公开(公告)号：WO99024107A1

公开(公告)日：1999-05-20

申请号：PCT/US1998/023857

申请日：1998-11-07

IPC: C08G64/06 ,  A61K9/20 ,  A61K38/00 ,  A61L17/10 ,  A61L27/18 ,  A61L27/58 ,  A61L31/06 ,  A61L31/14 ,  C07K14/00 ,  C08G63/672 ,  C08G63/685 ,  C08G64/04 ,  C08G64/12 ,  C08G64/16 ,  C08G64/18 ,  C08G64/42 ,  C08G69/10 ,  C08G69/44 ,  C08L101/16 ,  A61M31/00

CPC classification number: A61L27/58 ,  A61K9/204 ,  A61K38/00 ,  A61L17/10 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  C07K14/001 ,  C08G63/672 ,  C08G63/6856 ,  C08G63/6858 ,  C08G64/045 ,  C08G64/12 ,  C08G64/1641 ,  C08G64/183 ,  C08G69/10 ,  C08G69/44 ,  C08L69/00

Abstract: A polymer with a hydrolytically labile backbone and having structure (VIII) wherein R9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof; R12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis; each R7 is independently an alkylene group containing up to four carbon atoms; A is selected from: (a) and (b) wherein R8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms; k is between about 5 and about 3,000; and x and f independently range from zero to less than one.

Abstract translation: 具有水解不稳定骨架并具有结构（VIII）的聚合物，其中R9是具有至少18个碳原子的具有侧挂羧酸基团的烷基，芳基或烷基芳基或其苄基酯; R12是具有至多18个碳原子的烷基，芳基或烷基芳基，其具有侧链羧酸酯基，其选自含有至多18个碳原子的直链和支链烷基和烷基芳基酯以及共价键合到其上的生物和药学活性化合物的酯衍生物， 条件是酯基不是苄基或通过氢解除去的基团; 每个R 7独立地是含有至多4个碳原子的亚烷基; A选自：（a）和（b）其中R8选自饱和和不饱和的，取代和未取代的含有至多18个碳原子的烷基，芳基和烷基芳基; k在约5至约3,000之间; x和f独立地从零到小于1。