公开(公告)号：WO2011135477A1

公开(公告)日：2011-11-03

申请号：PCT/IB2011/051617

申请日：2011-04-14

Applicant: VERENCHIKOV, Anatoly

Inventor： VERENCHIKOV, Anatoly

IPC: H01J49/40 ,  H01J49/00

CPC classification number: H01J49/401 ,  H01J49/0031 ,  H01J49/0036 ,  H01J49/22 ,  H01J49/40 ,  H01J49/406

Abstract: A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E- trap sensitivity.

Abstract translation: 公开了用于操作具有扩展飞行路径的开放静电捕集器（E-trap）或多遍TOF质谱仪的方法，装置和算法。 采用一串具有不等时间间隔的起始脉冲来触发分析仪中的离子包注入，获取长谱来接收整个串中的离子，并通过在数据分析阶段消除或计算重叠信号来重构真正的光谱 同时使用峰值组的逻辑分析。 该方法对于其中光谱稀疏的串联质谱特别有用。 该方法提高了分析仪和检测器的占空比，动态范围和空间电荷吞吐量，以及E-trap分析仪的响应时间。 它允许飞行延伸，而不会降低E-陷阱灵敏度。

公开(公告)号：WO2007000587A3

公开(公告)日：2008-03-27

申请号：PCT/GB2006002361

申请日：2006-06-27

Applicant: THERMO FINNIGAN LLC ,  MAKAROV ALEXANDER ALEKSEEVICH

Inventor： MAKAROV ALEXANDER ALEKSEEVICH

IPC: H01J49/42

CPC classification number: H01J49/282 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/22 ,  H01J49/424 ,  H01J49/425

Abstract: This invention relates generally to multi-reflection electrostatic systems, and more particularly to improvements in and relating to the Orbitrap electrostatic ion trap. A method of operating an electrostatic ion trapping device having an array of electrodes operable to mimic a single electrode is proposed, the method comprising determining three or more different voltages that, when applied to respective electrodes of the plurality of electrodes, generate an electrostatic trapping field that approximates the field that would be generated by applying a voltage to the single electrode, and applying the three or more so determined voltages to the respective electrodes. Further improvements lie in measuring a plurality of features from peaks with different intensities from one or more collected mass spectra to derive characteristics, and using the measured characteristics to improve the voltages to be applied to the plurality of electrodes.

Abstract translation: 本发明一般涉及多反射静电系统，更具体地涉及Orbitrap静电离子阱的改进和涉及。 提出了一种操作具有可操作以模拟单个电极的电极阵列的静电离子捕获装置的方法，所述方法包括确定当施加到所述多个电极中的各个电极时产生静电捕获场的三个或更多个不同的电压 其近似于将通过向单个电极施加电压而产生的场，以及将三个或更多个如此确定的电压施加到各个电极。 进一步的改进在于从具有不同强度的峰与一个或多个收集的质谱测量多个特征以导出特性，并且使用测量的特性来改善施加到多个电极的电压。

公开(公告)号：WO2019020196A1

公开(公告)日：2019-01-31

申请号：PCT/EP2017/069198

申请日：2017-07-28

Applicant: TOFWERK AG

Inventor： KNOCHENMUSS, Richard ,  ROHNER, Urs

IPC: H01J49/00 ,  H01J49/06 ,  H01J49/22 ,  H01J49/40

CPC classification number: H01J49/403 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/22

Abstract: The invention relates to an apparatus (1) and a method for determining a mass spectrum from a continuous ion beam (50). The method comprises a deflection phase of deflecting the ion beam (50) away from an initial direction to a deflected ion beam (51) by applying a timely changing deflecting force with a deflection unit (3) to ions in the ion beam passing a deflection zone (52), whereby a direction of the deflected ion beam (51) is changed in time according to a deflection modulation function. The method further comprises a pass phase of passing the deflected ion beam (51) to a position sensitive detector (4), a detection phase of detecting with the position sensitive detector (4) the ions of the deflected ion beam (51), whereby ion arrival information is obtained for each detected ion, and a mass spectrum determination phase of determining the mass spectrum from the ion arrival information of the detected ions and the deflection modulation function by a calculation unit (5). Thereby, at a first point in time, the deflected ion beam (51) has a first direction, and later, at a second point in time, the deflected ion beam (51) has for a first time since the first point in time again the first direction, while between the first point in time and the second point in time, the direction of the deflected ion beam (51) differs from the first direction and is changed in time away from directions taken up since the first point in time, wherein at least at a third point in time which is either before the first point in time or after the second point in time, the deflected ion beam (51) has a same direction as at a fourth point in time between the first point in time and the second point in time. Additionally, the method comprises a base change rate estimation step of estimating a base change rate for running the deflection modulation function at, wherein if the deflection modulation function is run at the base change rate, a time interval between the first point in time and the second point in time is longer than a difference between times slowest and fastest ions expected in the ion beam (50) require to pass from a centre of the deflection zone (52) to the position sensitive detector (4), wherein the mass spectrum is determined from the ion beam (50) with the deflection phase, the pass phase, the detection phase and the mass spectrum determination phase by running the deflection modulation function at an effective change rate which is larger than the base change rate.

公开(公告)号：WO2016017712A1

公开(公告)日：2016-02-04

申请号：PCT/JP2015/071538

申请日：2015-07-29

Applicant: 保坂 俊

Inventor： 保坂　俊

IPC: H01J49/06 ,  G01N27/62 ,  H01J49/26 ,  H05H5/03 ,  H05H7/04 ,  H05H7/22 ,  H05H9/00 ,  H05H13/04

CPC classification number: H01J49/06 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/20 ,  H01J49/22 ,  H01J49/326 ,  H01J49/38 ,  H01J49/4205 ,  H01J49/4215 ,  H05H5/03 ,  H05H7/04 ,  H05H7/22 ,  H05H9/00 ,  H05H13/04

Abstract: 　加速器や質量分析装置を小型化し安価に作製し、誰もが利用できるようにする。第１主基板（３０１）、第１主基板（３０１）の上面に付着した第１上部基板（３０２）、および第１主基板（３０１）の下面に付着した第１下部基板（３０３）を含む複数の基板から構成される質量分析装置（３００）であり、質量分析室（３０８）は、第１主基板（３０１）に形成された、第１主基板（３０１）の上面から第１主基板（３０１）の下面へ貫通する貫通室であり、基板面に垂直方向（Ｚ方向）が上部基板（３０２）および下部基板（３０３）に、Ｚ方向と直角方向でありかつ荷電粒子（３１８）の進行方向（Ｘ方向）の両側は第１主基板側板（３０１－４，３０１－５）に、およびＺ方向およびＸ方向に直角方向（Ｙ方向）の両側面は第１主基板（３０１）に囲まれており、荷電粒子（３１８）の入射する第１主基板側板（３０１－４）は中央孔（３１０－４）が空いていて、荷電粒子（３１８）は前記第１主基板側板（３０１－４）に形成された中央孔（３１０－４）より質量分析室（３０８）へ入射する。

Abstract translation: 本发明的目的是廉价地制造加速装置和质量分析装置，并且具有紧凑的尺寸，使其能够被任何人使用。 质量分析装置（300）由多个基板构成，包括第一主基板（301），粘附到第一主基板（301）的上表面的第一上基板（302），第一下基板 （303）粘附到第一主衬底（301）的下表面。 质量分析室（308）是形成在第一主基板（301）中并从第一主基板（301）的上表面延伸到第一主基板（301）的下表面的通道，并封入 在与Z方向正交的方向（方向X）的两侧封闭的上基板（302）和下基板（303）垂直于基板表面（Z方向）的方向为 通过第一主基板侧板（301-4,301-5）推进带电粒子（318），并且通过第一主体在与Z方向和X方向正交的方向（Y方向）的两个侧面上包围 基板（301）。 在带电粒子（318）入射的第一主基板侧板（301-4）中打开中心孔（310-4），带电粒子（318）从 形成在第一主衬底侧板（301-4）中的中心孔（310-4）。

公开(公告)号：WO2014089910A1

公开(公告)日：2014-06-19

申请号：PCT/CN2013/001508

申请日：2013-12-06

Applicant: 株式会社岛津制作所 ,  蒋公羽 ,  程玉鹏 ,  张小强 ,  孙文剑

Inventor： 蒋公羽 ,  程玉鹏 ,  张小强 ,  孙文剑

IPC: H01J49/02

CPC classification number: G01N27/622 ,  G01N27/624 ,  H01J49/004 ,  H01J49/22

Abstract: 一种离子迁移率分析器（010）和其组合设备以及离子迁移率分析方法。该离子迁移率分析器（010）包含围绕分析空间的电极系统（011），以及对该电极系统（011）附加沿一空间轴方向运动的离子迁移电势场的电源装置。在待测离子迁移率分析过程中，通过将待测离子（801，802，803）始终置于该运动的离子迁移电势场中，并保持该离子迁移电势场运动方向与待测离子（801，802，803）在该离子迁移电势场所受的电场力方向始终相同，理论可以形成无限长的迁移路径，区分迁移率或粒径差异极小的离子。通过该离子迁移电势场的非线性化，可以实现对多种迁移率离子的同时空间束缚与分离效果。该分析器可以与多种离子源，检测器，质量分析器，其他离子迁移率分析器及色谱光谱分析手段结合，并易于通过复用电源与电极形成大规模分析器阵列。

公开(公告)号：WO2014057345A2

公开(公告)日：2014-04-17

申请号：PCT/IB2013002293

申请日：2013-10-11

Applicant: DH TECHNOLOGIES DEV PTE LTD

Inventor： BABA TAKASHI

IPC: H01J37/317

CPC classification number: H01J49/062 ,  H01J49/0031 ,  H01J49/067 ,  H01J49/22

Abstract: An ion guide is provided having an enclosure extending longitudinally around a central axis from a proximal inlet end to a distal outlet end. The proximal inlet end receives a plurality of ions entrained in a gas flow through an inlet orifice. A deflection plate is disposed within the enclosure between the proximal and distal ends and deflects at least a portion of the gas flow away from a central direction of the gas flow. A plurality of electrically conductive, elongate elements extend from the proximal end to the distal end within the enclosure and generate an electric field via a combination of RF and DC electric potentials. The electric field deflects the entrained ions away from the central direction of the gas flow proximal to the deflection plate and confines the deflected ions in proximity of the elongated elements as the ions travel downstream.

Abstract translation: 提供离子引导件，其具有围绕中心轴线从近端入口端部至远端出口端部纵向延伸的外壳。 近端入口端容纳夹带在通过入口孔的气流中的多个离子。 偏转板在近端和远端之间的外壳内设置，并使气流的至少一部分偏离气流的中心方向。 多个导电细长元件从外壳内的近端延伸到远端，并通过RF和DC电势的组合产生电场。 电场使夹带的离子偏离靠近偏转板的气流的中心方向，并且当离子向下游行进时，将偏转的离子限制在细长元件附近。

公开(公告)号：WO2018140120A1

公开(公告)日：2018-08-02

申请号：PCT/US2017/061918

申请日：2017-11-16

Applicant: VARIAN SEMICONDUCTOR EQUIPMENT ASSOCIATES, INC.

Inventor： LIKHANSKII, Alexandre

IPC: H01L21/67 ,  H01J37/317 ,  H01L21/265

CPC classification number: H01J49/22 ,  H01J27/024 ,  H01J37/05 ,  H01J37/08 ,  H01J49/061 ,  H01J49/48 ,  H01J2237/053 ,  H01J2237/057 ,  H01J2237/0817 ,  H01J2237/31701

Abstract: An apparatus which has the capability of filtering unwanted species from an extracted ion beam without the use of a mass analyzer magnet is disclosed. The apparatus includes an ion source having chamber walls that are biased by an RF voltage. The use of RF extraction causes ions to exit the ion source at different energies, where the energy of each ion species is related to its mass. The extracted ion beam can then be filtered using only electrostatic energy filters to eliminate the unwanted species. The electrostatic energy filter may act as a high pass filter, allowing ions having an energy above a certain threshold to reach the workpiece. Alternatively, the electrostatic energy filter may act as a low pass filter, allowing ions having an energy below a certain threshold to reach the workpiece. In another embodiment, the electrostatic energy filter operates as a bandpass filter.

公开(公告)号：WO2014075204A1

公开(公告)日：2014-05-22

申请号：PCT/CN2012/001534

申请日：2012-11-13

Applicant: 北京理工大学

Inventor： 徐伟 ,  熊行创 ,  江游 ,  黄泽建 ,  方向

IPC: H01J49/26

CPC classification number: H01J49/422 ,  H01J49/22

Abstract: 一种选择性离子弹射、传输和富集的装置和方法以及质量分析器，在线性离子阱（1）的一端设有中心线电极（DC1）、顶部线电极（DC2）和底部线电极（DC3），中心线电极（DC1）通过线性离子阱的中心，中心线电极（DC1）位于顶部线电极（DC2）和底部线电极（DC3）的中间，在中心线电极（DC1）上施加第一直流电压，在顶部线电极（DC2）和底部线电极（DC3）上施加第二直流电压，第一直流电压与第二直流电压的极性相反；给线性离子阱的y电极施加双极性交流电压，以激发其共振频率与交流电压信号的频率匹配的离子，被激发的离子受到顶部线电极（DC2）和底部线电极（DC3）上施加的电压的作用；在选中的离子通过中心线电极（DC1）、顶部线电极（DC2）和底部线电极（DC3）之后，去除选中的离子在y和z方向上过量的动能。

公开(公告)号：WO2013173320A1

公开(公告)日：2013-11-21

申请号：PCT/US2013/040926

申请日：2013-05-14

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  OBERREIT, Derek, Robert ,  HOGAN, Christopher, Joseph

Inventor： OBERREIT, Derek, Robert ,  HOGAN, Christopher, Joseph

IPC: H01J49/02 ,  H01J49/22 ,  G01N27/62

CPC classification number: G01N27/622 ,  G01N33/0027 ,  H01J49/06 ,  H01J49/22

Abstract: A drift tube ion mobility spectrometry sample introduction scheme allows introduction of a sample packet at ground voltages. The sample packet of ionized particles is captured by subjecting particles within a defined region to an electric field at an elevated voltage. The ionized particles in the captured packet then migrate through the drift tube down the voltage gradient according to their electrical mobility. The particles are directed to a high sensitivity detector, such as a condensation particle counter (CPC), for detection.

Abstract translation: 漂移管离子迁移光谱法样品引入方案允许在接地电压下引入样品包。 电离粒子的样品包是通过在规定的区域内将颗粒以升高的电压进行电场来捕获的。 捕获的包中的电离粒子随后通过漂移管沿电压梯度移动，根据它们的电迁移率。 颗粒被引导到高灵敏度检测器，例如凝结颗粒计数器（CPC），用于检测。

公开(公告)号：WO2013091019A1

公开(公告)日：2013-06-27

申请号：PCT/AU2012/001590

申请日：2012-12-21

Applicant: BRUKER BIOSCIENCES PTY LTD

Inventor： KALINITCHENKO, Iouri

IPC: H01J49/22

CPC classification number: H01J49/061 ,  H01J49/067 ,  H01J49/22

Abstract: There is provided an ion reflector for use with a mass spectrometer for directing a flow of ions between two distinct axes of travel. The reflector includes an electric field capable of causing a flow of ions focused through a first spatial region to be focused toward a second spatial region, whereby the first and second spatial regions are aligned with respective axes of travel.

Abstract translation: 提供了一种用于质谱仪的离子反射器，用于在两个不同的行进轴线之间引导离子流。 反射器包括能够引起聚焦在第一空间区域上的离子流朝向第二空间区域聚焦的电场，由此第一和第二空间区域与相应的行进轴线对齐。