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公开(公告)号：WO2020136657A1
公开(公告)日：2020-07-02
申请号：PCT/IL2019/051420
申请日：2019-12-27
摘要： A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle: (ii) at least one adjuvant, and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.
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公开(公告)号：WO2020136657A9
公开(公告)日：2020-07-02
申请号：PCT/IL2019/051420
申请日：2019-12-27
摘要： A polymeric nanoparticle is disclosed which comprises: (i) at least one disease-associated antigen which is capable of producing a T-cell response, wherein the disease-associated antigen is encapsulated in the nanoparticle: (ii) at least one adjuvant, and (iii) a dendritic cell targeting moiety which is attached to the outer surface of the nanoparticle. Use of the nanoparticle for treating diseases associated with abnormal cell growth or an infection is also disclosed.
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3.发明申请POLYAMINATED POLYGLUTAMIC ACID-CONTAINING COMPOUNDS AND USES THEREOF FOR DELIVERING OLIGONUCLEOTIDES 审中-公开含聚氨酯的含聚氨酯的化合物及其用于交付寡糖的用途
公开(公告)号：WO2017056095A1
公开(公告)日：2017-04-06
申请号：PCT/IL2016/051071
申请日：2016-09-30
发明人： SATCHI-FAINARO, Ronit , SCOMPARIN, Anna , POLYAK, Dina , KRIVITSKY, Adva , ELIYAHU, Shay , GIBORI, Hadas
CPC分类号： C08G69/48 , A61K31/7088 , A61K38/00 , C08G69/10 , C12N15/113 , C12N15/1137 , C12N2310/14 , C12N2310/141 , C12N2320/31 , C12N2320/32 , C12Y207/11001
摘要： Polymers useful for associating therewith oligonucleotides and for delivering the oligonucleotides into a cell, conjugates comprising these polymers and an oligonucleotide associated therewith, and compositions comprising same are provided. Also provided are uses of these conjugates in, for example, gene therapy, and particularly gene silencing. The disclosed polymers feature a PGA backbone, and amine-terminated pendant groups attached to at least 40 % of the backbone units, and optionally further comprise alkyl pendant groups and/or other nitrogen-containing pendant groups attached to other one or more portions of the backbone units. The disclosed polymers can be cross-linked or can form a part of a block-copolymer.
摘要翻译： 提供了可用于与寡核苷酸缔合并将寡核苷酸递送至细胞的聚合物，包含这些聚合物的缀合物和与其相关的寡核苷酸以及包含其的组合物。 还提供了这些缀合物在例如基因治疗中的用途，特别是基因沉默。 所公开的聚合物具有PGA主链，并且连接至至少40％的主链单元的胺封端的侧基，并且任选地还包含连接到其它一个或多个部分的烷基侧基和/或其它含氮侧基 骨干单位。 所公开的聚合物可以是交联的或可以形成嵌段共聚物的一部分。
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公开(公告)号：WO2017145164A9
公开(公告)日：2017-08-31
申请号：PCT/IL2017/050236
申请日：2017-02-24
发明人： SATCHI-FAINARO, Ronit , PISAREVSKY, Evgeni , ELDAR-BOOCK, Anat , BEN-SHUSHAN, Dikla , EPSHTEIN, Yana , SCOMPARIN, Anna
摘要： Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.
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公开(公告)号：WO2017145164A1
公开(公告)日：2017-08-31
申请号：PCT/IL2017/050236
申请日：2017-02-24
发明人： SATCHI-FAINARO, Ronit , PISAREVSKY, Evgeni , ELDAR-BOOCK, Anat , BEN-SHUSHAN, Dikla , EPSHTEIN, Yana , SCOMPARIN, Anna
CPC分类号： A61K9/5153 , A61K47/645
摘要： Polymeric conjugates comprising a polymeric matrix having associated therewith an agent that down-regulates an activity or expression of a polypeptide associated with onset or progression of melanoma, and optionally and preferably, an additional agent that acts in synergy with said agent, are provided. Synthetic methodologies for preparing these conjugates and uses thereof in treating melanoma and other cancerous diseases are also provided.
摘要翻译： 包含聚合物基质的聚合物缀合物，所述聚合物基质具有与其相关的下调与黑素瘤的发作或进展相关的多肽的活性或表达的试剂，以及任选且优选地，协同作用的另外的试剂 与所述代理商一起提供。 还提供了用于制备这些缀合物的合成方法及其在治疗黑素瘤和其他癌症疾病中的用途。
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公开(公告)号：WO2016203478A1
公开(公告)日：2016-12-22
申请号：PCT/IL2016/050639
申请日：2016-06-16
IPC分类号： C07D491/22 , C07D487/04 , C07D401/12 , A61K47/48 , A61K31/497 , A61K31/519 , A61K31/4188 , A61K31/436 , A61P35/00
CPC分类号： A61K47/555 , A61K31/4184 , A61K31/4188 , A61K31/436 , A61K31/4745 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/519 , A61K47/54 , A61P35/00 , C07D215/44 , C07D487/04 , C07D491/22
摘要： The present invention provides heteroarene-based drag derivatives having a "clickable" ketone group, as well as conjugates of said drug derivatives with targeting moieties capable of binding to extracellular antigens; and pharmaceutical compositions comprising them.
摘要翻译： 本发明提供具有“可点击”酮基团的基于杂芳基的阻滞衍生物，以及所述药物衍生物与能够结合细胞外抗原的靶向部分的缀合物; 和包含它们的药物组合物。
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