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公开(公告)号：WO2017145164A9
公开(公告)日：2017-08-31
申请号：PCT/IL2017/050236
申请日：2017-02-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： SATCHI-FAINARO, Ronit , PISAREVSKY, Evgeni , ELDAR-BOOCK, Anat , BEN-SHUSHAN, Dikla , EPSHTEIN, Yana , SCOMPARIN, Anna
Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.
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公开(公告)号：WO2017145164A1
公开(公告)日：2017-08-31
申请号：PCT/IL2017/050236
申请日：2017-02-24
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： SATCHI-FAINARO, Ronit , PISAREVSKY, Evgeni , ELDAR-BOOCK, Anat , BEN-SHUSHAN, Dikla , EPSHTEIN, Yana , SCOMPARIN, Anna
CPC classification number: A61K9/5153 , A61K47/645
Abstract: Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.
Abstract translation: 包含聚合物基质的聚合物缀合物，所述聚合物基质具有与其相关的下调与黑素瘤的发作或进展相关的多肽的活性或表达的试剂，以及任选且优选地，协同作用的另外的试剂 与所述代理商一起提供。 还提供了用于制备这些缀合物的合成方法及其在治疗黑素瘤和其他癌症疾病中的用途。
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公开(公告)号：WO2017143200A1
公开(公告)日：2017-08-24
申请号：PCT/US2017/018386
申请日：2017-02-17
Inventor： HUR, Byul , HARDY, John , EISENSTADT, William, R. , SCHMIDT, Christine, E.
CPC classification number: A61K9/0097 , A61B5/0008 , A61B5/0022 , A61B5/0031 , A61B5/01 , A61B5/14532 , A61B5/4839 , A61B5/746 , A61B2505/07 , A61B2560/0209 , A61B2562/043 , A61M31/002 , G06F19/00 , G16H40/67
Abstract: Wireless and non-wireless drug delivery integrated circuits, systems, and methods of delivering therapeutic pharmaceutical compounds are provided. The system can include a control module, a wireless drug delivery integrated circuit, a first electrode and a second electrode that are both attached to the wireless drug delivery integrated circuit, an electroactive polymer, and a pharmaceutical compound. The electroactive polymer and the pharmaceutical compound can be formed as films on one of the electrodes and, when placed in a solution, a voltage potential can be applied across the electrodes causing the pharmaceutical compound to be released into the solution.
Abstract translation: 提供了无线和非无线药物输送集成电路，系统和输送治疗药物化合物的方法。 该系统可以包括控制模块，无线药物输送集成电路，都连接到无线药物输送集成电路的第一电极和第二电极，电活性聚合物和药物化合物。 电活性聚合物和药物化合物可以形成为一个电极上的薄膜，并且当置于溶液中时，可以在电极上施加电压电势，使药物化合物释放到溶液中。
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公开(公告)号：WO2017142164A1
公开(公告)日：2017-08-24
申请号：PCT/KR2016/011977
申请日：2016-10-24
Applicant: ㈜메디프레소
Abstract: 본 발명은 항암제 약물전달체 및 이의 제조방법에 관한 것으로서, 보다 상세하게는 종양조직 부위 또는 종양 제거부위에 도포되어 겔로 전환되어 견고하게 부착되어 항암제 약물을 방출하게 되는 항암제 약물전달체 및 이의 제조방법에 관한 것이다.
Abstract translation:
本发明的抗癌药物递送系统，并且作为其涉及一种方法，用于制备，更具体地涉及肿瘤组织部位，或施加到肿瘤切除部位牢固地连接被转换成射出的抗癌药物的凝胶癌症 药物输送系统及其制造方法本发明涉
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公开(公告)号：WO2017115991A1
公开(公告)日：2017-07-06
申请号：PCT/KR2016/011909
申请日：2016-10-21
Applicant: 한국과학기술원
IPC: A61K9/127 , A61K41/00 , A61K31/282 , A61K31/403 , A61K47/48 , A61K47/30 , A61K33/24 , A61K49/04 , A61K49/00
CPC classification number: A61K9/127 , A61K31/282 , A61K31/403 , A61K33/24 , A61K41/00 , A61K47/30 , A61K49/00 , A61K49/04
Abstract: 본 발명은 항암제 및 인도시아닌 그린이 캡슐화된 리포좀 복합체를 포함하는 암 치료용 조성물 및 이의 제조방법에 관한 것으로, 구체적으로는 리포좀, 항암제 및 인도시아닌그린을 포함하는 복합체를 포함하고, 치료적으로 유효한 광 조사시 발생하는 인도시아닌 그린에 의한 광열효과와 항암제에 의한 암 치료효능을 동시에 가지는 암 치료용 조성물 및 이를 제조할 수 있는 방법에 관한 것이다.
Abstract translation:
本发明涉及抗癌剂和用于在传递臂绿色包含脂质体包封的复杂治疗非的组合物和它们的制备方法，并且具体地包括脂质体，抗癌剂和交付时绘制不 包括复合物和，在一个方式的治疗，该组合物和制造用于治疗癌症与癌症治疗功效的相同，由于作为由绿色抗癌剂光热效果并不在生成的同时输送时，一个有效的光照射。
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Patent Agency Ranking
公开(公告)号：WO2017105138A1
公开(公告)日：2017-06-22
申请号：PCT/KR2016/014821
申请日：2016-12-16
Applicant: 주식회사 삼양바이오팜
IPC: A61K9/107 , A61K47/14 , A61K47/30 , A61K9/00 , A61K31/7088
CPC classification number: A61K9/00 , A61K9/107 , A61K31/7088 , A61K47/14 , A61K47/30
Abstract: 본 발명은 수상에서 음이온성 약물과 양이온성 화합물을 정전기적 결합을 이용하여 나노입자를 형성시키는 단계; 및 상기 나노입자를 양친성 고분자 및 임의로 폴리락트산염으로 이루어진 고분자 미셀 안에 포함시키는 단계를 포함함으로써, 정전기적 결합과 소수성 결합을 증가시켜 제형의 음이온 약물 봉입률을 높임으로써 음이온성 약물 전달용 조성물의 제조 수득률을 증가시키는 제조 방법에 관한 것이다.
Abstract translation:
本发明包括使用静电耦合到阴离子药物和在水中以形成纳米颗粒中的阳离子化合物的工序; 和纳米颗粒的两亲性聚合物和任选的用于通过包括包含在由乳酸盐，静电耦合，并通过增加阴离子药物递送组合物的制剂中的阴离子性药物包封率，以增加疏水性结合的聚合物胶束的步骤的聚 用于提高产量的生产方法。
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公开(公告)号：WO2017072774A1
公开(公告)日：2017-05-04
申请号：PCT/IL2016/051167
申请日：2016-10-28
Applicant: SOLUBEST LTD
Inventor： TEMTSIN-KRAYZ, Galia , GLOZMAN, Sabina , KAZHDAN, Pavel
CPC classification number: A61K9/006 , A61K9/1611 , A61K9/1623 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K31/05 , A61K31/352 , A61K31/4045 , A61K31/5377 , A61K31/573 , A61K38/28
Abstract: The present application relates to a pharmaceutical composition for transmucosal administration of an active lipophilic compound through the oral mucosa comprising a lipophilic active compound, a polymeric matrix formed by two or more water-soluble polymers and a rapid dissolution agent. At least one of the water-soluble polymers is an amphiphilic polymer and at least one is either a hydrophilic polymer or an amphiphilic polymer with a hydrophobic-hydrophilic balance different from the first amphiphilic polymer. In addition, the polymeric matrix is not crosslinked and no covalent interaction occurs between the two or more polymers and between the polymers and the lipophilic active compound, which is interwoven with the aforesaid polymeric matrix.
Abstract translation: 本申请涉及通过口腔粘膜透粘膜给予活性亲脂性化合物的药物组合物，其包含亲脂性活性化合物，由两种或更多种水溶性聚合物形成的聚合物基质和快速溶解 剂。 至少一种水溶性聚合物是两亲聚合物，并且至少一种是亲水聚合物或具有不同于第一种两亲聚合物的疏水 - 亲水平衡的两亲聚合物。 此外，聚合物基质不交联，并且在两种或更多种聚合物之间以及聚合物与与上述聚合物基质交织的亲脂性活性化合物之间不发生共价相互作用。
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48.发明申请COMPOSITIONS FOR AN INJECTABLE, IN SITU FORMING NEUROSCAFFOLD AND METHODS OF USING THE SAME 审中-公开用于形成神经细胞的可注射的组合物及其使用方法
公开(公告)号：WO2017059175A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054614
申请日：2016-09-30
Applicant: PIXARBIO CORPORATION
Inventor： CRISCIONE, Jason, M. , REYNOLDS, Francis, M. , DAI, Haining , BADER, Rebecca, A.
IPC: A61L27/52 , A61K9/10 , A61K9/127 , A61K31/095 , A61K47/30
CPC classification number: A61L27/18 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2400/06 , A61L2430/32 , A61L2430/40 , C08L71/02 , C08L67/04
Abstract: Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.
Abstract translation: 公开了可通过自由组装可生物降解的聚合物微粒，纳米颗粒或其任何组合通过无铜点击化学或迈克尔型加成偶联反应原位形成的可注射的可生物降解的神经支架。 可注射的可生物降解的神经支架在具有脊髓损伤或局部神经障碍的受试者中提供3-D结构支持，神经保护和/或随后的再生。
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49.发明申请PHARMACEUTICAL COMPOSITION INCLUDING DUTASTERIDE AND CAPSULE FORMULATION COMPRISING THE SAME 审中-公开药物组合物，包括杀虫剂和包含其中的胶囊制剂
公开(公告)号：WO2017043913A1
公开(公告)日：2017-03-16
申请号：PCT/KR2016/010159
申请日：2016-09-09
Inventor： BAIK, Taegon , KIM, Seyeon , AHN, Kyeongjin , KIM, Ju-hee , PARK, Young-joon
CPC classification number: A61K31/58 , A61K9/4866
Abstract: The present disclosure relates to a pharmaceutical composition comprising dutasteride and propylene glycol monolaurate, and a capsule formulation comprising the same.
Abstract translation: 本公开涉及包含度他雄胺和丙二醇单月桂酸酯的药物组合物和包含其的胶囊制剂。
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公开(公告)号：WO2017040939A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/050122
申请日：2016-09-02
Inventor： PARVIN, Bahram , CHENG, Qingsu
IPC: A61K31/713 , A61K47/30 , C12Q1/68
CPC classification number: A61K31/713 , C12Q1/689
Abstract: Methods of labeling, identifying and differentiating microorganisms using functionalized Buckyballs are provided herein. The invention further provides methods for imaging or inhibiting gene expression using functionalized Buckyballs of the invention. The invention also provides a system for labeling, identifying and differentiating microorganisms.
Abstract translation: 本文提供使用官能化巴克球标记，鉴定和分化微生物的方法。 本发明还提供使用本发明的官能化巴克球来成像或抑制基因表达的方法。 本发明还提供了用于标记，鉴定和分化微生物的系统。
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