公开(公告)号：WO2018209211A1

公开(公告)日：2018-11-15

申请号：PCT/US2018/032286

申请日：2018-05-11

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： GEORGIOU, George ,  STONE, Everett ,  CRAMER, Shira

IPC: C12N9/88 ,  A61K38/51

CPC classification number: C12N9/88 ,  A61B17/225 ,  A61K9/0019 ,  A61K31/7076 ,  A61K38/00 ,  A61K38/16 ,  A61K38/38 ,  A61K38/51 ,  A61K45/06 ,  A61K47/60 ,  A61K47/61 ,  A61P35/00 ,  C07K14/001 ,  C07K14/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12Y404/01001 ,  A61K2300/00

Abstract: Methods and compositions related to the engineering of a protein with L-cyst(e)ine degrading enzyme activity are described. For example, disclosed are modified cystathionine- ϒ- lyases comprising one or more amino acid substitutions and capable of degrading L- cyst(e)ine. Furthermore, compositions and methods are provided for the treatment of cancer and cystinuria using the disclosed modified enzymes or nucleic acids encoding said enzymes.

公开(公告)号：WO2018045199A2

公开(公告)日：2018-03-08

申请号：PCT/US2017/049668

申请日：2017-08-31

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： TOMICH, John M. ,  REECK, Gerald ,  AVILA FLORES, Luz Adriana ,  CHANDRASEKAR, Raman

IPC: A01N57/08 ,  A01N25/00

CPC classification number: A01N25/006 ,  A01N25/08 ,  A01N25/12 ,  A01N57/08 ,  A61K9/5146 ,  A61K47/6455 ,  C07K7/02 ,  C07K14/001

Abstract: Described herein are nucleic acid-peptide capsule complexes or nanoparticles comprising pre-formed peptide capsules and nucleic acids bound the exterior surface of the capsule, such that the wrap around the capsule membrane. The peptide capsules comprise bilayer membrane defining a liquid-receiving interior space and comprises a plurality of branched, amphipathic peptides. Method of making and using such complexes for delivering nucleic acids in vivo and in vitro are also described.

Abstract translation: 本文描述了核酸 - 肽胶囊复合物或纳米颗粒，其包含预先形成的肽胶囊和结合胶囊外表面的核酸，使得包裹胶囊膜。 肽胶囊包含限定液体接收内部空间并包含多个分支的两亲性肽的双层膜。 还描述了制备和使用这种用于体内和体外递送核酸的复合物的方法。

公开(公告)号：WO2017177115A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/026564

申请日：2017-04-07

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： BHATIA, Sangeeta, N. ,  IRVINE, Darrell, J. ,  WITTRUP, Karl, Dane ,  WARREN, Andrew, David ,  DUDANI, Jaideep, S. ,  MEHTA, Naveen, K.

IPC: B82Y5/00 ,  A61K47/48 ,  A61K39/00 ,  C12Q1/37 ,  C07K7/00

CPC classification number: G01N33/5088 ,  B82Y5/00 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C07K2319/31 ,  C07K2319/50 ,  C12Q1/37 ,  G01N33/574 ,  G01N2333/96425

Abstract: In some aspects, the disclosure provides compositions and methods for detecting and monitoring the activity of proteases in vivo using affinity assays. The disclosure relates, in part, to the discovery that biomarker nanoparticles targeted to the lymph nodes of a subject are useful for the diagnosis and monitoring of certain medical conditions ( e.g. , metastatic cancer, infection with certain pathogenic agents).

Abstract translation: 在一些方面，本公开内容提供了使用亲和力测定来检测和监测体内蛋白酶活性的组合物和方法。 本公开内容部分涉及发现靶向受试者淋巴结的生物标志物纳米颗粒可用于诊断和监测某些医学病症（例如转移性癌症，用某些病原体感染 ）。

公开(公告)号：WO2017049009A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/052012

申请日：2016-09-15

Applicant: GENENTECH, INC. ,  F. HOFFMANN LA-ROCHE AG

Inventor： HANNOUSH, Rami ,  KALUARACHCHI, Harini ,  NILE, Aron ,  NOLAND, Cameron ,  ZHANG, Yingnan ,  ZHOU, Lijuan ,  GAO, Xinxin

IPC: C07K14/81 ,  A61K38/00 ,  C07K14/415 ,  C07K14/47

CPC classification number: C07K14/415 ,  A61K9/0051 ,  A61K9/5031 ,  A61K38/00 ,  A61K38/168 ,  A61K47/34 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/811 ,  C07K2319/70

Abstract: Provided are non-naturally occurring cystine knot peptides (CKPs) that bind to VEGF-A. Additionally, provided are methods of using non-naturally occurring CKPs that bind to VEGF-A, including diagnostic and therapeutic compositions and methods. Non-naturally CKPs that bind low density lipoprotein receptor-related protein 6 (LRP6) are also provided.

Abstract translation: 提供了结合VEGF-A的非天然存在的胱氨酸结多肽（CKP）。 另外，提供了使用结合VEGF-A的非天然存在的CKP的方法，包括诊断和治疗组合物和方法。 还提供了结合低密度脂蛋白受体相关蛋白6（LRP6）的非天然CKP。

公开(公告)号：WO2017037150A1

公开(公告)日：2017-03-09

申请号：PCT/EP2016/070568

申请日：2016-09-01

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UREKA SARL

Inventor： GUICHARD, Gilles ,  COLLIE, Gavin ,  PULKA-ZIACH, Karolina ,  LOMBARDO, Caterina ,  FREMAUX, Juliette

IPC: C07K7/02 ,  C08L75/02

CPC classification number: C07K7/02 ,  C07K14/001 ,  C08L75/02

Abstract: The present description provides compositions and methods for producing therapeutic oligomeric compounds. In another aspect the description provides methods for administering the oligomeric compounds for the treatment and prevention of disease in a mammal. In particular, the disclosure relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the disclosure may optionally be administered with at least one of a pharmaceutically acceptable excipient, additional pharmacologically active agent or a combination thereof.

Abstract translation: 本说明书提供了用于制备治疗性低聚化合物的组合物和方法。 在另一方面，本说明书提供了用于治疗和预防哺乳动物疾病的寡聚化合物的方法。 特别地，本公开涉及包含各种新型寡聚化合物及其药学上可接受的盐的药物。 本公开的化合物可以任选地与药学上可接受的赋形剂，额外的药理学活性剂或其组合中的至少一种一起施用。

公开(公告)号：WO2016209173A1

公开(公告)日：2016-12-29

申请号：PCT/SG2016/050291

申请日：2016-06-24

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： CHO, Nam-Joon ,  JACKMAN, Joshua Alexander

IPC: C07K7/08 ,  A61K38/04 ,  A61P31/00

CPC classification number: C07K14/001 ,  A01N25/04 ,  A01N47/44 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K38/00 ,  A61K47/60 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  C07K7/08 ,  C07K14/005 ,  C07K14/1833 ,  Y02A50/385

Abstract: Provided herein are anti-infective peptides and uses thereof, in one embodiment, provided herein is a peptide that is 16 to 26 amino acid residues in length and comprises the following amino acid sequence: X 1 X 2 SWLRDX 3 X 4 TX 5 LQSX 6 L, wherein X 1 is S or G or A; X 2 is S or G, X 3 is V or I, X 4 is W or L, X 5 is W, K, A or L and X 6 is W, K, L or A. The anti-infective peptides may comprise D amino acids, L amino acids or a combination thereof. In certain embodiments, the anti-infective peptides are peglyated, modified to include a hydrophilic polymer, stapled or iipidated. Also provided herein are compositions comprising the anti-infective peptides, and methods of treatment and disinfecting using the anti-infective peptides. The anti-infective peptides provided herein are useful against a broad spectrum of bacteria and viruses.

Abstract translation: 本文提供了抗感染肽及其用途，在一个实施方案中，本文提供了长度为16至26个氨基酸残基的肽，并且包含以下氨基酸序列：X1X2SWLRDX3X4TX5LQSX6L，其中X1为S或G或A; X2是S或G，X3是V或I，X4是W或L，X5是W，K，A或L，X6是W，K，L或A.抗感染肽可以包含D氨基酸，L 氨基酸或其组合。 在某些实施方案中，抗感染肽被PEG化，被修饰以包括亲水性聚合物，被缝合或脂质化。 本文还提供了包含抗感染肽的组合物，以及使用抗感染肽的治疗和消毒方法。 本文提供的抗感染肽可用于广谱的细菌和病毒。

公开(公告)号：WO2016161516A1

公开(公告)日：2016-10-13

申请号：PCT/CA2016/050403

申请日：2016-04-08

Applicant: FELDAN BIO INC.

Inventor： GUAY, David ,  DEL'GUIDICE, Thomas ,  LEPETIT-STOFFAES, Jean-Pascal

IPC: C07K19/00 ,  A61K47/48 ,  C07K14/00 ,  C07K7/06 ,  C07K7/08 ,  C12N5/07

CPC classification number: C07K14/001 ,  C07K14/00 ,  C07K2319/01 ,  C07K2319/10 ,  C07K2319/21 ,  C12N15/907 ,  C12N2501/60 ,  C12N2501/998

Abstract: The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target eukaryotic cells. More specifically, the present description relates to synthetic peptides and polypeptide-based shuttle agents comprising an endosome leakage domain (ELD) operably linked to a cell penetrating domain (CPD), or an ELD operably linked to a histidine-rich domain and a CPD. Compositions, kits, methods and uses relating to same are also described.

Abstract translation: 本说明书涉及可用于增加多肽货物对靶真核细胞的细胞溶质的转导效率的合成肽。 更具体地，本说明书涉及合成肽和基于多肽的穿梭剂，其包含可操作地连接到细胞穿透结构域（CPD）的内体渗漏结构域（ELD）或可操作地连接到富含组氨酸的结构域和CPD的ELD。 还描述了与其相关的组合物，试剂盒，方法和用途。

公开(公告)号：WO2016111971A1

公开(公告)日：2016-07-14

申请号：PCT/US2016/012124

申请日：2016-01-05

Applicant: ELI LILLY AND COMPANY

Inventor： ALSINA-FERNANDEZ, Jorge ,  BOKVIST, Bengt Krister ,  COSKUN, Tamer ,  CUMMINS, Robert Chadwick

IPC: C07K14/575 ,  C07K14/605 ,  A61K38/26

CPC classification number: A61K38/16 ,  A61K38/00 ,  A61K45/06 ,  C07K14/001 ,  C07K14/575 ,  C07K14/605

Abstract: The present invention relates to dual incretin peptide mimetic compounds that agonize receptors for both human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and may be useful for treating type 2 diabetes mellitus (T2D).

Abstract translation: 本发明涉及激动人葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1）的受体的双重肠促胰岛素肽模拟化合物，并且可用于治疗2型糖尿病（T2D） 。

公开(公告)号：WO2016054310A1

公开(公告)日：2016-04-07

申请号：PCT/US2015/053387

申请日：2015-10-01

Applicant: PLANT HEALTH CARE, INC.

Inventor： WEI, Zhongmin ,  ZORNETZER, Gregory, A. ,  BORNICK, Stephen

IPC: C12N15/82 ,  A61K38/00 ,  C12P21/06

CPC classification number: A01N37/46 ,  A01N25/02 ,  A01N25/12 ,  A01N37/22 ,  A01N43/36 ,  A01N43/54 ,  A01N43/90 ,  A01N47/44 ,  A01N51/00 ,  A01N63/00 ,  A01N63/02 ,  C07K7/08 ,  C07K14/001 ,  C07K14/195 ,  C07K14/24 ,  C07K14/27 ,  C07K14/415 ,  C07K2319/00 ,  C07K2319/20 ,  C12N15/8279 ,  C12N15/8283

Abstract: Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post- harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.

Abstract translation: 公开了显示改善的溶解度，稳定性，耐化学降解或这些性质的组合的过敏反应引发肽。 使用这些肽或融合多肽或编码其的DNA构建体来调节植物生物化学信号传导，赋予对植物的抗病性，增强植物生长，赋予生物胁迫的耐受性，赋予非生物胁迫耐受性和耐受性，赋予植物抗干旱性 还观察到从观赏植物中除去，对水果或蔬菜赋予收获后疾病或收获后的干燥抗性，或增加水果或蔬菜成熟度的寿命。

公开(公告)号：WO2015184100A2

公开(公告)日：2015-12-03

申请号：PCT/US2015/032897

申请日：2015-05-28

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

Inventor： GAVATHIOTIS, Evripidis

IPC: G01N33/574 ,  A61K38/16

CPC classification number: C07K14/001 ,  A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/474 ,  G01N33/502 ,  G01N33/574 ,  G01N33/68 ,  G01N2333/4703 ,  G01N2500/02 ,  G01N2500/04

Abstract: Methods are provided for identifying an agent that directly modulates a Bcl-2- associated x-protein (BAX) by promoting or disrupting dimerization of the BAX. Agents that directly modulate BAX by affecting dimerization are also provided.

Abstract translation: 提供了通过促进或破坏BAX二聚化来鉴定直接调节Bcl-2相关的x-蛋白（BAX）的药剂的方法。 还提供了通过影响二聚化来直接调节BAX的药剂。