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    LIGANDS FOR G-PROTEIN COUPLED RECEPTORS
    3.
    发明申请
    LIGANDS FOR G-PROTEIN COUPLED RECEPTORS 审中-公开
    G蛋白偶联受体的配体

    公开(公告)号：WO2006024815A1

    公开(公告)日：2006-03-09

    申请号：PCT/GB2005/003134

    申请日：2005-08-10

    Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  GRAINGER, David, John ,  FOX, David, John

    Inventor： GRAINGER, David, John ,  FOX, David, John

    IPC: C07D453/06

    CPC classification number: C07D225/02 ,  C07D207/273 ,  C07D211/76 ,  C07D223/12 ,  C07D487/08

    Abstract: The invention relates to the generation of a library of compounds enriched in agonist and antagonists for members of the G-protein coupled class of receptors (GPCRs). The library contains compounds of general formula (I) wherein y is any integer from 1 to 8; z is one integer from 0 to 8 with the proviso that y and z cannot simultaneously be 1; X is -CO-(Y) k -(R 1 ) n or SO 2 -(Y) k -(R 1 ) n ; k is 0 or 1; y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or y is a cycloalkenyl or polycycloalkenyl group; each R 1 is independently selected from hydrogen or an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl, alkylamino, alkylaminoalkyl, alkylaminodialkyl, charged alkylaminotrialkyl or charged alkylcarboxylate radical of 1 to 20 carbon atoms; or each R 1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl, aminodialkyl, charged aminotrialkyl, or carboxylate radical; and n is any integer from 1 to m, where m is the maximum number of substitutions permissible on the cyclo-group Y; or alternatively R 1 may be selected from a peptido radical, for example having from 1 to 4 peptidic moieties linked together by peptide bonds (for example a peptido radical of 1 to 4 amino acid residues).

    Abstract translation: 本发明涉及产生富含G-蛋白偶联受体类（GPCR）成员的激动剂和拮抗剂的化合物文库。 该文库含有通式（I）的化合物，其中y为1至8的整数; z为0至8的整数，条件是y和z不能同时为1; X是-CO-（Y）

    ANTI-INFLAMMATORY AGENTS
    6.
    发明申请
    ANTI-INFLAMMATORY AGENTS 审中-公开
    抗炎药物

    公开(公告)号：WO2006134384A1

    公开(公告)日：2006-12-21

    申请号：PCT/GB2006/002217

    申请日：2006-06-14

    Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  GRAINGER, David, John ,  FOX, David, John

    Inventor： GRAINGER, David, John ,  FOX, David, John

    IPC: A61K31/55 ,  C07D223/10 ,  A61P29/00 ,  A61K31/4015 ,  A61K31/45 ,  C07D211/76 ,  C07D207/26 ,  C07D225/02

    CPC classification number: C07D223/12 ,  A61K31/4015 ,  A61K31/45 ,  A61K31/55 ,  C07D207/267 ,  C07D207/273 ,  C07D211/76

    Abstract: The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder, but excluding (S)-3-(r-methylcyclohexylcarbonylamino)-caprolactam: wherein z is 1,2,3 or 4; A is -CO- or -SO2-; Q is linear or branched alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, akylamino, alklylaminoalkyl, haloalkyl, aryl or substituted aryl; T 1 and T 2 together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T 1 and T 2 may be independently be substituted by a group R 1 , where R 1 is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R 1 is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical.

    Abstract translation: 本发明提供了通式（I）的化合物及其盐的化合物，药物组合物及其用途，用于制备治疗炎症性疾病但不包括（S）-3-（R-甲基环己基羰基氨基） - 己内酰胺的药物： 其中z为1,2,3或4; A是-CO-或-SO 2 - ; Q是直链或支链烷基，烯基，炔基，烷氧基，烷氧基，氨基烷基，烷基氨基，烷基氨基烷基，卤代烷基，芳基或取代的芳基; T 1和T 2一起构成由n个另外的碳原子组成的环烷基，环烯基或多环烷基，其中n在2和7之间; 并且与T 1和T 2所形成的环中的碳原子键合的每个氢原子可以独立地被基团R 1， 其中R 1独立地选自具有1至20个碳原子的烷基，卤代烷基，烷氧基，卤代烷氧基，烯基，炔基或烷基氨基; 或每个R 1独立地选自氟，氯，溴，碘，羟基，烷氧基，氨基，氨基烷基或氨基二烷基。

    ANTI-INFLAMMATORY AGENTS
    8.
    发明申请
    ANTI-INFLAMMATORY AGENTS 审中-公开
    抗炎药物

    公开(公告)号：WO2005053702A2

    公开(公告)日：2005-06-16

    申请号：PCT/GB2004/005030

    申请日：2004-11-30

    Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  GRAINGER, David, John ,  FOX, David, John

    Inventor： GRAINGER, David, John ,  FOX, David, John

    IPC: A61K31/55

    CPC classification number: C07D223/12 ,  A61K31/55 ,  Y02A50/411

    Abstract: The invention relates to the use of 3-aminocaprolactam derivatives for preparing a medicament intended to prevent or treat inflammatory disorders, and uses compounds of general formula (I) or a pharmaceutically acceptable salts thereof; wherein X is -CO-R 1 or-S0 2 -R 2 , and R 1 and R 2 are carbonaceous substituents.

    Abstract translation: 本发明涉及3-氨基己内酰胺衍生物用于制备预防或治疗炎症性疾病的药物的用途，并且使用通式（I）的化合物或其药学上可接受的盐; 其中X是-CO-R 1或-SO 2 -R 2，R 1和R 2是含碳取代基。

    STRUCTURED LIGHT SYSTEM FOR ROBUST GEOMETRY ACQUISITION
    9.
    发明申请
    STRUCTURED LIGHT SYSTEM FOR ROBUST GEOMETRY ACQUISITION 审中-公开
    用于坚固几何采集的结构光系统

    公开(公告)号：WO2013091016A1

    公开(公告)日：2013-06-27

    申请号：PCT/AU2012/001587

    申请日：2012-12-21

    Applicant: CANON KABUSHIKI KAISHA ,  BATTLE, David John ,  MAUNDER, David John ,  BONE, Donald James

    Inventor： BATTLE, David John ,  MAUNDER, David John ,  BONE, Donald James

    IPC: G01B11/25

    CPC classification number: G01B11/2513 ,  B25J9/1697 ,  G05B2219/37131

    Abstract: Disclosed is a method of determining coordinates (790) of a reference point (780) on an object in three-dimensional space in a scene captured by an image sensor. The object is irradiated by light sources (710,720) which are modulated at a different spatio-temporal frequency. The method generates a composite phase signal (630,640) on the object by a predetermined geometric arrangement of the light sources, and captures (910) the composite phase signal at the reference point with the image sensor. A processing arrangement determines, from the captured composite phase signal, a set of measured positioning parameters (measured carrier phase ψ lm ) independent of a position of the image sensor. The measured positioning parameters from the light sources are used for determining the coordinates of the reference point.

    Abstract translation: 公开了一种确定由图像传感器捕获的场景中的三维空间中的对象上的参考点（780）的坐标（790）的方法。 该物体被不同时空频率调制的光源（710,720）照射。 该方法通过光源的预定几何布置在物体上产生复合相位信号（630,640），并且利用图像传感器捕获（910）参考点处的复合相位信号。 处理装置从捕获的复合相位信号中确定独立于图像传感器的位置的一组测量的定位参数（测量的载波相位psilm）。 来自光源的测量的定位参数用于确定参考点的坐标。

    ANTI-INFLAMMATORY AGENTS
    10.
    发明申请
    ANTI-INFLAMMATORY AGENTS 审中-公开
    抗炎剂

    公开(公告)号：WO2006018609A2

    公开(公告)日：2006-02-23

    申请号：PCT/GB2005/003139

    申请日：2005-08-10

    Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  GRAINGER, David, John ,  FOX, David, John

    Inventor： GRAINGER, David, John ,  FOX, David, John

    IPC: A61K31/439 ,  A61K31/55 ,  C07D453/06 ,  C07D487/08

    CPC classification number: A61K31/55 ,  A61K31/439 ,  C07D451/14

    Abstract: The invention provides compounds, compositions, and uses of compounds of general formula (I) or pharmaceutically acceptable salts thereof, for the preparation of a medicament intended to treat an inflammatory disorder wherein y is any integer from 1 to 8; z is any integer from 1 to 8; with the proviso that y and z cannot both equal 1; X is -C -(Y) k -(R 1 ) n or SO 2 -(Y) k (R 1 ) n ; k is 0 or 1; Y is a cycloalkyl or polycyloalkyl group (such as an adamantyl, adamantanemethyl, bicyclooctyl, cyclohexyl, cyclopropyl group); or Y is a cycloalkenyl or polycycloalkenyl group.

    Abstract translation: 本发明提供了通式（I）化合物或其药学上可接受的盐在制备用于治疗炎性病症的药物中的化合物，组合物和用途，其中y是1的任何整数 到8; z是1至8中的任何整数; 条件是y和z不能等于1; X是-C-（Y）k-（R 1）n或SO 2 - （Y） （R 1 ） n ; k是0或1; Y为环烷基或多环烷基（如金刚烷基，金刚烷甲基，二环辛基，环己基，环丙基）; 或Y是环烯基或多环烯基。

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