公开(公告)号：WO2010059611A3

公开(公告)日：2010-11-18

申请号：PCT/US2009064762

申请日：2009-11-17

Applicant: SCHERING CORP ,  TING PAULINE C ,  ASLANIAN ROBERT G ,  CAO JIANHUA ,  CAPLEN MARY ANN ,  CHAN TIN-YAU ,  KIM HYUNJIN ,  KIM JAE-HUN ,  KUANG RONGZE ,  LEE JOE F ,  WU HEPING

Inventor： TING PAULINE C ,  ASLANIAN ROBERT G ,  CAO JIANHUA ,  CAPLEN MARY ANN ,  CHAN TIN-YAU ,  KIM HYUNJIN ,  KIM JAE-HUN ,  KUANG RONGZE ,  LEE JOE F ,  WU HEPING

IPC: C07D213/74 ,  A61K31/422 ,  A61K31/427 ,  C07D401/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D493/10

CPC classification number: C07D413/12 ,  A61K31/422 ,  A61K31/427 ,  C07D213/74 ,  C07D401/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/08 ,  C07D493/10

Abstract: The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase ("DGAT") inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use of the compounds for treating or preventing a cardiovascular disease, a metabolic disorder, obesity or an obesity-related disorder, diabetes, dyslipidemia, a diabetic complication, impaired glucose tolerance or impaired fasting glucose. An illustrative compound of the invention is shown with this abstract.

Abstract translation: 本发明涉及作为二酰基甘油酰基转移酶（“DGAT”）抑制剂的新型杂环化合物，包含杂环化合物的药物组合物以及该化合物用于治疗或预防心血管疾病，代谢障碍，肥胖症或肥胖相关病症的用途， 糖尿病，血脂异常，糖尿病并发症，葡萄糖耐量降低或空腹血糖受损。 本摘要显示了本发明的说明性化合物。

公开(公告)号：WO2008115381A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/003257

申请日：2008-03-12

Applicant: SCHERING CORPORATION ,  ALBANY MOLECULAR RESEARCH, INC. ,  TING, Pauline, C. ,  ASLANIAN, Robert, G. ,  CAO, Jianhua ,  KIM, David, Won-Shik ,  KUANG, Rongze ,  ZHOU, Gang ,  HERR, Robert, Jason ,  ZYCH, Andrew, John ,  YANG, Jinhai ,  WU, Heping ,  ZORN, Nicolas

Inventor： TING, Pauline, C. ,  ASLANIAN, Robert, G. ,  CAO, Jianhua ,  KIM, David, Won-Shik ,  KUANG, Rongze ,  ZHOU, Gang ,  HERR, Robert, Jason ,  ZYCH, Andrew, John ,  YANG, Jinhai ,  WU, Heping ,  ZORN, Nicolas

IPC: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D515/22 ,  A61K31/501 ,  A61P31/00

CPC classification number: C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D515/22

Abstract: In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions.

Abstract translation: 在其许多实施方案中，本发明提供了作为葡聚糖合酶抑制剂的取代的哒嗪酮化合物，制备这些化合物的方法，包括一种或多种这些化合物的药物，制备药物制剂的方法，包括一种或多种这样的化合物或一种或多种这样的化合物 以及其他抗真菌剂，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与葡聚糖合酶相关的一种或多种真菌感染的方法。

公开(公告)号：WO2007002057A1

公开(公告)日：2007-01-04

申请号：PCT/US2006/023937

申请日：2006-06-19

Applicant: SCHERING CORPORATION ,  ASLANIAN, Robert, G. ,  BERLIN, Michael, Y. ,  HUANG, Ying ,  MCCORMICK, Kevin, D. ,  MUTAHI, Mwangi, W. ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  TOM, Wing, C. ,  ZHENG, Junying

Inventor： ASLANIAN, Robert, G. ,  BERLIN, Michael, Y. ,  HUANG, Ying ,  MCCORMICK, Kevin, D. ,  MUTAHI, Mwangi, W. ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  TOM, Wing, C. ,  ZHENG, Junying

IPC: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  A61P3/04 ,  A61P29/00 ,  A61P37/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14

Abstract: Disclosed are compounds of the formula (I); or a pharmaceutically acceptable salt thereof, wherein: M 1 and M 3 are CH or N; M 2 is CH, CF or N; Y is -C(=O)-, -C(=S)-, -(CH2)q-, -C(=NOR 7 )- or -SO 1-2 -; Z is a bond or optionally substituted alkylene or alkenylene; R1 is H, alkyl, alkenyl, or optionally substituted cycloalkyl, aryl, heteroaryl, heterocycloalkyl or a group of the formula (II); where ring A is a monoheteroaryl ring; R 2 is optionally substituted alkyl, alkenyl, aryl, heteroaryl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; compositions and methods of treating allergy-induced airway responses, congestion, obesity, metabolic syndrome nonalcoholic fatty liver disease, hepatic steatosis, nonalcoholic steatohepatitis, cirrhosis, hepatacellular carcinoma or cognition deficit disorders using said compounds, alone or in combination with other agents.

Abstract translation: 公开了式（I）的化合物; 或其药学上可接受的盐，其中：M 1和M 3是CH或N; M 2是CH，CF或N; Y是-C（= O） - ， - C（= S） - ， - （CH 2）q - ， - C（= NOR 7） - 或-SO 1 - / SUB> - ; Z是键或任选取代的亚烷基或亚烯基; R 1是H，烷基，烯基或任选取代的环烷基，芳基，杂芳基，杂环烷基或式（II）的基团; 其中环A是单杂芳基环; R 2是任选取代的烷基，烯基，芳基，杂芳基，环烷基或杂环烷基; 其余变量如规范中所定义; 使用所述化合物单独或与其它试剂组合治疗过敏引起的气道反应，充血，肥胖，代谢综合征非酒精性脂肪性肝病，肝脂肪变性，非酒精性脂肪性肝炎，肝硬化，肝细胞癌或认知缺陷障碍的组合物和方法。

公开(公告)号：WO2005121130A2

公开(公告)日：2005-12-22

申请号：PCT/US2005/019131

申请日：2005-06-01

Applicant: SCHERING CORPORATION ,  GUO, Zhuyan ,  ORTH, Peter ,  ZHU, Zhaoning ,  MAZZOLA, Robert, D. ,  CHAN, Tin, Yau ,  VACCARO, Henry, A. ,  MC KITTRICK, Brian ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  ZHOU, Guowei ,  PALIWAL, Sunil ,  WONG, Shing-Chun ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  ROSNER, Kristin, E. ,  SHIPPS, Gerald, W., Jr. ,  SIDDIQUI, M., Arshad ,  BELANGER, David, B. ,  DAI, Chaoyang ,  LI, Dansu ,  GIRIJAVALLABHAN, Vinay, M. ,  POPOVICI-MULLER, Janeta ,  YU, Wensheng ,  ZHAO, Lianyun

Inventor： GUO, Zhuyan ,  ORTH, Peter ,  ZHU, Zhaoning ,  MAZZOLA, Robert, D. ,  CHAN, Tin, Yau ,  VACCARO, Henry, A. ,  MC KITTRICK, Brian ,  KOZLOWSKI, Joseph, A. ,  LAVEY, Brian, J. ,  ZHOU, Guowei ,  PALIWAL, Sunil ,  WONG, Shing-Chun ,  SHIH, Neng-Yang ,  TING, Pauline, C. ,  ROSNER, Kristin, E. ,  SHIPPS, Gerald, W., Jr. ,  SIDDIQUI, M., Arshad ,  BELANGER, David, B. ,  DAI, Chaoyang ,  LI, Dansu ,  GIRIJAVALLABHAN, Vinay, M. ,  POPOVICI-MULLER, Janeta ,  YU, Wensheng ,  ZHAO, Lianyun

IPC: C07D409/12

CPC classification number: C07D409/14 ,  C07C235/06 ,  C07C235/08 ,  C07C235/10 ,  C07C2601/08 ,  C07D207/20 ,  C07D207/26 ,  C07D209/44 ,  C07D215/14 ,  C07D217/06 ,  C07D263/32 ,  C07D295/185 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D513/04

Abstract: This invention relates to compounds of the Formula (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF-α or combinations thereof.

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的盐，溶剂合物或异构体，其可用于治疗由MMP，ADAM，TACE，TNF-α或其组合介导的疾病或病症。

公开(公告)号：WO1989012637A1

公开(公告)日：1989-12-28

申请号：PCT/US1989002502

申请日：1989-06-12

Applicant: SCHERING CORPORATION ,  TING, Pauline, C. ,  SHERLOCK, Margaret, H. ,  TOM, Wing, C. ,  KAMINSKI, James, J.

Inventor： SCHERING CORPORATION

IPC: C07D471/04

CPC classification number: C07D213/74 ,  C07D213/61 ,  C07D471/04

Abstract: Heterobicyclic and heterocyclic intermediate compounds and their use in treating inflammation, hyperproliferative skin conditions such as psoriasis and allergy are disclosed.