = (F m '-F t )/F m ' (calculated photochemical activity of photosystem II (PSII) signaling full reduction of plastoquinone pool between PSII and PSI, which indicates start of anaerobic conditions that induces synthesis of hydrogenase enzyme for subsequent H 2 production that signal oxidation of plastoquinone pool asmain factor to regulate H 2 under sulfur depletion.

Abstract translation: 原位荧光法监测硫耗尽藻类培养物在硫耗尽条件下产生H2的能力的状态，包括：a）提供含硫的藻类培养; b）照亮文化; c）测定多次生产气相中H 2百分比的起始点，以确定在厌食症后立即获得的点，以获得作为时间函数的H2数据; 和d）确定三个原位荧光参数的任何突变; i）增加Ft（光适应细胞中叶绿素荧光的稳态水平）; ii）Fm'降低（光适应细胞中最大饱和光诱导荧光水平）; 和iii）降低DELTA F / Fm'=（Fm'-Ft）/ Fm'（计算的光系统II（PSII）的光化学活性信号PSII和PSI之间的plastoquinone池的完全还原，这表明诱导合成的厌氧条件开始 的氢化酶用于随后的H2生成，其在硫消耗下信号氧化Plastoquinone池主要因素来调节H2。