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公开(公告)号：WO2017200700A1
公开(公告)日：2017-11-23
申请号：PCT/US2017/028770
申请日：2017-04-21
Applicant: PIXARBIO CORPORATION
Inventor： KHALIL, Amer , CRISCIONE, Jason, M. , REYNOLDS, Francis, M. , DAI, Haining
IPC: A61P25/08 , A61K31/55 , A61K31/195
Abstract: Provided herein are methods for treating surgical incisional pain or wound pain in a subject using disclosed compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier.
Abstract translation: 本文提供了使用公开的包含抗惊厥药和生物可降解载体的组合物治疗受试者中的手术切口疼痛或伤口疼痛的方法，其中所述药剂掺入生物可降解载体内。
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2.发明申请COMPOSITIONS COMPRISING NAV1.7 SELECTIVE INHIBITORS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME 审中-公开包含用于治疗急性，手术后或慢性疼痛的NAV1.7选择性抑制剂的组合物及使用该组合物的方法
公开(公告)号：WO2017147147A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/018869
申请日：2017-02-22
Applicant: PIXARBIO CORPORATION
Inventor： REYNOLDS, Francis, M. , CRISCIONE, Jason, M. , LANGER, Robert, Samuel , TILLEY, Dana , DAI, Haining
CPC classification number: A61K9/1647 , A61K9/0024 , A61K31/40 , A61K31/4015 , A61K31/416 , A61K31/427
Abstract: Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising a Na v 1.7 selective inhibitor and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.
Abstract translation: 本文提供了用于治疗受试者的急性，慢性或术后疼痛的组合物，所述组合物包含Na v 1.7选择性抑制剂和生物可降解载体，其中所述 试剂被包含在可生物降解的载体内。 本文还公开了治疗受试者疼痛的方法和用于制备用于治疗受试者的急性，慢性或术后疼痛的组合物的试剂盒。
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Patent Agency Ranking3.发明申请COMPOSITIONS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME 审中-公开治疗急性，手术后或慢性疼痛的组合物及使用该组合物的方法
公开(公告)号：WO2016081236A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/060093
申请日：2015-11-11
Applicant: PIXARBIO CORPORATION , ARMSTRONG, Patrick, A. , CHEN, Xi
Inventor： ARMSTRONG, Patrick, A. , CHEN, Xi , CRISCIONE, Jason, M. , WERTH, Nicholas, B. , REYNOLDS, Francis, M. , DAI, Haining , LANGER, Robert, Samuel
IPC: A61K31/55 , A61K31/195 , A61K31/4166 , A61P25/08
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/0024 , A61K9/1682 , A61K9/19 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K31/195 , A61K31/197 , A61K31/4166 , A61K31/55 , A61K31/7048 , A61P29/00
Abstract: Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.
Abstract translation: 本文提供了用于治疗受试者的急性，慢性或术后疼痛的组合物，所述组合物包含抗惊厥剂和生物可降解载体，其中所述试剂掺入可生物降解载体内。 本文还公开了治疗受试者疼痛的方法和用于制备用于治疗受试者的急性，慢性或术后疼痛的组合物的试剂盒。
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4.发明申请COMPOSITIONS FOR AN INJECTABLE, IN SITU FORMING NEUROSCAFFOLD AND METHODS OF USING THE SAME 审中-公开用于形成神经细胞的可注射的组合物及其使用方法
公开(公告)号：WO2017059175A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/054614
申请日：2016-09-30
Applicant: PIXARBIO CORPORATION
Inventor： CRISCIONE, Jason, M. , REYNOLDS, Francis, M. , DAI, Haining , BADER, Rebecca, A.
IPC: A61L27/52 , A61K9/10 , A61K9/127 , A61K31/095 , A61K47/30
CPC classification number: A61L27/18 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2400/06 , A61L2430/32 , A61L2430/40 , C08L71/02 , C08L67/04
Abstract: Disclosed are injectable, biodegradable neuroscaffolds formed in situ by self-assembling biodegradable polymeric microparticles, nanoparticles, or any combination thereof, via copper-free click chemistry or Michael-type addition coupling reactions. The injectable, biodegradable neuroscaffolds provide 3-D structural support, neuroprotection, and/or subsequent regeneration in a subject with a spinal cord injury or a focal neurological disorder.
Abstract translation: 公开了可通过自由组装可生物降解的聚合物微粒，纳米颗粒或其任何组合通过无铜点击化学或迈克尔型加成偶联反应原位形成的可注射的可生物降解的神经支架。 可注射的可生物降解的神经支架在具有脊髓损伤或局部神经障碍的受试者中提供3-D结构支持，神经保护和/或随后的再生。
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公开(公告)号：WO2016081445A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/061066
申请日：2015-11-17
Applicant: PIXARBIO CORPORATION , ARMSTRONG, Patrick, A. , CHEN, Xi
Inventor： ARMSTRONG, Patrick, A. , CHEN, Xi , CRISCIONE, Jason, M. , WERTH, Nicholas, B. , REYNOLDS, Francis, M. , DAI, Haining , LANGER, Robert, Samuel
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/0024 , A61K9/1682 , A61K9/19 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K31/195 , A61K31/197 , A61K31/4166 , A61K31/55 , A61K31/7048 , A61P29/00
Abstract: Provided herein are methods for treating epilepsy or seizure disorders comprising administering a composition to a subject, the composition comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier.
Abstract translation: 本文提供了治疗癫痫或癫痫发作障碍的方法，包括向受试者施用组合物，所述组合物包含抗惊厥剂和可生物降解的载体，其中所述试剂掺入可生物降解的载体内。
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6.发明申请COMPOSITIONS FOR TREATING ACUTE, POST-OPERATIVE, OR CHRONIC PAIN AND METHODS OF USING THE SAME 审中-公开治疗急性，手术后或慢性疼痛的组合物及其使用方法
公开(公告)号：WO2016081022A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/017112
申请日：2015-02-23
Applicant: PIXARBIO CORPORATION
Inventor： CRISCIONE, Jason, M. , WERTH, Nicholas, B. , REYNOLDS, Francis, M. , DAI, Haining , LANGER, Robert, S. , ARMSTRONG, Patrick, A. , CHEN, Xi
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/0024 , A61K9/1682 , A61K9/19 , A61K9/5031 , A61K9/5146 , A61K9/5153 , A61K31/195 , A61K31/197 , A61K31/4166 , A61K31/55 , A61K31/7048 , A61P29/00
Abstract: Provided herein are compositions for treating acute, chronic, or post-operative pain in a subject, said compositions comprising an anticonvulsant agent and a biodegradable carrier, wherein the agent is incorporated within the biodegradable carrier. Methods of treating pain in a subject and kits for producing compositions for treating acute, chronic or post-operative pain in in a subject are also disclosed herein.
Abstract translation: 本文提供了用于治疗受试者的急性，慢性或手术后疼痛的组合物，所述组合物包含抗惊厥剂和可生物降解的载体，其中所述试剂掺入可生物降解的载体内。 本发明还公开了治疗受试者的疼痛的方法和用于制备用于治疗受试者中急性，慢性或手术后疼痛的组合物的试剂盒。
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7.发明申请COMPOSITIONS FOR INHIBTING INFLAMMATION IN A SUBJECT WITH A SPINAL CORD INJURY AND METHODS OF USING THE SAME 审中-公开用于抑制患有脊髓损伤的受试者的炎症的组合物及其使用方法
公开(公告)号：WO2016025789A1
公开(公告)日：2016-02-18
申请号：PCT/US2015/045199
申请日：2015-08-14
Applicant: PIXARBIO CORPORATION
Inventor： CRISCIONE, Jason M. , REYNOLDS, Francis M. , DAI, Haining
IPC: A61K39/395 , A61K45/00 , A61K45/06 , A61P25/28
CPC classification number: A61K9/1647 , A61K9/0019 , A61K9/0085 , A61K31/192 , A61K31/416 , A61K31/4418 , A61K31/65 , A61K39/395 , A61K45/06 , A61K47/58 , A61K47/6845 , A61K47/6937 , A61P25/28 , C07K16/241
Abstract: Provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of specifically reducing TNF-α signaling and a biodegradable carrier. Further provided herein are compositions for inhibiting inflammation in a subject with a spinal cord injury comprising one or more agents capable of modulating MCP-1 signaling and a biodegradable carrier. Methods of treating inflammation in a subject having a spinal cord injury and kits for producing the compositions are also disclosed.
Abstract translation: 本文提供了用于抑制脊髓损伤的受试者的炎症的组合物，其包含一种或多种能够特异性降低TNF-α信号传导的试剂和可生物降解的载体。 本文还提供用于抑制患有脊髓损伤的受试者中的炎症的组合物，其包含一种或多种能够调节MCP-1信号传导的试剂和可生物降解的载体。 还公开了在具有脊髓损伤的受试者中治疗炎症的方法和用于制备组合物的试剂盒。
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