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    VITAMIN D FORMULATIONS AND THERAPEUTIC USES THEREOF
    2.
    发明申请
    VITAMIN D FORMULATIONS AND THERAPEUTIC USES THEREOF 审中-公开
    维生素D制剂及其治疗用途

    公开(公告)号：WO2017205939A1

    公开(公告)日：2017-12-07

    申请号：PCT/AU2017/050543

    申请日：2017-06-03

    申请人： INDIGO RIDGE PTY LTD

    发明人： CUMMING, Alistair

    IPC分类号： A61K31/592 ,  A61K31/593

    CPC分类号： A61K31/593 ,  A61K9/2031

    摘要： The present invention provides a formulation comprising: Vitamin D, or a salt, derivative or metabolite thereof; one or more polyethylene glycols having a molecular weight of about 1000- 4000 Da; and one or more polyethylene glycols having a molecular weight of about 500-800 Da. The formulation may be configured to be administered by retention in the buccal cavity, and particularly in the sublingual region of the buccal cavity. Also provides are methods of treating or preventing a condition associated with a deficiency in or resistance to Vitamin D or a derivative or a metabolite thereof, comprising the step of administering to a subject the present formulations. The condition associated with a deficiency in or resistance to Vitamin D, or a derivative or a metabolite thereof may be a bone mineralisation disorder or a bone remodelling disorder, or a mineral metabolism disorder.

    摘要翻译： 本发明提供了一种制剂，其包含：维生素D或其盐，衍生物或代谢物; 一种或多种分子量为约1000-4000Da的聚乙二醇; 和一种或多种分子量为约500-800Da的聚乙二醇。 该制剂可以配置为通过保留在颊腔中，并且特别是在颊腔的舌下区域中进行给药。 还提供了治疗或预防与维生素D或其衍生物或代谢物的缺乏或抗性有关的病症的方法，包括将本制剂给予受试者的步骤。 与维生素D或其衍生物或代谢物的缺乏或抗性相关的病症可以是骨矿化障碍或骨重塑障碍或矿物质代谢障碍。

    ABUSE DETERRENT SOFT CHEWABLE DRUG FORMULATIONS
    3.
    发明申请
    ABUSE DETERRENT SOFT CHEWABLE DRUG FORMULATIONS 审中-公开
    滥用柔软咀嚼药物配方

    公开(公告)号：WO2017151571A1

    公开(公告)日：2017-09-08

    申请号：PCT/US2017/019869

    申请日：2017-02-28

    申请人： FIRST TIME US GENERICS LLC ,  DIXIT, Manesh

    发明人： DIXIT, Manesh ,  PEWAR, Vaibhav ,  PATEL, Rushi ,  PATEL, Mineshkumar

    IPC分类号： A61K9/20 ,  A61K31/485

    CPC分类号： A61K9/2095 ,  A61K9/0056 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/2077 ,  A61K31/137 ,  A61K31/222 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/522 ,  A61P25/30

    摘要： The present disclosure relates to oral, abuse deterrent, edible soft chewable dosage forms for delivery of drugs that are susceptible to abuse to a human or animal subject. The dosage forms are provided as chewable tablets manufactured using a compression (tablet) press. The edible soft chew dosage forms can be administered to subjects that are unable to swallow conventional tablets or capsules whole. One or more abuse deterrent measures in the dosage forms prevent the conversion of the dosage form into a residue or extract suitable for non-oral administration, such as intranasal or intravenous abuse. The present disclosure also relates to processes of preparing the dosage form. Such soft chew dosage forms have hardness less than 2 kilopond, preferably less than 1 kilopond, more preferably no measurable hardness when measured with tablet hardness tester and friability less than 1%, preferably less than 0.5 %, more preferably less than 0.1% for 100 rotations (per USP); 200 rotations or 300 rotations.

    摘要翻译： 本公开涉及用于将易于滥用的药物递送至人类或动物受试者的口服，滥用威慑，可食用软咀嚼剂型。 提供的剂型是作为使用压片机（压片机）制造的咀嚼片。 可食用的软咀嚼剂型可以给予不能吞服常规片剂或胶囊整体的受试者。 剂型中的一种或多种滥用威慑措施防止剂型转化为适合非口服给药的残留物或提取物，例如鼻内或静脉内滥用。 本公开还涉及制备该剂型的方法。 这样的软咀嚼剂型具有小于2千克的硬度，优选小于1千克的硬度，更优选当用片剂硬度测试仪测量时不具有可测量的硬度，并且脆碎度小于1％，优选小于0.5％，更优选小于0.1％ 轮换（每USP）; 200转或300转。

    ABUSE DETERRENT PHARMACEUTICAL DOSAGE FORMS
    7.
    发明申请
    ABUSE DETERRENT PHARMACEUTICAL DOSAGE FORMS 审中-公开
    滥用药物剂量形式

    公开(公告)号：WO2017103111A1

    公开(公告)日：2017-06-22

    申请号：PCT/EP2016/081434

    申请日：2016-12-16

    申请人： UNIVERSITÄT BASEL

    发明人： HUWYLER, Jörg ,  PUCHKOV, Maxim

    IPC分类号： A61K9/20 ,  A61K31/00

    CPC分类号： A61K9/204 ,  A61K9/2009 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K31/00 ,  A61K31/765 ,  A61K2300/00

    摘要： The present invention relates to solid oral pharmaceutical dosage forms that provide extended release of active ingredients and have abuse deterrent properties and the methods of making the same. More particularly, the present invention relates to solid oral extended release abuse deterrent dosage forms comprising at least one polycaprolactone (PCL) and at least one gelling agent.

    摘要翻译： 本发明涉及提供活性成分的延长释放并具有滥用威慑性质的固体口服药物剂型及其制备方法。 更具体地说，本发明涉及包含至少一种聚己酸内酯（PCL）和至少一种胶凝剂的固体口服缓释剂滥用威慑剂型。

    SOLID DOSAGE FORM IMMEDIATE DRUG RELEASE AND APPARATUS AND METHOD FOR MANUFACTURE THEREOF
    9.
    发明申请
    SOLID DOSAGE FORM IMMEDIATE DRUG RELEASE AND APPARATUS AND METHOD FOR MANUFACTURE THEREOF 审中-公开
    固体剂型即刻药物释放及其制造装置和方法

    公开(公告)号：WO2017075096A1

    公开(公告)日：2017-05-04

    申请号：PCT/US2016/058935

    申请日：2016-10-26

    申请人： BLAESI, Aron, H.

    发明人： BLAESI, Aron, H. ,  SAKA, Nannaji

    IPC分类号： A61K9/00

    CPC分类号： A61K9/0007 ,  A61K9/1635 ,  A61K9/1641 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/7007

    摘要： A solid pharmaceutical dosage form includes a drug-containing solid and a nondrug-containing matrix. The drug-containing solid includes one or more drug- containing structural elements that are embedded in or attached to the nondrug- containing matrix. The drug-containing structural elements include one of zero- dimensional elements, one-dimensional elements, two-dimensional elements, or combinations thereof. The drug-containing structural elements are a solidified liquid or paste. The pharmaceutical dosage form has a size greater than an average thickness of the one or more drug-containing structural elements.

    摘要翻译： 固体药物剂型包括含有药物的固体和不含药物的基质。 含有药物的固体包括一种或多种嵌入或附着于不含药物的基质中的含有药物的结构元素。 含有药物的结构元素包括零维元素，一维元素，二维元素或其组合中的一种。 含有药物的结构元件是固化液体或糊状物。 药物剂型的尺寸大于一种或多种含药物结构元件的平均厚度。