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    PURIFICATION OF REPTILIAN HYALURONIC ACID AND ITS USE FOR SOFT AND HARD TISSUE REPAIR AND REGENERATION
    4.
    发明申请
    PURIFICATION OF REPTILIAN HYALURONIC ACID AND ITS USE FOR SOFT AND HARD TISSUE REPAIR AND REGENERATION 审中-公开

    公开(公告)号：WO2021108790A1

    公开(公告)日：2021-06-03

    申请号：PCT/US2020/062563

    申请日：2020-11-30

    Applicant: LACERTA LIFE SCIENCES, LLC

    Inventor： SANDERS, Mitchell, C. ,  WEI, Da

    IPC: A61K31/728 ,  A61L17/10 ,  A61L27/20 ,  A61K35/12

    Abstract: An ultra-rapid method for the isolation and purification of high molecular weight hyaluronic acid (HA) from the skin of reptiles (rHA), that utilizes an extraction buffer that inhibits unwanted hyaluronidases, filtration to remove cell debris and precipitated proteins, and a highly substituted anion exchange column at a low pH with a high salt elution to maximize the yield and purity of rHA per kilogram of skin. Our findings suggest that rHA is high molecular weight (>2mDa) and has a profound ability to enhance cell migration and proliferation for wound repair and regeneration. Preliminary evidence suggests that scaffolds of rHA are ideal for biomaterial engineering that could be incorporated into several medical devices and pharmaceutical products. We have identified novel crosslinking methods to streamline esterification of rHA for advanced wound care products as well as novel conjugates to improve the osteogenic and osteoconductive potential of rHA for bone regeneration and repair.

    MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF
    5.
    发明申请
    MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF 审中-公开

    公开(公告)号：WO2021042044A1

    公开(公告)日：2021-03-04

    申请号：PCT/US2020/048773

    申请日：2020-08-31

    Applicant: TEPHA, INC.

    Inventor： WILLIAMS, Simon F. ,  RIZK, Said ,  MARTIN, David P. ,  LIMEM, Skander ,  GUO, Kai ,  LOPEZ, German Oswaldo Hohl ,  GANATRA, Amit

    IPC: A61L17/00 ,  A61L17/06 ,  A61L17/10 ,  A61L27/18 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58

    Abstract: Resorbable implants, coverings and receptacles comprising poly(butylene succinate) and copolymers thereof have been developed. The implants are preferably sterilized, and contain less than 20 endotoxin units per device as determined by the limulus amebocyte lysate (LAL) assay, and are particularly suitable for use in procedures where prolonged strength retention is necessary, and can include one or more bioactive agents. The implants may be made from fibers and meshes of poly(butylene succinate) and copolymers thereof, or by 3d printing molding, pultrusion or other melt or solvent processing method. The implants, or the fibers preset therein, may be oriented.. These coverings and receptacles may be used to hold, or partially/fully cover, devices such as pacemakers and neurostimulators. The coverings, receptacles and implants described herein, may be made from meshes, webs, lattices, non-wovens, films, fibers, foams, molded, pultruded, machined and 3D printed forms.

    METHODS OF MANUFACTURING MESH SUTURES FROM POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF
    6.
    发明申请
    METHODS OF MANUFACTURING MESH SUTURES FROM POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF 审中-公开

    公开(公告)号：WO2020092065A1

    公开(公告)日：2020-05-07

    申请号：PCT/US2019/057441

    申请日：2019-10-22

    Applicant: TEPHA, INC.

    Inventor： RIZK, Said ,  SHAH, Bhavin ,  GANATRA, Amit ,  LIMEM, Skander ,  MARTIN, David P. ,  WILLIAMS, Simon F.

    IPC: A61L17/00 ,  A61L17/10

    Abstract: Resorbable multifilament yarns and monofilament fibers including poly-4-hydroxybutyrate and copolymers thereof with high tenacity or high tensile strength have been developed. The yarns and fibers are produced by cold drawing the multifilament yarns and monofilament fibers before hot drawing the yarns and fibers under tension at temperatures above the melt temperature of the polymer or copolymer. These yarns and fibers have prolonged strength retention in vivo making them suitable for soft tissue repairs where high strength and strength retention is required. The multifilament yarns have tenacities higher than 8.1 grams per denier, and in vivo, retain at least 65% of their initial strength at 2 weeks. The monofilament fibers retain at least 50% of their initial strength at 4 weeks in vivo . The monofilament fibers have tensile strengths higher than 500 MPa. These yarns and fibers may be used to make various medical devices for various applications, including mesh sutures.

    HYBRID SUTURE WITH MONOFILAMENT AND BRAIDED CONSTRUCTION
    9.
    发明申请
    HYBRID SUTURE WITH MONOFILAMENT AND BRAIDED CONSTRUCTION 审中-公开
    混合与混合施工

    公开(公告)号：WO2015013385A1

    公开(公告)日：2015-01-29

    申请号：PCT/US2014/047780

    申请日：2014-07-23

    Applicant: ARTHREX, INC.

    Inventor： DREYFUSS, Peter J. ,  DOONEY, JR., Thomas

    IPC: A61L17/10

    CPC classification number: A61B17/06166 ,  A61L17/10 ,  A61L17/105 ,  A61L17/145

    Abstract: A hybrid monofilament/braided surgical suture that combines a monofilament with a braided construction. The hybrid surgical suture may be formed by braiding yarns of high tenacity fibers tightly over a core in the form of a monofilament yarn. The monofilament may be any type of material, for example, a nylon, silk, polyester, polyethylene or polypropylene filament, among many others. The stiffness properties of the hybrid surgical suture allow the suture to be pushed through small and very small diameter tubes and cannulations (such as Lasso instruments, for example) yet fix securely with existing fixation devices (such as knotless suture anchors).

    Abstract translation: 混合单丝/编织手术缝合线，将单丝与编织结构相结合。 可以通过将高韧性纤维的丝线紧密地编织在单丝纱线形式的芯上来形成混合手术缝合线。 单丝可以是任何类型的材料，例如尼龙，丝，聚酯，聚乙烯或聚丙烯丝等。 混合手术缝合线的刚度性质允许缝合线被推动穿过小而非常小直径的管和插管（例如Lasso仪器），但仍然与现有的固定装置（例如无缝缝合锚）固定固定。

    DUAL DIAMETER, DUAL DENSITY EPTFE SUTURE
    10.
    发明申请
    DUAL DIAMETER, DUAL DENSITY EPTFE SUTURE 审中-公开
    双直径，双密度EPTFE

    公开(公告)号：WO2014116780A1

    公开(公告)日：2014-07-31

    申请号：PCT/US2014/012662

    申请日：2014-01-23

    Applicant: GENESEE BIOMEDICAL, INC. ,  SHAEFERS, Hans-Joachim ,  PETERSON, Robyn ,  MATHISON, Woodrow G.

    Inventor： SHAEFERS, Hans-Joachim ,  PETERSON, Robyn

    IPC: A61F2/24 ,  A61L17/10 ,  A61B17/04

    CPC classification number: A61B17/06166 ,  A61B2017/00243 ,  A61B2017/00862 ,  A61B2017/06057 ,  A61B2017/0618 ,  A61F2/2442 ,  A61L17/10 ,  C08L27/18

    Abstract: A suture for use in cardiac valve repair comprises a flexible rod of ePTFE (expanded polytetrafluoroethylene) formed with end sections of a first diameter and a center section of a second diameter, the second diameter being greater than the first diameter, and the end sections having a length sufficient to enable one to be fastened to the other. In one embodiment, the first diameter is about 1-1.6 mm and the second diameter is between about 1.8-4 mm. The center section can be about 2-9 cm in length. Surgical needles are preferably provided attached to the distal ends of the end sections. The center section has a density less than the end sections, the density of the center section being chosen to promote tissue ingrowth following implantation in heart tissue. Representative density range for the center section is 0.25-0.35 g/cm 3 .

    Abstract translation: 用于心脏瓣膜修复的缝线包括形成有第一直径的端部部分和第二直径的中心部分的第二直径大于第一直径的ePTFE（膨胀聚四氟乙烯）的柔性杆，并且端部部分具有 足够使其能够紧固到另一个的长度。 在一个实施例中，第一直径为约1-1.6mm，第二直径为约1.8-4mm。 中心部分的长度可以约为2-9厘米。 手术针优选地设置在端部的远端附近。 中心部分的密度小于末端部分，中心部分的密度被选择为促进植入心脏组织后的组织向内生长。 中心部分的代表性密度范围为0.25-0.35g / cm3。

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