公开(公告)号：WO2017044731A1

公开(公告)日：2017-03-16

申请号：PCT/US2016/050928

申请日：2016-09-09

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason, Charles

IPC: A61B5/00 ,  A61B10/00 ,  A61K9/00 ,  A61M37/00 ,  A61N1/30 ,  G01N33/52

CPC classification number: A61B10/0064 ,  A61B5/0531 ,  A61B5/14521 ,  A61B5/4266 ,  A61B2010/0009 ,  A61N1/205 ,  A61N1/30 ,  A61N1/325

Abstract: The disclosed invention provides a sweat sensor device (100) capable of high performance stimulation and sensing at the same site on the skin (12), by mechanically colocating the sensing and stimulation components (102, 104) when stimulation and sensing are needed, and by mechanically removing one or both of the stimulation or sensing components (104, 102) when stimulation and/or sensing are not needed.

Abstract translation: 所公开的发明提供了一种汗液传感器装置（100），其能够在需要刺激和感测时机械地共同定位感测和刺激部件（102,104），从而能够在皮肤（12）上的相同部位进行高性能刺激和感测;以及 通过在不需要刺激和/或感测时机械地去除刺激或感测部件（104,102）中的一个或两个。

公开(公告)号：WO2017031393A1

公开(公告)日：2017-02-23

申请号：PCT/US2016/047686

申请日：2016-08-19

Applicant: UNIVERSITY OF CINCINNATI

Inventor： SAGLE, Laura

IPC: G01N33/483 ,  G01N33/48 ,  G01N33/487 ,  G03F7/00 ,  G03F7/004 ,  G03F7/09

CPC classification number: G01N33/54373 ,  G01N33/48707 ,  G01N33/54346 ,  G03F7/40

Abstract: Methods for fabricating a localized surface plasmon renosance (LSPR) biosensing microfluidic or spot-plate device that combines the techniques photolithography and hole-mask colloidal lithography in a unique way to yield highly sensitive yet cost-efficient devices capable of miniaturization and portability, along with the devices and methods of utilizing the devices are disclosed. The desired device pattern is transferred to a photoresist on a substrate using photolithography; at least two coats of polymer are spin-coated onto the substrate to form a polymer layer, a plurality of polystyrene particles of a desired shape and size are drop-coated on the polymer layer, a nanomeric layer of gold is deposited thereover, the polystyrene particles are removed, the hole-mask is etched, a plasmonic metal is deposited into the holes, and the polymer layer and photoresist are then removed prior to optionally sealing with a cover.

Abstract translation: 用于制造局部表面等离子体激元（LSPR）生物传感微流体或点平板装置的方法，其以独特的方式组合技术光刻和孔掩模胶体光刻，以产生能够小型化和便携性的高灵敏度且成本有效的装置，以及 公开了利用装置的装置和方法。 使用光刻将期望的器件图案转移到衬底上的光致抗蚀剂; 将至少两层聚合物涂覆在基材上以形成聚合物层，将多个具有所需形状和尺寸的聚苯乙烯颗粒滴涂在聚合物层上，在其上沉积金纳米层，聚苯乙烯 去除颗粒，蚀刻孔掩模，将等离子体激元金属沉积到孔中，然后在用盖子任选地密封之前将聚合物层和光致抗蚀剂除去。

公开(公告)号：WO2016149173A1

公开(公告)日：2016-09-22

申请号：PCT/US2016/022269

申请日：2016-03-14

Applicant: UNIVERSITY OF CINCINNATI

Inventor： BRANAM, Barton

IPC: A61B17/16 ,  A61B17/17 ,  A61B17/56

CPC classification number: A61B17/1675 ,  A61B17/1615 ,  A61B17/1617 ,  A61B17/162

Abstract: A modular reamer system that allows for intra-articular assembly of a low profile reamers for drilling bone tunnels in joint ligament reconstruction, and having particular utility in a retrograde technique for drilling a femoral tunnel in anterior cruciate ligament reconstruction. The reamer system components include a holder that may be detachably coupled to a reamer, and a guide pin that may be detachably coupled to the reamer, utilized in a surgical method that then permits the joint space to be free of tools during femoral drilling, enabling the knee to be held in a more relaxed surgical position, increasing fluid flow and therefore visibility during the drilling operation.

Abstract translation: 一种模块式铰刀系统，其允许用于在关节韧带重建中钻孔骨隧道的小型铰刀的关节内组装，并且在用于在前十字韧带重建中钻孔股骨隧道的逆行技术中具有特别的用途。 铰刀系统部件包括可拆卸地联接到铰刀的保持器和可拆卸地联接到铰刀的引导销，其以外科手术方法使用，然后允许关节空间在股骨钻孔期间没有工具，使得能够 膝盖被保持在更放松的手术位置，增加流体流动并且因此在钻孔操作期间可见。

公开(公告)号：WO2016130905A1

公开(公告)日：2016-08-18

申请号：PCT/US2016/017726

申请日：2016-02-12

Applicant: UNIVERSITY OF CINCINNATI

Inventor： SONNER, Zachary, Cole ,  HEIKENFELD, Jason, C.

IPC: A61B10/00 ,  A61N1/32

CPC classification number: A61B5/14521 ,  A61B5/053 ,  A61B5/0533 ,  A61B5/4266 ,  A61B10/0064 ,  A61B2560/0412 ,  A61B2562/166 ,  A61N1/0428 ,  A61N1/325

Abstract: A sweat sensing device (20) comprises at least one sweat generation unit (22) capable of initiating sudomotor axon reflex (SAR) sweating in an indirect stimulation region and at least one analysis unit (24, 26) capable of sensing a physiological parameter of sweat, collecting a sweat sample, or a combination thereof. The at least one analysis unit (24, 26) is located above the indirect stimulation region when the sweat sensing device is placed on skin.

Abstract translation: 汗液感测装置（20）包括至少一个汗液产生单元（22），其能够启动间接刺激区域中的运动轴突反射（SAR）出汗和至少一个能够感测生理参数的分析单元（24,26） 汗水，收集汗液样品或其组合。 当汗液感测装置放置在皮肤上时，至少一个分析单元（24,26）位于间接刺激区域上方。

公开(公告)号：WO2016028764A1

公开(公告)日：2016-02-25

申请号：PCT/US2015/045671

申请日：2015-08-18

Applicant: UNIVERSITY OF CINCINNATI

Inventor： SHANOV, Vesselin, N. ,  CHASWAL, Vibhor ,  SALUNKE, Pravahan ,  JOSHI, Madhura ,  ZHANG, Guangqi ,  SCHULZ, Mark, J ,  YARMOLENKO, Sergey, N. ,  NIENABER, Doug

IPC: A61L27/04 ,  A61L27/58 ,  A61L31/02 ,  A61L31/14 ,  A61F2/82 ,  C30B11/00 ,  C30B13/00 ,  C30B15/00 ,  C22C23/00

CPC classification number: A61L27/047 ,  A61B17/80 ,  A61B17/86 ,  A61B2017/00526 ,  A61F2/3099 ,  A61F2002/0858 ,  A61L27/58 ,  A61L31/02 ,  A61L31/022 ,  A61L31/148 ,  C25D11/30 ,  C30B11/00 ,  C30B11/02 ,  C30B13/00 ,  C30B15/00 ,  C30B23/00 ,  C30B25/00 ,  C30B29/02 ,  C30B33/005

Abstract: A biomedical implant (16, 18) is formed from magnesium (Mg) single crystal (10). The biomedical implant (16, 18) may be biodegradable. The biomedical implant (16, 18) may be post treated to control the mechanical properties and/or corrosion rate thereof said Mg single crystal (10) without changing the chemical composition thereof. A method of making a Mg single crystal (10) for biomedical applications includes filling a single crucible (12) with more than one chamber with polycrystalline Mg, melting at least a portion of said polycrystalline Mg, and forming more than one Mg single crystal (10) using directional solidification.

Abstract translation: 生物医学植入物（16,18）由镁（Mg）单晶（10）形成。 生物医学植入物（16,18）可以是可生物降解的。 可以对生物医学植入物（16,18）进行后处理以控制所述Mg单晶（10）的机械性能和/或腐蚀速率，而不改变其化学组成。 制造用于生物医学应用的Mg单晶（10）的方法包括用多晶Mg填充具有多于一个室的单个坩埚（12），熔化所述多晶Mg的至少一部分，并形成多于一个Mg单晶（ 10）使用定向凝固。

公开(公告)号：WO2015184097A2

公开(公告)日：2015-12-03

申请号：PCT/US2015/032893

申请日：2015-05-28

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason, C.

IPC: A61B5/053 ,  A61B5/00

CPC classification number: A61B10/0064 ,  A61B5/0531 ,  A61B5/0537 ,  A61B5/14521 ,  A61B5/4266 ,  A61B5/6833 ,  A61B2560/0412

Abstract: A sweat sensor device (400c) for sensing sweat on the skin (12) includes one or more sweat sensors (420) and a volume-reducing component that provides a volume-reduced pathway (480) for sweat between the one or more sweat sensors (420) and sweat glands in said skin (12) when the device (400c) is positioned on said skin (12). The volume-reducing component may include a volume -reducing material (470) and a pressure-permeated component (460), a sweat dissolvable material (490), a mechanically compliant material (570) for conforming to the skin (12), an adhesive with a vertically anisotropic sweat pathway, and microcapsules (1385) including a barrier material. The presence of a volume-reducing component reduces the sweat volume and decreases the sampling interval.

Abstract translation: 一种用于感测皮肤（12）上的汗水的汗液传感器装置（400c）包括一个或多个汗液传感器（420）和减少体积的部件，其为一个或多个汗液传感器之间的汗液提供体积减小的通道（480） 当所述装置（400c）位于所述皮肤（12）上时，所述皮肤（420）和所述皮肤（12）中的汗腺。 体积减小部件可以包括体积减小材料（470）和压力透过部件（460），汗液可溶材料（490），用于与皮肤（12）一致的机械柔顺材料（570）， 具有垂直各向异性汗液通道的粘合剂和包含阻挡材料的微胶囊（1385）。 降低体积的组件的存在降低了汗量，并减少了采样间隔。

公开(公告)号：WO2015161234A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/026444

申请日：2015-04-17

Applicant: UNIVERSITY OF CINCINNATI

Inventor： RIDGWAY, William

IPC: A61K39/395 ,  C07K16/00 ,  C12P21/08

CPC classification number: C07K16/2896 ,  A61K31/7016 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/75

Abstract: Disclosed are methods and compositions for treating Type I diabetes in a subject. Agents selected from a TLR4 agonist, a TLR4/MD-2 agonist, or a combination thereof may be used in the disclosed methods and compositions. Also disclosed are methods of restoring adaptive immune T cell tolerance, treating pernicious insulitis, improving immune tolerance, and treating autoimmune diseases using the disclosed methods and compositions.

Abstract translation: 公开了用于治疗受试者的I型糖尿病的方法和组合物。 选自TLR4激动剂，TLR4 / MD-2激动剂或其组合的药剂可用于所公开的方法和组合物中。 还公开了使用所公开的方法和组合物来恢复适应性免疫T细胞耐受性，治疗恶性胰岛炎，改善免疫耐受性和治疗自身免疫性疾病的方法。

公开(公告)号：WO2015153276A1

公开(公告)日：2015-10-08

申请号：PCT/US2015/022708

申请日：2015-03-26

Applicant: THE PROCTER & GAMBLE COMPANY ,  UNIVERSITY OF CINCINNATI

Inventor： FAIRWEATHER, Neil, Thomas ,  GIBSON, Michael, Steven ,  GUAN, Hairong ,  CHAKRABORTY, Sumit ,  DAI, Huiguang ,  BHATTACHARYA, Papri

IPC: C07C29/149 ,  C07C33/22 ,  C07C33/46 ,  C07C31/125 ,  C07C31/20

CPC classification number: C07C29/149 ,  B01J31/16 ,  B01J31/20 ,  B01J31/2295 ,  B01J31/2476 ,  B01J2231/64 ,  B01J2231/643 ,  B01J2531/842 ,  C07C33/22 ,  C07C33/46 ,  C07C31/125 ,  C07C31/207

Abstract: The homogeneous hydrogenation of organic carbonyls, especially esters, under relatively mild conditions using iron hydrido-borohydride catalyst complexes having amino-phosphine pincer ligands. The catalyst and process are well-suited for catalyzing the hydrogenation of a wide variety of organic carbonyls, such as hydrogenation of fatty acid esters to alcohols. In particular embodiments, the process can be carried out in the absence of solvent.

Abstract translation: 使用具有氨基膦化合物配体的铁氢化氢化硼催化剂配合物，在相对温和的条件下，有机羰基化合物，特别是酯的均相氢化。 催化剂和方法非常适用于催化多种有机羰基化合物的氢化，例如将脂肪酸酯氢化成醇。 在具体实施方案中，该方法可以在不存在溶剂的情况下进行。

公开(公告)号：WO2015058064A1

公开(公告)日：2015-04-23

申请号：PCT/US2014/061098

申请日：2014-10-17

Applicant: UNIVERSITY OF CINCINNATI

Inventor： HEIKENFELD, Jason, C.

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/053 ,  A61B10/00 ,  A61B18/00 ,  A61B18/12

CPC classification number: A61B5/0531 ,  A61B5/14521 ,  A61B5/4266 ,  A61B5/443 ,  A61B5/7221 ,  A61B5/7292 ,  A61B10/0064 ,  A61B2018/00654 ,  A61B2018/124 ,  A61B2562/0295 ,  A61B2562/168

Abstract: Devices that sense sweat and are capable of providing chronological assurance are described. The device (600) uses at least one sensor (620) to measure sweat or its components and to determine a sweat sampling rate. The chronological assurance is determined, at least in part, using the sweat sampling rate. The sweat sampling rate may be determined, at least in part, using a sweat volume (640) and/or a sweat generation rate, both of which may be measured or predetermined.

Abstract translation: 描述感觉汗水并且能够提供按时间顺序的保证的装置。 装置（600）使用至少一个传感器（620）来测量汗液或其组分并确定汗液采样率。 至少部分地使用汗水采样率来确定时间顺序的保证。 可以至少部分地使用汗液体积（640）和/或产汗率确定汗液采样率，这两者可以被测量或预定。

公开(公告)号：WO2014159984A1

公开(公告)日：2014-10-02

申请号：PCT/US2014/025568

申请日：2014-03-13

Applicant: UNIVERSITY OF CINCINNATI ,  KELLEY, Todd ,  NISTOR, Vasile ,  CASSTEVENS, Earnest, Christopher ,  MILLER, Justin ,  STEGMAN, Jacob, James

Inventor： KELLEY, Todd ,  NISTOR, Vasile ,  CASSTEVENS, Earnest, Christopher ,  MILLER, Justin ,  STEGMAN, Jacob, James

IPC: A61B17/56

CPC classification number: A61B17/1746 ,  A61B17/15 ,  A61B17/175 ,  A61B2017/568 ,  A61B2090/034 ,  A61F2/4609 ,  A61F2002/3401 ,  A61F2002/4687 ,  G06F19/00 ,  Y10T29/49826

Abstract: A patient- specific total hip arthroplasty system including surgical guide and jig instrumentation modeled by computer aided design using image data derived from a specific patient's relevant anatomy. Patient- specific jigs fit surface topography of portions of the acetabulum and femur of the patient and are designed to guide surgical implantation at very precise geometries unique to each patient. Patient- specific pin-locating jigs, pin-rail and spacer systems, acetabular reaming and impacting jigs, and femoral resection and version jigs are fabricated pre-operatively according to the models. Methods for fabricating jig components of the system and methods of performing a total hip arthroplasty utilizing the system are also disclosed.

Abstract translation: 一种患者特异性全髋关节置换系统，包括通过计算机辅助设计建模的手术导管和夹具仪器，使用从特定患者相关解剖结果得出的图像数据。 患者特异性夹具适合患者髋臼和股骨部分的表面形貌，并被设计为以非常精确的几何形状引导手术植入，每个患者独特。 根据模型预先制作患者特定的针定位夹具，针轨和间隔系统，髋臼铰孔和冲击夹具以及股骨切除和版本夹具。 还公开了用于制造系统的夹具部件的方法和使用该系统执行全髋关节置换术的方法。