公开(公告)号：WO02002773A2

公开(公告)日：2002-01-10

申请号：PCT/US2001/020755

申请日：2001-06-28

IPC分类号： G01N33/50 ,  A61K39/395 ,  A61K47/48 ,  A61K49/00 ,  A61P1/04 ,  A61P17/06 ,  A61P25/00 ,  A61P29/00 ,  A61P37/06 ,  C07K16/24 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/13 ,  C12P21/08 ,  G01N33/15 ,  G01N33/53 ,  G01N33/68 ,  A61K51/10 ,  C12N15/63 ,  G01N33/577

CPC分类号： C07K16/245 ,  A61K47/6845 ,  A61K2039/505 ,  C07K14/545 ,  C07K16/46 ,  C07K16/468 ,  C07K2317/10 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/76 ,  G01N33/6869

摘要： Antibodies having dual specificity for two different but structurally related antigens are provided. The antibodies can be, for example, entirely human antibodies, recombinant antibodies, or monoclonal antibodies. Preferred antibodies have dual specificity for IL-1 alpha and IL-1 beta and neutralize IL-1 alpha and IL-1 beta activity in vitro and in vivo . An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting two different but structurally related antigens (e.g., IL-1 alpha and IL-1 beta ) and for inhibiting the activity of the antigens, (e.g., in a human subject suffering from a disorder in which IL-1 alpha and/or IL-1 beta activity is detrimental.

摘要翻译： 提供了对两种不同但结构相关抗原具有双重特异性的抗体。 抗体可以是例如完全是人抗体，重组抗体或单克隆抗体。 优选的抗体对IL-1α和IL-1β具有双重特异性，并在体外和/或体内中和IL-1α和IL-1β活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测两种不同但结构相关的抗原（例如，IL-1α和IL-1β）并用于抑制抗原的活性（例如，在受试者的受试者中 来自其中IL-1α和/或IL-1β活性是有害的病症。

公开(公告)号：WO99037779A1

公开(公告)日：1999-07-29

申请号：PCT/US1999/001081

申请日：1999-01-19

IPC分类号： A61K38/00 ,  A61K47/48 ,  C07K16/24 ,  C12N15/13 ,  C07K19/00 ,  C12N5/10 ,  C12N15/85

CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K47/60 ,  A61K47/6845 ,  A61K47/6883 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2319/00

摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

摘要翻译： 描述了用于诊断应用和治疗炎性疾病的人源化抗IL-8单克隆抗体及其变体。 还描述了由共价连接到非蛋白质聚合物上的抗体片段形成的缀合物，其中缀合物的表观尺寸为至少约500kD。 与未衍生的亲本抗体片段相比，缀合物显示出显着改善的循环中的半衰期，平均停留时间和/或清除率。

公开(公告)号：WO9837200A3

公开(公告)日：1999-01-28

申请号：PCT/US9803337

申请日：1998-02-20

申请人： GENENTECH INC ,  HSEI VANESSA ,  KOUMENIS IPHIGENIA ,  LEONG STEVEN R ,  PRESTA LEONARD R ,  SHAHROKH ZAHRA ,  ZAPATA GERARDO A

发明人： HSEI VANESSA ,  KOUMENIS IPHIGENIA ,  LEONG STEVEN R ,  PRESTA LEONARD R ,  SHAHROKH ZAHRA ,  ZAPATA GERARDO A

IPC分类号： A61K38/00 ,  A61K47/48 ,  A61P37/00 ,  C07K16/24 ,  C12N15/13 ,  C07K19/00 ,  C12N5/10 ,  C12N15/85

CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K47/60 ,  A61K47/6845 ,  A61K47/6883 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

公开(公告)号：WO98037200A2

公开(公告)日：1998-08-27

申请号：PCT/US1998/003337

申请日：1998-02-20

IPC分类号： A61K38/00 ,  A61K47/48 ,  A61P37/00 ,  C07K16/24 ,  C12N15/13 ,  C07K19/00 ,  C12N5/10 ,  C12N15/85

CPC分类号： C07K16/244 ,  A61K38/00 ,  A61K47/60 ,  A61K47/6845 ,  A61K47/6883 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

摘要： Humanized anti-IL-8 monoclonal antibodies and variants thereof are described for use in diagnostic applications and in the treatment of inflammatory disorders. Also described is a conjugate formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugate exhibits substantially improved half-life, mean residence time, and/or clearance rate in circulation as compared to the underivatized parental antibody fragment.

摘要翻译： 描述了用于诊断应用和治疗炎性疾病的人源化抗IL-8单克隆抗体及其变体。 还描述了由共价连接到非蛋白质聚合物上的抗体片段形成的缀合物，其中缀合物的表观尺寸为至少约500kD。 与未衍生的亲本抗体片段相比，缀合物显示出显着改善的循环中的半衰期，平均停留时间和/或清除率。

公开(公告)号：WO1996000783A1

公开(公告)日：1996-01-11

申请号：PCT/IB1995000497

申请日：1995-06-20

申请人： CIBA-GEIGY AG ,  CAROZZI, Nadine, Barbara ,  KOZIEL, Michael, Gene

发明人： CIBA-GEIGY AG

IPC分类号： C12N15/13

CPC分类号： A01N63/02 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  C07K14/21 ,  C07K14/325 ,  C07K16/18 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/8286 ,  Y02A40/162

摘要： Antibodies, monoclonal antibodies or fragments thereof which bind to brush border membrane vesicles of insect gut and the gene or genes which encode these proteins are provided. The monoclonal antibodies bind the gut of a target insect but do not bind to mammalian brush border membranes or to plant microsomes. The antibodies and the genes encoding them find use in constructing hybrid toxins for control of insect pest.

摘要翻译： 提供了结合昆虫肠的刷状膜囊泡的抗体，单克隆抗体或其片段以及编码这些蛋白质的基因或基因。 单克隆抗体结合目标昆虫的肠道，但不结合哺乳动物刷牙膜或植物微粒体。 抗体和编码它们的基因用于构建用于控制害虫的杂交毒素。

公开(公告)号：WO1995001568A1

公开(公告)日：1995-01-12

申请号：PCT/US1994007087

申请日：1994-06-22

申请人： AMERICAN BIOGENETIC SCIENCES, INC.

发明人： AMERICAN BIOGENETIC SCIENCES, INC. ,  GARGAN, Paul, E. ,  PLOPLIS, Victoria, A. ,  PLEASANTS, Julian, R.

IPC分类号： G01N33/53

CPC分类号： G01N33/86 ,  A61K38/00 ,  A61K39/39533 ,  A61K47/6815 ,  A61K47/6843 ,  A61K47/6845 ,  C07K14/75 ,  C07K16/18 ,  C07K16/36 ,  G01N33/531 ,  G01N33/573 ,  G01N2333/745 ,  G01N2333/75 ,  G01N2333/972 ,  G01N2333/9723 ,  Y10S424/809 ,  Y10S435/962 ,  Y10S435/972 ,  Y10S435/975 ,  Y10S436/808 ,  A61K2300/00 ,  A61K38/49 ,  A61K38/164

摘要： The subject invention relates a method for the production of monoclonal antibodies. The method utilizes an immunized germfree animal. The invention also provides methods for the use of such monoclonal antibodies, and polyclonal antibodies derived from an immunized germfree animal, for in vitro and in vivo clinical diagnostics and therapeutics. Also, the subject invention provides a fibrin-specific monoclonal antibody.

摘要翻译： 本发明涉及生产单克隆抗体的方法。 该方法利用免疫的无菌动物。 本发明还提供了使用这种单克隆抗体的方法，以及衍生自免疫的无菌动物的多克隆抗体用于体外和体内临床诊断和治疗。 而且，本发明提供了一种纤维蛋白特异性单克隆抗体。

公开(公告)号：WO1992008495A1

公开(公告)日：1992-05-29

申请号：PCT/US1991008268

申请日：1991-11-07

申请人： ABBOTT BIOTECH, INC.

发明人： ABBOTT BIOTECH, INC. ,  GILLIES, Stephen, D.

IPC分类号： A61K47/48

CPC分类号： C07K14/525 ,  A61K38/00 ,  A61K47/6813 ,  A61K47/6845 ,  A61K47/6877 ,  A61K2039/505 ,  C07K14/5255 ,  C07K14/535 ,  C07K16/06 ,  C07K16/18 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/33 ,  C07K2319/75

摘要： Immunoconjugates for the selective delivery of a cytokine to a target cell are disclosed. The immunoconjugates are comprised of an immunoglobulin heavy chain having a specificity for the target cell, such as a cancer or virus-infected cell, and a cytokine, such as lymphotoxin, tumor necrosis factor alpha, interleukin-2, or granulocyte-macrophage colony stimulating factor, joined via Aits amino terminal amino acid to the carboxy-Aterminus of the immunoglobulin. Nucleic acid sequences encoding these immunoconjugates and methods of their preparation by genetic engineering techniques are also disclosed.

摘要翻译： 公开了将细胞因子选择性递送至靶细胞的免疫偶联物。 免疫缀合物由对靶细胞例如癌症或病毒感染的细胞以及细胞因子如淋巴毒素，肿瘤坏死因子α，白介素-2或粒细胞 - 巨噬细胞集落刺激的特异性的免疫球蛋白重链组成 因子，通过Aits氨基末端氨基酸连接到免疫球蛋白的羧基末端。 还公开了编码这些免疫缀合物的核酸序列及其通过基因工程技术制备的方法。

公开(公告)号：WO1992000383A1

公开(公告)日：1992-01-09

申请号：PCT/FR1991000491

申请日：1991-06-20

申请人： CIS BIO INTERNATIONAL ,  QUASH, Gérard ,  SACCAVINI, Jean-Claude ,  EL ALAOUI, Saïd ,  BOHY, Joëlle ,  AUMAITRE, Elisabeth

发明人： CIS BIO INTERNATIONAL

IPC分类号： C12P21/08

CPC分类号： C07K16/44 ,  A61K38/00 ,  A61K47/6845 ,  C07K16/18

摘要： Antibody, or its fragments, specifically recognizing the transglutaminase-induced Nε-(η-glutamyl)-lysine isopeptide formed between the η-carboxamide group of a glutamine residue in a protein, and the ε-NH¿2? group of a lysine residue which is free or in a protein, and the η-carboxyl group of glutamic acid which is free or in a protein. An immunogen consisting of the N?ε¿-(η-glutamyl)-lysine isopeptide is also described, as are the diagnostic and therapeutic uses thereof.

公开(公告)号：WO1991019501A1

公开(公告)日：1991-12-26

申请号：PCT/US1991003592

申请日：1991-05-22

申请人： CYTEL CORPORATION

发明人： CYTEL CORPORATION ,  PAULSON, James, C. ,  PEREZ, Mary, S. ,  GAETA, Federico, C., A.

IPC分类号： A61K31/70

CPC分类号： C07H15/10 ,  A61K9/1271 ,  A61K31/70 ,  A61K31/715 ,  A61K38/13 ,  A61K47/543 ,  A61K47/549 ,  A61K47/6845 ,  A61K47/6911 ,  C07H3/06 ,  C07H15/04 ,  C07K16/18 ,  C12N9/1051 ,  G01N33/56972

摘要： Novel selectin ligands have been identified and various uses for the ligands and antibodies reactive thereto are provided, including targeted delivery of liposome formulations.

摘要翻译： 已经鉴定了新的选择蛋白配体，并且提供了与其反应的配体和抗体的各种用途，包括脂质体制剂的靶向递送。

公开(公告)号：WO1989012093A1

公开(公告)日：1989-12-14

申请号：PCT/US1989002521

申请日：1989-06-08

申请人： BAYLOR COLLEGE OF MEDICINE

发明人： BAYLOR COLLEGE OF MEDICINE ,  EMERY, Jared, M. ,  LAM, Dominic, M.-K. ,  KELLEHER, Peter, J.

IPC分类号： C12N05/00

CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K47/6817 ,  A61K47/6843 ,  A61K47/6845

摘要： Cytotoxic compositions and methods for their use are provided for preventing proliferation of remnant lens epithelial cells following extracapsular extraction. The cytotoxic compositions comprise monoclonal antibodies specific for lens epithelial cells which are introduced into the anterior chamber of the eye where they bind specifically to any lens epithelial cells. The method may be used at the time of extracapsular cataract extraction or may be used subsequently to remove a second cataract resulting from proliferation of remnant lens epithelial cells.

摘要翻译： 提供了细胞毒性组合物及其使用方法，以防止囊外提取后残留的晶状体上皮细胞的增殖。 细胞毒性组合物包含特异于镜片上皮细胞的单克隆抗体，其被引入眼睛的前房，其特异性地结合到任何晶状体上皮细胞。 该方法可以在囊外白内障摘除时使用，或者可以随后用于去除由残余晶状体上皮细胞增殖引起的第二白内障。