公开(公告)号：WO2003050843A3

公开(公告)日：2003-06-19

申请号：PCT/GB2002/005628

申请日：2002-12-12

Applicant: MICROMASS LIMITED ,  BATEMAN, Robert, Harold ,  HOYES, John, Brian ,  WILDGOOSE, Jason, Lee ,  GILBERT, Anthony, James

Inventor： BATEMAN, Robert, Harold ,  HOYES, John, Brian ,  WILDGOOSE, Jason, Lee ,  GILBERT, Anthony, James

IPC: H01J49/42

Abstract: A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P x T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.

公开(公告)号：WO03050843A2

公开(公告)日：2003-06-19

申请号：PCT/GB0205628

申请日：2002-12-12

Applicant: MICROMASS LTD ,  BATEMAN ROBERT HAROLD ,  HOYES JOHN BRIAN ,  WILDGOOSE JASON LEE ,  GILBERT ANTHONY JAMES

Inventor： BATEMAN ROBERT HAROLD ,  HOYES JOHN BRIAN ,  WILDGOOSE JASON LEE ,  GILBERT ANTHONY JAMES

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/062

Abstract: A method of mass spectrometry is disclosed wherein ions are trapped for a period of time T within an AC or RF ion guide maintained at a pressure P wherein the product P x T is at least 1 mbar-ms. The effect of trapping the ions according to a preferred embodiment is that singly charged ions which may, for example, comprise unwanted background ions are substantially lost from the trap whereas multiply charged analyte ions are maintained within the ion trap and can then be released for subsequent mass analysis.

Abstract translation: 公开了一种质谱法，其中将离子俘获在维持在压力P的AC或RF离子导向器内的一段时间T内，其中产物P x T至少为1毫巴。 捕获根据优选实施方案的离子的效果是，可以例如包含不想要的背景离子的单电荷离子从捕获阱基本上丢失，而多电荷分析物离子保持在离子阱内，然后可以释放以用于随后的 质量分析。

公开(公告)号：WO9938191A3

公开(公告)日：1999-10-07

申请号：PCT/GB9900250

申请日：1999-01-25

Applicant: MICROMASS LTD ,  BATEMAN ROBERT HAROLD ,  GILBERT ANTHONY JAMES ,  MERREN THOMAS OLIVER ,  HOYES JOHN BRIAN ,  COTTRELL JONATHAN CHARLES

Inventor： BATEMAN ROBERT HAROLD ,  GILBERT ANTHONY JAMES ,  MERREN THOMAS OLIVER ,  HOYES JOHN BRIAN ,  COTTRELL JONATHAN CHARLES

IPC: H01J49/02 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/0036 ,  H01J49/025 ,  H01J49/40

Abstract: An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises collection electrodes (36, 38; 39) of different surface areas. In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). Microchannel multiplier plates (31, 32) may be arranged in front of the collection electrodes (36, 38; 39). In an alternative embodiment the collection electrodes consist of a grid (42) or, more preferably, a wire electrode (50) disposed in front of a plate-like electrode (43).

Abstract translation: 公开了一种用于飞行时间质谱仪（1）的离子检测器（27）。 具有扩展动态范围的离子检测器（27）包括具有不同表面积的收集电极（36,38; 39）。 在一个实施例中，收集电极（36,38; 39）形成为由更大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。 微通道乘法器板（31,32）可以布置在收集电极（36,38; 39）的前面。 在替代实施例中，收集电极由设置在板状电极（43）前面的格栅（42）或更优选地布线电极（50）组成。

公开(公告)号：WO9938190A3

公开(公告)日：1999-10-07

申请号：PCT/GB9900248

申请日：1999-01-25

Applicant: MICROMASS LTD ,  BATEMAN ROBERT HAROLD ,  GILBERT ANTHONY JAMES ,  MERREN THOMAS OLIVER ,  HOYES JOHN BRIAN ,  COTTRELL JONATHAN CHARLES

Inventor： BATEMAN ROBERT HAROLD ,  GILBERT ANTHONY JAMES ,  MERREN THOMAS OLIVER ,  HOYES JOHN BRIAN ,  COTTRELL JONATHAN CHARLES

IPC: H01J49/02 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/0036 ,  H01J49/025 ,  H01J49/40

Abstract: An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises at least one microchannel plate electron multiplier (42, 32) together with first and second collection electrodes (36, 38; 39). The second collection electrode (36, 38) is arranged such that in receives more electrons per ion entering the ion detector (27) than the first collection electrode (39). In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). In an alternative embodiment a second microchannel plate electron multiplier is arranged between the first collection electrode (46) and the second collection electrode (47). In this embodiment the first collection electrode consists either of a grid electrode (42) or more preferably of a wire electrode, and the second collection electrode consists of a plate-like electrode (43).

Abstract translation: 公开了用于飞行时间质谱仪（1）的离子检测器（27）。 具有扩展的动态范围的离子检测器（27）包括与第一和第二收集电极（36,38; 39）一起的至少一个微通道板电子倍增器（42,32）。 第二收集电极（36,38）被布置为使得与第一收集电极（39）相比，每个离子进入离子检测器（27）接收更多的电子。 在一个实施例中，收集电极（36,38; 39）形成为由较大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。 在替代实施例中，第二微通道板电子倍增器被布置在第一收集电极（46）和第二收集电极（47）之间。 在该实施例中，第一收集电极由网格电极（42）或更优选为线电极组成，并且第二收集电极由板状电极（43）组成。

公开(公告)号：WO1989012315A1

公开(公告)日：1989-12-14

申请号：PCT/GB1989000602

申请日：1989-06-01

Applicant: VG INSTRUMENTS GROUP LIMITED ,  BATEMAN, Robert, Harold

Inventor： VG INSTRUMENTS GROUP LIMITED

IPC: H01J49/32

CPC classification number: H01J49/22 ,  H01J49/32

Abstract: The invention relates to a variable dispersion double-focusing mass spectrometer comprising at least a magnetic sector analyzer (4) preceding an electrostatic analyzer (6), which analyzers cooperate to form a direction and velocity focused image on a multichannel detector (34) locatable in the focal plane of the electrostatic analyzer (6). The geometrical parameters of the electrostatic analyzer are selected so that the magnification of the electrostatic analyzer is substantially zero, which makes it possible to use a variable radius electrostatic analyzer to vary the extent of the mass spectrum imaged on the detector (34) while still maintaining double focusing. A variable radius electrostatic analyzer suitable for use in the invention is also described.

Abstract translation: 本发明涉及一种可变色散双重聚焦质谱仪，其至少包括静电分析仪（6）之前的磁性扇形分析仪（4），该分析仪协作在多通道检测器（34）上形成方向和速度聚焦图像，该多通道检测器 静电分析仪（6）的焦平面。 选择静电分析仪的几何参数，使得静电分析仪的放大率基本为零，这使得可以使用可变半径静电分析仪来改变在检测器（34）上成像的质谱的程度，同时仍然保持 双重聚焦。 还描述了适用于本发明的可变半径静电分析仪。