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    PROCESS FOR PRODUCING 3-NORCEPHEM COMPOUNDS
    52.
    发明申请
    PROCESS FOR PRODUCING 3-NORCEPHEM COMPOUNDS 审中-公开
    生产3-NORCEPHEM化合物的方法

    公开(公告)号：WO1997047627A1

    公开(公告)日：1997-12-18

    申请号：PCT/JP1997001994

    申请日：1997-06-09

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  SASAOKA, Michio ,  TORII, Sigeru ,  TANAKA, Hideo ,  KIKUCHI, Ryo ,  KAMEYAMA, Yutaka

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: C07D501/08

    CPC classification number: C07D501/00 ,  Y02P20/55

    Abstract: A process for producing 3-norcephem compounds represented by general formula (2) characterized by reacting a halogenated beta -lactam compound represented by general formula (1) with a hydride reagent in the presence of a monovalent copper compound, wherein R1 represents hydrogen or optionally protected amino; R2 represents optionally substituted aryl; n is 0 to 2; R3 represents hydrogen or a carboxylate-protective group; X represents halogeno; and Y represents halogeno or a leaving group; in formula (2) R1 and R3 are each as defined above.

    Abstract translation: 一种制备由通式（2）表示的3-对映异构体化合物的方法，其特征在于在一价铜化合物存在下使通式（1）表示的卤代β-内酰胺化合物与氢化物试剂反应，其中R 1表示氢或任选地 保护氨基; R2代表任选取代的芳基; n为0〜2; R 3表示氢或羧酸酯保护基; X表示卤素; Y代表卤代或离去基团; 在式（2）中，R 1和R 3各自如上所定义。

    PROCESSES FOR THE PREPARATION OF 'beta'-LACTAM DERIVATIVE
    54.
    发明申请
    PROCESSES FOR THE PREPARATION OF 'beta'-LACTAM DERIVATIVE 审中-公开
    制备β-LACTAM衍生物的方法

    公开(公告)号：WO1996029334A1

    公开(公告)日：1996-09-26

    申请号：PCT/JP1996000575

    申请日：1996-03-08

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  TORII, Sigeru ,  TANAKA, Hideo ,  SASAOKA, Michio ,  KAMEYAMA, Yutaka ,  WADA, Isao ,  AMANO, Yasuhisa

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: C07D501/08

    CPC classification number: C07D513/04 ,  C07D205/09 ,  C07D205/095 ,  C07D501/00

    Abstract: A process for the preparation of an allenyl- beta -lactam compound which comprises reacting the hydroxyl group of a beta -lactam compound of general formula (1) with a reactive functional derivative of a sulfonic acid of the general formula (2): R -SO2-X to form a beta -lactam compound of general formula (3) and reacting the formed compound with a basic anion-exchange resin containing a tertiary organic base immobilized thereon to attain the preparation of an allenyl- beta -lactam compound of general formula (4) and the stable isolation thereof from the reaction mixture in a high yield at a high purity. Another process for the preparation of an allenyl- beta -lactam compound which comprises reacting the hydroxyl group of a beta -lactam compound of general formula (1) with a reactive functional derivative of a sulfonic acid of the general formula (2): R -SO2-X to form a beta -lactam compound of general formula (3), reacting the formed compound with a tertiary organic base to form an allenyl- beta -lactam compound of general formula (4) and treating the resulting reaction mixture with both an acidic cation-exchange resin and a basic anion-exchange resin either alternately or simultaneously to isolate the compound of general formula (4) from the reaction mixture stably. A process of preparing a 3-halocephem derivative of general formula (6) by reacting an allenyl- beta -lactam compound of general formula (4) with a halogenating agent in the presence of a sulfinate or thiolate ion scavenger.

    Abstract translation: 一种制备丙烯烯基-β-内酰胺化合物的方法，包括使通式（1）的β-内酰胺化合物的羟基与通式（2）的磺酸的反应性官能衍生物反应： 5> -SO 2 -X，以形成通式（3）的β-内酰胺化合物，并使所形成的化合物与含有固定在其上的叔有机碱的碱性阴离子交换树脂反应以获得丙烯酰基β-内酰胺化合物的制备 的通式（4），并以高纯度从反应混合物中稳定分离。 制备丙烯烯基-β-内酰胺化合物的另一种方法包括使通式（1）的β-内酰胺化合物的羟基与通式（2）的磺酸的反应性官能衍生物反应： 5> -SO 2 -X，形成通式（3）的β-内酰胺化合物，使所形成的化合物与叔有机碱反应，形成通式（4）的烯丙基-β-内酰胺化合物，并处理得到的反应混合物 与酸性阳离子交换树脂和碱性阴离子交换树脂交替或同时地从反应混合物中稳定地分离出通式（4）的化合物。 通过在亚硫酸盐或硫醇盐离子清除剂的存在下使通式（4）的烯丙基-β-内酰胺化合物与卤化剂反应制备通式（6）的3-卤代头孢衍生物的方法。

    PROCESS FOR THE PRODUCTION OF 'beta'-LACTAM COMPOUNDS
    55.
    发明申请
    PROCESS FOR THE PRODUCTION OF 'beta'-LACTAM COMPOUNDS 审中-公开
    生产β--LACTAM化合物的方法

    公开(公告)号：WO1996028422A1

    公开(公告)日：1996-09-19

    申请号：PCT/JP1996000549

    申请日：1996-03-07

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  TORII, Sigeru ,  TANAKA, Hideo ,  SASAOKA, Michio ,  KAMEYAMA, Yutaka

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: C07D205/08

    CPC classification number: C07D499/00 ,  C07D205/09

    Abstract: A process for the production of a halogenated beta -lactam compound represented by general formula (2) which comprises replacing the hydroxyl group of a halogenated beta -lactam compound represented by general formula (1) with a halogen atom or a leaving group. Another process for the production of an exomethylene penam compound represented by general formula (5) which comprises reducing a halogenated beta -lactam compound represented by general formula (2) with at least the equimolar amount of a metal having a standard oxidation-reduction potential of -0.3 (V/SCE) or below and 0.0001 to 10 times by mol as much a metal compound having a standard oxidation-reduction potential higher than that of the former metal, or employing the electrolytic reduction method.

    Abstract translation: 一种制备由通式（2）表示的卤代β-内酰胺化合物的方法，其包括用卤原子或离去基团取代由通式（1）表示的卤代β-内酰胺化合物的羟基。 用于生产由通式（5）表示的异亚丙基双酚A化合物的另一种方法，其包括用至少等摩尔量的具有标准氧化还原电位的金属还原由通式（2）表示的卤代β-内酰胺化合物 -0.3（V / SCE）以下，0.0001〜10倍摩尔，具有比前述金属高的标准氧化还原电位的金属化合物，或采用电解还原法。

    SPIROPYRAN COMPOUND
    56.
    发明申请
    SPIROPYRAN COMPOUND 审中-公开
    螺旋体化合物

    公开(公告)号：WO1995024409A1

    公开(公告)日：1995-09-14

    申请号：PCT/JP1995000396

    申请日：1995-03-10

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  HAMA, Hiroshi ,  NAKANO, Shinji

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: C07D517/10

    CPC classification number: C07D517/10 ,  C09K9/02

    Abstract: A novel compound suitable for use as a photochromic material. It is a salt of a spiropyran compound represented by general formula (1), with an acid compound, wherein R represents C1-C20 alkyl, aralkyl, hydroxyethyl, acryloxyethyl or methacryloxyethyl; R to R represent each hydrogen, C1-C6 alkyl, etc.; R represents hydrogen, vinyl, -CH2OR or -CH2OCOC(R )=CH2; R represents hydrogen or C1-C4 alkyl; R represents hydrogen or methyl; and X represents oxygen or sulfur.

    Abstract translation: 适用于光致变色材料的新型化合物。 它是由通式（1）表示的螺吡喃化合物的盐与酸化合物，其中R 1表示C 1 -C 20烷基，芳烷基，羟乙基，丙烯酰氧基乙基或甲基丙烯酰氧基乙基; R 2至R 7表示每个氢，C 1 -C 6烷基等; R 8表示氢，乙烯基，-CH 2 OR 9或-CH 2 OCOC（R 10）= CH 2; R 9表示氢或C 1 -C 4烷基; R 10表示氢或甲基; X表示氧或硫。

    RESIN COMPOSITION FOR A MOLD, MOLD AND MOLDING METHOD USING THE SAME MOLD
    57.
    发明申请
    RESIN COMPOSITION FOR A MOLD, MOLD AND MOLDING METHOD USING THE SAME MOLD 审中-公开
    使用相同模具的模具，模具和模制方法的树脂组合物

    公开(公告)号：WO1995018708A1

    公开(公告)日：1995-07-13

    申请号：PCT/JP1994002300

    申请日：1994-12-28

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  ICHIKAWA, Yasuhiko ,  SAKANE, Koji ,  TSUJIKAWA, Yozoburo ,  TASAKA, Takio

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: B29C33/38

    CPC classification number: B29C33/30 ,  B29C33/3807 ,  B29C33/448 ,  B29C45/1703 ,  B29K2023/00 ,  B29K2055/02 ,  B29K2059/00 ,  B29K2077/00 ,  B29K2079/085 ,  B29K2081/04 ,  B29K2105/08 ,  B29K2105/126 ,  B29K2105/16 ,  B29K2105/251 ,  B29K2995/0096

    Abstract: The present invention relates to a resin composition for a mold, a mold constructed by using the composition and a molding method using the mold. This resin composition comprises a thermoplastic resin, an inorganic fibrous reinforcing material and an inorganic particulate filler, and has a bending strength of 1000 kgf/cm or higher, a modulus of elasticity in bending of 70000 kgf/cm or higher, and it can be cut and worked. The heat deformation temperature of the composition may be higher than 180 DEG C. With this composition it is possible to provide a core or a cavity in a mold which is cut and finished with a good dimensional precision, at low cost and in a short period and is durable and recyclable. The mold can be applied to various types of molding methods using various types of materials and when so used it can provide molded products with good precision and at low costs.

    Abstract translation: 本发明涉及一种模具用树脂组合物，使用该组合物构成的模具和使用该模具的成型方法。 该树脂组合物包含热塑性树脂，无机纤维增强材料和无机颗粒填料，弯曲强度为1000kgf / cm 2以上，弯曲弹性模量为70000kgf / cm 2或 更高，可以削减和工作。 组合物的热变形温度可以高于180℃。通过该组合物，可以在模具中提供芯或空腔，其以低成本和短时间以良好的尺寸精度进行切割和精加工 并且是耐用和可回收的。 该模具可以应用于使用各种类型的材料的各种成型方法，并且当这样使用时，其可以以高成本提供高精度和低成本的模制产品。

    PROCESS FOR PRODUCING 3-SUBSTITUTED CEPHEM COMPOUND
    58.
    发明申请
    PROCESS FOR PRODUCING 3-SUBSTITUTED CEPHEM COMPOUND 审中-公开
    生产3-取代的CEPHEM化合物的方法

    公开(公告)号：WO1995013281A1

    公开(公告)日：1995-05-18

    申请号：PCT/JP1994001859

    申请日：1994-11-04

    Applicant: OTSUKA KAGAKU KABUSHIKI KAISHA ,  TORII, Shigeru ,  TANAKA, Hideo ,  SASAOKA, Michio ,  SHIROI, Takashi

    Inventor： OTSUKA KAGAKU KABUSHIKI KAISHA

    IPC: C07D501/08

    CPC classification number: C07D501/00 ,  Y02P20/55

    Abstract: A process for producing a 3-substituted cephem compound from an allenyl- beta -lactam compound which can readily be prepared from an inexpensive penicillin compound in a short reaction path. The process comprises reacting an allenyl- beta -lactam compound with an organohalogen compound in the presence of an at least equimolar amount of a metal having a standard oxidation-reduction potential of -0.3 V/SCE or less and 0.0001 - 0.5 mol, per mole of the lactam, of a metallic compound having a standard oxidation-reduction potential higher than that of the above metal.

    Abstract translation: 一种从丙烯烯基-β-内酰胺化合物制备3-取代的头孢烯化合物的方法，其可以在短的反应途径中由便宜的青霉素化合物制备。 该方法包括在至少等摩尔量的具有-0.3V / SCE或更低的标准氧化还原电位和0.0001-0.5mol的摩尔的金属的存在下，使烯丙基β-内酰胺化合物与有机卤素化合物反应 的内酰胺，具有比上述金属高的标准氧化还原电位的金属化合物。

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