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    AMORPHOUS EFAVIRENZ AND THE PRODUCTION THEREOF
    51.
    发明申请
    AMORPHOUS EFAVIRENZ AND THE PRODUCTION THEREOF 审中-公开
    无定形埃维列宁及其生产

    公开(公告)号：WO2007014393A2

    公开(公告)日：2007-02-01

    申请号：PCT/US2006/029822

    申请日：2006-07-28

    Applicant: ISP INVESTMENTS INC. ,  DONEY, John, Alfred

    Inventor： DONEY, John, Alfred

    IPC: A61K9/16 ,  A61K31/536 ,  A61P31/18

    CPC classification number: A61K9/1635 ,  A61K9/1617 ,  A61K9/4866 ,  A61K31/536 ,  A61K31/538

    Abstract: Efavirenz compositions of enhanced bioavailability are described that contain efavirenz with at least one solubility-enhancing polymer. Described methods toproduce the bioenhanced products comprise solvent spray drying. One aspect of themethod includes the steps of providing a mixture comprising efavirenz, a solubility-enhancing polymer and a single solvent, a solvent blend or solvent/non-solvent blend removing and then evaporating the mixture to form amorphous efavirenz.

    Abstract translation: 描述了依非韦伦增强生物利用度的组合物，其含有依法韦仑和至少一种增强溶解度的聚合物。 所描述的生产增强产品的方法包括溶剂喷雾干燥。 该方法的一个方面包括提供包含依夫维瑞，溶解度增强聚合物和单一溶剂，溶剂混合物或溶剂/非溶剂混合物的混合物的步骤，所述溶剂混合物或溶剂/非溶剂混合物除去，然后蒸发混合物以形成无定形依法韦仑。

    BENZOQUINONES OF ENHANCED BIOAVAILABILITY
    52.
    发明申请
    BENZOQUINONES OF ENHANCED BIOAVAILABILITY 审中-公开
    增强生物利用度的苯醌

    公开(公告)号：WO2007014392A2

    公开(公告)日：2007-02-01

    申请号：PCT/US2006/029821

    申请日：2006-07-28

    Applicant: ISP INVESTMENTS INC. ,  OLSEN, Stephen ,  DONEY, John, Alfred ,  SHORES, Christophen, Steven

    Inventor： OLSEN, Stephen ,  DONEY, John, Alfred ,  SHORES, Christophen, Steven

    IPC: A61K9/16 ,  A61K9/26 ,  A61K9/48 ,  A61K9/36

    CPC classification number: A61K31/122 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K31/12

    Abstract: Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q10. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising benzoquinone, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous benzoquinone. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.

    Abstract translation: 描述了增强溶解度和生物利用度的苯醌组合物，其含有至少一种具有至少一种增溶聚合物的苯醌。 在一个实施方案中，苯醌是辅酶Q10。 所描述的生产生物强化产品的方法包括干混和溶剂喷雾干燥。 该方法的一个方面包括以下步骤：提供包含苯醌，增溶溶解聚合物和溶剂的混合物，并除去溶剂以形成无定形苯醌。 由本发明的组合物和方法制造的产品包括用于人和动物的药物，营养品，化妆品和个人护理产品。

    SOIL SETTLING COMPOSITION
    57.
    发明申请
    SOIL SETTLING COMPOSITION 审中-公开

    公开(公告)号：WO2005047186A3

    公开(公告)日：2005-05-26

    申请号：PCT/US2004/032493

    申请日：2004-09-30

    Applicant: ISP INVESTMENTS INC.

    Inventor： SHAH, Purvita ,  JUREK, Michael, J.

    IPC: C11D003/37

    Abstract: A soil settling composition which can rapidly precipitate soil in dirty water includes an aqueous solution of a settling agent which is a polymeric composition of a water soluble polymer, or copolymer thereof, optionally having in situ-formed substantially water-insoluble, crosslinked resinous particles of the polymer or copolymer substantially uniformly dispersed in the composition as a second phase.

    DELIVERY SYSTEM FOR WOOD TREATMENT CHEMICALS
    58.
    发明申请
    DELIVERY SYSTEM FOR WOOD TREATMENT CHEMICALS 审中-公开
    木材处理化学品输送系统

    公开(公告)号：WO2004112475A2

    公开(公告)日：2004-12-29

    申请号：PCT/US2004016222

    申请日：2004-05-21

    Applicant: ISP INVESTMENTS INC

    Inventor： NARAYANAN KOLAZI S

    IPC: B27K3/50 ,  C09D15/00 ,  A01N

    CPC classification number: C09D15/00 ,  A01N43/88 ,  A01N53/00 ,  B27K3/153 ,  B27K3/343 ,  B27K3/36 ,  B27K3/38 ,  B27K3/50 ,  C08L63/00 ,  C08L97/02 ,  A01N25/04 ,  A01N31/08 ,  A01N31/10 ,  A01N31/12

    Abstract: A wood treatment concentrate includes by weight; (a) 0,1-10% of an active wood treatment chemical, (b) 50-99% of a microemulsion concentrate including: (i) 0.03-80%, preferably 40-70%, of a castor oil ethoxylate or tristyryl phenol ethoxylate, (ii) 0-10%, preferably 0.005-6%, of an ethoxylated phosphoric acid ester as pH buffer, (iii) 0.002-40%, preferably 0.05-29%, of a N-C8-C18 alkyl pyrrolidone and (iv) 0-60%, preferably 0.15-40%, of a N-C1-C4 alkyl pyrrolidone, and (v) 0-30%, preferably 0.5-15%, of an ethylene oxide/propylene oxide block copolymer; and (c) 1-50% of a substituted phenol. The use formulation includes (d) water of dilution.

    Abstract translation: 木材处理浓缩物包括重量; （a）活性木材处理化学品的0,1-10％，（b）50-99％的微乳液浓缩物，包括：（i）0.03-80％，优选40-70％的蓖麻油乙氧基化物或三苯乙烯基 苯酚乙氧基化物，（ii）0-10％，优选0.005-6％的作为pH缓冲剂的乙氧基化磷酸酯，（iii）0.002-40％，优选0.05-29％的N-C8-C18烷基吡咯烷酮 和（iv）0-60％，优选0.15-40％的N-C 1 -C 4烷基吡咯烷酮，和（v）0-30％，优选0.5-15％的环氧乙烷/环氧丙烷嵌段共聚物; 和（c）1-50％的取代苯酚。 使用制剂包括（d）稀释水。

    PROCESS FOR THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE
    59.
    发明申请
    PROCESS FOR THE PREPARATION OF DEXMETHYLPHENIDATE HYDROCHLORIDE 审中-公开
    制备去甲基苯乙烯盐酸盐的方法

    公开(公告)号：WO2004080959A3

    公开(公告)日：2004-11-25

    申请号：PCT/US2004006565

    申请日：2004-03-04

    Applicant: ISP INVESTMENTS INC

    Inventor： GUTMAN ARIE ,  ZALTSMAN IGOR ,  SHALIMOV ANTON ,  SOTRIHIN MAXIM ,  NISNEVICH GENNADY ,  YUDOVICH LEV ,  FEDOTEV IRINA

    IPC: A61K31/445 ,  A61K31/4458 ,  C07D20060101 ,  C07D211/22 ,  C07D211/34

    CPC classification number: C07D211/34

    Abstract: The present invention provides a new and efficient process for the preparation of the dexmethylphenidate hydrochloride with high optical purity, the process comprising: (a) reacting a solution of threo-N-Boc-ritalinic acid with (S)-1-phenylethylamine, separating precipitated solid salt of (R,R)-enriched N-Boc-ritalinic acid with (S)-1-phenylethylamine from the reaction mixture and recrystallizing, reslurring and/or trituring of said salt; (b) mixing the solid salt of (R,R)-N-Boc-ritalinic acid and (S)-1- phenylethylamine obtained in step (a) with aqueous acid and separating (R,R)-N-Boc-ritalinic acid from the mixture; and (c) reacting the (R,R)-N-Boc-ritalinic acid prepared in step (b) with hydrogen chloride and methanol to give dexmethylphenidate hydrochloride with optical purity of at least 99% ee. The present invention further provides salt of (R,R)-N-Boc-ritalinic acid with (S)-1-phenylethylamine as new intermediate in the preparation of dexmethylphenidate hydrochloride.

    Abstract translation: 本发明提供了一种制备高光学纯度右旋哌甲酯盐酸盐的新颖有效的方法，该方法包括：（a）使苏-N-Boc-利他宁酸与（S）-1-苯乙胺溶液反应，分离 （R，R） - 富集的N-Boc-利他宁酸与（S）-1-苯乙胺的固体盐从反应混合物中沉淀出来，并对所述盐进行重结晶，再润湿和/或研磨; （b）将步骤（a）中得到的（R，R）-N-Boc-利他宁酸和（S）-1-苯乙基胺的固体盐与酸水溶液混合并分离（R，R）-N-Boc-利他尼酸 来自混合物的酸; （c）使步骤（b）中制备的（R，R）-N-Boc-利他宁酸与氯化氢和甲醇反应，得到光学纯度为至少99％ee的右旋哌甲酯盐酸盐。 本发明进一步提供了（R，R）-N-Boc-利他宁酸与（S）-1-苯乙基胺的盐作为制备右旋哌甲酯盐酸盐的新中间体。

    LITHIUM SALT OF POLYACETYLENE AS RADIATION SENSITIVE FILAMENTS AND PREPARATION AND USE THEREOF
    60.
    发明申请
    LITHIUM SALT OF POLYACETYLENE AS RADIATION SENSITIVE FILAMENTS AND PREPARATION AND USE THEREOF 审中-公开
    聚苯乙烯的盐酸盐作为辐射敏感性膜，其制备和使用

    公开(公告)号：WO2004095065A2

    公开(公告)日：2004-11-04

    申请号：PCT/US2004007273

    申请日：2004-03-10

    Applicant: ISP INVESTMENTS INC

    Inventor： ANYUMBA JANETTE ,  LEWIS DAVID F ,  SHIH HSIAO-YI ,  YU XIANG

    IPC: G01J20060101 ,  G01N21/00 ,  G01T20060101 ,  G03C1/76 ,  G03F7/025 ,  G03F7/029 ,  G01T

    CPC classification number: G03F7/025 ,  G03F7/029

    Abstract: This invention relates to photochromic filaments composed of the lithium salt of a conjugated, polymerizable polyacetylene having a carboxylic acid or carboxylate terminal group wherein the length to width ratio of said filaments is between about 5000:1 and about 5:1 and the average length of the filament is up to about 5cm. The invention also pertains to the use of said salts in maximized radiation sensitivity for imaging, radiation dose measurement or mapping and detection of radiation fields.

    Abstract translation: 本发明涉及由具有羧酸或羧酸酯端基的共轭可聚合聚乙炔的锂盐组成的光致变色长丝，其中所述长丝的长宽比为约5000:1至约5:1，平均长度为 灯丝长达约5厘米。 本发明还涉及使用所述盐以最大的辐射敏感度进行成像，辐射剂量测量或辐射场的映射和检测。

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